CN105029396A - Health-caring product or drug composition for protecting liver - Google Patents
Health-caring product or drug composition for protecting liver Download PDFInfo
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- CN105029396A CN105029396A CN201510166136.4A CN201510166136A CN105029396A CN 105029396 A CN105029396 A CN 105029396A CN 201510166136 A CN201510166136 A CN 201510166136A CN 105029396 A CN105029396 A CN 105029396A
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Abstract
The invention provides a health-caring product or drug composition for protecting liver, which is composed of following raw materials, by weight, 1-3 parts of hawthorn, 1-2 parts of pawpaw, 1-2 parts of smoked plums and 1-2 parts of fingered citron. The invention also provides an application of the health-caring product or drug composition. The composition can significantly improve various main indexes after liver damage and can achieve significant liver protecting effect, and is reasonable in compatibility of components, wherein the raw materials are cooperated with each other and achieve a synergistic effect. The activity of the composition is better than the single materials.
Description
Technical field
The present invention relates to a kind of health products of protecting the liver or pharmaceutical composition.
Background technology
The generation of chemical damage is relevant with everyday exposure chemical toxicant, alcohol and some medicines, and these factors easily cause compromised liver function.All there are some to the virose material of liver in the Nature and human industry's production process, be called " hepatotropic poison ", these poisonous substances are general susceptible in crowd, incubation period is short; the process of pathology is directly related with the dosage of infection, can cause liver necrosis of liver cells in various degree, steatosis, cirrhosis and liver cancer.
Along with growth in the living standard, the contact probability of people to alcohol is in rising trend.Thus, the probability of alcohol to hepar damnification is too increased.Alcoholic liver injury easily develops into AML.AML (ALD) is the common disease of developed country, is the Etiological causing cirrhosis.China consumes big country as a wine, and the crowd that drinks is comparatively large, causes the trend increased gradually as fatty liver, cirrhosis etc. have to relevant disease of drinking clinically.But AML does not have specific drug so far, the essential measure improving body condition is abstinence from alcohol, and alcohol addiction makes abstinence from alcohol to drink crowd comparatively difficulty concerning major part.Thus, while responsible drinking, be also badly in need of that there is the health food protecting the liver function and prevent alcohol to the infringement of liver.
At present, reported that the medicine with anti-liver injury has tens of kinds, as Chinese caterpillar fungus, rheum officinale, pseudo-ginseng, the Radix Astragali, kuh-seng, the red sage root, the fruit of Chinese wolfberry, the fruit of Chinese magnoliavine, glossy ganoderma, purslane, gynostemma pentaphylla, Ligusticum wallichii etc., wherein, be no lack of the Chinese medicine of integration of drinking and medicinal herbs.Therefore, from Chinese medicine, find the medicine that can be used for preventing liver injury, also just become the focus of research.
Publication number be CN101028500A application discloses a kind of new Chinese medicine composition.Said composition is made up of Chinese yam, Semen Lablab Album, lily, Flos Semen Lablab Album, the membrane of a chicken's gizzard, Poria cocos, rde bean, coix seed, spina date seed, Buddha's hand, citron, trifoliate orange, cape jasmine, dark plum, pawpaw, balloonflower root, Fructus Hordei Germinatus, purple perilla (perilla leaf), radix polygonati officinalis, the root of kudzu vine, Radix Glycyrrhizae, fresh Rhizoma Phragmitis, Fermented Soybean, ginger, oyster, hawthorn, lotus leaf, lophatherum gracile, chrysanthemum, the root of Dahurain angelica, peppermint, fructus amomi, wrinkled giant hyssop, mulberry leaf, orange peel (dried orange peel), radish seed etc.Said composition has appetizing, tasty and refreshing, the effect of sobering up.In this prescription, flavour of a drug are more, certainly will bring higher treatment cost to patient.Therefore, research and develop a kind of flavour of a drug composition Traditional Chinese medicine composition few and evident in efficacy and seem particularly necessary.
