CN105030994B - Prevent the drug and preparation method thereof that aquatic livestock steals dead disease - Google Patents
Prevent the drug and preparation method thereof that aquatic livestock steals dead disease Download PDFInfo
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Abstract
The invention discloses the drugs and preparation method thereof that prevention aquatic livestock steals dead disease, are made of felwort, Radix Glycyrrhizae, Herba Euphorbiae Humifusae, the bark of ash, granatum, Cortex Phellodendri, Radix Isatidis, hawthorn, rheum officinale, the coptis, Schisandra chinensis, Chinese gall.Preparation method include medicinal material directly crush, medicinal material extract respectively be made extract, medicinal material mixing extract three kinds of different methods of extract are prepared.The present invention can significantly reduce the disease dead steathily of aquatic livestock, significantly improve its production performance, improve the immunocompetence and disease resistance of body, and have natural no drug residue, safe to use, have no toxic side effect.
Description
Technical field
The present invention relates to the drugs and preparation method thereof that prevention aquatic livestock steals dead disease, belong to field of veterinary.
Background technology
" steal dead disease ", also referred to as " death stealing ", " emitting bottom ", also known as EMS (Deaths syndrome) or " acute hepatopancrease is bad
Incruable disease " refers to a kind of state of an illness occurred in the aquaculture middle and later periods.It occurs mainly in high density and supports pond, be more than 28 in water temperature
Under DEG C environment, when cultivation 60~80 days, is easier to occur.It is more complicated about the reason for stealing dead disease, mainly it is summarized as following two originals
Cause：1. causing since throwing seedling density is excessive, feeds excess, cultivation amount has been more than seriously pond environment saturation.Breeding water body water
Matter situation is bad, and excreta, residual bait, other organic matters of aquatic livestock etc. slowly decompose under the action of heterotrophicy bacteria, generates
The noxious materials such as a large amount of hydrogen sulfide, ammonia nitrogen.Bottom is formed under the decomposition of bacterium and dissolves hypoxgia, causes aquatic livestock
The gill damage or be poisoned to death.2. weather reason.First, falling heavy rain, this aspect makes water salinity, temperature and dissolved oxygen refer to
Mark declines so that being generated to aquatic livestock stress.On the other hand but also algae is dead, aquatic livestock ingests dead algae, will produce
Raw sky stomach jejunum；Another kind causes to aquatic livestock loss of appetite the reason is that high temperature season, water body environment deterioration and then causes sky
Intestines sky stomach.
Steal that dead disease is main to be concentrated to use based on antibiotic about aquatic livestock at present, this makes aquatic livestock generate drug resistance
Property, and do not meet the requirement of food security.The invention belongs to plant-based medicine not only effectively preventing aquatic livestock steal it is dead
Disease, and have the characteristics that no drug residue, have no drug resistance, the death rate of aquatic livestock can be efficiently reduced.
Invention content
The object of the present invention is to provide it is a kind of can be clearing heat and detoxicating, improve the disease resistance of aquatic products, reduce and steal dead sick incidence
Drug and preparation method thereof.
The present invention is achieved by the following technical solutions：
5-10 parts of felwort crushed material, 1-5 parts of Radix Glycyrrhizae crushed material, 5-10 parts of Herba Euphorbiae Humifusae crushed material, bark of ash crushed material 1-5
Part, 1-5 parts of granatum crushed material, 1-5 parts of Cortex Phellodendri crushed material, 1-5 parts of Radix Isatidis crushed material, 1-5 parts of hawthorn crushed material, Rhubarb Powder
Mince 1-5 parts, 1-5 parts of coptis crushed material, Fructus Schisandrae Chinensis powder mince 1-5 parts, gallnut extract minces 2-8 parts.
Prevent the preparation method that aquatic livestock steals the drug of dead disease：It by medicinal material, cleans, dry, is respectively crushed into 80-120
Purpose crushed material is stirred 10-20min to get finished product.
The present invention is achieved by the following technical solutions：
5-10 parts of Radix Gentianae extract, 1-5 parts of licorice, 5-10 parts of Herba Euphorbiae Humifusae extract, cortex fraxini extract 1-5
Part, 1-5 parts of pomegranate rind extract, 1-5 parts of phellodendron extract, 1-5 parts of isatis root extract, 1-5 parts of haw thorn extract, rheum officinale carry
1-5 parts of object, 1-5 parts of coptis extract, 1-5 parts of Schisandra chinens P.E, 2-8 parts of nutgall extractive are taken, 10- is stirred
20min is to get finished product.
The present invention is achieved by the following technical solutions：
5-10 parts of felwort, 1-5 parts of Radix Glycyrrhizae, 5-10 parts of Herba Euphorbiae Humifusae, 1-5 parts of the bark of ash, 1-5 parts of granatum, 1-5 parts of Cortex Phellodendri,
1-5 parts of Radix Isatidis, 1-5 parts of hawthorn, 1-5 parts of rheum officinale, 1-5 parts of the coptis, 1-5 parts of Schisandra chinensis, 2-8 parts of Chinese gall.
The preparation method that aquatic livestock steals the drug of dead disease is prevented, is included the following steps：
(1) medicinal material needed for the above extract cleaned respectively, dried, respectively extracting in water, concentration, drying, detection symbol
The amount of the medicinal material needed for above-mentioned formula is weighed after standardization；
(2) by said extracted object mixing 10-20min, mixture is obtained.
The present invention is achieved by the following technical solutions：
5-10 parts of felwort, 1-5 parts of Radix Glycyrrhizae, 5-10 parts of Herba Euphorbiae Humifusae, 1-5 parts of the bark of ash, 1-5 parts of granatum, 1-5 parts of Cortex Phellodendri,
1-5 parts of Radix Isatidis, 1-5 parts of hawthorn, 1-5 parts of rheum officinale, 1-5 parts of the coptis, 1-5 parts of Schisandra chinensis, 2-8 parts of Chinese gall.
(1) medicinal material cleaned, dry, weigh, be ground into coarse powder.
(2) the 6-12 times of water measured is added in above-mentioned coarse powder, decocted 1-5 times, each 1-4h, heat filtering, merging filtrate, concentration
Reflux, when being back to medicinal extract, be dried in vacuo, crush after extract.
The pharmacological action of Chinese medicine used is as follows：
Felwort：Heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire.For jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, under band, eczema itch, irascibility mesh
Red, syrigmus is deaf, hypochondriac pain bitter taste, persistent erection, convulsion.
Radix Glycyrrhizae：It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Herba Euphorbiae Humifusae：It is clearing heat and detoxicating, cooling blood and hemostasis, removing dampness through diuresis and removing jaundice.For dysentery, diarrhea is spat blood, and hematuria is had blood in stool, uterine bleeding,
Boil carbuncle swells, jaundice with damp-heat pathogen.
The bark of ash：Heat-clearing and damp-drying drug, inducing astrigency stop dysentery, stop-band, improving eyesight.For damp-heat dysentery, leukorrhea with reddish discharge, red eye, swell pain, mesh life
Screen film.
Granatum：Relieving diarrhea with astringents, hemostasis, expelling parasite.For chronic diarrhea, protracted dysentery is had blood in stool, rectal prolapse, uterine bleeding, under band, abdominal pain due to enterositosis.
Cortex Phellodendri：Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, with lower pruritus vulvae, heat gonorrhea is puckery
Bitterly, tinea pedis Wei lame, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.For fire excess from yin deficiency,
Night sweat hectic fever due to yin.
Radix Isatidis：It is clearing heat and detoxicating, cool blood relieving sore-throat.It is malicious when for warm epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, mumps, rotten larynx pellet
Acute diseases such as cholera and sunstroke, major part pestilence, erysipelas, carbuncle swells.
Hawthorn：Food digesting stomach fortifying, scattered stasis change turbid lipid-loweringing.For meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, hemostasis warp
It closes, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.Charred FRUCTUS CRATAEGI promoting digestion effect enhancing.For meat
Dyspepsia is stagnant, and rush down dysentery is not well.
Rheum officinale：Heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It stagnates constipation for real heat, blood
Hot hematemesis, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice urine
It is red, stranguria, oedema；Externally treating burns and scalds.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI rushes down
It exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is stasis of blood haemorrhage for blood-head.
The coptis：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, internal heat are vomitted
High Sheng, dysphoria and insomnia, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, and carbuncle swells treat sore；Control eczema, wet sore, duct stream outside
Purulence.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.It is mutually tied for fever and chills, damp and hot middle resistance,
Feeling of fullness is vomitted.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, acid regurgitation is vomitted.
Schisandra chinensis：Restrain astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For long-last cough and virtual asthma, emission, enuresis frequent micturition, chronic diarrhea
Incessantly, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.
