CN105055558A - Traditional Chinese medicine combination for treating gout - Google Patents

Traditional Chinese medicine combination for treating gout Download PDF

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Publication number
CN105055558A
CN105055558A CN201510432558.1A CN201510432558A CN105055558A CN 105055558 A CN105055558 A CN 105055558A CN 201510432558 A CN201510432558 A CN 201510432558A CN 105055558 A CN105055558 A CN 105055558A
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chinese medicine
gout
traditional chinese
herba
medicine combination
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刘向荣
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Abstract

The invention discloses a traditional Chinese medicine combination for treating gout. The traditional Chinese medicine combination is tablets which are prepared by, by weight, 120g of common clubmoss herb, 100g of pangolin, 80g of clematis root, 80g of Chinese hydrangea vine rhizome, 60g of scandent schefflera stem and leaf, 80g of Chinese dicliptera herb, 100g of garden balsam stem, 80g of incised notopterygium rhizome and 60g of diamond grass. The traditional Chinese medicine combination is accurate in treatment effect, convenient to use, safe, painless and free of toxic and side effect, forming of uric acid can be inhibited, blood circulation can be promoted, human immunity can be enhanced, and the objective of treating both symptoms and root causes is achieved.

Description

A kind of Chinese medicine composition for the treatment of gout
Technical field
The application relates to a kind of Chinese medicine composition, particularly relates to a kind of Chinese medicine composition for the treatment of gout.
Background technology
The present invention is application number 201410048940.8, February 8 2014 applying date, a kind of divisional application for the treatment of the Chinese medicine composition of gout of denomination of invention.Gout is that purine metabolic disturbance causes uric acid to synthesize to increase and the metabolic disease that causes.Also uric acid level can be caused to rise because the uric acid clearance of kidney declines during renal dysfunction.Uric acid in blood plasma reaches capacity, and causes monosodium urate crystallization deposition relatively to lack in the tissue of blood vessel around distal joint.The appearance of this crystallization can cause simple joint or multiarticulate acute inflammation synovitis gout comparatively common in male, big toe is modal affected area, and 50% ~ 70% first attack betides this.Metatarsophalangeal joint can be there is and get involved in the patient with gout of 90% in its certain period in life.Other foot area that may get involved have dorsal portion, heel and ankle.Except involving joint, uric acid crystal can also be deposited on subcutaneous, is referred to as tophus.Up to the present, gout there is no the method for radical cure, multiplex steroidal anti-inflammatory drugs, glucocorticoid, allopurinol, colchicine etc. clinically, this quasi drugs energy rapid pain relief, but also cure the symptoms, not the disease, this quasi drugs toxic and side effects is comparatively large simultaneously, and long-term taking, has detrimental effect to human gastrointestinal tract, hepatic and renal function.Also disclose the Chinese medicine composition of some treatment gouts in prior art, but actual effect is not good as expected.
Summary of the invention
Based on the defect of prior art, the object of the present invention is to provide a kind of Chinese medicine composition and system thereof for the treatment of gout
Preparation Method, easy to use, safe no pain, has no side effect, and uric acid can be suppressed to be formed, blood circulation promoting, strengthens immunity of human body itself, reaches the object for the treatment of both the principal and secondary aspects of a disease.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for gout, make tablet by the crude drug of following weight portion: Herba Lycopodii 100g, Squama Manis 80g, Radix Clematidis 80g, Cortex schizophragmatis integrifolii radicis 80g, Ramulus et Folium Tupidanthi celyptrati 60g, Herba Diclipterae Chinensis 80g, Herba speranskiae tuberculatae 100g, Rhizoma Et Radix Notopterygii 80g, diamond grass 60g.
Treat a Chinese medicine composition for gout, be made up of the crude drug of following weight portion: Herba Lycopodii 10-15 part, Squama Manis 8-12 part, Radix Clematidis 5-8 part, Cortex schizophragmatis integrifolii radicis 5-8 part, Ramulus et Folium Tupidanthi celyptrati 5-8 part, Herba Diclipterae Chinensis 5-10 part, Herba speranskiae tuberculatae 8-12 part, Rhizoma Et Radix Notopterygii 5-8 part, diamond grass 5-8 part.
Preferably, be made up of the crude drug of following weight portion: Herba Lycopodii 10-12 part, Squama Manis 8-10 part, Radix Clematidis 6-8 part, Cortex schizophragmatis integrifolii radicis 6-8 part, Ramulus et Folium Tupidanthi celyptrati 6-8 part, Herba Diclipterae Chinensis 6-10 part, Herba speranskiae tuberculatae 8-10 part, Rhizoma Et Radix Notopterygii 6-8 part, diamond grass 6-8 part.