Summary of the invention
The object of the present invention is to provide a kind of health products of protecting the liver or pharmaceutical composition.Present invention also offers Preparation Method And The Use.
The invention provides a kind of health products of protecting the liver or pharmaceutical composition, it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 1 ~ 3 part, pawpaw 1 ~ 2 part, dark plum 1 ~ 2 part, Buddha's hand 1 ~ 2 part.
Further, it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 3 parts, pawpaw 2 parts, dark plum 1 ~ 2 part, Buddha's hand 1 part.
Preferably, it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 3 parts, pawpaw 2 parts, dark plum 2 parts, Buddha's hand 1 part.
Wherein, it prepares by the following method:
(1) raw material is taken by proportioning;
(2) get raw material directly to pack, obtain formulation; Or, get the powder of raw material or the water of raw material or/and ethanol extract, add acceptable auxiliary material in health products or medicine, be prepared into formulation.
Further, described formulation is through gastrointestinal administration formulation.Such as, described formulation is medicinal tea, granule, powder, tablet, pill, capsule or oral liquid.
Present invention also offers the preparation method of above-mentioned health products or pharmaceutical composition, it comprises following operating procedure:
(1) raw material is taken by proportioning;
(2) get raw material directly to pack, obtain health products or pharmaceutical composition; Or, get the powder of raw material or the water of raw material or/and ethanol extract, add acceptable auxiliary material in health products or medicine, be prepared into health products or pharmaceutical composition.
Present invention also offers above-mentioned health products or the purposes of pharmaceutical composition in the health products preparing prevention or treatment alcoholic liver injury or medicine.
Further, described hepatic injury is acute alcohol-induced hepatic injury.
Further, described health products or medicine reduce serum transaminase, triglycerides, and the health products of liver MDA or medicine.
Composition provided by the invention significantly can improve the every leading indicator after hepatic injury, have significant hepatoprotective effect, and compatibility is precise and appropriate, and each raw material complements each other, and has played synergy, and activity is more better than each single raw material.
Below by detailed description of the invention, the present invention is described in further details, but be not limitation of the present invention, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
Detailed description of the invention
The preparation of embodiment 1 present composition
Get hawthorn 15g, pawpaw 10g, dark plum 10g, Buddha's hand 5g, boiling 3 times, collect decocting liquid, obtain decoction.
The preparation of embodiment 2 present composition
Get hawthorn 3g, pawpaw 2g, dark plum 1g, Buddha's hand 1g, pack, is prepared into medicinal tea.
The preparation of embodiment 3 present composition
Get hawthorn 10g, pawpaw 10g, dark plum 10g, Buddha's hand 10g, first use 95% alcohol extract 2 times, merge alcohol extract, then boiling 2 times, collect decocting liquid; Alcohol extract merges with decocting liquid after reclaiming ethanol, after concentrated, add appropriate filler and is prepared into granule.
The preparation of embodiment 4 present composition
Get hawthorn 15g, pawpaw 10g, dark plum 10g, Buddha's hand 5g, with 60 ~ 65% alcohol extract 3 times, merge alcohol extract, after reclaiming ethanol, spraying dry, adds appropriate filler and is prepared into capsule.
Beneficial effect of the present invention is illustrated below by way of test example.
1. prescription medicine
The present composition, by hawthorn, pawpaw, dark plum, Buddha's hand etc. for primary raw material forms.
Hawthorn, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Pawpaw, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Dark plum, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Buddha's hand, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality requirement.
2. present composition liver protective effect optimum proportioning screening:
2.1.1 Experimental agents
For determining optimum proportioning dosage, setting various dose proportioning group carries out Preliminary screening, is respectively:
Proportioning group 1 (hawthorn: pawpaw: dark plum: Buddha's hand=1:1:1:1, i.e. hawthorn 10g, pawpaw 10g, dark plum 10g, Buddha's hand 10g);
Proportioning group 2 (hawthorn: pawpaw: dark plum: Buddha's hand=3:2:1:1, i.e. hawthorn 17.2g, pawpaw 11.4g, dark plum 5.7g, Buddha's hand 5.7g);
Proportioning group 3 (hawthorn: pawpaw: dark plum: Buddha's hand=3:2:2:1, i.e. hawthorn 15g, pawpaw 10g, dark plum 10g, Buddha's hand 5g); Water boiling concentration is that 80g crude drug in whole/100ml medicinal extract is for subsequent use respectively.
