CN102988764B - Chinese medicinal preparation for resisting coccidiosis and preparation method thereof - Google Patents
Chinese medicinal preparation for resisting coccidiosis and preparation method thereof Download PDFInfo
- Publication number
- CN102988764B CN102988764B CN201210555607.7A CN201210555607A CN102988764B CN 102988764 B CN102988764 B CN 102988764B CN 201210555607 A CN201210555607 A CN 201210555607A CN 102988764 B CN102988764 B CN 102988764B
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- preparation
- rhizoma rhei
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention discloses a Chinese medicinal preparation for resisting coccidiosis and a preparation method thereof. The Chinese medicinal preparation is prepared by extracting, concentrating and refining the following raw material drugs in parts by weight: 2 to 10 parts of Chinese rhubarb, 1 to 10 parts of common bletilla pseudobulb, 1 to 10 parts of garden burnet, and 2 to 10 parts of hairyvein agrimony. According to the Chinese medicinal preparation for resisting coccidiosis and the preparation method thereof, the preparation is prepared by extracting, concentrating and preparing the Chinese medicinal drugs, has the effects of clearing heat and cooling blood, and astringing to stop bleeding, and is used for treating bloody stools caused by coccidiosis; and the Chinese medicinal preparation is simple in preparation and high in safety, and convenient to drink (mixed drinking with 2.5 to 5g for each chick), cannot cause drug resistance, and is advantageous to treatment of coccidiosis.
Description
Technical field
The invention belongs to anticoccidial technical field, relate to Chinese medicine preparation of a kind of anti-chicken coccidiosis and preparation method thereof.
Background technology
Chicken coccidiosis is that the multiple coccidiosis by Eimeria parasitizes caused a kind of protozoacide in Intestinum Gallus domesticus epithelial cell, and with the easy infection of the chicken in 0.5～2 monthly age, sickness rate reaches 30%～100%, and mortality rate reaches 20%～80%.Once morbidity, death rate increases, feedstuff-meat ratio declines, and has a strong impact on culture benefit.The loss that the whole world causes because of chicken coccidiosis is every year just up to 2,000,000,000 dollars, China every year for the expense of anticoccidial drug up to 600,000,000～1,800,000,000 yuan.Chicken coccidiosis has become one of major disease of restriction poultry farming sound development.
At present, chemicals is the major way of prevention coccidiosis, as Robenidine, clopidol, Amprolium, monensin, Maduramicin, halofuginone hydrobromide, nicarbazine, sulfonamides etc.But the drug resistance that conventional chemical medicine anticoccidial drug prolonged application causes, the toxic and side effects that heavy dose of application causes, the medicine that use lack of standardization causes is residual at Carnis Gallus domesticus, internal organs and egg, and harm food safety is getting into a difficult position aquaculture aspect control coccidiosis.
Herbal control coccidiosis is with a long history, just has the record of " Herba Aconiti Ochranthi parasite killing louse, Folium Salicis Babylonicae is controlled horse disease " on the > > of < < Sheng Nong's herbal classic; The prosperous horse collection > > that treats of < < unit of the Ming Dynasty has recorded the 12 taste parasite killing medical herbs such as sulfur, Rhizoma Osmundae in detail.Modern age, Chinese veterinarian studies confirm that flavour of a drug and the prescription of a collection of control coccidiosis, as Radix Dichroae, Radix Sophorae Flavescentis, the Radix Pulsatillae, Fructus Bruceae, Bulbus Allii, Herba Artemisiae Annuae etc.Main Function mechanism comprises the growth of inhibition coccidiosis, enhancing human body immunity function, hemostasis, antidiarrheal, dysentery relieving etc.Chinese herbal medicine treatment coccidiosis have toxic and side effects little, use safety, drug withdrawal is not recurred and be difficult for producing the advantages such as drug resistance and drug residue.Chinese herbal and crude drugs preparations has become an important directions for the treatment of and preventing coccidiosis of chicken.
Existing Chinese herbal medicine is for the prescription research relevant with preparation of coccidiosis treatment, but most products be take powder preparation formulation as main, can not mix drink administration, and modern intensive feed lot is used inconvenience; And rest on through proved recipe level, from modern pharmacology angle, do not illustrate its mechanism of action, do not carry out the clinical trial of standard, can not prove its effectiveness from modern lemology angle.
