CN105031161A - Nursing liquid for local infection of diabetic foot and preparation method thereof - Google Patents
Nursing liquid for local infection of diabetic foot and preparation method thereof Download PDFInfo
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Abstract
The invention specifically relates to a nursing liquid for local infection of a diabetic foot, which belongs to the technical field of medicine. The nursing liquid is prepared from the following traditional Chinese bulk drugs by weight: 18 to 32 parts of solanum nigrum, 3 to 9 parts of herb of hairyfruit violet, 6 to 12 parts of root of manyflower glorybower, 6 to 12 parts of herb of hairyfruit violet, 6 to 12 parts of aloe, 9 to 15 parts of alder shoot and 6 to 12 parts of mulberry bark. The nursing liquid is capable of purging heat, removing blood stasis, eliminating swelling and stopping bleeding, is used for adjunctive treatment of local infection of the diabetic foot and has the characteristics of high drug effect and a total effective rate.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of conditioning liquid for diabetic foot local infection and preparation method thereof.
Background technology
Diabetes (diabetesmellitus, DM) are commonly encountered diseases, frequently-occurring disease, and the diabetics in the whole world is more than 1.7 hundred million.The sickness rate of diabetes mellitus in China increases very fast, and sickness rate is only second to India, occupies second place of the world.World Health Organization (WHO) has reminded China should watch out for the harm of diabetes in the recent period.Diabetes problem is troubling, because the many acute and chronic complicating diseases of diabetes all can have serious consequences to patient.Diabetic foot (diabeticfoot, DF) is the chronic complicating diseases of diabetes, is amputation, the main cause that disables, and consequence harm is serious, and medical expense spending is huge.In the U.S., in all non-traumatic amputations patients, the amputation reason of 50% patient is that diabetic infection control is not good.Therefore, how in clinical treatment, effectively to control diabetic infection, become the problem that in clinical treatment, can not be ignored.
In recent years due to antibiotic extensive use, make to cause clinically the bacterial spectrum of infection to occur obviously to change, the phenomenon of bacterial resistance is also more and more many, conditioned pathogen and post the infection of growing caused by bacterium and also increase.Because the multidrug resistance that diabetic foot ulcers position antibacterial occurs, therefore treat often unsatisfactory curative effect.
In view of this, the present inventor have developed a kind of easy to use, determined curative effect and without the pure Chinese medicinal preparation of obvious toxic-side effects, to meet the demand of extensive patients.
Summary of the invention
The object of this invention is to provide a kind of conditioning liquid for diabetic foot local infection and preparation method thereof.This conditioning liquid is used for adjuvant therapy of diabetes foot, has obvious effective rate high, the feature that total effective rate is high.
The present invention is achieved through the following technical solutions:
For a conditioning liquid for diabetic foot local infection, be made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 18-32 part, Herba Violae Collinae 3-9 part, Radix Clerodenri Cyrtophylli 6-12 part, Herba Violae Collinae 6-12 part, Aloe 6-12 part, Alnus cremastogyne Burkill 9-15 part, Cortex Mori 6-12 part.
Preferably, the above-mentioned conditioning liquid for diabetic foot local infection, be made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 21-27 part, Herba Violae Collinae 5-7 part, Radix Clerodenri Cyrtophylli 8-10 part, Herba Violae Collinae 8-10 part, Aloe 8-10 part, Alnus cremastogyne Burkill 10-14 part, Cortex Mori 8-10 part.
Preferred, the above-mentioned conditioning liquid for diabetic foot local infection, be made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 24 parts, Radix Clerodenri Cyrtophylli 9 parts, Herba Violae Collinae 9 parts, Aloe 9 parts, Alnus cremastogyne Burkill 12 parts, Cortex Mori 9 parts.
The preparation method of the above-mentioned conditioning liquid for diabetic foot local infection, comprises the steps:
Various raw material is taken according to required weight portion, decoct with water extraction secondary, first time adds injection volume 10 times amount soak by water 2 hours, and second time adds injection volume 4 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.11 ~ 1.17, lets cool, add ethanol and reach 75% to alcohol content, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter; It is 1.15 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, and add the water dilution of equivalent, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000 parts, filter, sterilizing, to obtain final product.
