CN105055576A - Compound traditional Chinese medicine for preventing and treating livestock and poultry colibacillosis and preparation method thereof - Google Patents
Compound traditional Chinese medicine for preventing and treating livestock and poultry colibacillosis and preparation method thereof Download PDFInfo
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- CN105055576A CN105055576A CN201510556822.2A CN201510556822A CN105055576A CN 105055576 A CN105055576 A CN 105055576A CN 201510556822 A CN201510556822 A CN 201510556822A CN 105055576 A CN105055576 A CN 105055576A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention provides a compound traditional Chinese medicine for preventing and treating livestock and poultry colibacillosis and a preparation method thereof, and belongs to traditional Chinese medicine technologies for livestock and poultry. According to theories of Chinese veterinarian and a medication needed scientific formula for dialectical treatment, the compound traditional Chinese medicine is characterized by consisting of six traditional Chinese medicines namely coptis root, dark plum fruit, medicine terminalia fruit, largehead atractylodes rhizome, milkvetch root and divaricate saposhnikovia root, and the preparation method comprises the steps of: decocting for extraction by using water, and removing impurities by virtue of the methods of filtration, centrifugation and the like to prepare oral liquid. When the compound traditional Chinese medicine is used for treating the livestock and poultry colibacillosis, the liquid is added with water to adjust the concentration to be 20.0mg/mL for drinking or pouring administration for ill livestock and poultry; and when the compound traditional Chinese medicine is used for preventing the livestock and poultry colibacillosis, the liquid is added with water to adjust the prevention concentration to be 2.0mg/mL for drinking or pouring administration for livestock and poultry. The effective rate of the compound traditional Chinese medicine for treating escherichia coli of calf diarrhea is 100%, and the cure rate reaches 100%. The effective rate of the compound traditional Chinese medicine for treating chicken colibacillosis white scours is 100%, and the cure rate reaches 90%. The prevention effective rate of the compound traditional Chinese medicine for treating calf and chicken colibacillosis is 100%. The compound traditional Chinese medicine oral liquid is a pure traditional Chinese medicine preparation, does not have toxic or side effects and residues, and has very good effects of preventing and treating the livestock and poultry colibacillosis.
Description
Technical field
The invention belongs to veterinary drug, relate generally to prescriptions of Chinese medicine and preparation method thereof.
Background technology
Colibacillosis is that a kind of common transmittable of various poultry is sick, although the chemicalses such as Antibiotics have good therapeutical effect to primary disease, but due to use antibiotics lack of standardization, escherichia coli are caused to produce drug resistance to some Antibiotics, amount of therapeutic continues to increase, cause the animal derived food such as meat, egg antibiotics to remain, human health is worked the mischief.Six-element Chinese medicine in this prescription is all from natural plants, and without any side effects to morbidity poultry body, noresidue in poultry body, does not also develop immunity to drugs, cheap.In vitro tests shows, this medicine has good inhibitory action to escherichia coli; In vivo test shows, the calf diarrhea that this medicine causes Escherichia coli and the white scour of chicken, having good therapeutical effect, can substituting antibiotics for preventing and treating poultry colibacillosis.
Summary of the invention
The present invention seeks to substitute antibiotics control poultry colibacillosis for developing Chinese medicine.This herbal mixture does not produce Resistant strain to escherichia coli, noresidue in poultry body and products thereof, promotes that aquaculture develops in a healthy way, for human lives provides safe animal foods.
The present invention realizes like this: according to the clinical main symptom of colibacillosis, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to traditional Chinese veterinary medicine is theoretical, utilize extracorporeal bacteria inhibitor test, filter out there is good fungistatic effect prescriptions of Chinese medicine by Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Radix Saposhnikoviae 5g, by water boiling and extraction active ingredient, remove impurity, prepare oral liquid.