Summary of the invention
Chinese medicine preparation providing a kind of anti-chicken coccidiosis and preparation method thereof is provided the problem that the present invention solves, and this Chinese medicine preparation has the effect of anthelmintic, hemostasis, causes the treatment of hemafecia for chicken coccidiosis.
The present invention is achieved through the following technical solutions:
A Chinese medicine preparation for anti-chicken coccidiosis, is made by the crude drug of following mass fraction: 2～10 parts of Radix Et Rhizoma Rhei, 1～10 part of Pseudobulbus Bletillae (Rhizoma Bletillae), 2～10 parts of 1～10 part of Radix Sanguisorbae and Herba Agrimoniaes.
Further, by the crude drug of following mass fraction, made: 3～8 parts of Radix Et Rhizoma Rhei, 2～6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 3～8 parts of 2～6 parts of Radix Sanguisorbaes and Herba Agrimoniaes.
By quality ratio described, Radix Et Rhizoma Rhei: Herba Agrimoniae=1:1～1.5, Radix Et Rhizoma Rhei: Pseudobulbus Bletillae (Rhizoma Bletillae)=1:1～2, Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Sanguisorbae=1:1～1.5.
The described crude drug by following mass fraction is made: 4 parts of Radix Et Rhizoma Rhei, 3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 4 parts of 3 parts of Radix Sanguisorbaes and Herba Agrimoniaes.
A preparation method for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 2～10 parts of Radix Et Rhizoma Rhei, 1～10 part of Pseudobulbus Bletillae (Rhizoma Bletillae), 2～10 parts of 1～10 part of Radix Sanguisorbae and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 60～80% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine preparation of anti-chicken coccidiosis.
The alcohol reflux twice of volumetric concentration 60～80% for described Radix Et Rhizoma Rhei, each 1～2h, filters, and merging filtrate is also received ethanol, obtains Radix Et Rhizoma Rhei extract.
In described step 3), decoct with water and extract twice, each 2～3h, collecting decoction, filters, and filtrate is concentrated.
Described secondary extractum and the mass ratio of sucrose are 1:10～20.
Described in gallic acid, the gallic acid content of the Chinese medicine preparation of every gram of anti-chicken coccidiosis is no less than 2 milligrams.
Compared with prior art, the present invention has following useful technique effect:
1, the medicine that is used for the treatment of chicken coccidiosis provided by the invention is pure Chinese medicinal preparation, clearing away heat and cooling blood, and anastaltic effect, can be used in treatment and prevention chicken coccidiosis, and the protective rate of coccidium infection is reached to 100%.The drug resistance that produces drug residue, generation with chemical medicine treatment chicken coccidiosis is compared, and safety significantly promotes, definite effect; It is applied, and can effectively reduce the risk of Fowl meat, egg product drug residue.
2, the Chinese medicine preparation of anti-chicken coccidiosis provided by the invention, shows through modern pharmacology research: can obviously reduce docking mice bleeding amount of wound, can obviously shorten clotting time of mice; Can suppress acetic acid induced mice abdominal cavity capillary permeability hyperfunction, there is antiinflammatory action; In the test of acetic acid colitis Rats ' Intestinal Mucosal ulcer, the total colectomy contraction in length of rat, weight increase, weight index of the colon increase are all improved significantly, can obviously reduce mucosa injury index, there is antiulcer action.
3, the medicine that is used for the treatment of chicken coccidiosis provided by the invention, is Chinese medicine granules, can mixed feeding or the administration (every chicken 2.5～5g every day) of mixed drink, and safe, can not cause Drug resistance, be conducive to the treatment of anti-chicken coccidiosis; Compare with traditional Chinese powder medicine, have easy to use, effect rapidly, bioavailability high.
The specific embodiment
The invention provides Chinese medicine preparation of a kind of anti-chicken coccidiosis and preparation method thereof, this Chinese medicine preparation is formed through extracting, concentrate, refining by Chinese crude drug.Below in conjunction with specific embodiment, the present invention is described in further detail, and the explanation of the invention is not limited.
Embodiment 1
A preparation for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 4 parts of Radix Et Rhizoma Rhei, 3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 4 parts of 3 parts of Radix Sanguisorbaes and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 75% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine granules of anti-chicken coccidiosis.