2.1.2 animal used as test
KM mouse, body weight 18-22g, male and female half and half, Da Shuo bio tech ltd, Chengdu provides, the animal quality certification number: SCXK (river) 2008-24
2.1.3 experiment reagent
In serum, glutamic-pyruvic transaminase (ALT) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 201201102; In serum, glutamic-oxalacetic transaminease (AST) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121104; Triglycerides in Serum (TG) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121030; Liver MDA (MDA) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121024.
2.1.4 laboratory apparatus
Ultraviolet-uisible spectrophotometer, refrigerated centrifuge.
2.2 experimental technique
2.2.1 on the impact of acute alcohol-induced hepatic injury mouse
2.2.1.1 on the impact of acute alcohol-induced hepatic injury mice serum ALT
Get 60 mouse and be divided into 5 groups at random, be respectively blank group, model group, proportioning 1 group, proportioning 2 groups, proportioning 3 groups.Except blank group, often group presses 15ml/kg body weight gavage 50% ethanol, and after 1h, often group is all according to 0.1ml/10g body weight gavage liquid, and blank group and model group give the physiological saline of same volume, continuous 14d.After last administration, water 16h is can't help in feed, and eyeball excise method puts to death mouse.Get blood separation of serum, survey ALT by kit method, each administration group result compares with model control group carries out variance analysis.
2.2.2 on the impact of acute alcohol-induced hepatic injury mice serum AST
Experiment grouping and dosage are with 2.1.Get blood separation of serum, survey AST by kit method, each administration group result compares with model control group carries out variance analysis.
2.2.3 on the impact of acute alcohol-induced hepatic injury mice serum TG
Experiment grouping and dosage are with 2.1.Get blood separation of serum, survey AST by kit method, each administration group result compares with model control group carries out variance analysis.
2.2.4 on the impact of acute alcohol-induced hepatic injury murine liver tissue MDA
Experiment grouping and dosage are with 2.1.Get hepatic homogenate after putting to death mouse, survey MDA by kit method, each administration group result compares with model control group carries out variance analysis.
2.2.5. experimental result is in table 1
Table 1 various dose proportioning on the impact of mouse ALT, AST, TG, MDA (
n=12)
Note: compare with model group, * P < 0.05, * * P < 0.01
From table 1, compare with model group, present composition different ratio dosage group 2,3 all significantly can reduce mice serum ALT level (P<0.01); Proportioning dosage group 1 can reduce mice serum ALT level (P<0.05). and present composition different ratio dosage group 2,3 all significantly significantly reduces serum AST levels (P<0.01); Proportioning dosage group 1 reduces serum AST levels (P<0.05). and present composition different ratio dosage group all reduces the level (P<0.05) of serum TG.Present composition different ratio dosage group 2,3 all significantly significantly reduces liver MDA level (P<0.01); Proportioning dosage group 1 reduces liver MDA level (P<0.05).
To sum up test, each proportioning group all can improve the indices protected the liver, there is good hepatoprotective effect, and the hepatoprotective effect of proportioning group 3 and 2 is excellent compared with proportioning group 1, and the composite factors such as the mouthfeel of food, health food, color and luster are it can be used as to take into account, then proportioning group 3 (hawthorn: pawpaw: dark plum: Buddha's hand=3:2:2:1, i.e. hawthorn 15g, pawpaw 10g, dark plum 10g, Buddha's hand 5g) be optimum dose proportion.
2.3 present composition liver protective effects are better than the checking of simple:
2.3.1 experiment material
2.3.1.1 Experimental agents
Hawthorn, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Pawpaw, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Dark plum, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality regulation requirement.