Conditioning liquid for diabetic foot local infection of the present invention, has purgating heat and breaking stasis, and effect of detumescence hemostasis, for diabetic foot local infection.
The usage and dosage of lotion of medication of the present invention is: Chinese medicine nursing liquid 2000ml, be heated to about 40 DEG C, pour in clean basin, be dipped in medicinal liquid by trouble foot and carry out foam washing, the water surface, stamping joint more than 10cm, adds hot water in immersion gradually, water temperature is made to maintain about 40 DEG C, each immersion 30 minutes, every day 2 times, changes dressings after foot bath.
In the Chinese medicine for the treatment of leukorrheal diseases of the present invention,
Herba Solani Nigri is the herb of plant of Solanaceae Herba Solani Nigri SolanumnigrumL..Herb is used as medicine, can dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing.
Radix Clerodenri Cyrtophylli calls smelly, wild country bone, soil Cortex Lycii.Source is the root of Verbenaceae Herba Diclipterae Chinensis.Nature and flavor are bitter, cold.Function cures mainly heat clearing away, and removing toxic substances, dispels the wind, dehumidifying.Control encephalitis b, epidemic encephalitis, the high heat of flu, headache, enteritis, dysentery, jaundice, toothache, epistaxis, laryngopharynx swelling and pain.Removing heat from blood is brought down a fever, and separates skin pyretic toxicity.Control macule, pruritus, centipete bite.Clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, dissipating blood stasis stops blooding.Control enteritis, bacillary dysentery, pharyngolaryngitis, tonsillitis, parotitis, cold, fever, gingiva bleeding gingival hemorrhage."
Herba Violae Collinae another name Semen Caryae Cathayensis, arrow grass, key bit dish, silver ground spoon, Bai Maoye Herba Violae, Herba Violae, pregnant grass.For the herb of Violaceae plant comospore common violet ViolacollinaBess..Bitter in the mouth; Pungent; Cold in nature.Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main sore swollen toxin; Lung abscess; Traumatic injury pain; Knife injury is hemorrhage; Exogenous cough.
Aloe be liliaceous plant Aloe vulgaris AloebarbadensisMiller, Aloe ferox Miller AloeferoxMiller or other belong to the dry product of concentrated juice of kindred plant leaf together.Hardship, cold.Return liver, stomach, large intestine channel.Removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Alnus cremastogyne Burkill is the browse of Betulaceae alder.Cool in nature, bitter and puckery flavor.Resolving heat and reducing pathogenic fire, hemostasis antidiarrheal.Control haematemesis, epistaxis, watery diarrhea, dysentery, impetigo.
Diabetic foot belongs to motherland's medical science necrosis category.The traditional Chinese medical science thinks diabetes complication, the not outer endogenous cause of ill of the cause of disease and exopathogenic factor.Interior because long-term surfeit delicious food savoury, transporting and transforming function of the spleen and stomach is neglected one's duty, and accumulate in accumulated heat, disappear bright cloudy Tianjin; Or because of direct stimulation, feelings will is unsuccessful, mechanism of qi pent-up, fire-transformation impairment of YIN; Or the ferritic deficiency of YIN, sexual overstrain, labor is for excessively, and phase heated is contained, and disappear bright kidney essense, then becomes to quench one's thirst." Shengji Zonglu quench one's thirst door " cloud: " person of quenching one's thirst ... not smelting for a long time, then meridians Kui is puckery, stays in muscle, becomes carbuncle ".Quench one's thirst with the passing of time, consumption impairment of QI is cloudy, yin asthenia generating intrinsic heat, accumulation of heat blood stasis, and passages through which vital energy circulates loses supports, and causes numbness of the skin.Exopathogenic factor mostly is being invaded by exogenous pathogen or wound, evil poison invasion and attack, and stagnate venation, and blood stasis is not all right, and stasis of blood heat-transformation of a specified duration, accumulates in pyretic toxicity, and skin and flesh is gradually rotten, sends out as necrosis.With the passing of time, kidney yin loss, liver loses self-restraint to necrosis, and Liver and kidney is all empty, later stage deficiency of YIN affecting YANG, and yang deficiency can cause the serious symptom of poison of deep-seated sore intruding inward internal organs, or yin-yang all loss, and the touching difficulty of feelings of causing a disease more.
