CN105055199B - A kind of gentle desquamation compositions and its preparation method and application - Google Patents
A kind of gentle desquamation compositions and its preparation method and application Download PDFInfo
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- CN105055199B CN105055199B CN201510377981.6A CN201510377981A CN105055199B CN 105055199 B CN105055199 B CN 105055199B CN 201510377981 A CN201510377981 A CN 201510377981A CN 105055199 B CN105055199 B CN 105055199B
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Abstract
The present invention relates to a kind of gentle desquamation compositions, its composition is made up of piroctone olamine salt, surfactant, co-solvent, pipewort plant extracts, auxiliary plant extracts and water.Wherein, described surfactant comprises at least the combination of one or both of dodecyl polyethers sulfate, alkylamide propyl-betaine；Described co-solvent comprises at least propane diols, butanediol, one kind in ethanol or any a variety of combination；The auxiliary plant extracts comprises at least Flos Caryophylli extract, Ginger P.E, Flos Chrysanthemi Indici extract, Chinese rhubarb extract, one kind in Fructus Rubi extract or any a variety of combination.Invention additionally discloses the preparation method and application of gentle desquamation compositions.Anti-dandruff effect of desquamation compositions of the present invention is notable, and with property is gentle, bland feature.
Description
Technical field
The present invention relates to a kind of hair care product, specifically a kind of gentle anti-dandruff combination for being used to have one's hair wash, take care of hair
Thing and its preparation method and application.
Background technology
As current living environment pollution problem is increasingly subject to pay attention to, people are to " natural, organic, environmentally friendly, green " consumption
The preference degree of product is growing day by day.In terms of commodity, requirement of the consumer to hair washing product also improves constantly, on the one hand, needs
There is efficient product confrontation healthy pressure as caused by environmental pollution；On the other hand, also require that product property is gentle, can make
Human and environment reaches the poised state of harmony and natural.At the same time, according to incompletely statistics, China there are about 60% adult's difference
Perplexed by the problems such as hair oil secreted Sheng, dandruff is excessive to degree, wherein severe there are about 15%, the far super American-European state of ratio
Family.Therefore, necessary increasing strength, associated efficient gentle personal care product is developed.
Hair washing at present, anti-dandruff agent the most commonly used in hair products are Octopiroxes, abbreviation OCT.It is a kind of
Broad spectrum antimicrobial agent, it can effectively suppress the growth of bacterium and fungi.Using OCT be to human body according to conventional amount used it is safe, still,
Received much concern always during independent long-term use of OCT, the problems such as the excitant of product, sensitization.There is expert or even suggest batch (-type)
Using the hair care product containing OCT, to reduce excitants of the OCT to scalp.
It is to introduce the extract of natural botanical source that a kind of solution OCT, which stimulates the method for sex chromosome mosaicism, and carrying out compounding with OCT makes
With while its anti-microbial property is kept, reducing its excitant to scalp.Natural plant extracts contain antibacterial, antiallergic into
Point, stimulation, allergic symptom caused by extraneous chemicals can be alleviated.However, due to natural plant extracts complicated component, its
In some compositions may interfere with OCT play fungistatic effect；Meanwhile natural plant extracts are often containing carbohydrate, protein, ammonia
The organic matter of the suitable mushroom breeding such as base acid, if choosing improper the problem of mushroom being caused to grow on the contrary.Therefore have to through
Science collocation screening is crossed, could obtain can both suppress colony growth breeding, can alleviate stimulation, mistake caused by chemical substance again
The preferred compositions of the symptom such as quick.
The content of the invention
It is an object of the invention to for above the shortcomings of the prior art, there is provided a kind of external application, chaff can be suppressed
The gentle desquamation compositions of not plump chlosma.
It is a further object of the present invention to provide a kind of preparation method of gentle desquamation compositions.
The third object of the present invention is to provide a kind of application of gentle desquamation compositions.
In order to realize the purpose of the present invention, the present invention uses following concrete technical scheme：A kind of gentle desquamation compositions,
It is made up of following degree component：
Preferably, the degree of the auxiliary plant extracts is 3~11%
Wherein, the surfactant is comprised at least in dodecyl polyethers sulfate, alkylamide propyl-betaine
One or two kinds of combinations.