Embodiment 2
A preparation for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 4 parts of Radix Et Rhizoma Rhei, 3.5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 4 parts of 3.5 parts of Radix Sanguisorbaes and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 70% for Radix Et Rhizoma Rhei, be total to reflux, extract, twice, each 1h, filters, and merging filtrate is also received ethanol, obtains Radix Et Rhizoma Rhei extract;
3) decoct with water after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed and extract twice, each 2～3h, collecting decoction, filters, and it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose (mass ratio is 1:10), mix rear granulation, dry, obtain the Chinese medicine preparation of anti-chicken coccidiosis.
Embodiment 3
A preparation for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 2 parts of Radix Et Rhizoma Rhei, 4 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 3 parts of 6 parts of Radix Sanguisorbaes and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 80% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine granules of anti-chicken coccidiosis.
Embodiment 4
A preparation for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 3 parts of Radix Et Rhizoma Rhei, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 3 parts of 6 parts of Radix Sanguisorbaes and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 75% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine granules of anti-chicken coccidiosis.
Embodiment 5
A preparation for the Chinese medicine preparation of anti-chicken coccidiosis, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 5 parts of Radix Et Rhizoma Rhei, 4 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of 8 parts of Radix Sanguisorbaes and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 70% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine granules of anti-chicken coccidiosis.
The medicine of prepared treatment chicken colibacillosis is carried out to pharmacodynamics test research below, result shows, prepared medicine has hemostasis, antiinflammatory, anti-diarrhea effect.Specifically comprise:
1, anastalsis
Kunming kind male rat, is divided into 2 groups at random, and 10 every group, administration group gavage granule 3.0g of the present invention crude drug/kg, matched group gavages corresponding dosage normal saline.Successive administration 4 days, after administration on the 4th, 30min mice is docked it is bled naturally fast, and in record unit time, blood flow drips number; After administration, mouse orbit venous plexus blood sampling after 1 hour, detects the blood clotting time (the results are shown in Table 1).
Table 1 on the impact of docking mice amount of bleeding (
n=10)
With the comparison of blank group: * P<0.05, * * P<0.01, as follows.
The demonstration of table 1 result, Chinese medicine preparation of the present invention can reduce docking mice bleeding amount of wound, can shorten clotting time of mice, has anastalsis.
2, antiinflammatory action
Kunming mouse is divided into 2 groups at random, and 10 every group, administration group gavage granule 3.0g of the present invention crude drug/kg, matched group gavages corresponding dosage normal saline.After successive administration 3 days, each Mus intravenous injection 0.5% AZO-blue normal saline solution (0.1ml/10kg), lumbar injection 0.6% acetic acid (0.2ml/ only) immediately, after 20 minutes, de-cervical vertebra is put to death, and opens abdominal cavity, with 6ml normal saline, divides and washs abdominal cavity for several times, collect cleaning mixture, after merging, add normal saline to 10ml, centrifugal 15 minutes of 3000r/min, gets supernatant and measures absorbance (the results are shown in Table 2) in 590nm.
The hyperfunction impact of table 2 Dichlorodiphenyl Acetate induced mice capillary permeability (n=10,
)
| Group | Dosage (g crude drug/kg) | The dye strength that intraperitoneal penetrates (ug/ml) |
| Matched group | - | 16.309±2.402 |
| Administration group | 3.0 | 12.913±2.521* |
The demonstration of table 2 result, Chinese medicine preparation of the present invention can suppress increasing of lumbar injection acetic acid induced mice abdominal cavity capillary permeability, shows that this product has antiinflammatory action.
3, antiulcer action
SD rat experiment chamber is conventional raises, with acetic acid induced ulcer colitis, and 10 every group, administration group gavage granule 3.0g of the present invention crude drug/kg, matched group gavages corresponding dosage normal saline, once a day, continuous 6 days.Modeling the 7th day, measures rat colon weight, colon length and Breadth Maximum, measures weight index of the colon, the situation (the results are shown in Table 3) of evaluation Injured colonic mucosa.
The impact of table 3 Dichlorodiphenyl Acetate rat colonitis (
n=10)
The demonstration of table 2 result, Chinese medicine preparation of the present invention is in acetic acid induced ulcer colitis rat, and can resist colon contraction in length and weight increases, and improves weight index of the colon, reduces mucosa injury index.
4, security verification
Chinese medicine preparation of the present invention fails to measure LD
50.Mouse stomach maximum dosage-feeding is 720g crude drug/kg body weight, is equivalent to 225 times of mice effective dose (3.2g crude drug/kg), bouncing still after 7 days, and none death, puts to death for 7 days afterwards, and postmortem naked eyes have no internal organs abnormal change.
