CN105055365A - Process for manufacturing pullulan hollow capsules - Google Patents
Process for manufacturing pullulan hollow capsules Download PDFInfo
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- CN105055365A CN105055365A CN201510466717.XA CN201510466717A CN105055365A CN 105055365 A CN105055365 A CN 105055365A CN 201510466717 A CN201510466717 A CN 201510466717A CN 105055365 A CN105055365 A CN 105055365A
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- China
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- pullulan
- pulullan polysaccharide
- liquor
- celsius
- glue
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Abstract
The invention relates to a process for manufacturing pullulan hollow capsules. The process is characterized by comprising process steps of 1), selecting pullulan with the viscosity of 3-15 centipoise, adding the pullulan into hot water with the temperature of 40-80 Celsius degrees to prepare pullulan liquor with the weight concentration of 20-25%, uniformly stirring the pullulan liquor, preserving heat of the pullulan liquor, allowing the pullulan liquor to stand still and removing bubble; 2), arranging the prepared pullulan liquor in glue tanks of hollow capsule production lines, and dipping glue under the condition that the temperatures of molds range from minus 40 Celsius degrees to 0 Celsius degree under the control; 3), regulating the temperature of setting wind within intervals ranging from minus 40 Celsius degrees to 0 Celsius degree so as to prevent membranes formed by the pullulan liquor from flowing on the molds until the shapes of the membranes are fixed; 4), drying, cutting and sleeving the membranes and warehousing finished products. The process has the advantages that gel is omitted in production procedures, and accordingly the process is high in safety, drying speed and production efficiency.
Description
Technical field
The present invention relates to a kind of processing technology of pulullan polysaccharide empty capsule, belong to medicinal hollow capsule manufacture technology field.
Background technology
Gelatin hollow capsule (Emptycapsule): add by pharmagel cap that adjuvant is made, body two saves capsule shells and form.Be mainly used in splendid attire solid drugs.As made powder, health product, medicament etc. by oneself, for user solves the problem of difficult entrance, mouthfeel difference, really achieve good medicine no longer bitter to the taste.Capsules is more and more welcome, first the elongate form of capsule, is easy to swallow, and is dosage form most popular with consumers; In addition, what capsule can cover content very effectively makes us uncomfortable taste and abnormal smells from the patient.The size of capsule has varied, comprises No. 00 lengthening, No. 00, No. 0, No. 1, No. 2, No. 3, No. 4 and No. 5 capsules.Capsule also can stamp word, trade mark and pattern, present unique customization outward appearance.
Pulullan polysaccharide (Pullulan) is a kind of outer water solublity cement polysaccharide of born of the same parents of fermented by Aureobasidium pullulans produced similar glucosan, xanthan gum.This polysaccharide is by the maltotriose recurring unit of α-Isosorbide-5-Nitrae glycosidic bond connection through α-1, the straight-chain polysaccharide that 6 glycosidic bonds are polymerized, molecular weight 20,000 ~ 2,000,000, the degree of polymerization 100 ~ 5000.(general merchandise molecular weight is about 200,000. be approximately made up of 480 maltotrioses).This polysaccharide has two important characteristics: high resilience in structure, dissolubility is larger.The film property of pulullan polysaccharide, gas barrier property, plasticity, viscosity are all comparatively strong, and have the good characteristics such as soluble in water, nontoxic, colorless and odorless, have been widely used in the fields such as medicine, food, light industry, chemical industry and oil.On May 19th, 2006. health ministry has issued No. 8 bulletin, and pulullan polysaccharide is one of newly-increased four kinds of food additive products, can be used as fruit glaze agent and thickening agent in confection, chocolate-coated, diaphragm, complex flavor section and fruit-vegetable juice beverage.
Pulullan polysaccharide empty capsule: refer to the Capsules that uses pulullan polysaccharide to be main material production is one of main at present plant hollow capsule.
Existing pulullan polysaccharide empty capsule manufacturing techniques: the production process of existing Capsules, formed after utilizing mould to dip in glue, sizing, drying, cutting, fit in glue, because mould is barrel-like structure, as liquid pectin can not fast shaping on mould, glue will trickle, and causes producing unsuccessfully.
The gelatin itself that traditional gelatin hollow capsule uses has the characteristic of gel.That is gelatin glue below 40 degrees Celsius in, the strand of gelatin is wound around mutually from disordered state, forms network structure, thus is formed with the immobilising similar g., jelly-like of elasticity and is called gel, and gelatine capsule is exactly utilize this characteristic of gelatin to produce.
Pulullan polysaccharide empty capsule is one of Capsules of the plant origin that consumption is maximum in the world at present.Pulullan polysaccharide because itself not there is gel-type, so when configuration pulullan polysaccharide glue, need to add gel or the composite material of gel.Its production procedure is as accompanying drawing 1.Because gel is generally high viscosity colloid, has a strong impact on the concentration of glue, caused production efficiency to decline.Gel huge number, capsule contents species is huger, and gellant and capsule 's content may react, and cause the potential risk of safety.
Explanation of nouns:
1. dip in glue: refer to and immerse in glue by hollow capsule mold, make glue stick to the process of molding on mould.
2. gel or gellant: refer to that a class is at high temperature liquid, freeze after the cooling period and become the material of immobilising similar g., jelly-like, mainly comprise gelatin (Gelatin), agar (Agar-Agar), carrageenan (Carrageenan), gellan gum (GellanGum) etc. in pharmacy and food service industry.
Summary of the invention
The object of this invention is to provide in a kind of production process and do not add gel, the processing technology of safety is high, rate of drying is fast, production efficiency is high pulullan polysaccharide empty capsule.
Processing step of the present invention is as follows:
1) viscosity is selected to be 50-180mm
2the pulullan polysaccharide of/s, adding temperature is the pulullan polysaccharide solution that the hot water of 40 ~ 80 degrees Celsius is configured to by weight densitometer 20 ~ 25%, stirs, is incubated, leaves standstill removing bubble;
2) be put in hollow capsule production line glue groove by the pulullan polysaccharide solution of configuration, mold temperature controls to carry out dipping in glue between subzero 40 ~ 0 degrees Celsius;
3) 40 degrees below zero to 0 Celsius spends the interval interior temperature regulating sizing wind, and the film that pulullan polysaccharide solution is formed can not trickle on mould, until shape is fixed;
4) drying, cutting, fit, finished product warehouse-in.
Holding temperature described in step 1 is not less than 20 degrees Celsius.
Do not use gel in step 2, utilize the principle sizing that in glue, water freezes below 0 degree Celsius.
The principle that step 3 utilizes water can directly distil below 0 degree Celsius is dry.
Advantage of the present invention is as follows:
The present invention abandons in traditional production technology and gel must be utilized to make the characteristic of colloidal gel, but utilize the characteristic that water freezes below 0 degree Celsius, do not need in production process to add gel, the sublimation of water is utilized in the process of sizing, shape below 0 degree Celsius, have the following advantages:
1, the present invention eliminates when producing plant hollow capsule and adds gel or the composite unsafe factor that may cause of gel.When capsule filling content, as long as compatibility safety between experiment pulullan polysaccharide and content, do not need the compatibility safety of testing gel and the content added, add the convenience of use, improve safety.
2, because traditional pulullan polysaccharide empty capsule gel viscosity of adding in the process of producing is all higher, the serious concentration that have impact on glue, causes dry difficulty, the present invention does not add gel, the concentration of glue can be increased, improve rate of drying, thus improve production efficiency.
Accompanying drawing explanation
Fig. 1 is existing pulullan polysaccharide empty capsule manufacturing techniques figure;
Fig. 2 is production technology figure of the present invention.
Detailed description of the invention
Embodiment 1:
20 kilograms of viscosity of weighing are 50mm
2/ s pulullan polysaccharide, adds the deionized water that 60 kilograms of temperature are 60 degrees Celsius, and stirring to leave standstill becomes the glue that uniform concentrations by weight is 25%, dips in glue, use the temperature of subzero 10 degrees Celsius to carry out drying with the mould that temperature is subzero 14 degree Celsius.The sample obtained is example 1.
Through practical measurement, pulullan polysaccharide capsule thickness meets the thickness of pulullan polysaccharide capsule, because China does not have the standard of pulullan polysaccharide at present, tests, all reach requirement according to the standard of " Chinese Pharmacopoeia " gelatin hollow capsule.
Embodiment 2:
20 kilograms of viscosity of weighing are 180mm
2the pulullan polysaccharide of/s, add 80 kilograms of temperature be 60 degrees Celsius remove example water, stir leave standstill, being configured to concentrations by weight is 20% pulullan polysaccharide solution.
The mould setting subzero 35 degrees Celsius dips in glue, regulate between subzero 30 degree to 40 degree Celsius according to the thickness requirement of Capsules when controlling Capsules thickness, use minus 20 degrees temperature Celsius to carry out drying, the sample obtained is example 2, according to standard testing, all reach requirement.
Embodiment 3:
The 20 kilograms of viscosity of weighing of weighing 20 kilograms are 100mm
2the pulullan polysaccharide of/s, adds the deionized water that 60 kilograms of temperature are 40 degrees Celsius, stirs and leaves standstill, become the glue that uniform concentrations by weight is 25%, dip in glue with the mould that temperature is subzero 5 degree Celsius, uses the temperature of subzero 30 degrees Celsius of setting to carry out drying.Required thickness according to capsule regulates between minus 20 degrees Celsius to 40 degrees below zero, and the sample obtained is embodiment 3, according to standard testing, reaches requirement.
Analyze and compare with embodiment 1, solution concentration is identical, although mold temperature increases, baking temperature is lower, successfully counteract the heat effect of pulullan polysaccharide solution to mould, standard compliant pulullan polysaccharide empty capsule product can be produced equally.
Meanwhile, we reach a conclusion, and use the deionized water dissolving pulullan polysaccharide of 40 degrees Celsius, can obtain uniform pulullan polysaccharide solution equally, but the time of removing required for bubble is long.
Embodiment 4:
20 kilograms of viscosity of weighing are 180mm
2the pulullan polysaccharide of/s, add 80 kilograms of temperature be 60 degrees Celsius remove example water, stir leave standstill, being configured to concentrations by weight is 20% pulullan polysaccharide solution.
The mould of setting zero degrees celsius dips in glue, regulates, because pulullan polysaccharide solution trickles on mould, can not shape, the failure of an experiment when controlling Capsules thickness according to the thickness requirement of Capsules between subzero 40 to 45 degree Celsius.
Conclusion: according to embodiment 1, example 2, example 3, all can produce and meet Pharmacopoeia of the People's Republic of China standard, and meets the pulullan polysaccharide empty capsule of client's instructions for use thickness.
Claims (4)
1. a processing technology for pulullan polysaccharide empty capsule, is characterized in that: processing step is as follows:
1) viscosity is selected to be 50-180mm
2the pulullan polysaccharide of/s, adding temperature is the pulullan polysaccharide solution that the hot water of 40 ~ 80 degrees Celsius is configured to by weight densitometer 20 ~ 25%, stirs, is incubated, leaves standstill removing bubble;
2) be put in hollow capsule production line glue groove by the pulullan polysaccharide solution of configuration, mold temperature controls to carry out dipping in glue between subzero 40 ~ 0 degrees Celsius;
3) 40 degrees below zero to 0 Celsius spends the interval interior temperature regulating sizing wind, and the film that pulullan polysaccharide solution is formed can not trickle on mould, until shape is fixed;
4) drying, cutting, fit, finished product warehouse-in.
2. the processing technology of pulullan polysaccharide empty capsule according to claim 1, is characterized in that: the holding temperature described in step 1 is not less than 20 degrees Celsius.
3. the processing technology of pulullan polysaccharide empty capsule according to claim 1, is characterized in that: do not use gel in step 2, utilizes the principle sizing that in glue, water freezes below 0 degree Celsius.
4. the processing technology of pulullan polysaccharide empty capsule according to claim 1, is characterized in that: the principle that step 3 utilizes water can directly distil below 0 degree Celsius is dry.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510466717.XA CN105055365B (en) | 2015-07-31 | 2015-07-31 | A kind of manufacture craft of pulullan polysaccharide empty capsule |
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| CN201510466717.XA CN105055365B (en) | 2015-07-31 | 2015-07-31 | A kind of manufacture craft of pulullan polysaccharide empty capsule |
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| CN105055365A true CN105055365A (en) | 2015-11-18 |
| CN105055365B CN105055365B (en) | 2018-01-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429889A (en) * | 2011-11-30 | 2012-05-02 | 无锡福祈制药有限公司 | Large ring lactone type medicament capsule and preparation method thereof |
| CN103330696A (en) * | 2013-06-05 | 2013-10-02 | 绍兴康可胶囊有限公司 | Method for preparing colored empty capsules by employing natural colorants |
| CN103877067A (en) * | 2014-03-31 | 2014-06-25 | 江苏力凡胶囊有限公司 | Empty capsule capable of controlling disintegration time limit, and preparation method thereof |
| CN104248765A (en) * | 2014-08-16 | 2014-12-31 | 浙江药联胶丸有限公司 | Pulullan hollow capsule |
-
2015
- 2015-07-31 CN CN201510466717.XA patent/CN105055365B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429889A (en) * | 2011-11-30 | 2012-05-02 | 无锡福祈制药有限公司 | Large ring lactone type medicament capsule and preparation method thereof |
| CN103330696A (en) * | 2013-06-05 | 2013-10-02 | 绍兴康可胶囊有限公司 | Method for preparing colored empty capsules by employing natural colorants |
| CN103877067A (en) * | 2014-03-31 | 2014-06-25 | 江苏力凡胶囊有限公司 | Empty capsule capable of controlling disintegration time limit, and preparation method thereof |
| CN104248765A (en) * | 2014-08-16 | 2014-12-31 | 浙江药联胶丸有限公司 | Pulullan hollow capsule |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
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| Publication number | Publication date |
|---|---|
| CN105055365B (en) | 2018-01-02 |
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Effective date of registration: 20180108 Address after: 714000 Shaanxi city of Weinan Province Economic and Technological Development Zone Hou Cassia Road middle Patentee after: Shaanxi Jiayuan Bioengineering Co., Ltd. Address before: 014010 the Inner Mongolia Autonomous Region Kun District of Baotou City Road No. 16 Hua Xi Ulan apartment 1007 Patentee before: Liu Baiping |