The co-solvent comprises at least any combination more than one or both of propane diols, butanediol, ethanol.
The pipewort plant extracts and auxiliary plant extracts are water-soluble solid powder.
The auxiliary plant extracts comprises at least Flos Caryophylli extract, Ginger P.E, Flos Chrysanthemi Indici extract, rheum officinale extraction
Any combination more than one or both of thing, Fructus Rubi extract, wherein, the Flos Caryophylli extract, Ginger P.E, open country
The degree of chrysanthemum extract, Chinese rhubarb extract, Fructus Rubi extract in formula is 1~5%.
The preparation method of the pipewort plant extracts and auxiliary plant extracts comprises the steps of：By plant material
(pipewort, cloves, ginger, chrysanthemum indicum, raspberry or rheum officinale) crushed 40~60 mesh sieves, add plant material powder weight 8
~15 times of water, heating (temperature is 80-95 DEG C) refluxing extraction 2 times, the time is 40-100 minutes, merges extract solution；By filtrate
The 1/8 to 1/10 of original volume is concentrated under reduced pressure into, it is molten for 75% ethanol with volume by volume concentration after purification is decolourized in macroporous resin column
It is colourless that liquid is eluted to eluent, collects eluent；By eluent, reduced vacuum concentrates at 50~80 DEG C, then in 70 DEG C of baking ovens
In be dried to it is powdered.Wherein, the macroporous resin column can use GDXl04 macroporous absorbent resins.
A kind of preparation method of gentle desquamation compositions, it is comprised the steps of：By surfactant and alcohols hydrotropy
60~80 DEG C are heated to after agent mixing, is stirred after addition piroctone olamine salt and is allowed to dissolve, added after being cooled to 40~50 DEG C
Enter Flos Eriocauli extract and auxiliary plant extracts, stirring and dissolving is uniform.
The gentle desquamation compositions are applied in cosmetic formulations, and its mass percentage content is 2~10% (quality
Percentage).Preferred mass percentage composition is 3~6%.
The present invention prepares natural plant extracts using conventional method, and uses above-mentioned technique and OCT compounding uses, this
On the one hand composition has outstanding antibacterial, antibacterial, antiallergic ability；On the other hand, it is low to the excitant of human body, there is protection head
The effect of skin.
Compared with prior art, the beneficial effects of the invention are as follows：Chemical anti-dandruff agent is combined with auxiliary plant extracts to be made
With reducing excitant of the chemical anti-dandruff agent to skin (scalp) while anti-dandruff effect is improved；Avoid because of long-term use of chemistry
Anti-dandruff agent and caused by skin (scalp) damage problem.
Embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
Unless stated otherwise, described content is weight/mass percentage composition；Reagent, raw material employed in embodiment are
It is commercially available.The experimental method of unreceipted actual conditions in embodiment, is generally carried out according to normal condition.
A kind of gentle desquamation compositions, are made up of following table weight percent composition：
Parameter is as follows used by plant extracts preparation method in above-described embodiment：
Wherein, D101 is D101 macroporous absorbent resins, and AB-8 is AB-8 macroporous absorbent resins.
The preparation method of above-mentioned plant extracts：To need the plant material that extracts be simply mixed after in an oven 70 DEG C it is dry
Dry 20 hours, grinding and sieving；After being prepared by above-mentioned solid-liquid ratio, heating and refluxing extraction 2 times, merge extract solution twice, depressurized
Filter；Filtrate decompression is concentrated into the above-mentioned volume ratio specified, and supernatant is crossed into post after standing 24 hours, active ingredient volume ratio is dense
Spend and eluted for 75% ethanol solution, collect eluent, drying to powdered after 60 DEG C of vacuum rotary steams, obtaining plant extracts；
The step of preparation method of the gentle desquamation compositions of above-described embodiment is：By surfactant and co-solvent
70 DEG C are heated to after mixing, is stirred after addition piroctone olamine salt and is allowed to dissolve, pipewort is added after being cooled to 45 DEG C and is carried
Take thing and auxiliary plant extracts, stirring and dissolving.