Herbal mixture preparation method is as follows: (1) takes Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Radix Saposhnikoviae 5g in prescription, is mixed by above-mentioned Six-element Chinese medicine; (2) first time adds water after 400mL soaks 1h and decocts, after intense fire boils, and slow fire boiling 45min; Second time adds 250mL soak by water, after intense fire boils, and slow fire boiling 30min; (3) decoct medicinal liquid by twice to merge, utilize 8 layers of filtered through gauze, filtrate, with the centrifugal 10min of 3000r/min, is got supernatant, is abandoned precipitation; (4) utilize Rotary Evaporators by supernatant concentration to 32.5mL, preparing crude drug content is 2.0g/mL oral liquid.
This medicine side's principle processed: colibacillosis is common transmittable digestive tract disease, primary disease with diarrhoea, dehydration, exhaustion is for main clinic symptoms.According to the dialectical argumentation theory of traditional Chinese veterinary medicine, prescription should with heat clearing and damp drying, and relieving diarrhea with astringents, the loose wind that induces sweat, QI invigorating are the principles of formulating prescriptions.In side, Rhizoma Coptidis is heat clearing and damp drying, is monarch drug; Fructus Mume, Fructus Chebulae's relieving diarrhea with astringents are ministerial drug; The Rhizoma Atractylodis Macrocephalae, Radix Astragali spleen invigorating QI invigorating are adjuvant drug, and in addition, the Radix Astragali has the repair of promotion intestinal mucosal injury; Radix Saposhnikoviae has the loose wind that induces sweat, and can improve the heat clearing away effect of Rhizoma Coptidis, for making medicine.Six-element Chinese medicine use in conjunction, has good treatment and effect to poultry colibacillosis.
The present invention has the following advantages: in (1) animal foods, the chemical medicinal residue such as antibiotics is one of principal element endangering food safety at present, utilize Chinese medicine to substitute antibiotics control poultry colibacillosis, effectively can control the chemical drugss such as antibiotics residual in poultry body; (2) in livestock and poultry disease control and prevention, the abuse of antibiotics, easily produces Resistant strain, threatens human health, utilizes Chinese medicine to substitute antibiotics control poultry colibacillosis, can prevent the generation of escherichia coli Resistant strain; (3) chemical medicinal residue such as antibiotics in animal foods, easily causes allergic reaction after people is edible, threatens human health, utilize Chinese medicine to substitute antibiotics and can prevent anaphylaxis from producing; (4) clinical test results shows, this medical treatment poultry colibacillosis is evident in efficacy, effective percentage 100%, and cure rate reaches more than 90%; (5) the Six-element Chinese medicine in we is all conventional Chinese herbal medicine, cheap, is easy to apply.
Detailed description of the invention
Below embodiment of the present invention is described in detail.
Herbal mixture of a kind of prevention and therapy poultry colibacillosis and preparation method thereof, its prescription is made up of Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Radix Saposhnikoviae 5g Six-element Chinese medicine.
Herbal mixture of prevention and therapy poultry colibacillosis and preparation method thereof is as follows: (1) takes Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, a Radix Saposhnikoviae 5g, is mixed by above-mentioned Six-element Chinese medicine; (2) first time adds water after 400mL soaks 1h and decocts, after intense fire boils, and slow fire boiling 45min; Second time adds 250mL soak by water, after intense fire boils, and slow fire boiling 30min; (3) decoct medicinal liquid by twice to merge, utilize 8 layers of filtered through gauze, filtrate, with the centrifugal 10min of 3000r/min, is got supernatant, is abandoned precipitation; (4) utilize Rotary Evaporators by supernatant concentration to 32.5mL, preparing crude drug content is 2g/mL oral liquid.
The range of application of this medicine: to poultry colibacillosis have treatment and preventive effect, especially to calf and chickling colibacillosis effect more remarkable.
The using method of this medicine: when being used for the treatment of the diarrhoea that E.coli of calf causes, gavage crude drug content is 2.0g/mL oral liquid 15-25mL at every turn, and being used in conjunction 3-5 days can cure.When being used for the treatment of the Hakuri that chickling escherichia coli cause, be that to be watered preparation crude drug content be 20.0mg/mL to 2.0g/mL oral liquid by crude drug content, freely drink, being used in conjunction 3-5 days can cure.During for preventing chicken colibacillosis, being that to be watered preparation crude drug content be 2.0mg/mL to 2.0g/mL oral liquid by crude drug content, being used in conjunction 3 days, the generation of colibacillosis can be controlled.