Buddha's hand, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd of Sichuan Province, meets " Chinese Pharmacopoeia " (version in 2010) quality requirement.
Proportioning group 3 (hawthorn: pawpaw: dark plum: Buddha's hand=3:2:2:1, i.e. hawthorn 15g, pawpaw 10g, dark plum 10g, Buddha's hand 5g.
Hawthorn, pawpaw, dark plum, each simple of Buddha's hand and proportioning group 3, water boiling concentration is that 80g crude drug in whole/100ml medicinal extract is for subsequent use respectively.
2.3.1.2 animal used as test
KM mouse, Da Shuo bio tech ltd, Chengdu provides, body weight 18-22g, male and female half and half, the animal quality certification number: animal credit number: SCXK (river) 2008-24.
2.3.1.3 experiment reagent
In serum, glutamic-pyruvic transaminase (ALT) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 201201102; In serum, glutamic-oxalacetic transaminease (AST) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121104;
Triglycerides in Serum (TG) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121030; Liver MDA (MDA) measures kit, and Bioengineering Research Institute is built up in Nanjing, lot number: 20121024.
2.3.1.4 laboratory apparatus
Ultraviolet-uisible spectrophotometer, refrigerated centrifuge.
2.3.2. experimental technique
2.3.2.1 on the impact of acute alcohol-induced hepatic injury mice serum ALT, AST, TG
Get 90 mouse and be divided into 9 groups at random, be respectively blank group, model group, hawthorn group, pawpaw group, dark plum group, Buddha's hand group, composition high dose group, dosage group, composition low dose group in composition.Except blank group, often group presses 15ml/kg body weight gavage 50% ethanol, and after 1h, often group is all according to 0.2ml/10g body weight gavage liquid, and blank group and model group give the physiological saline of same volume, continuous 14d.After last administration, water 16h is can't help in feed, and eyeball excise method puts to death mouse.Get blood separation of serum, survey ALT, AST, TG by kit method, each administration group result compares with model control group carries out variance analysis.
2.3.2.2 on the impact of acute alcohol-induced hepatic injury murine liver tissue MDA
Experiment grouping and dosage are with 2.1.Get hepatic homogenate after putting to death mouse, survey MDA by kit method, each administration group result compares with model control group carries out variance analysis.
2.3.3. experimental result is in table 2
Table 2 protect the liver drink on the impact of mouse ALT, AST, TG, MDA (
n=10)
Note: compare with model group, * P < 0.05, * * P < 0.01, compares with middle dosage group,
▽p<0.05,
▽ ▽p<0.01.
From table 2, compared with model group, hawthorn group and each dosage group of the present composition all significantly can reduce ALT, AST, MDA, TG level (P<0.01 or <0.05), and pawpaw, dark plum group can reduce ALT, AST, MDA level (P<0.05); Buddha's hand group only has reducing effect (P<0.05) to ALT level, and AST, TG, MDA is only had to the trend of reduction.Compared with individually dosed group of each flavour of a drug; in the present composition under same dose, dosage group all significantly can reduce ALT, AST, MDA, TG level (P<0.05); show that in medicine of the present invention, the combination of each flavour of a drug serves the effect of Synergistic for protection liver function, it is evident in efficacy is better than being used alone of each flavour of a drug in this composition.
In mice serum ALT, AST, TG level and liver organization, the height of MDA level evaluates the objective indicator whether tested material has hepatoprotective effect, prescription in this experiment reduces MDA level in acute alcoholism mice serum alt, AST, TG level and liver homogenate, describes the present composition and has clear and definite hepatoprotective effect.
To sum up study, composition provided by the invention can obviously improve the indices protected the liver, and has significant hepatoprotective effect.
Claims (10)
1. the health products protected the liver or a pharmaceutical composition, is characterized in that: it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 1 ~ 3 part, pawpaw 1 ~ 2 part, dark plum 1 ~ 2 part, Buddha's hand 1 ~ 2 part.
2. health products according to claim 1 or pharmaceutical composition, is characterized in that: it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 3 parts, pawpaw 2 parts, dark plum 1 ~ 2 part, Buddha's hand 1 part.
3. health products according to claim 1 and 2 or pharmaceutical composition, is characterized in that: it is the preparation be prepared from by the raw material of following weight proportion:
Hawthorn 3 parts, pawpaw 2 parts, dark plum 2 parts, Buddha's hand 1 part.
4. the health products according to claims 1 to 3 any one or pharmaceutical composition, is characterized in that: it prepares by the following method:
(1) raw material is taken by proportioning;
(2) get raw material directly to pack, obtain formulation; Or, get the powder of raw material or the water of raw material or/and ethanol extract, add acceptable auxiliary material in health products or medicine, be prepared into formulation.
5. health products according to claim 4 or pharmaceutical composition, is characterized in that: described formulation is through gastrointestinal administration formulation.
6. health products or pharmaceutical composition according to claim 1 or 5, is characterized in that: described formulation is medicinal tea, granule, powder, tablet, pill, capsule or oral liquid.
7. the preparation method of health products or pharmaceutical composition described in claims 1 to 3 any one, is characterized in that: it comprises following operating procedure:
(1) raw material is taken by proportioning;
(2) get raw material directly to pack, obtain health products or pharmaceutical composition; Or, get the powder of raw material or the water of raw material or/and ethanol extract, add acceptable auxiliary material in health products or medicine, be prepared into health products or pharmaceutical composition.
8. health products described in claim 1 ~ 6 any one or the purposes of pharmaceutical composition in the health products preparing prevention or treatment alcoholic liver injury or medicine.
9. purposes according to claim 8, is characterized in that: described hepatic injury is acute alcohol-induced hepatic injury.
10. purposes according to claim 9, is characterized in that: described health products or medicine reduce serum transaminase, triglycerides, and the health products of liver MDA or medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510166136.4A CN105029396A (en) | 2014-04-15 | 2015-04-09 | Health-caring product or drug composition for protecting liver |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410151838 | 2014-04-15 | ||
| CN201510166136.4A CN105029396A (en) | 2014-04-15 | 2015-04-09 | Health-caring product or drug composition for protecting liver |
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| CN105029396A true CN105029396A (en) | 2015-11-11 |
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| CN201510166136.4A Pending CN105029396A (en) | 2014-04-15 | 2015-04-09 | Health-caring product or drug composition for protecting liver |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902834A (en) * | 2016-06-08 | 2016-08-31 | 西南医科大学 | Food, health-care product or medicine composition with health-care effect and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535709A (en) * | 2012-07-09 | 2014-01-29 | 贾洪章 | Healthcare food for chemical liver injury |
| CN103623222A (en) * | 2013-11-27 | 2014-03-12 | 泸州百草堂健康产品有限公司 | Food, health-care product or medicinal composition with liver-protecting effect |
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2015
- 2015-04-09 CN CN201510166136.4A patent/CN105029396A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535709A (en) * | 2012-07-09 | 2014-01-29 | 贾洪章 | Healthcare food for chemical liver injury |
| CN103623222A (en) * | 2013-11-27 | 2014-03-12 | 泸州百草堂健康产品有限公司 | Food, health-care product or medicinal composition with liver-protecting effect |
Non-Patent Citations (4)
| Title |
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| 季昌群等: "《解酒护肝宜吃的食物》", 29 February 2012 * |
| 张穗坚: "《中国地道药材鉴别使用手册》", 31 December 2002, 广东旅游出版社 * |
| 张连富等: "《药食兼用资源与生物活性成分》", 30 September 2005, 化学工业出版社 * |
| 范青生: "《保健食品配方原理与依据》", 31 January 2007, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902834A (en) * | 2016-06-08 | 2016-08-31 | 西南医科大学 | Food, health-care product or medicine composition with health-care effect and preparation method and application thereof |
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Application publication date: 20151111 |