Comparative example 1-2 and gentle desquamation compositions embodiment 9-14, is made up of following table weight percent composition：
The preparation method of above-mentioned plant extracts：To need the plant material that extracts be simply mixed after in an oven 70 DEG C it is dry
Dry 20 hours, 60 mesh sieve after crushing；After being prepared by solid-liquid ratio for 1/9, heating and refluxing extraction 2 times, merging is extracted twice
Liquid, it is filtered under diminished pressure；The 1/8 of original volume is concentrated filtrate to, supernatant is crossed into D101 macroporous resin columns after standing 24 hours,
Active ingredient percent by volume elutes for 75% ethanol solution, collects eluent, is being dried after 60 DEG C of vacuum rotary steams to powder
Shape, obtain plant extracts.
The step of preparation method of the gentle desquamation compositions of above-described embodiment is：By surfactant and co-solvent
70 DEG C are heated to after mixing, is stirred after addition piroctone olamine salt and is allowed to dissolve, pipewort is added after being cooled to 45 DEG C and is carried
Take thing and auxiliary plant extracts, stirring and dissolving.
Effect experiment
Comparative example 1-2 and embodiment 9-14 antibacterial experiment in vitro
The generation internal factor of chlosma is that human body hair follicle secretion grease excessively blocks hair follicle hole, so as to produce inflammation simultaneously
Chlosma is promoted to grow.Therefore, the anti-dandruff effect of composition is mutually tied using antibacterial ring test with human body evaluation (on probation to pay a return visit)
The mode of conjunction carries out anti-dandruff efficacy assessments.
Test method：The Malassezia furfur activated is configured to bacteria suspension, takes bacteria suspension 0.3mL to be applied to
On Leeming＆Notman culture medium flat plates.After above-mentioned flat board containing bacterium is placed into 10min, opened in aseptic superclean bench flat
Plate lid, flat board (about 20min) is dried up with sterile wind.4 Oxford cups are placed with each flat board, 1 negative control (is free of test specimens
Product) Oxford cup, other three 100 μ L testing samples of instillation.After being placed with, Oxford cup is gently pressed with aseptic nipper, makes it be close to put down
Plate surface, plate is covered, puts and culture 7 days is inverted in 30 DEG C of constant incubators, the diameter of inhibition zone is recorded with vernier caliper measurement,
Average value is calculated, carries out comparative study.
The judgement of fungistatic effect：Bacteriostatic diameter >=20mm is very effective " +++ "；20mm ＞ bacteriostatic diameters >=15mm is height
Effect " ++ "；15mm ＞ bacteriostatic diameters >=10mm is middle effect "+"；Bacteriostatic diameter ＜ 10mm are invalid.3 repetition experiments have antibacterial
Exercising result person, it is qualified to be judged to.Negative control group produces without antibacterial ring size, and otherwise test data is invalid.
Result of the test is as follows：
Wherein, the antibacterial circle diameter of low irritant desquamation compositions prepared by embodiment 9 is 23.89 ± 0.2mm, is pole
Sensitive " +++ ", there is strong fungistatic effect.
Comparative example 1-2 and embodiment 9-14 3T3 red untake Phototoxicity experiments
3T3-NRU experiments are a kind of short-term monolayer cell culture pilot systems, by the use of 3T3 cells as study subject,
According to the dimethyl diaminophenazine chloride Dye uptake amount principle directly proportional to the amount of survivaling cell in culture medium, commented using cytotoxicity as terminal
Valency tested material is with skin irritation/corrosivity of evaluating chemical thing.