Clinical efficacy: to E.coli of calf diarrhoea, effective percentage 100%, cure rate reaches 100%.Chickling escherichia coli Hakuri, effective percentage 100%, cure rate reaches 90%.In applying, this medicine all has significant curative effect to various serotype escherichia coli.
Toxicity or side effect: utilize white mice to do acute toxicity and long term toxicity test, result shows: herbal mixture oral liquid does not show any toxicity or side effect.
Hypersensitive test: utilize Cavia porcellus to do hypersensitive test, result shows: herbal mixture oral liquid does not have anaphylaxis.
Claims (2)
1. prevent and treat herbal mixture of poultry colibacillosis and preparation method thereof for one kind, it is characterized in that this prescription is made up of Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Radix Saposhnikoviae 5g.
2. a herbal mixture preparation method described in claim 1, is characterized in that: (1) takes Rhizoma Coptidis 10g, Fructus Mume 15g, Fructus Chebulae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Radix Saposhnikoviae 5g in prescription, is mixed by above-mentioned Six-element Chinese medicine; (2) first time adds water after 400mL soaks 1h and decocts, after intense fire boils, and slow fire boiling 45min; Second time adds 250mL soak by water, after intense fire boils, and slow fire boiling 30min; (3) decoct medicinal liquid by twice to merge, utilize 8 layers of filtered through gauze, filtrate, with the centrifugal 10min of 3000r/min, is got supernatant, is abandoned precipitation; (4) utilize Rotary Evaporators by supernatant concentration to 32.5mL, preparing crude drug content is 2g/mL oral liquid.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477173A (en) * | 2016-01-28 | 2016-04-13 | 张慧 | Medicine for bee colibacillosis |
| CN107184875A (en) * | 2017-05-19 | 2017-09-22 | 信阳农林学院 | A kind of antibacterial Chinese medicine for veterinary use preparation |
| CN109480088A (en) * | 2018-12-14 | 2019-03-19 | 河北维尔利动物药业集团有限公司 | It is a kind of prevent and treat Chinese ephedra chicken escherichia coli infection nutrition peck brick and preparation method thereof |
| CN112603942A (en) * | 2021-01-13 | 2021-04-06 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine compound for treating calf gastrointestinal diseases and preparation method and application thereof |
| CN112618600A (en) * | 2021-01-13 | 2021-04-09 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine compound for treating calf gastrointestinal diseases and preparation method thereof |
| CN113018411A (en) * | 2021-04-26 | 2021-06-25 | 文仕元 | Traditional Chinese medicine formula for treating viral diarrhea and yellow and white dysentery of suckling-period piglets and preparation and using methods thereof |
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| CN102429967A (en) * | 2011-12-29 | 2012-05-02 | 甘肃农业大学 | Traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry and application thereof |
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- 2015-09-02 CN CN201510556822.2A patent/CN105055576A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102429967A (en) * | 2011-12-29 | 2012-05-02 | 甘肃农业大学 | Traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477173A (en) * | 2016-01-28 | 2016-04-13 | 张慧 | Medicine for bee colibacillosis |
| CN107184875A (en) * | 2017-05-19 | 2017-09-22 | 信阳农林学院 | A kind of antibacterial Chinese medicine for veterinary use preparation |
| CN109480088A (en) * | 2018-12-14 | 2019-03-19 | 河北维尔利动物药业集团有限公司 | It is a kind of prevent and treat Chinese ephedra chicken escherichia coli infection nutrition peck brick and preparation method thereof |
| CN112603942A (en) * | 2021-01-13 | 2021-04-06 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine compound for treating calf gastrointestinal diseases and preparation method and application thereof |
| CN112618600A (en) * | 2021-01-13 | 2021-04-09 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine compound for treating calf gastrointestinal diseases and preparation method thereof |
| CN113018411A (en) * | 2021-04-26 | 2021-06-25 | 文仕元 | Traditional Chinese medicine formula for treating viral diarrhea and yellow and white dysentery of suckling-period piglets and preparation and using methods thereof |
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Application publication date: 20151118 |
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