Primary disease main pathogenic is " heat " and " stasis of blood ", and belong to deficiency in origin and excess in superficiality, this be the hepatic and renal YIN deficiency, and the four stages in the course of an epidemic febrile disease is not enough, is designated as pyretic toxicity, blood stasis, expectorant are turbid, dialectically belongs to hot-forging dies more.Laying equal stress on inside and outside treatment is answered, develops simultaneously in Chinese and Western, outstanding heavy outer smelting.Treatment by oral administration of medicines is based on heat clearing away supplementing QI and nourishing YIN, activating blood circulation to dissipate blood stasis and dredge the collateral.But because of this disease " send out in four ends, medicine difficulty reaches ", so the local external treatment of foot gangrene has epochmaking effect.Diabetic foot gangrene is common with wet gangrene, flesh is good for degeneration necrosis and is often betided health heavy burden position, the thick tough vola of skin and heel portion, focus exists deeply, because of the high sugared many water in local, diabetics body's immunity is low, very easily accompanying infection, and because of neuropathy, make lower limb feel to go down or disappear, tissue injury is not easily discovered, and increases the weight of infection chance.Once infect, restive, pus is Channel Group not easily, and infection can aggravate again gangrenous proximad and spread.Local necrosis is infected, uses Chinese medicine lotion lavation, play the effect that heat-clearing and toxic substances removing, antiinflammatory are antibacterial, improve blood fortune.
In the prescription of the conditioning liquid for diabetic foot local infection of the present invention, wherein Herba Solani Nigri, Herba Violae Collinae, Aloe, Cortex Mori, energy clearing away heat-fire, rushes down the pyretic toxicity of diabetic foot local necrosis infection, and has removing mass stagnant, the merit of blood stasis of living.Radix Clerodenri Cyrtophylli, have removing heat from blood bring down a fever detumescence hemostasis effect.Alnus cremastogyne Burkill is puckery, cold, have in puckery clearly, can resolving heat and reducing pathogenic fire, to help Radix Et Rhizoma Rhei to purge heat the power of poison, have again effect of removing dampness, detumescence, hemostasis.Three medicines are harmonious, and play purgating heat and breaking stasis, the effect of detumescence hemostasis.
Effective effect of the present invention is:
Compared with matched group, conditioning liquid of the present invention is used for the treatment of diabetic foot local infection, 1 the course for the treatment of obvious effective rate up to 55.56%, and matched group cure rate only has 21.43%, and both have significant difference (p < 0.01); 1 the course for the treatment of total effective rate up to 100%, and matched group effective percentage only has 42.86%, and both have significant difference (p < 0.01).
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described, so that those skilled in the art more understands the present invention, but does not limit the present invention with this.
Embodiment 1
Prescription: Herba Solani Nigri 240g, Herba Violae Collinae 60g, Radix Clerodenri Cyrtophylli 90g, Herba Violae Collinae 90g, Aloe 90g, Alnus cremastogyne Burkill 120g, Cortex Mori 90g.
Preparation method:
Various raw material is taken according to required weight portion, decoct with water extraction secondary, first time adds injection volume 10 times amount soak by water 2 hours, and second time adds injection volume 4 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.11 ~ 1.17, lets cool, add ethanol and reach 75% to alcohol content, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter; It is 1.15 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, and add the water dilution of equivalent, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 10000ml, filter, sterilizing, to obtain final product.
Embodiment 2
Prescription: Herba Solani Nigri 210g, Herba Violae Collinae 70g, Radix Clerodenri Cyrtophylli 80g, Herba Violae Collinae 100g, Aloe 80g, Alnus cremastogyne Burkill 140g, Cortex Mori 80g.
Preparation method is with embodiment 1.
Embodiment 3
Prescription: Herba Solani Nigri 270g, Herba Violae Collinae 50g, Radix Clerodenri Cyrtophylli 100g, Herba Violae Collinae 80g, Aloe 100g, Alnus cremastogyne Burkill 100g, Cortex Mori 100g.
Preparation method is with embodiment 1.
Embodiment 4
Prescription: Herba Solani Nigri 180g, Herba Violae Collinae 90g, Radix Clerodenri Cyrtophylli 60g, Herba Violae Collinae 120g, Aloe 60g, Alnus cremastogyne Burkill 150g, Cortex Mori 60g.
Preparation method is with embodiment 1.
Embodiment 5
Prescription: Herba Solani Nigri 320g, Herba Violae Collinae 30g, Radix Clerodenri Cyrtophylli 120g, Herba Violae Collinae 60g, Aloe 120g, Alnus cremastogyne Burkill 90g, Cortex Mori 120g.
Preparation method is with embodiment 1.
Carried out clinical pharrnacokinetics test to the preparation of embodiments of the invention l, Details as Follows:
1 clinical data
1.1 case selection
Choose patients with diabetic foot 32 example.
1.1.2 diagnostic criteria:
1.1.2.1 name diagnosis
Ward off the diabetes diagnostic criterion that the sick diagnosis of urine meets wHO formulation in 1999: (diabetes branch of Chinese Medical Association and diabetes mellitus in China magazine editorial board passed through discussion in the joint conference of Shanghai in October, 1999), clinical symptoms+random Vein blood serum >=11.0mmol/L, or limosis vein blood slurry blood glucose >=7.0mmol/L, or oral glucose tolerance test 2 hr iv plasma glucose >=11.0mmol/L.
1.1.2.2 diabetic foot diagnosis
Meet first the national diabetic foot academic conference of Chinese Medical Association's diabetes association in October nineteen ninety-five discuss and pass through " warding off inspection method and the diagnostic criteria (draft) of urine foot disease (acromelic gangrene) ".
(1) medical history: previously have diabetes medical history or be admitted to hospital and be diagnosed as diabetes.
(2) symptom: acra blood supply insufficiency, skin sends out cool, purple group, pain, numbness, insensitive or lose, the deformity etc. of toes or foot has high-risk foot performance.
(3) sign: acra festers, infection suppurates or blackening necrosis etc. have dryness or wet gangrene performance, and meet 0 ~ 5 grade of gangrenous standard.
(4) auxiliary examination: foot x-ray shows that sclerotin, osteoarthrosis destroy, in osteomyelitis or pseudarthrosis, the change of Charoot joint etc., lower limb vascular color ultrasound, MR, CT, DSA show: the performances such as vascular occlusion attenuates, Oligemia, flow velocity are slow.
1.1.2.3 the classification of diabetic foot
Discuss and pass through " inspection method of diabetic foot (acromelic gangrene) and diagnostic criteria (draft) " according to first the national diabetic foot academic conference of Chinese Medical Association's diabetes association in October nineteen ninety-five, the Wagner classification with reference to colleague's accreditation both at home and abroad:
0 grade: skin is without open focus.Normal performance acra blood supply insufficiency, skin is cool, the purple thread or pale of color, numb, and twinge causalgia, insensitive or forfeiture, has the high-risk foot performances such as the deformity of toes or foot concurrently.
1 grade: acra skin has open focus.Vesicle, blood blister, clavus or callus, cold injury or scald and other skin hinder the skin superficial ulcer caused, but focus not yet involves deep tissue.
2 grades: infection focus invades deep muscle tissue.Often have slight Feng Wo cellulites, multiple pus stove and tunnel, or infect and expand along spatium intermusculare, or vola, instep connectivity are used to infections or gangrene, purulent secretion is more, acra skin dry gangrene, but flesh is good for ligament and is there is no destruction.
3 grades: flesh is good for ligament tissue and is destroyed.Cellulitis merges and forms large vomica, and purulent secretion and slough increase, but bone destruction is still not obvious.
4 grades: severe infections oneself cause bone destruction, osteomyelitis and osteoarthrosis destroy, or form pseudarthrosis, partly refer to that toe or part brothers occur moist or dryness is seriously gangrenous.
5 grades: the major part of foot or whole infection of foot or ischemia, cause serious moist or dry gangrene, acra blackening, corpse are done, and ordinary wave and articulatio talocruralis and shank, generally take surgery high amputation more.
1.1.3 inclusive criteria
(1) diagnostic criteria of above diabetic foot is met.
(2) clinical scale belongs to 1 ~ 4 grade of patient with diabetic feet.
(3) diabetic foot once debridement, stitching, amputation, section bad person of toe postoperation recovery.
(4) foot ulcers secretions antibacterial culturing (+) person.
1.1.4 exclusion standard
(1) other non-diabetic acromelic gangrenes.
(2) foot portions secretion antibacterial culturing (-) person.
(3) except diabetic foot local art mouth, also there is the severe infections person of other organs, system.
(4) can not accept or mismatch therapist.
1.2 general clinical datas
In table 1.
Table 1 is selected in clinical characteristic (x scholar s)
| Matched group | Treatment group | |
| Number of cases | 14 | 18 |
| Age (year) | 64.00 scholar 9.61 | 63.30 scholar 8.18 |
| Sex (male/female) | 8/6 | 10/8 |
| Diabetic duration (year) | 8.45 scholar 7.15 | 9.66 scholar 7.90 |
| Foot pathological changes (year) | 5.11 scholar 4.68 | 5.01 scholar 3.94 |
Note: the baseline characteristic of two groups of cases compares, every situation is all through statistical test, and P value is all greater than 0.1, the no significant difference of two groups of cases in physical data is described, has comparability.
2 methods
2.1 Primary Care
L () controls blood glucose: control blood glucose with short-acting insulin subcutaneous injection, Monitoring Blood Glucose situation, adjusts insulin dose at any time, makes fasting glucose <10mmol/L.
(2) infection: according to the check result of foot portions secretion antibacterial culturing+susceptibility, select sensitive antibiotic.
(3) improve microcirculation: every day 0.9% quiet of normal saline ten Alprostadil (time triumphant) 10ug, 0.9% normal saline+quiet of puerarin 10ml.
(4) change dressings: cut in time, row runs through drain, and be interrupted and nibble debridement, every day changes dressings.
2.2 western medical treatment groups (matched group): with hydrogen peroxide and irrigate the wound with salt solution outward.
2.3 thirsty cellulitis wash washout side's treatment group (treatment group):
Adopt Chinese medicine nursing liquid 2000ml prepared by the embodiment of the present invention 1, be heated to about 40 DEG C, pour in clean basin, be dipped in medicinal liquid by trouble foot and carry out foam washing, the water surface, stamping joint more than 10cm, adds hot water in immersion gradually, water temperature is made to maintain about 40 DEG C, each immersion 30 minutes, every day 2 times, changes dressings after foot bath.It within 15 days, was 1 course for the treatment of.
2.4 observation item
Two groups of clinical symptoms improve situation: the diabetic foot Syndrome Scale standards of grading in " new Chinese medicine guideline of clinical investigations " that clinicing symptom observation reference Department of Medical Administration of Ministry of Health of the People's Republic of China (1999) is formulated.
The development degree of the symptom and signs such as pain, redness, Pi Wen, secretions is remembered respectively "-~ +++ ", according to symptom weight classified estimation before treatment and after the course for the treatment of of treatment.
2.5 curative effect judging standard
With reference to necrosis efficacy assessment standard in " disease of tcm Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates for 1994.
Effective: wound surface local pain disappears, and secretions obviously reduces, the red work of granulation, around without red and swollen, skin temperature recovers normal.
Effective: wound surface local pain alleviates, secretions reduces, the red work of granulation, and create all rednesses and disappear half, skin temperature drop is low.
Invalid: pain is without alleviating or increasing the weight of, and secretions has no minimizing, and wound surface situation is without improvement.
2.6 cases reject standard
L () is mismatched treatment or cannot be judged curative effect person because data is incomplete.
(2) because a variety of causes such as drug allergy exit this researcher.
2.7 statistical analysis
Use SPS11.0 statistical package to carry out data statistic analysis, enumeration data adopts x inspection; Measurement data adopts t inspection, compares employing variance analysis between group.
3 results
3.1 liang of group Clinical efficacy comparisons
Treatment group total effective rate is apparently higher than matched group.In table 2.
In table 2.
Table 2 patient with diabetic feet Clinical efficacy comparison (n, %)
| n | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 18 | 12(55.56%)* | 8(44.44%) | 0(5.55%) | 100%* |
| Matched group | 14 | 3(21.43%) | 3(21.43%) | 8(57.14%) | 42.86% |
Note: * is compared with matched group, and P<0.01, there were significant differences for both total effective rates.
Before and after 3.2 liang of group treatments, clinical symptoms improvement is compared
In table 3.
Claims (4)
1., for a conditioning liquid for diabetic foot local infection, be made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 18-32 part, Herba Violae Collinae 3-9 part, Radix Clerodenri Cyrtophylli 6-12 part, Herba Violae Collinae 6-12 part, Aloe 6-12 part, Alnus cremastogyne Burkill 9-15 part, Cortex Mori 6-12 part.
2. the conditioning liquid for diabetic foot local infection according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 21-27 part, Herba Violae Collinae 5-7 part, Radix Clerodenri Cyrtophylli 8-10 part, Herba Violae Collinae 8-10 part, Aloe 8-10 part, Alnus cremastogyne Burkill 10-14 part, Cortex Mori 8-10 part.
3. the conditioning liquid for diabetic foot local infection described according to claim 3, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight:
Herba Solani Nigri 24 parts, Radix Clerodenri Cyrtophylli 9 parts, Herba Violae Collinae 9 parts, Aloe 9 parts, Alnus cremastogyne Burkill 12 parts, Cortex Mori 9 parts.
4. the preparation method of the conditioning liquid for diabetic foot local infection described described in claim 1 or 2 or 3, comprises the steps:
Various raw material is taken according to required weight portion, decoct with water extraction secondary, first time adds injection volume 10 times amount soak by water 2 hours, and second time adds injection volume 4 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.11 ~ 1.17, lets cool, add ethanol and reach 75% to alcohol content, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter; It is 1.15 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, and add the water dilution of equivalent, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000 parts, filter, sterilizing, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262107A (en) * | 1999-02-03 | 2000-08-09 | 林桂芬 | Health-care series of Chinese medicines for foot-therapy and its dedicated appliance |
| CN102284054A (en) * | 2011-08-30 | 2011-12-21 | 苗恕芬 | Lavipeditum Chinese medicine composition for treating diabetes |
-
2015
- 2015-07-07 CN CN201510393238.XA patent/CN105031161A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262107A (en) * | 1999-02-03 | 2000-08-09 | 林桂芬 | Health-care series of Chinese medicines for foot-therapy and its dedicated appliance |
| CN102284054A (en) * | 2011-08-30 | 2011-12-21 | 苗恕芬 | Lavipeditum Chinese medicine composition for treating diabetes |
Non-Patent Citations (3)
| Title |
|---|
| 任秀喜等: "鲜芦荟汁在糖尿病足溃疡护理中的应用", 《现代中西医结合杂志》 * |
| 高怀林等: "《糖尿病足的科学防治》", 30 April 2015, 人民军医出版社 * |
| 黄新等: "外用中药治疗糖尿病足的文献应用分析", 《中医药信息》 * |
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