CN105028406A - Use of 2,4-di-tert-butylphenol and bactericide - Google Patents
Use of 2,4-di-tert-butylphenol and bactericide Download PDFInfo
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- CN105028406A CN105028406A CN201510354182.7A CN201510354182A CN105028406A CN 105028406 A CN105028406 A CN 105028406A CN 201510354182 A CN201510354182 A CN 201510354182A CN 105028406 A CN105028406 A CN 105028406A
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Abstract
The invention provides use of 2,4-di-tert-butyl phenol and a bactericide. The bactericide comprises 2,4-di-tert-butyl phenol and one or more conventional auxiliary materials, wherein 2,4-di-tert-butyl phenol accounts for 0.05 to 99 percent of the 2,4-di-tert-butyl phenol bactericide by mass; the conventional auxiliary materials account for 1 to 99.95 percent of the 2,4-di-tert-butyl phenol bactericide by mass. The bactericide is applied to prevention and treating of common diseases of fruit, vegetable, wheat and rice, and is safe to people and livestock, environmentally friendly and novel, thereby having a profound significance in ecological environment protection, human health care and comprehensive control of diseases.
Description
Technical field
The present invention relates to a kind of novelty teabag and 2,4-DTBP bactericide of 2,4-DTBP of technical field of pesticide.
Background technology
Plant disease is one of natural calamity of serious harm agricultural production.Estimate according to FAO (Food and Agriculture Organization of the United Nation), global grain and Cotton Production are lost in more than 10% because of disease throughout the year, plant disease not only can cause the minimizing of crop yield, and to a certain extent also serious threat to the quality safety of agricultural product and international trade thereof.Have a lot because of large area outburst and the popular event bringing major disaster to the mankind of plant disease in history, the great case that famous " being hard up greatly in Ireland " is namely the harm of the severe epidemic due to potato late blight in 1845 and causes.Therefore, bactericide produces thereupon, and along with the development in epoch, constantly weed out the old and bring forth the new, but, along with human civilization and scientific and technical progress, and people are for the attention of environment and food security, find efficient, safety, low toxicity, low-residual and environmentally friendly bactericide become people needs problem demanding prompt solution.
2,4-DTBP is called for short the tertiary phenol of 2,4-bis-, and being extensively present in plant, is also the important intermediate of fine chemical product, mainly for the preparation of helping antioxidant, ultra-violet absorber, light stabilizer, dyestuff and textile auxiliary, resin.In addition, also for the synthesis of spices.In addition, now studies have reported that it has very strong biological action, comprise antioxidation, kill bacterial action and cytotoxicity.
Through finding existing technical literature retrieval, there is no 2,4-DTBP at present and preparing the application report in bactericide; There is no at present a kind of, harmonious bactericide to mammalian safe good with environment compatibility yet.
Summary of the invention
The present invention is directed to prior art above shortcomings, provide that a kind of efficient, noresidue, production cost are low, economical and practical, the purposes of a kind of 2,4-DTBP of environmental friendliness, high comprehensive performance and bactericide.
The present invention seeks to be achieved through the following technical solutions:
The invention provides a kind of purposes of 2,4-DTBP, namely 2,4-DTBP is for the preparation of bactericide.
Bactericide of the present invention can be applied in the common disease aspects such as control fruit, vegetables, wheat, paddy rice, and the disease of concrete control comprises: the scab, anthracnose, brown spot, ring spot etc. of apple, pears, peach; The powdery mildew, downy mildew, anthracnose etc. of grape, watermelon, cucumber, muskmelon; Wheat powdery mildew; Rice blast, banded sclerotial blight etc.; The powdery mildew of vegetables, vertical withered, downy mildew, anthracnose etc.
The invention provides a kind of 2,4-DI-tert-butylphenol compounds bactericide, described bactericide is by 2,4-DI-tert-butylphenol compounds (i.e. bulk drug) and customary adjuvant form, wherein the quality of 2,4-DTBP accounts for the 0.05%-99% of 2,4-DTBP bactericide quality, customary adjuvant accounts for the 1%-99.95% of 2,4-DTBP bactericide quality.
Preferably, described customary adjuvant to refer in solubilizer, synergist, emulsifier, bleeding agent one or more.
Preferably, described solubilizer is neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea are withered, take Chinese honey locust etc. all in one or more.
Preferably, described emulsifier is one or more in spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent etc.
Preferably, described synergist is one or more in Tea Saponin, APEO etc.
Preferably, described bleeding agent is azone etc.