The medicine of prepared treatment chicken coccidiosis has been carried out to clinical experimental study below, to verify its therapeutic effect to chicken coccidiosis.
15 age in days Ai Wei mattresses are little public young 180, are divided at random 3 groups, 60 every group.Administration group give present composition granule (mixed drink, 2.5g/kg), successive administration 5 days, healthy group, not administration of infected group; 16 ages in days, it is 1 * 10 that infected group, every chicken of administration group gavage egg capsule liquid 1mL(concentration
5individual/mL), health is organized not counteracting toxic substances.
After counteracting toxic substances, observed and recorded is respectively organized incidence, 24 ages in days, and each organizes chicken by the execution of only weighing, and cuts open and gets caecum, carries out caecum lesion and scores, and with Maxwell counting chamber, carries out coccidian oocyst numeration (the results are shown in Table 4).
Table 4 pair infects the therapeutical effect of coccidiosis chicken
Table 4 result shows, Chinese medicine preparation of the present invention can significantly promote the survival rate (compare with infected group there were significant differences) that infects coccidiosis chicken, the weightening finish that coccidium infection causes slack-off (compare with infected group there were significant differences) can be improved, coccidian oocyst number in host (compare with infected group there were significant differences) can be significantly reduced.
Claims (7)
1. a Chinese medicine preparation for anti-chicken coccidiosis, is characterized in that, by the crude drug of following mass fraction, is made: 2～10 parts of Radix Et Rhizoma Rhei, 1～10 part of Pseudobulbus Bletillae (Rhizoma Bletillae), 2～10 parts of 1～10 part of Radix Sanguisorbae and Herba Agrimoniaes.
2. the Chinese medicine preparation of anti-chicken coccidiosis as claimed in claim 1, is characterized in that, by the crude drug of following mass fraction, is made: 3～8 parts of Radix Et Rhizoma Rhei, 2～6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 3～8 parts of 2～6 parts of Radix Sanguisorbaes and Herba Agrimoniaes.
3. the Chinese medicine preparation of anti-chicken coccidiosis as claimed in claim 1, is characterized in that, by the crude drug of following mass fraction, is made: 4 parts of Radix Et Rhizoma Rhei, 3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 4 parts of 3 parts of Radix Sanguisorbaes and Herba Agrimoniaes.
4. a preparation method for the Chinese medicine preparation of anti-chicken coccidiosis, is characterized in that, comprises the following steps:
1) get respectively the crude drug of following mass fraction and pulverize: 2～10 parts of Radix Et Rhizoma Rhei, 1～10 part of Pseudobulbus Bletillae (Rhizoma Bletillae), 2～10 parts of 1～10 part of Radix Sanguisorbae and Herba Agrimoniaes;
2) get the alcohol reflux of volumetric concentration 60～80% for Radix Et Rhizoma Rhei, filter, collect filtrate and receive ethanol, obtain Radix Et Rhizoma Rhei extract;
3) after the medicinal residues after Radix Et Rhizoma Rhei reflux, extract, and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Herba Agrimoniae are fully mixed, decoct with water extraction, filter, it is 1.10～1.20 extractum that filtrate is concentrated into relative density, obtains extractum one time;
4) extractum and Radix Et Rhizoma Rhei extract are merged, be concentrated into relative density and be 1.20～1.25 extractum, obtain secondary extractum, then add sucrose, mix rear granulation, dry, obtain the Chinese medicine preparation of anti-chicken coccidiosis.
5. the preparation method of the Chinese medicine preparation of anti-chicken coccidiosis as claimed in claim 4, is characterized in that, the alcohol reflux twice of volumetric concentration 60～80% for described Radix Et Rhizoma Rhei, and each 1～2h, filters, and merging filtrate is also received ethanol, obtains Radix Et Rhizoma Rhei extract.
6. the preparation method of the Chinese medicine preparation of anti-chicken coccidiosis as claimed in claim 4, is characterized in that, in described step 3), decoct with water and extract twice, and each 2～3h, collecting decoction, filters, and filtrate is concentrated.
7. the preparation method of the Chinese medicine preparation of anti-chicken coccidiosis as claimed in claim 4, is characterized in that, the mass ratio of secondary extractum and sucrose is 1:10～20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210555607.7A CN102988764B (en) | 2012-12-19 | 2012-12-19 | Chinese medicinal preparation for resisting coccidiosis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210555607.7A CN102988764B (en) | 2012-12-19 | 2012-12-19 | Chinese medicinal preparation for resisting coccidiosis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102988764A CN102988764A (en) | 2013-03-27 |
| CN102988764B true CN102988764B (en) | 2014-07-23 |
Family
ID=47918198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210555607.7A Active CN102988764B (en) | 2012-12-19 | 2012-12-19 | Chinese medicinal preparation for resisting coccidiosis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102988764B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014032632A2 (en) * | 2012-06-27 | 2017-06-27 | Kemin Ind Inc | compositions and method for controlling coccidiosis in animals, and method for reducing sporozoite activity in an animal. |
| US10568923B2 (en) | 2012-06-27 | 2020-02-25 | Kemin Industries, Inc. | Plant parts and extracts having anticoccidial activity |
| CN103585462B (en) * | 2013-11-13 | 2016-01-13 | 河南牧翔动物药业有限公司 | A kind of anticoccidial herb mixture and preparation method thereof |
| CN115887546A (en) * | 2022-12-27 | 2023-04-04 | 中国农业科学院兰州畜牧与兽药研究所 | Anti-coccidiosis pharmaceutical composition and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014940A (en) * | 2008-05-02 | 2011-04-13 | 株式会社太平洋 | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100788A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Chinese medicinal preparation for preventing and treating chicken coccidiosis |
-
2012
- 2012-12-19 CN CN201210555607.7A patent/CN102988764B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014940A (en) * | 2008-05-02 | 2011-04-13 | 株式会社太平洋 | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102988764A (en) | 2013-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2754064C (en) | Plant extract compositions for the treatment of influenza and inflammation | |
| CN102988764B (en) | Chinese medicinal preparation for resisting coccidiosis and preparation method thereof | |
| CN105641149A (en) | Toxin-removing oral liquid containing fineleaf schizonepeta herbs and divaricate saposhnikovia roots and preparation method of oral liquid | |
| CN104288217B (en) | A kind of Chinese medicine composition and purposes | |
| CN105434511B (en) | A kind of hymsleya amabilis medicine materical crude slice and its preparation method and application | |
| CN105708998A (en) | Traditional Chinese medicine composition for preventing and treating chicken coccidiosis and application thereof | |
| CN102357158A (en) | Medicament for preventing and curing avian infectious laryngotracheitis and preparation method thereof | |
| CN103860656A (en) | Traditional Chinese medicinal composition, and preparation method and application thereof | |
| CN101637519A (en) | Traditional Chinese veterinary medicine for reinforcing detoxifying function of liver and kidney of livestock and poultry | |
| CN105395644A (en) | Traditional Chinese medicinal composition for preventing and treating coccidiosis in chicken as well as preparation method and application of traditional Chinese medicinal composition | |
| CN103432420B (en) | A kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof and detection method | |
| CN104367673B (en) | A kind of Chinese medicine composition treating Eimeria species | |
| CN101224226B (en) | Novel clinical uses of big nilgiri nettle | |
| CN103417653B (en) | Veterinary-use compound pure Chinese herbal medicine for treating coccidium and preparation method of oral liquid of same | |
| CN102631479B (en) | Traditional Chinese medicine composition for improving damp heat constitution, preparation and preparation method thereof | |
| CN105031245B (en) | A kind of Chinese medicine composition of anti-Eimeria Tenella | |
| CN104547898A (en) | Formula of eimeria tenella disease resistant traditional Chinese medicine with fresh bamboo juice as main ingredient | |
| CN104721629A (en) | TCM (traditional Chinese medicine) preparation for treating pediatric iron-deficiency anemia and preparing method thereof | |
| CN104042898B (en) | Traditional Chinese medicine composition for treating fetomaternal blood group incompatibility and preparation method thereof | |
| CN108524746A (en) | A kind of Chinese medicine composition of prevention fowl cough | |
| CN102512511B (en) | Ginseng taste liver-protecting tablet for treating liver injury and preparation method thereof | |
| CN109939176B (en) | A Chinese medicinal composition for treating diabetes, and its preparation method | |
| CN108210588A (en) | A kind of pharmaceutical composition and preparation method with tranquilizing effect | |
| CN104940428A (en) | Blood sugar reducing composition containing fructus lycii and application thereof | |
| Zhao et al. | Study on the protective effect of Gehua Jiecheng Decoctionon mice with acute alcoholism |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |