CN105052988A - Antibacterial agent and preparation method - Google Patents
Antibacterial agent and preparation method Download PDFInfo
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- CN105052988A CN105052988A CN201510488758.9A CN201510488758A CN105052988A CN 105052988 A CN105052988 A CN 105052988A CN 201510488758 A CN201510488758 A CN 201510488758A CN 105052988 A CN105052988 A CN 105052988A
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- antibacterial agent
- cmc
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- zinc
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an antibacterial agent with the structural formula shown in the specification. The invention further discloses a preparation method of the antibacterial agent. The antibacterial agent is good in antibacterial effect, green and safe and does not affect the health.
Description
Technical field
The present invention relates to water-treatment technology field, refer in particular to a kind of antibacterial agent and preparation method.
Background technology
In prior art, the filter core that Household water purifier usage amount is larger is active carbon or NACF, and it adsorbs heterochromatic peculiar smell excellent performance, but along with service time extends, easy breed bacteria, causes secondary pollution to drinking water.
Therefore, antibacterial active carbon filter core produces thus, but in prior art, antibacterial activity carbon filter core adds Inorganic Ag System Antimicrobial Agents mostly, and it can play certain antibacterial action, but its more or less dialysis out, health effect is caused to human body.
In view of this, for solving the problem, the invention provides a kind of antibacterial agent of green safety in family's water purification catridge, this case produces thus.
Summary of the invention
The object of the present invention is to provide a kind of antibacterial agent and preparation method, its good anti-bacterial effect, green safety, can not be unhealthful.
A kind of antibacterial agent, structural formula is:
A kind of Antibacterial agent preparation method, comprises the following steps:
One, prepare CMC: the mass percent that the shitosan getting 5-10g is dissolved in 50-100ml is in 20-25% acetum, with the acetone precipitation of 200-300ml, then proceed to in the reaction bulb stirred, the mass percent adding 5-10ml is the isopropyl alcohol of 25-30%NaOH solution and 5-10ml, drip 6-12ml chloroacetic acid solution while stirring, by the liquid microwave reaction 1-5min mixed, reaction terminates rear adjust pH to neutral, be the methanol wash of 80-85% by volume fraction again, be drying to obtain CMC;
Two, prepare CMC zinc: get above-mentioned CMC and be made into the solution that mass fraction is 30-60%, add Zn (NO under stirring at room temperature
3)
2, Zn (NO
3)
2weight be 3 times of carboxymethyl chitosan solution weight, WZn (NO
3)
2: W carboxymethyl chitosan solution=3:1, reaction 1-2h, has reacted rear acetone crystallization, then has used methanol wash, be finally placed in 40-60 DEG C of vacuum drying, obtained antibacterial agent CMC zinc.
Further, reaction terminates rear watery hydrochloric acid adjust pH to neutral.
After adopting such scheme, antibacterial agent CMC zinc prepared by the present invention confirms after tested: CMC reaches more than 99.99% through chelated zinc antibacterial effect, and any harmful material can not be separated out, the antibacterial agent as a kind of green safety can effectively be applied in family's water purification catridge.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
A kind of antibacterial agent, structural formula is:
A kind of Antibacterial agent preparation method, comprises the following steps:
One, prepare CMC: the shitosan getting 5-10g, molecular formula is:
the mass percent being dissolved in 50-100ml is in 20-25% acetum, and with the acetone precipitation of 200-300ml, then proceed to in the reaction bulb stirred, the mass percent adding 5-10ml is the isopropyl alcohol of 25-30%NaOH solution and 5-10ml, generates
drip 6-12ml chloroacetic acid solution while stirring,
By the liquid microwave reaction 1-5min mixed,
reaction terminates rear watery hydrochloric acid adjust pH to neutral, then is the methanol wash of 80-85% by volume fraction, dry, obtains CMC;
Two, prepare CMC zinc: get above-mentioned CMC and be made into the solution that mass fraction is 30-60%, add Zn (NO under stirring at room temperature
3)
2, Zn (NO
3)
2weight be 3 times of carboxymethyl chitosan solution weight, WZn (NO
3)
2: W carboxymethyl chitosan solution=3:1, reaction 1-2h,
react rear acetone crystallization, then used methanol wash, be finally placed in 40-60 DEG C of vacuum drying, obtained antibacterial agent CMC zinc.
Test process: the Escherichia coli liquid getting two parts of identical amounts, portion adds CMC zinc antibacterial agent and stirs, and after leaving standstill 1min, sampling is tested respectively.CMC zinc anti-bacteria test result:
| Bacterial classification | Blank sample bacterial number after 24h/ | After 24h through antimicrobial treatment bacterial number/ | Antimicrobial efficiency |
| Escherichia coli | 4.2*10^5 | 0 | 99.99 |
Test result shows: CMC reaches more than 99.99% through chelated zinc antibacterial effect and can not separate out any harmful material, and the antibacterial agent as a kind of green safety can effectively be applied in family's water purification catridge.
Claims (3)
1. an antibacterial agent, is characterized in that: structural formula is:
2. a kind of Antibacterial agent preparation method as claimed in claim 1, is characterized in that: comprise the following steps:
One, prepare CMC: the mass percent that the shitosan getting 5-10g is dissolved in 50-100ml is in 20-25% acetum, with the acetone precipitation of 200-300ml, then proceed to in the reaction bulb stirred, the mass percent adding 5-10ml is the isopropyl alcohol of 25-30%NaOH solution and 5-10ml, drip 6-12ml chloroacetic acid solution while stirring, by the liquid microwave reaction 1-5min mixed, reaction terminates rear adjust pH to neutral, be the methanol wash of 80-85% by volume fraction again, drying, obtains CMC;
Two, prepare CMC zinc: get above-mentioned CMC and be made into the solution that mass fraction is 30-60%, add Zn (NO under stirring at room temperature
3)
2, Zn (NO
3)
2weight be 3 times of carboxymethyl chitosan solution weight, WZn (NO
3)
2: W carboxymethyl chitosan solution=3:1, reaction 1-2h, has reacted rear acetone crystallization, then has used methanol wash, be finally placed in 40-60 DEG C of vacuum drying, obtained antibacterial agent CMC zinc.
3. a kind of Antibacterial agent preparation method as claimed in claim 2, is characterized in that: reaction terminates rear watery hydrochloric acid adjust pH to neutral.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510488758.9A CN105052988A (en) | 2015-08-11 | 2015-08-11 | Antibacterial agent and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510488758.9A CN105052988A (en) | 2015-08-11 | 2015-08-11 | Antibacterial agent and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105052988A true CN105052988A (en) | 2015-11-18 |
Family
ID=54482722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510488758.9A Pending CN105052988A (en) | 2015-08-11 | 2015-08-11 | Antibacterial agent and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105052988A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106135263A (en) * | 2016-05-14 | 2016-11-23 | 海南正业中农高科股份有限公司 | Compositions containing organic zinc and application thereof |
| CN107141408A (en) * | 2017-06-12 | 2017-09-08 | 厦门建霖健康家居股份有限公司 | A kind of antibacterial polymer and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1431229A (en) * | 2003-01-09 | 2003-07-23 | 武汉大学 | Carboxymethyl chitosan, its preparing method and usage |
| US20080114096A1 (en) * | 2006-11-09 | 2008-05-15 | Hydromer, Inc. | Lubricious biopolymeric network compositions and methods of making same |
| CN104356253A (en) * | 2014-10-22 | 2015-02-18 | 西安莹朴生物科技股份有限公司 | Preparation method for carboxymethyl chitosan |
-
2015
- 2015-08-11 CN CN201510488758.9A patent/CN105052988A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1431229A (en) * | 2003-01-09 | 2003-07-23 | 武汉大学 | Carboxymethyl chitosan, its preparing method and usage |
| US20080114096A1 (en) * | 2006-11-09 | 2008-05-15 | Hydromer, Inc. | Lubricious biopolymeric network compositions and methods of making same |
| CN104356253A (en) * | 2014-10-22 | 2015-02-18 | 西安莹朴生物科技股份有限公司 | Preparation method for carboxymethyl chitosan |
Non-Patent Citations (1)
| Title |
|---|
| 袁文 等: "羧甲基壳聚糖的制备及其抗菌性能研究进展", 《食品研究与开发》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106135263A (en) * | 2016-05-14 | 2016-11-23 | 海南正业中农高科股份有限公司 | Compositions containing organic zinc and application thereof |
| CN106135263B (en) * | 2016-05-14 | 2019-07-30 | 海南正业中农高科股份有限公司 | Composition and application thereof containing organic zinc |
| CN107141408A (en) * | 2017-06-12 | 2017-09-08 | 厦门建霖健康家居股份有限公司 | A kind of antibacterial polymer and preparation method thereof |
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| C06 | Publication | ||
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Application publication date: 20151118 |