Take certain 2,4-DI-tert-butylphenol compounds dissolution with solvents, selection adds various auxiliary material, as, solubilizer, synergist, emulsifier, bleeding agent etc., according to various technique, make various forms of bactericide, such as: pulvis, missible oil, suspending agent, dry suspending agent, emulsifiable concentrate, sustained release agent, aqueous emulsion, spray etc.Wherein, solvent can be one or more in all organic solvents such as water, ethanol, methyl alcohol, acetone, cyclohexanone, benzinum, petroleum aromatic, purified petroleum benzin, ethyl acetate, toluene, dimethylbenzene.
The application of the above-mentioned 2,4-DTBP bactericide of the present invention, is specially: joined in 2,4-DTBP bactericide by water under stirring at normal temperature, makes it be diluted to after 2,4-DTBP and bulk drug account for the concentration of 0.5-30wt% to spray to use.
Compared with prior art, the present invention has following beneficial effect:
The invention provides a kind of to person poultry safety, environmentally friendly novel harmonious bactericide, all there is profound significance to the comprehensive regulation of ecological environmental protection, human health and disease.Compared with traditional agricultural chemicals, the present invention has following characteristics and advantage:
(1) features such as 2,4-DTBP is a kind of natural products, has nontoxic, easy degraded are friendly for people, animal and ecotope, safety;
(2) 2,4-DTBP source is easily, and esterification can be utilized to synthesize, also can from plant extracting directly, method is simple, can carry out large-scale industrial production;
(3) the present invention is that Late Cambrian 2,4-DTBP has antifungal bioactivity, and is mixed with bactericide first.Through experiment, be 92.8% to powdery mildew of cucumber preventive effect.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
Embodiment is for bactericidal agent for preventing and treating powdery mildew of cucumber of the present invention below, and the effect of controlling plant diseases of the present invention is described.
Embodiment 1
Take 2,4-DTBP 2.8g, use 19.4g dissolve with ethanol solution, add 8.3g Tween-80, dissolve, conveniently technique, makes the present invention 2,4-DI-tert-butylphenol compounds bactericide, then thin up in made 2,4-DTBP bactericide, makes 2,4-DI-tert-butylphenol compounds, namely the concentration of bulk drug is 1%.Finally, the 2,4-DTBP bactericide after dilution is carried out indoor pot method to cucumber white powder and measures, method is carried out according to the raw potted plant determination method of powdery mildew surveyed in SOP in country's southern pesticides discovery center.
Test concrete grammar: adopt cauline leaf spraying method by medicament even spraying on cucumber seedling; Set the blank of not adding medicine simultaneously; Dry in the shade examination material in fume hood or greenhouse 24h.About 24h spray inoculation powdery mildew germ spore suspension after chemicals treatment, often processes 4 repetitions.Postvaccinal examination material moves in thermostatic chamber under light (26-28 DEG C), and 7-8 days " Invest, Then Investigate " disease severity, compare with blank, calculate control efficiency.Investigate each process, its preventive effect is 64.2%.
Embodiment 2
Take 2,4-DI-tert-butylphenol compounds 88g, uses 18g acetic acid ethyl dissolution, adds the 2.9g such as emulsifier wherein, conveniently technique, make 2,4-DTBP bactericide of the present invention, then made 2, thin up in 4-DI-tert-butylphenol compounds bactericide, make 2,4-DTBP, namely the concentration of bulk drug is 15%.Finally, adopt indoor pot method to give birth to survey in the 2,4-DTBP bactericide after dilution to powdery mildew of cucumber, draw after result of the test statistics, its preventive effect is 79.6%.
Embodiment 3
Take 2,4-DI-tert-butylphenol compounds 103g, dissolve with 45g ethanol, add 58g such as emulsifier span-20 grade wherein, conveniently technique, make the present invention 2,4-DI-tert-butylphenol compounds bactericide, then thin up in made 2,4-DTBP bactericide, the concentration of 2,4-DTBP and bulk drug is made to be 29%.Finally, adopt indoor pot method to give birth to survey in the 2,4-DTBP bactericide after dilution to powdery mildew of cucumber, draw after result of the test statistics, its preventive effect is 92.8%.
Embodiment 4
Take 2,4-DI-tert-butylphenol compounds 20g, dissolves with 50g methyl alcohol, adds emulsifier tween-245 wherein, the 59g such as Arlacel-20, conveniently technique, makes 2,4-DTBP bactericide of the present invention, then made 2, thin up in 4-DI-tert-butylphenol compounds bactericide, makes the concentration of 2,4-DTBP and bulk drug be 8%.Finally, adopt field plot experiment with reference to national agricultural chemicals field trial criterion and carry out field control effectiveness test to powdery mildew of cucumber, statistical results after 7 days, preventive effect reaches 83.4%.
Embodiment 5
Take 2,4-DI-tert-butylphenol compounds 300g, use 26g petroleum ether dissolution, add the auxiliary material 24g such as emulsifier, synergist, solubilizer wherein, conveniently technique, make the present invention 2,4-DI-tert-butylphenol compounds bactericide, then thin up in made 2,4-DTBP bactericide, the concentration of 2,4-DTBP and bulk drug is made to be 19%.Finally, adopt field plot experiment with reference to national agricultural chemicals field trial criterion and carry out field control effectiveness test to powdery mildew of cucumber, statistical results after 7 days, preventive effect reaches 89.5%.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (9)
1. a purposes for 2,4-DTBP, is characterized in that, by 2,4-DTBP for the preparation of bactericide.
2. the purposes of 2,4-DTBP according to claim 1, is characterized in that, described bactericide refers to the bactericide being applied in control fruit, vegetables, wheat, paddy rice common disease aspect.
3. one kind 2,4-DI-tert-butylphenol compounds bactericide, it is characterized in that, described bactericide is made up of 2,4-DTBP and customary adjuvant, and wherein 2, the quality of 4-DI-tert-butylphenol compounds accounts for 2, the 0.05%-99% of 4-DI-tert-butylphenol compounds bactericide quality, customary adjuvant accounts for the 1%-99.95% of 2,4-DTBP bactericide quality.
4. 2,4-DTBP bactericide according to claim 3, is characterized in that, described customary adjuvant to refer in solubilizer, synergist, emulsifier, bleeding agent one or more.
5. according to claim 42,4-DI-tert-butylphenol compounds bactericide, it is characterized in that, described solubilizer is neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea are withered, take in Chinese honey locust one or more.
6. 2,4-DTBP bactericide according to claim 4, is characterized in that, described emulsifier is one or more in spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
7. 2,4-DTBP bactericide according to claim 4, is characterized in that, described synergist is one or more in Tea Saponin, APEO.
8. 2,4-DTBP bactericide according to claim 4, is characterized in that, described bleeding agent is azone.
9. described in an any one of claim 3-8 2, the application of 4-DI-tert-butylphenol compounds bactericide, it is characterized in that, under stirring at normal temperature, water is joined 2, in 4-DI-tert-butylphenol compounds bactericide, make it be diluted to after 2,4-DTBP and bulk drug account for the concentration of 0.5-30wt% to spray to use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510354182.7A CN105028406A (en) | 2015-06-23 | 2015-06-23 | Use of 2,4-di-tert-butylphenol and bactericide |
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| CN201510354182.7A CN105028406A (en) | 2015-06-23 | 2015-06-23 | Use of 2,4-di-tert-butylphenol and bactericide |
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| CN105028406A true CN105028406A (en) | 2015-11-11 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109619098A (en) * | 2019-02-14 | 2019-04-16 | 浙江大学 | A kind of rice antimicrobial agent and its application |
| CN111228245A (en) * | 2020-02-27 | 2020-06-05 | 华侨大学 | Application of phenolic compound and pharmaceutically acceptable salt thereof in preparation of anti-hepatitis B virus medicine |
| CN111234829A (en) * | 2020-03-10 | 2020-06-05 | 浙江农林大学 | Active compound missible oil preparation for improving pH value of soil, water-soluble preparation and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101228870A (en) * | 2007-12-31 | 2008-07-30 | 浙江林学院 | Compounds of agricultural chemical killing acarus and bacteria and uses thereof |
-
2015
- 2015-06-23 CN CN201510354182.7A patent/CN105028406A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101228870A (en) * | 2007-12-31 | 2008-07-30 | 浙江林学院 | Compounds of agricultural chemical killing acarus and bacteria and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周宝利等: "2,4-二叔丁基苯酚对番茄叶霉病及幼苗生长的影响", 《生态学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109619098A (en) * | 2019-02-14 | 2019-04-16 | 浙江大学 | A kind of rice antimicrobial agent and its application |
| CN109619098B (en) * | 2019-02-14 | 2020-07-14 | 浙江大学 | Rice antibacterial agent and application thereof |
| CN111228245A (en) * | 2020-02-27 | 2020-06-05 | 华侨大学 | Application of phenolic compound and pharmaceutically acceptable salt thereof in preparation of anti-hepatitis B virus medicine |
| CN111234829A (en) * | 2020-03-10 | 2020-06-05 | 浙江农林大学 | Active compound missible oil preparation for improving pH value of soil, water-soluble preparation and application |
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