CN105030690B - Vitamin C sustained-release granular formulation and its production method - Google Patents
Vitamin C sustained-release granular formulation and its production method Download PDFInfo
- Publication number
- CN105030690B CN105030690B CN201510398281.5A CN201510398281A CN105030690B CN 105030690 B CN105030690 B CN 105030690B CN 201510398281 A CN201510398281 A CN 201510398281A CN 105030690 B CN105030690 B CN 105030690B
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- CN
- China
- Prior art keywords
- attapulgite
- citric acid
- vitamin
- acid solution
- aqueous citric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 50
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 229930003268 Vitamin C Natural products 0.000 title claims abstract description 24
- 239000011718 vitamin C Substances 0.000 title claims abstract description 24
- 235000019154 vitamin C Nutrition 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 238000009472 formulation Methods 0.000 title claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 238000013268 sustained release Methods 0.000 title claims abstract description 12
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 66
- 229960000892 attapulgite Drugs 0.000 claims abstract description 40
- 229910052625 palygorskite Inorganic materials 0.000 claims abstract description 40
- 239000002245 particle Substances 0.000 claims abstract description 23
- 239000008187 granular material Substances 0.000 claims abstract description 17
- 239000011812 mixed powder Substances 0.000 claims abstract description 13
- 229920001353 Dextrin Polymers 0.000 claims abstract description 9
- 239000004375 Dextrin Substances 0.000 claims abstract description 9
- 235000019425 dextrin Nutrition 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 238000007654 immersion Methods 0.000 claims abstract description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims 1
- 244000144972 livestock Species 0.000 abstract description 12
- 239000011248 coating agent Substances 0.000 abstract description 4
- 238000000576 coating method Methods 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000251511 Holothuroidea Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000027272 reproductive process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses vitamin C sustained-release granular formulation and its production method, granule component：Vc 3.5% 6%, dextrin 3.5% 6%, aqueous citric acid solution 0.5% 2%, polyethylene glycol 1 2%, surplus is attapulgite, and granule is spherical, a diameter of 1mm 10mm of spheric granules.Production method step is as follows：(1) attapulgite is added into running water immersion curing；(2) it is pressed into sheet and dries；(3) pulverize and sieve；(4) the attapulgite particle that diameter is about 1mm is made；(5) aqueous citric acid solution is sprayed；(6) Vc mixed powders are wrapped in the surface of attapulgite particle；And coating is handled.Advantage of the present invention：1. easy to use, Vc granules directly can be shed in water, targeted release, be easy to the absorption of aquatic livestock.2. being easy to store, Vc granules use citric acid used as stabilizers, are not easily decomposed during storage.3. Vc granules have a slow-release function, purposes is larger.
Description
Technical field
It is especially a kind of to be grown as aquatic livestock, breed nutrient the present invention relates to aquatic livestock technical field
Vitamin C sustained-release granular formulation and its production method.
Background technology
Vitamin C (Vitamin C, Ascorbic Acid) is called L-AA, is a kind of water soluble vitamin, with
Lower abbreviation Vc.Vc is trophism element essential in aquatic livestock growth, reproductive process.Vc can not only improve animal machine
The immunocompetence of body, strengthens the resistance against diseases of animal body, and still sustain life and grow essential material.Work as Vc
Problems with can be caused when measuring insufficient：1. the metabolic disturbance of aquatic livestock, premunition declines, and is susceptible to suffer from infectious disease；2. aquatic products
The rate of body weight gain and feed conversion rate of animal all decline, death rate rise.
However, most aquatic livestock itself can not synthesize vitamin C, it is necessary to be absorbed from food.In aquaculture
Middle addition Vc, there are following 3 aspects：1. the anti-stress ability of aquatic livestock can be improved, Vc can improve aquatile pair
The adaptability of body anoxic and low temperature；2. the resistance against diseases of aquatic livestock can be improved, Vc can mitigate the toxic action of heavy metal,
And the wound of aquatic animal is promoted to heal；3. Vc improves the breeding of aquatic livestock to promoting growth of animal, promoting skeleton development
Rate, it is respectively provided with obvious effect.
At present, the Vc product categories of in the market are a lot, such as crystallize Vc, coating Vc, Vc sulfuric ester and Vc phosphates.On
It is different to state the influence of Vc products light, heat, oxygen, inorganic salts, humidity etc., during using and storing, Vc loss is equal
It is very serious.Such as crystallization Vc mix and pelletization in there is 25%-50% to be destroyed, in water immersion and jetsam during again
There is 30%-60% to be destroyed, and normal temperature storage loses weekly the 10%-15% for content, such aquatic livestock can be taken the photograph in water
The Vc amounts got are very little.Therefore, the stability of Vc products how is improved, turns into the important of various countries this area scientist research
One of problem.