Chinese gall：It astringes the lung fall fire, relieving diarrhea with astringents, arrest sweating, hemostasis, hygroscopic sore.For chronic cough of deficiency lung, lung feverish cough, long
Protracted dysentery is rushed down, spontaneous sweating is quenched one's thirst, hemorrhoid blood of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, skin moisture fester.
Beneficial effects of the present invention：
1, the present invention has effects that clearing heat and detoxicating, antibacterial anti-inflammatory, can effectively inhibit bacterium and virus, effective anti-
Control dead disease steathily.
2, the present invention is Chinese herbal and crude drugs preparations, naturally, no drug residue, has no drug resistance, can ensure food security.
3, the present invention is by different preparation processes, to select most suitable preparation method.
Specific implementation mode
Embodiment 1
5 parts of felwort crushed material, 1 part of Radix Glycyrrhizae crushed material, 5 parts of Herba Euphorbiae Humifusae crushed material, 1 part of bark of ash crushed material, granatum powder
Mince 1 part, 1 part of Cortex Phellodendri crushed material, 1 part of Radix Isatidis crushed material, 1 part of hawthorn crushed material, 1 part of rheum officinale crushed material, coptis crushed material 1
Part, Fructus Schisandrae Chinensis powder mince 1 part, gallnut extract minces 2 parts.
Prevent the preparation method that aquatic livestock steals the drug of dead disease：By medicinal material, clean, it is dry, be respectively crushed into 80 purposes
Crushed material is stirred 10min to get finished product.
Embodiment 2
8 parts of felwort crushed material, 3 parts of Radix Glycyrrhizae crushed material, 8 parts of Herba Euphorbiae Humifusae crushed material, 3 parts of bark of ash crushed material, granatum powder
Mince 3 parts, 3 parts of Cortex Phellodendri crushed material, 3 parts of Radix Isatidis crushed material, 3 parts of hawthorn crushed material, 3 parts of rheum officinale crushed material, coptis crushed material 3
Part, Fructus Schisandrae Chinensis powder mince 3 parts, gallnut extract minces 6 parts.
Prevent the preparation method that aquatic livestock steals the drug of dead disease：By medicinal material, clean, it is dry, be respectively crushed into 100 purposes
Crushed material is stirred 15min to get finished product.
Embodiment 3
10 parts of felwort crushed material, 5 parts of Radix Glycyrrhizae crushed material, 10 parts of Herba Euphorbiae Humifusae crushed material, 5 parts of bark of ash crushed material, granatum
5 parts of crushed material, 5 parts of Cortex Phellodendri crushed material, 5 parts of Radix Isatidis crushed material, 5 parts of hawthorn crushed material, 5 parts of rheum officinale crushed material, the coptis crush
5 parts of object, Fructus Schisandrae Chinensis powder mince 5 parts, gallnut extract minces 8 parts.
Prevent the preparation method that aquatic livestock steals the drug of dead disease：By medicinal material, clean, it is dry, be respectively crushed into 120 purposes
Crushed material is stirred 20min to get finished product.
Embodiment 4
5 parts of Radix Gentianae extract, 1 part of licorice, 5 parts of Herba Euphorbiae Humifusae extract, 1 part of cortex fraxini extract, granatum carry
Take 1 part of object, 1 part of phellodendron extract, 1 part of isatis root extract, 1 part of haw thorn extract, 1 part of Chinese rhubarb extract, coptis extract 1
Part, 1 part of Schisandra chinens P.E, 2 parts of nutgall extractive.
The preparation method that aquatic livestock steals the drug of dead disease is prevented, is included the following steps：
(1) medicinal material needed for the above extract cleaned respectively, dried, extracting in water, concentration, drying, detection accord with respectively
The amount of the medicinal material needed for above-mentioned formula is weighed after standardization；
(2) by said extracted object mixing 10min, mixture is obtained.
Embodiment 5
8 parts of Radix Gentianae extract, 3 parts of licorice, 8 parts of Herba Euphorbiae Humifusae extract, 3 parts of cortex fraxini extract, granatum carry
Take 3 parts of object, 3 parts of phellodendron extract, 3 parts of isatis root extract, 3 parts of haw thorn extract, 3 parts of Chinese rhubarb extract, coptis extract 3
Part, 3 parts of Schisandra chinens P.E, 6 parts of nutgall extractive.
The preparation method that aquatic livestock steals the drug of dead disease is prevented, is included the following steps：
(1) medicinal material needed for the above extract cleaned respectively, dried, extracting in water, concentration, drying, detection accord with respectively
The amount of the medicinal material needed for above-mentioned formula is weighed after standardization；
(2) by said extracted object mixing 15min, mixture is obtained.
Embodiment 6
10 parts of Radix Gentianae extract, 5 parts of licorice, 10 parts of Herba Euphorbiae Humifusae extract, 5 parts of cortex fraxini extract, granatum
5 parts of extract, 5 parts of phellodendron extract, 5 parts of isatis root extract, 5 parts of haw thorn extract, 5 parts of Chinese rhubarb extract, coptis extraction
5 parts of object, 5 parts of Schisandra chinens P.E, 8 parts of nutgall extractive.
The preparation method that aquatic livestock steals the drug of dead disease is prevented, is included the following steps：
(1) medicinal material needed for the above extract cleaned respectively, dried, extracting in water, concentration, drying, detection accord with respectively
The amount of the medicinal material needed for above-mentioned formula is weighed after standardization；
(2) by said extracted object mixing 20min, mixture is obtained.
Embodiment 7
5 parts of felwort, 1 part of Radix Glycyrrhizae, 5 parts of Herba Euphorbiae Humifusae, 1 part of the bark of ash, 1 part of granatum, 1 part of Cortex Phellodendri, 1 part of Radix Isatidis, hawthorn 1
Part, 1 part of rheum officinale, 1 part of the coptis, 1 part of Schisandra chinensis, 2 parts of Chinese gall.
(1) medicinal material cleaned, dry, weigh, be ground into coarse powder.
(2) above-mentioned coarse powder is added to the water of 6 times of amounts, is decocted 1 time, each 1h, heat filtering, merging filtrate, concentrating return-flow waits for
When being back to medicinal extract, be dried in vacuo, crush after extract.
Embodiment 8
8 parts of felwort, 3 parts of Radix Glycyrrhizae, 8 parts of Herba Euphorbiae Humifusae, 3 parts of the bark of ash, 3 parts of granatum, 3 parts of Cortex Phellodendri, 3 parts of Radix Isatidis, hawthorn 3
Part, 3 parts of rheum officinale, 3 parts of the coptis, 3 parts of Schisandra chinensis, 6 parts of Chinese gall.
(1) medicinal material cleaned, dry, weigh, be ground into coarse powder.
(2) above-mentioned coarse powder is added to the water of 10 times of amounts, is decocted 3 times, each 2h, heat filtering, merging filtrate, concentrating return-flow,
When being back to medicinal extract, be dried in vacuo, crush after extract.
Embodiment 9
10 parts of felwort, 5 parts of Radix Glycyrrhizae, 10 parts of Herba Euphorbiae Humifusae, 5 parts of the bark of ash, 5 parts of granatum, 5 parts of Cortex Phellodendri, 5 parts of Radix Isatidis, mountain
5 parts of short, bristly hair or beard, 5 parts of rheum officinale, 5 parts of the coptis, 5 parts of Schisandra chinensis, 8 parts of Chinese gall.
(1) medicinal material cleaned, dry, weigh, be ground into coarse powder.
(2) above-mentioned coarse powder is added to the water of 12 times of amounts, is decocted 5 times, each 4h, heat filtering, merging filtrate, concentrating return-flow,
When being back to medicinal extract, be dried in vacuo, crush after extract.
Test example
In South America, the season of dead disease is stolen in prawn outburst, selects 1000 tail of South America prawn, is divided into 10 groups, puts 10 area phases
Same 4 square metres of shrimp ponds middle-high density raising, the 1st group of feed of the feeding containing embodiment 1, the 2nd group of feeding contain embodiment 2
Feed, the 3rd group of feed of the feeding containing embodiment 3, the 4th group of feed of the feeding containing embodiment 4, the 5th group of feeding contain reality
Apply the feed of example 5, the 6th group of feed of the feeding containing embodiment 6, the 7th group of feed of the feeding containing embodiment 7, the 8th group of feeding contain
There are the feed of embodiment 8, the 9th group of feed of the feeding containing embodiment 9, the 10th group of feeding chow diet.Continuous feeding 28 days.
1 drug of the present invention of table steals South America prawn the preventive effect of dead disease
Test result：Compared with 10 groups of experiment, the drug of experiment 1-9 groups steals dead disease to South America prawn certain prevention
Effect, for the survival rate of shrimp all 70% or more, but as seen from the experiment, the effect of 9 groups of 6 groups of experiment and experiment is best, can
The generation of the effective dead disease of pre- anti-theft.
Claims (8)
1. a kind of prevention aquatic livestock steals the drug of dead disease, it is characterised in that be made of the Chinese medicine material of following portion rate：Rough gentian
5-10 parts careless, 1-5 parts of Radix Glycyrrhizae, 5-10 parts of Herba Euphorbiae Humifusae, 1-5 parts of the bark of ash, 1-5 parts of granatum, 1-5 parts of Cortex Phellodendri, 1-5 parts of Radix Isatidis,
1-5 parts of hawthorn, 1-5 parts of rheum officinale, 1-5 parts of the coptis, 1-5 parts of Schisandra chinensis, 2-8 parts of Chinese gall.
2. prevention aquatic livestock according to claim 1 steals the drug of dead disease, it is characterised in that by the medicine of following portion rate
Material crushed material forms：5-10 parts of felwort crushed material, 1-5 parts of Radix Glycyrrhizae crushed material, 5-10 parts of Herba Euphorbiae Humifusae crushed material, bark of ash crushed material
1-5 parts, it is 1-5 parts of granatum crushed material, 1-5 parts of Cortex Phellodendri crushed material, 1-5 parts of Radix Isatidis crushed material, 1-5 parts of hawthorn crushed material, big
Bloom mince 1-5 parts, 1-5 parts of coptis crushed material, Fructus Schisandrae Chinensis powder mince 1-5 parts, gallnut extract minces 2-8 parts.
3. prevention aquatic livestock according to claim 1 steals the drug of dead disease, it is characterised in that by the medicine of following portion rate
Material extract forms：5-10 parts of Radix Gentianae extract, 1-5 parts of licorice, 5-10 parts of Herba Euphorbiae Humifusae extract, cortex fraxini extract
1-5 parts, it is 1-5 parts of pomegranate rind extract, 1-5 parts of phellodendron extract, 1-5 parts of isatis root extract, 1-5 parts of haw thorn extract, big
Yellow extract 1-5 parts, 1-5 parts of coptis extract, 1-5 parts of Schisandra chinens P.E, 2-8 parts of nutgall extractive.
4. prevention aquatic livestock according to claim 1 steals the drug of dead disease, it is characterised in that by the medicine of following portion rate
Material mixing extraction is prepared：5-10 parts of felwort, 1-5 parts of Radix Glycyrrhizae, 5-10 parts of Herba Euphorbiae Humifusae, 1-5 parts of the bark of ash, 1-5 parts of granatum,
1-5 parts of Cortex Phellodendri, 1-5 parts of Radix Isatidis, 1-5 parts of hawthorn, 1-5 parts of rheum officinale, 1-5 parts of the coptis, 1-5 parts of Schisandra chinensis, 2-8 parts of Chinese gall.
5. prevention aquatic livestock according to claim 2 steals the preparation method of the drug of dead disease：By medicinal material, clean, it is dry,
It is respectively crushed into the crushed material of 80-120 mesh, is stirred 10-20min to get finished product.
6. prevention aquatic livestock according to claim 3 steals the preparation method of the drug of dead disease, include the following steps：
(1) medicinal material needed for the above extract cleaned respectively, dried, extracting in water, concentration, drying, detection meet mark respectively
The amount of the medicinal material needed for above-mentioned formula is weighed after standard；
(2) by said extracted object mixing 10-20min, mixture is obtained.
7. treatment aquatic livestock according to claim 4 steals the preparation method of the drug of dead disease：
(1) medicinal material cleaned, dry, weigh, be ground into coarse powder；
(2) the 6-12 times of water measured is added in above-mentioned coarse powder, decocted 1-5 times, each 1-2h, heat filtering, merging filtrate concentrates back
Stream, when being back to medicinal extract, be dried in vacuo, crush after extract.
8. the prevention aquatic livestock according to claim 5-7 any one steals the preparation method of the drug of dead disease, further include
Wherein add one or two kinds of mixture in auxiliary material silica, powdered rice hulls, sucrose.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125178A (en) * | 2010-12-27 | 2011-07-20 | 豆梅英 | Feed additive for preventing and treating virus caused death of aquatic livestock and preparation method thereof |
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2015
- 2015-08-11 CN CN201510489142.3A patent/CN105030994B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125178A (en) * | 2010-12-27 | 2011-07-20 | 豆梅英 | Feed additive for preventing and treating virus caused death of aquatic livestock and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 从对虾偷死症谈益生菌在水产养殖中的应用;任十七;《农家之友(理论版)》;20081231(第10期);53-56 * |
| 南美白对虾"偷死综合症"的病因分析及调控措施探讨;孙成波;《中国水产》;20081231(第03期);65-67 * |
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