More preferably, be made up of the crude drug of following weight portion: Herba Lycopodii 10 parts, celestial 6 parts of Squama Manis 8 parts of prestige fruits, Cortex schizophragmatis integrifolii radicis 6 parts, Ramulus et Folium Tupidanthi celyptrati 8 parts, Herba Diclipterae Chinensis 10 parts, Herba speranskiae tuberculatae 9 parts, Rhizoma Et Radix Notopterygii 6 parts, diamond grass 8 parts.
Or more preferably, Herba Lycopodii 12 parts, Squama Manis 10 parts, Radix Clematidis 8 parts, Cortex schizophragmatis integrifolii radicis 8 parts, Ramulus et Folium Tupidanthi celyptrati 6 parts, Canis famililiaris L.
Dish 8 parts, Herba speranskiae tuberculatae 10 parts, Rhizoma Et Radix Notopterygii 8 parts, diamond grass 6 parts.
The present invention treats the preparation method of the Chinese medicine composition of gout, comprises the steps: to take each component, pulverizes, soaks 2 hours, decocts 10-20 minute, filters, and filtrate concentrates, cooling; In concentrated solution, add ethanol, leave standstill 24 hours, filter, concentration and recovery ethanol, obtains extractum; Add suitable adjuvant, preparation pharmacy can accept dosage form.
Pharmaceutical composition of the present invention is wherein containing active constituents of medicine 0.1-1000mg, and all the other are pharmaceutically acceptable carrier.Pharmaceutical composition of the present invention, wherein active constituents of medicine can be the 0.1-99.9% of composition total weight by weight percentage, and all the other are pharmaceutically acceptable carrier.
Pharmaceutical composition of the present invention, wherein, described pharmaceutically acceptable carrier includes but not limited to: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonic acid of monovalence
Salt, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate, vegetable oil: soybean oil, midchain oil, olive oil, Oleum Camelliae, Petiolus Trachycarpi oil, Radix Angelicae Sinensis oil, Oleum Hippophae, Oleum Curcumae, Rhizoma Chuanxiong oil, pearl barley oil, safflower oil, Fructus Zanthoxyli oil, Oleum Bulbus Allii, phospholipid: Ovum Gallus domesticus Flavus lecithin, soybean phospholipid, hydrogenated yolk lecithin, hydrogenated soya phosphatide, synthetic phospholipid Polyethylene Glycol phospholipid or derivatives thereof, be selected from: Polyethylene Glycol-cephalin or derivatives thereof, PEG-CHOL or derivatives thereof, Polyethylene Glycol-two-fatty glyceride or derivatives thereof, Polyethylene Glycol-fatty acid ester or derivatives thereof, Polyethylene Glycol-fatty amine or derivatives thereof, Polyethylene Glycol-fatty alcohol or derivatives thereof and the Polyethylene Glycol phospholipid derivative containing fat-soluble macromolecule fragment, oleic acid or oleate, be selected from: oleic acid, oleic acid potassium salt, Oleic acid sodium salt, antioxidant: vitamin E, sodium sulfite, sodium thiosulfate, vitamin C, control the chelating agent of cation concn, be selected from: EDTA or other ionic complexing agent.
Pharmaceutical composition of the present invention, can exist in the form of a pharmaceutical preparation, can be the pharmaceutical dosage forms that any one can be taken, as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop, drop pill or patch.The preferred decoction of Chinese medicine composition of the present invention, powder, electuary, granule, tablet, capsule or injection.
Pharmaceutical composition of the present invention in use according to the situation determination usage and dosage of patient, as 2-3 time on the one.
Detailed description of the invention
The pharmacy below enumerating several pharmaceutical composition of the present invention can accept the preparation method of preparation, is understandable that,
Embodiment 1-4 is only used to the citing that technical solution of the present invention is described, not represent pharmaceutical composition of the present invention and only can prepare following several dosage form, those skilled in the art can use the practical situation of ordinary skill in the art means and patient to select
Select and prepare suitable dosage form.
Embodiment 1: decoction
Herba Lycopodii 30g, Squama Manis 24g, Radix Clematidis 18g, Cortex schizophragmatis integrifolii radicis 18g, Ramulus et Folium Tupidanthi celyptrati 24g, Herba Diclipterae Chinensis 30g, Herba speranskiae tuberculatae
27g, Rhizoma Et Radix Notopterygii 18g, diamond grass 24g.Pulverize, soak 2 hours, decoct 10-20 minute, filter, three times on the one.
Embodiment 2: granule
Herba Lycopodii 120g, Squama Manis 100g, Radix Clematidis 80g, Cortex schizophragmatis integrifolii radicis 80g, Ramulus et Folium Tupidanthi celyptrati 60g, Herba Diclipterae Chinensis 80g are deep
Grass 100g, Rhizoma Et Radix Notopterygii 80g, diamond grass 60g.Pulverize, soak 2 hours, decoct 10-20 minute, filter, filtrate concentrates,
Cooling; In concentrated solution, add ethanol, leave standstill 24 hours, filter, concentration and recovery ethanol, obtains extractum; 200g extractum is mixed homogeneously with mannitol 200g, starch 60g, granulates with 12 order stainless steel meshs on granulation machine, boiled bed drying, 12 mesh sieve granulate, subpackage.
Embodiment 3: tablet
Herba Lycopodii 100g, Squama Manis 80g, Radix Clematidis 80g, Cortex schizophragmatis integrifolii radicis 80g, Ramulus et Folium Tupidanthi celyptrati 60g, Herba Diclipterae Chinensis 80g, Herba speranskiae tuberculatae 100g, Rhizoma Et Radix Notopterygii 80g, diamond grass 60g.Pulverize, soak 2 hours, decoct 10-20 minute, filter, filtrate concentrates, cold
But; In concentrated solution, add ethanol, leave standstill 24 hours, filter, concentration and recovery ethanol, obtains extractum: continue concentrated, spraying dry; Add lactose 200g, mix homogeneously; Granulate, dry, tabletting, subpackage.
Effect example
Zoopery: Rats Wistar 60 is male entirely, body weight 200 ± 15g.Rat is divided into 6 groups at random, is respectively blank group, arthritis model group, the high, medium and low and western medicine group of Chinese medicine, often organize 10.
Experimental drug: Chinese drug-treated group: embodiment 1 decoction is concentrated into the decocting liquid of 7.5g/ml; Western medicine group: colchicine, is mixed with the solution of concentration 0.03mg/ml.
Experimental procedure: 60 rats are normally raised and start administration in 1 week, blank group is conventional raises, Chinese medicine high, normal, basic (7.2,3.6, the each 2ml of 1.8g/ml)+adenine, Western medicine administration group: each 2ml of colchicine+adenine, model group: each 2ml of normal saline+adenine, blank group normal saline 2ml, is gavage.The 2-4 days same first days of gavage.5th day gastric infusion 30min
After at the right ankle joint dorsal part of each Mus, insert articulatio tibiotarsalis intracavity from 45 degree of directions, injection 0.2mlMSU suspension; 6th, 7 days
Administration was with the 5th day.30min after administration in 7th day, chloral hydrate anesthesia, carotid artery gets blood, gets ankle joint synovial membrane group after execution
Knit, prepare serum and tissue homogenate, preserve to be measured.
Experimental result is as table 1
* P<0.01, compared with model group
Be not difficult to find out from above table, the impact on IL-8 and TNF level in joint fluid: compare with blank group, IL-8 and the TNF level of model group is increased significantly (P<0.01), and this test modeling success is described; Compare with model group, in colchicine group, Chinese medicine high dose group, Chinese medicine, the IL-8 level of dosage group all has obvious decline (P<0.01), the not statistically significant of Chinese medicine low dose group, though Chinese medicine senior middle school two dosage groups are without significant difference, also there is dose-effect relationship (in high dose > dosage).
Clinical case
Diagnostic criteria and include mark in: basic at present adopt American Rheumatism Association's gouty arthritis in 1977 to examine both at home and abroad
Disconnected standard.
Exclusion standard: have serious Liver and kidney function obstacle person, with the patient such as rheumatoid arthritis, rheumatic arthritis,
Do not judge curative effect person completely without method by regulation medication or data.
Physical data: observe case 116 example, man 66 example, female 50 example; Minimum 20 years old, maximum 82 years old; Wherein sole of the foot toe
Joint 45 example, ankle joint 15 example, knee joint 21 example, shoulder joint 10 example, elbow joint 12 example, carpal joint 13 example.The shortest person of the course of disease 5 days, most elder 40 years.The decoction giving medicine embodiment 1 is taken, and within 7 days, is a course for the treatment of, continuous 1-3 course for the treatment of.
Curative effect is passed judgment on: recovery from illness: clinical symptom disappearance after treatment, blood test uric acid index is down to normally.Effective: clinical symptom disappearance after treatment, but blood test uric acid index is not down to normally.Invalid: after treatment, clinical symptoms and blood uric acid index are without any change.
Therapeutic outcome: recovery from illness 78 example, accounts for 67.2%; Effective 38 examples, account for 32.8%; Invalid 0 example.
It should be noted that above-described embodiment is only for example of the present invention is clearly described, and be not limitation of the invention.For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description.And thus the apparent change of amplifying out or variation be still among protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for gout, it is characterized in that, make tablet by the crude drug of following weight portion: Herba Lycopodii 100g, Squama Manis 80g, Radix Clematidis 80g, Cortex schizophragmatis integrifolii radicis 80g, Ramulus et Folium Tupidanthi celyptrati 60g, Herba Diclipterae Chinensis 80g, Herba speranskiae tuberculatae 100g, Rhizoma Et Radix Notopterygii 80g, diamond grass 60g.
2. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that, comprise the steps: to take each component, pulverizes, soaks 2 hours, decocts 10-20 minute, filters, and filtrate concentrates, cooling; In concentrated solution, add ethanol, leave standstill 24 hours, filter, concentration and recovery ethanol, obtains extractum: continue concentrated, spraying dry; Add lactose 200g, mix homogeneously; Granulate, dry, tabletting, subpackage.
3. pharmaceutical composition is preparing the purposes in the medicine or health product for the treatment of gout as claimed in claim 1.
CN201510432558.1A 2014-02-08 2014-02-08 Traditional Chinese medicine combination for treating gout Pending CN105055558A (en)

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CN201510432558.1A Pending CN105055558A (en) 2014-02-08 2014-02-08 Traditional Chinese medicine combination for treating gout
CN201410048940.8A Active CN103830363B (en) 2014-02-08 2014-02-08 A kind of Chinese medicine composition for the treatment of gout
CN201510601830.4A Pending CN105125660A (en) 2014-02-08 2014-02-08 Traditional Chinese medicine composition, preparation method and health product prepared from traditional Chinese medicine composition
CN201510433984.7A Pending CN104958382A (en) 2014-02-08 2014-02-08 Traditional Chinese medicine composition for treating gout
CN201510525586.8A Withdrawn CN106806438A (en) 2014-02-08 2014-02-08 A kind of Chinese medicinal composition granules for treating gout
CN201510525596.1A Withdrawn CN106619856A (en) 2014-02-08 2014-02-08 Gout treating traditional Chinese medicine composition tablet
CN201510433972.4A Pending CN104958381A (en) 2014-02-08 2014-02-08 Traditional Chinese medicine composition for treating gout
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CN105943655A (en) * 2016-05-04 2016-09-21 昆明理工大学 Compound ointment for treating hemorrhoids and preparation method of compound ointment
CN106309557A (en) * 2016-11-11 2017-01-11 郭仕玖 Traditional Chinese medicine composition for treating gout and preparation method of composition
CN107184812A (en) * 2017-05-26 2017-09-22 严跃华 A kind of antipodagric Chinese prescription of toxin expelling kidney tonifying dampness removing and its preparation
CN114949067B (en) * 2022-05-27 2024-04-19 南方医科大学 Application of zanthoxylum oil in preparing medicine for preventing and/or treating hyperuricemia

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CN103830363B (en) 2015-08-26
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CN105125660A (en) 2015-12-09
CN105106717A (en) 2015-12-02
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CN103830363A (en) 2014-06-04
CN104958382A (en) 2015-10-07

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