The content of the invention
Be not easily decomposed during being stored it is an object of the invention to provide one kind, stability it is good, bioavailability is high, user
Just vitamin C sustained-release granular formulation and its production method.
The purpose of the present invention is achieved by the following technical solution：
Vitamin C sustained-release granular formulation, it is made up of by weight percentage following component：Vitamin C 3.5%-6%, dextrin
3.5%-6%, aqueous citric acid solution 0.5%-2%, polyethylene glycol 1-2%, surplus are attapulgite.
As the preferred technical solution of the present invention, the vitamin C is 5%, dextrin 5%, and aqueous citric acid solution is
1%.
As the preferred technical solution of the present invention, the polyethylene glycol is PEG-4000.
As the preferred technical solution of the present invention, the concentration of the aqueous citric acid solution is 20%.
As the preferred technical solution of the present invention, the granule is spherical, a diameter of 1mm-10mm of spheric granules.
The production method of vitamin C sustained-release granular formulation, comprises the following steps：
(1) attapulgite is added into running water immersion, is allowed to cure；
(2) sticky attapulgite is pressed into sheet with roller press and dried；
(3) the attapulgite piece that above-mentioned steps obtain is crushed and sieved with pulverizer；
(4) it is granulated by the use of the attapulgite less than 20 mesh as parent nucleus, adds the attapulgite more than 80 mesh, is made straight
The attapulgite particle that footpath is about 1mm, then carry out high temperature drying and sieving；
(5) the attapulgite particle of drying is added in rotary drum granulator, the aqueous citric acid solution of gross weight 1% will be accounted for
Uniformly it is sprayed at the surface of attapulgite particle；
(6) vitamin C of gross weight 5% will be accounted for be well mixed with the dextrin of equivalent, obtains Vc mixed powders；
(7) the Vc mixed powders are added in attapulgite particle equably, in batches, and in rotary drum granulator not
Rotated with stopping, until Vc mixed powders are equably wrapped in the surface of attapulgite particle；
(8) equably the attapulgite particle for being enclosed with the Vc mixed powders is entered using 1-2% PEG-4000
The processing of row coating.
As the preferred technical solution of the present invention, the concentration of aqueous citric acid solution is 20% in the step (5).
The step of aqueous citric acid solution is sprayed as the preferred technical solution of the present invention, in the step (5) is in rotary drum
What comminutor was carried out during continuously rotating.
The beneficial effects of the invention are as follows：Relative to prior art, Vc granules of the present invention have advantages below：1. user
Just, Vc granules directly can be shed in water, targeted release, can be advantageously used for the bottoms such as shrimp, crab, fish and sea cucumber and be dwelt
Thing, it is easy to the absorption of aquatic livestock.The very effective stress reaction for mitigating aquatic livestock of Vc particles energy, substantially reduces aquatic products and moves
Thing death rate caused by stress reaction.2. being easy to store, Vc granules of the present invention use citric acid in process of production
As stabilizer, vitamin C is set to be not easily decomposed during storage.After 3. Vc granules have slow-release function, particle to sink to the bottom
Just start slowly release Vc compositions, reduce Vc loss.4. Vc granule manufacturing process is simple, cost is cheap, biological utilisation
Rate is high, is advantageous to expand Vc use range.
Embodiment
With reference to specific embodiment, the invention will be further described：
Vitamin C sustained-release granular formulation, it is made up of by weight percentage following component：Vitamin C 3.5%-6%, dextrin
3.5%-6%, aqueous citric acid solution 0.5%-2%, polyethylene glycol 1-2%, surplus are attapulgite.
In the present embodiment, the vitamin C is 5%, dextrin 5%, aqueous citric acid solution 1%.The polyethylene glycol
For PEG-4000, the concentration of aqueous citric acid solution is 20%, and the granule is spherical, a diameter of 1mm- of spheric granules
10mm。
The production method of vitamin C sustained-release granular formulation, comprises the following steps：
(1) attapulgite is added into running water immersion, is allowed to cure；
(2) sticky attapulgite is pressed into sheet with roller press and dried；
(3) the attapulgite piece that above-mentioned steps obtain is crushed and sieved with pulverizer；
(4) it is granulated by the use of the attapulgite less than 20 mesh as parent nucleus, adds the attapulgite more than 80 mesh, is made straight
The attapulgite particle that footpath is about 1mm, then carry out high temperature drying and sieving；
(5) the attapulgite particle of drying is added in rotary drum granulator, the aqueous citric acid solution of gross weight 1% will be accounted for
Uniformly it is sprayed at the surface of attapulgite particle；
(6) vitamin C of gross weight 5% will be accounted for be well mixed with the dextrin of equivalent, obtains Vc mixed powders；
(7) the Vc mixed powders are added in attapulgite particle equably, in batches, and in rotary drum granulator not
Rotated with stopping, until Vc mixed powders are equably wrapped in the surface of attapulgite particle；
(8) equably the attapulgite particle for being enclosed with the Vc mixed powders is entered using 1-2% PEG-4000
The processing of row coating.
In the present embodiment, the concentration of aqueous citric acid solution is 20% in the step (5), wherein spraying aqueous citric acid solution
The step of carried out during rotary drum granulator continuously rotates, aqueous citric acid solution is uniformly sprayed onto attapulgite
The surface of particle.
Vitamin C sustained-release granular formulation of the present invention compared to various Vc products in the market, product stability, cost,
Bioavailability etc. is greatly improved.
Claims (1)
1. a kind of production method of vitamin C sustained-release granular formulation, the vitamin C sustained-release granular formulation is by following component by weight hundred
Divide than composition：Vitamin C is 5%, dextrin 5%, aqueous citric acid solution 1%, polyethylene glycol 1-2%, and surplus is concave convex rod
Soil；The polyethylene glycol is PEG-4000；The concentration of the aqueous citric acid solution is 20%；The granule to be spherical,
A diameter of 1mm-10mm of spheric granules；It is characterized in that the production method comprises the following steps：
(1) attapulgite is added into running water immersion, is allowed to cure；
(2) sticky attapulgite is pressed into sheet with roller press and dried；
(3) the attapulgite piece that above-mentioned steps obtain is crushed and sieved with pulverizer；
(4) it is granulated by the use of the attapulgite less than 20 mesh as parent nucleus, adds the attapulgite more than 80 mesh, diameter is made about
For 1mm attapulgite particle, high temperature drying and sieving are then carried out；
(5) the attapulgite particle of drying is added in rotary drum granulator, the aqueous citric acid solution for accounting for gross weight 1% is uniform
It is sprayed at the surface of attapulgite particle；
(6) vitamin C of gross weight 5% will be accounted for be well mixed with the dextrin of equivalent, obtains Vc mixed powders；
(7) the Vc mixed powders are added in attapulgite particle equably, in batches, and in rotary drum granulator ceaselessly
Rotated, until Vc mixed powders are equably wrapped in the surface of attapulgite particle；
(8) equably the attapulgite particle for being enclosed with the Vc mixed powders is wrapped using 1-2% PEG-4000
Film process；
The concentration of aqueous citric acid solution is 20% in the step (5)；In the step (5) the step of sprinkling aqueous citric acid solution
Carried out during rotary drum granulator continuously rotates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510398281.5A CN105030690B (en) | 2015-07-08 | 2015-07-08 | Vitamin C sustained-release granular formulation and its production method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510398281.5A CN105030690B (en) | 2015-07-08 | 2015-07-08 | Vitamin C sustained-release granular formulation and its production method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105030690A CN105030690A (en) | 2015-11-11 |
| CN105030690B true CN105030690B (en) | 2018-01-16 |
Family
ID=54438062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510398281.5A Expired - Fee Related CN105030690B (en) | 2015-07-08 | 2015-07-08 | Vitamin C sustained-release granular formulation and its production method |
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| Country | Link |
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| CN (1) | CN105030690B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105143A (en) * | 2008-08-06 | 2011-06-22 | 第一三共健康事业株式会社 | Stable pharmaceutical composition containing tranexamic acid and ascorbic acid |
| CN102824315A (en) * | 2012-09-25 | 2012-12-19 | 广西金海堂药业有限责任公司 | Preparation method of vitamin C micro-pill |
| CN103271026A (en) * | 2013-05-28 | 2013-09-04 | 姜堰市澳华生物科技有限公司 | Potassium permanganate compound granule and production method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102121082B1 (en) * | 2012-04-20 | 2020-06-10 | 디에스엠 아이피 어셋츠 비.브이. | Solid, color-stable l-ascorbic acid compositions |
-
2015
- 2015-07-08 CN CN201510398281.5A patent/CN105030690B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105143A (en) * | 2008-08-06 | 2011-06-22 | 第一三共健康事业株式会社 | Stable pharmaceutical composition containing tranexamic acid and ascorbic acid |
| CN102824315A (en) * | 2012-09-25 | 2012-12-19 | 广西金海堂药业有限责任公司 | Preparation method of vitamin C micro-pill |
| CN103271026A (en) * | 2013-05-28 | 2013-09-04 | 姜堰市澳华生物科技有限公司 | Potassium permanganate compound granule and production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| "维生素C微囊缓释片的制备";廖志平;《国际医药卫生导报》;20061231;第12卷(第12期);第106-107页 * |
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| Publication number | Publication date |
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| CN105030690A (en) | 2015-11-11 |
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