Experimental method：Balb/c3T3 fibroblasts are inoculated in containing 10% NBCS, 4mM glutamine, penicillin
In the DMEM culture mediums of (100IU) and streptomysin (100g/mL), in 37 DEG C, 5%CO2Under the conditions of cultivate.Balb/c3T3 is into fibre
Dimension passage is once tested afterwards.Tested material Fresh, all 4 kinds of tested materials use DMEM culture medium dissolved dilutions,
It is diluted to 8 concentration gradients.Positive control chlorpromazine (CPZ), with DMEM culture mediums dissolved dilution into 8 concentration gradients.Will
100 μ L density are 1 × 105(except periphery hole, periphery hole is blank to cell/mL cell suspension inoculation in 96 well culture plates
Control), while prepare 8 pieces of culture plates, after cultivating 24h, handled with the tested material and positive control of 8 concentration prepared thin
Born of the same parents, after cultivating 1h, one piece of culture plate of random selection is exposed to 1.67mW/cm2UVA under 50min (+UVA), another culture
Plate, which is placed in dark, places 50min (- UVA).Afterwards, rinsed with PBS and terminate exposure, be incubated 18~22h.Change neutrality
Red medium culture 3h, after washing away culture medium, (now matched somebody with somebody at 49: 50: 1 by volume with water, ethanol, acetic acid) with dimethyl diaminophenazine chloride extract solution
Dimethyl diaminophenazine chloride is extracted, using blank control as reference, absorbance (OD value) of the dimethyl diaminophenazine chloride extract solution in 540nm is measured with ELIASA.
96 orifice plate sample distribution tables are as follows：
Evaluation of result：Dose-effect relationship using illumination cultivation plate (+UVA) and lucifuge culture plate (- UVA) result leads to
Cross curve matching and calculate EC respectively50, and the light stimulus factor (PIF) is calculated as follows.
PIF=EC50(-UVA)/EC50(+UVA)
Phototoxicity judges：Tested material PIF ＜ 2, predict " without phototoxicity "；2 ＜ PIF ＜ 5, predict " there may be phototoxicity "；
PIF >=5, predict " having phototoxicity ".There is cytotoxicity on+UVA plates for tested material, and the no cytotoxicity on-UVA plates
Situation, PIF ' is calculated as follows：
PIF '=Cmax(-UVA)/EC50(+UVA)
CmaxFor the Cmax (- UVA) of tested material, PIF ' ＞ 1 then judge that tested material has phototoxicity.Positive control chlorine third
The acceptable standard of piperazine result is to have illumination (+UVA)： EC50=0.1~2.0 μ g/mL；CPZ no lights (- UVA)： EC50=
7.0~90.0 μ g/mL；Light stimulus factor PIF ＞ 6.The average dimethyl diaminophenazine chloride absorbance OD of solvent control540NRU≥0.4。
Result of the test is as shown in the table：
From result of the test, desquamation compositions of the invention can effectively mitigate excitant of the chemical anti-dandruff agent to cell.
Shampoo clinical evaluation made of comparative example 1-2 and embodiment 9-14 composition is tested
According to following list of ingredients respectively using the composition that comparative example 1-2 and embodiment 9-14 are obtained as anti-dandruff component,
Dandruff control shampoo containing is made.
The preparation method of shampoo is：
1) guar hydroxypropyltrimonium chloride (polymeric conditioner) and water are mixed at room temperature, with 3000rpm's
Speed homogeneous 10 minutes；
2) laureth (2EO) sodium sulfovinate, N- lauroyl glycine potassium, coconut palm are sequentially added after being warming up to 80 DEG C
Four kinds of oleamide CAB, LAA surfactants, stir；
3) material under She is added after being cooled to 40 DEG C, stirs, is discharged after room temperature is down to.
The shampoo that above-mentioned formula obtains is tried out by volunteer.
Volunteer requires：Choosing has the personage 270 of dandruff problem, and men and women half and half, the age between 18 years old to 65 years old, body
Body health.Volunteer is randomly divided into 9 groups, every group 15 male 15 female, using corresponding hair washing water sample, man washes hair 1 daily
Secondary, Ms washes hair 1 time every two days.Anti-dandruff effect is monitored when using 0 day, 7 days, 21 days, 28 days, it is correct by professional test personnel
The scurf order of severity is given a mark.
Evaluation method：Using " ten grades of point systems of tackness dandruff ", i.e., with scalp in selected viewing area and root of hair more than
How much the scurf number of attachment is scored in 4cm.0 grade indicates no dandruff；1~2 grade is the greyish white rough scales of small flakes；3~4
Level is as low as median size chip；5~6 grades are and the loose big and thin chip being connected of scalp；7~8 grades are big tackness
Chip；9~10 grades are the white thicker scales of skin that peel off to yellow with scalp close attachment.
Result of the test：It is as shown in the table, D0Before shampoo；D7After shampoo 7 days；D21Use shampoo 21 days
Afterwards；D28After dandruff control shampoo containing 28 days.Score as the arithmetic mean of instantaneous value of 30 subject's scorings.
From result of the test, the shampoo of the desquamation compositions containing the present invention has good anti-dandruff effect.
The specific embodiment of the present invention is described in detail above, but it is intended only as example, the present invention not by
It is limited to particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and
Substitute also all among scope of the invention.The impartial conversion made without departing from the spirit and scope of the invention and modification,
It all should be contained within the scope of the invention.
Claims (7)
1. a kind of gentle desquamation compositions, it is characterised in that be made up of following degree component：
Piroctone olamine salt 5 ~ 10%
Surfactant 10 ~ 30%
Co-solvent 5 ~ 10%
Flos Eriocauli extract 1 ~ 5%
Aid in plant extracts 1 ~ 25%
Water surplus
It is described auxiliary plant extracts comprise at least Flos Caryophylli extract, Ginger P.E, Flos Chrysanthemi Indici extract, Chinese rhubarb extract,
More than four kinds of any combination in Fructus Rubi extract.
2. a kind of gentle desquamation compositions as claimed in claim 1, it is characterised in that the surfactant comprises at least
The combination of one or both of dodecyl polyethers sulfate, alkylamide propyl-betaine.
3. a kind of gentle desquamation compositions as claimed in claim 1, it is characterised in that the co-solvent comprises at least
Any combination more than one or both of propane diols, butanediol or ethanol.
4. a kind of gentle desquamation compositions as claimed in claim 1, it is characterised in that the Flos Eriocauli extract and auxiliary
The preparation method of plant extracts comprises the steps of：Plant material be crushed into 40 ~ 60 mesh sieves, add plant material powder weight
8 ~ 15 times of water, heating and refluxing extraction 2 times, time are 40-100 minutes, merge extract solution；Concentrate filtrate to original volume
1/8 to 1/10, in macroporous resin column purification decolourize after with volume by volume concentration be 75% ethanol solution be eluted to eluent without
Color, collect eluent；By eluent, reduced vacuum concentrates at 50 ~ 80 DEG C, is then dried in 70 DEG C of baking ovens powdered.
A kind of 5. preparation method of gentle desquamation compositions as described in claim 1-4 is any, it is characterised in that comprising with
Lower step：60 ~ 80 DEG C are heated to after surfactant and co-solvent are mixed, is stirred after adding piroctone olamine salt
It is allowed to dissolve, Flos Eriocauli extract and auxiliary plant extracts, stirring and dissolving is added after being cooled to 40 ~ 50 DEG C.
6. a kind of gentle desquamation compositions as described in claim 1-4 is any, it is characterised in that applied to cosmetic formulations
In, its mass percentage content is 2 ~ 10%.
7. a kind of gentle desquamation compositions as claimed in claim 6, it is characterised in that applied to the matter in cosmetic formulations
It is 3 ~ 6% to measure degree.
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| MX2022003125A (en) * | 2019-09-17 | 2022-04-06 | Unilever Ip Holdings B V | Premix and composition and methods of preparing the same. |
| WO2023164938A1 (en) * | 2022-03-04 | 2023-09-07 | Clariant International Ltd. | Compositions comprising piroctone olamine |
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| CN1238682A (en) * | 1996-11-29 | 1999-12-15 | 尤尼利弗公司 | Antimicrobial personal care compositions |
| CN1245050A (en) * | 1998-08-19 | 2000-02-23 | 上海家化有限公司 | Dandruff-controlling shampoo containing active components of Chinese medicine garden sorrel and its preparing process |
| CN104337704A (en) * | 2013-07-30 | 2015-02-11 | 拜尔斯道夫股份有限公司 | Dandruff removing shampoo composition |
| CN104000749A (en) * | 2014-05-30 | 2014-08-27 | 纳爱斯集团有限公司 | Scalp nursing solution |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 Guangzhou High-tech Industrial Development Zone, Guangzhou, Guangdong Province, 15 Kelin Road, Guangzhou Science City Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |