CN105011946B - The method for measuring blood glucose value - Google Patents
The method for measuring blood glucose value Download PDFInfo
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- CN105011946B CN105011946B CN201510435515.9A CN201510435515A CN105011946B CN 105011946 B CN105011946 B CN 105011946B CN 201510435515 A CN201510435515 A CN 201510435515A CN 105011946 B CN105011946 B CN 105011946B
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- blood glucose
- glucose value
- potential difference
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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Abstract
The invention discloses a kind of method for measuring blood glucose value, it comprises the following steps：Two electrodes of probe assembly, are contacted two diverse locations of human skin surface by step 1 respectively, calculate the potential difference between two diverse locations；And step 2, according to blood glucose value and linear ratio relation's formula of potential difference, the blood glucose value of human body to be measured is calculated by the potential difference meter.The method according to the invention, due to without acupuncture treatment, it is thus only necessary to survey the potential difference between skin block at human body two, greatly reduce the acupuncture treatment pain of study subject.Further, since test paper need not be used, financial cost is greatly saved.
Description
Technical field
The present invention relates to a kind of method for measuring blood glucose, the side of the non-intrusion measurement blood glucose of more particularly to a kind of hurtless measure
Method.
Background technology
Blood glucose is one of important index for diabetes.Patient of diabetes must control all the life blood glucose value and and
When blood glucose value as take or injection insulin control foundation.All it was with coarse glucose in urine or cumbersome quiet before and after 1840
Arteries and veins serum measurement blood glucose value be used as foundation, initial stage glucose in urine be with Ban Shi liquid inustion test, after substituted by oxidizing ferment test paper method.By
In glucose in urine occur in blood glucose value more than 180mg/dL (10mmol/dL), erroneous judgement can be effectively caused plus alimentary glucosuria, now
Only also widely used in some relatively poor or medical resource deserts.And Venous serum is even more to be inconvenient to be also impossible to popularize
Timely blood glucose is tested at any time to diabetic to use.So scientists are being researched and developed a kind of most convenient and are being adapted at home always at that time
The instrument of the timely blood glucose of selftest, finally in 1956, inventor not Rayleigh with Tes-Tape principle by glucose oxidase
And hydrogen peroxide is applied on dry type test paper respectively, first blood glucose value test paper of color comparison of naked eye is developed, but is exactly also
Much one of formalities, it is necessary to blood is washed with water and dries, otherwise can sustained response cause to judge by accident.
Electrochemical techniques are applied to be started from 1981 in blood-sugar detecting instrument, and Medisense Abbotts of the U.S. opened in 1986
First substitution conventional colorimetric method is sent, volume smaller, is more convenient, and reaction time shorter electric chemical formula blood glucose pen has started the
The development of four generation blood-sugar detecting instruments, it is all to take electrochemical process to start within 2001 to current all blood-sugar detecting instruments.
5th generation blood-sugar detecting instrument main characteristics are based on micro- blood sampling volume and multiple location blood sampling, are pushed away by the U.S. in 2001
Go out Freestyle (free style) blood-sugar detecting instrument and opened the beginning, fall over each other the target of research and development as intrusive mood blood-sugar detecting instrument at present.
No matter all intrusive mood blood sugar test mode blood sampling volumes are how many or multiple location is taken a blood sample, glycosuria all can not be substantially helped
Patient does not have to prick blood, without the actual demand of consumptive material.So research and development at present are all the blood-sugar detecting instruments for moving towards non-intrusion type, mesh
The exploitation of former world various countries is all concentrated on is coupled transmitter generation using biochemical marker (enzyme, antibody, analog idiosyncrasy)
A kind of detectable signal, such as curtage, color or luminous intensity and thermal signal catch corresponding blood glucose value.Such as：
Electrochemical sensor is divided into two classes：External sensor (sensor of skin surface) and implantable subcutaneous sensor, its work
Principle is：The physical quantity of measurement change proportional to analyte concentration.But electrochemical sensor can only be in limited model
Interior use is enclosed, could not also really be applied to clinic.Optics aspect is with (FT-NIR) therapy of Fourier transform near infrared spectrum.Moral
The Heise of state and the Arnold in the U.S. et al. do a lot of work, and have made intensive studies.Measuring method be divided into transmission spectrum and
Inverse is composed.Heise etc. of Germany measured first with ATR (decay total reflection) technology glucose in human plasma and blood,
The concentration of the components such as protein, cholesterol, urea, uric acid and triglycerides.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
It has been the prior art well known to persons skilled in the art when being considered as recognizing or implying the information structure in any form.
The content of the invention
It is an object of the invention to provide a kind of carry-on noninvasive blood glucose value measurement method, sufferer can be exempted and pricked every time
The pain of blood and inconvenience, it is not required that using test paper consumptive material, except reducing the expenditure burden of sufferer, and it is avoided that environmental pollution,
Reduce environmental issue.
To achieve the above object, the present invention provides a kind of method for measuring blood glucose value, it comprises the following steps：Step
One, two electrodes of probe assembly are contacted to two diverse locations of human skin surface respectively, calculate this two different positions
Potential difference between putting；And step 2, according to blood glucose value and linear ratio relation's formula of potential difference, calculated by the potential difference
Go out the blood glucose value of human body to be measured.
Preferably, in above-mentioned technical proposal, step 3 is further included, at the time of it records the execution step 1；Wherein exist
Under at different moments, blood glucose value has different linear ratio relation's formulas from potential difference, according to it is recorded at the time of, select it is corresponding
Blood glucose value and potential difference linear ratio relation's formula, so as to calculate the blood glucose value of human body to be measured.
Preferably, in above-mentioned technical proposal, the human skin surface of diverse location is selected different at the time of to carry out current potential
Difference measurements.
Preferably, in above-mentioned technical proposal, described two electrodes are respectively first electrode and second electrode, the first electrode
The skin surface site of contact is selected from：Tiger's jaw area is close to the position of thumb, the middle part of the second nameless articulations digitorum manus, hand
Slap the intersection of the extended line of thumb longitudinal center axis and the extended line of forefinger longitudinal center axis under nature extended state
The middle part of palm and the back of the hand linkage section below position or little finger.
Preferably, in above-mentioned technical proposal, the skin surface site of the second electrode contact is the first segment of thumb
In the middle part of the finger belly of (topmost one saving).
Compared with prior art, the present invention has the advantages that：Due to without acupuncture treatment, it is thus only necessary to survey human body difference
Potential difference between skin site, greatly reduces the acupuncture treatment pain of study subject.Further, since test paper need not be used, greatly
Save financial cost greatly.
Brief description of the drawings
Fig. 1 is the flow chart of the method for measurement blood glucose value according to the present invention.
Fig. 2 is another flow chart of the method for measurement blood glucose value according to the present invention.
Fig. 3 is the schematic diagram at the touch position of palm area according to the present invention.
Fig. 4 is the schematic diagram for the exemplary measurement devices for realizing the blood sugar measuring method of the present invention.
Fig. 5 is the line chart between point (block) skin pricktest potential difference in cave according to the present invention and blood glucose value.
Fig. 6 is the blood glucose value of sieve formula blood glucose meter and the line chart of the relation of time.
Embodiment
Below in conjunction with the accompanying drawings, the embodiment of the present invention is described in detail, it is to be understood that the guarantor of the present invention
Protect scope and from the limitation of embodiment.
Explicitly indicated that unless otherwise other, otherwise in entire disclosure and claims, term " comprising " or its change
Change such as "comprising" or " including " etc. and will be understood to comprise stated element or part, and do not exclude other members
Part or other parts.
It should be noted that Step 1: Step 2: step 3 etc. is just for the sake of expression in the following detailed description
Different steps, not represents the order of the blood glucose value measurement method of the present invention, those skilled in the art can be according to actual feelings
Condition converts these sequence of steps, has no effect on the essence of the present invention.
Many experiments prove that organism is not only electrically conductive, but also biological electricity can also be produced in metabolic processes.
This biological electricity can project skin surface in Conducting forms, form skin electrical phenomena by the electrolyte of tissue.Acupuncture point
(block) is the contact of bioelectricity, and channels and collaterals are the passages (biological electric wave) for transmitting electric current.When physiology lesion is corresponding to relevant
Acupuncture point (block), current potential just changes, and excitation bioelectricity produces electromagnetic wave, is then passed to the channels and collaterals of whole body, passes to maincenter
Nerve, which is formed, to stimulate, and diseased region is adjusted.
The blood sugar detecting method of the present invention is to be urinated according to Chinese Clinical medical diagnosis with referring to related diabetes in the science of channels and collaterals
The relevant cave point (block) such as sugar, blood glucose, tests the potential difference between the skin cave point (block) of person under inspection and skin reference point
(namely voltage difference), then finds out the approximate formula collocation testing time through data analysis, then is converted into blood glucose value for be measured
Object reference is used.Preferably, the viewpoint that the science of channels and collaterals proposes is that human body walks different passages through which vital energy circulates, so this hair in the different division of day and night
Also with the division of day and night different positions can be selected to measure during bright test, and calculating blood glucose value is removed using appropriate formula.
It should be noted that among in one aspect of the invention, blood sugar detecting method of the invention simultaneously need not measure people
The specific magnitude of voltage of body different skin position, and need only to measure voltage difference (potential difference) therebetween.It is logical
Linear ratio relation between the value and blood glucose value of overpotential difference calculates blood glucose value, such rather than many prior arts, in advance
The mapping table between blood glucose value and voltage/resistance is first stored, so as to measure some electronic signal parameters to carry out blood glucose value
Lookup, this mode accuracy rate is very low, because the electric signal of the actually block of the human body overwhelming majority does not have at all with blood glucose value
There is any relation.
As shown in Figure 1, among one embodiment of blood glucose value measurement method according to the present invention, first, by probe groups
Two electrodes of part contact two diverse locations of human skin surface, one end of the two electrodes and contact human skin respectively
(skin site of two electrode contacts differs), the other end is connected with potential difference measurement instrument, so calculates this two not
With the potential difference between position.Then, according to blood glucose value and linear ratio relation's formula of potential difference, calculated by the potential difference
Go out the blood glucose value of human body to be measured.
As shown in Fig. 2, according to another embodiment, at the time of further including the record execution contact procedure.Inventor
It has been found that under at different moments, blood glucose value and potential difference have different linear ratio relation's formulas, therefore according to being recorded
At the moment, linear ratio relation's formula of corresponding blood glucose value and potential difference is selected, so as to calculate the blood glucose value of human body to be measured.
Preferably, inventor also found, different at the time of, one of electrode contacts different cave blocks, another electricity
The contact position of pole is not limited, it is only necessary to which two electrode contact locations differences (can be considered on the symmetrical position of human body
Same position), the blood glucose value so calculated can preferably coincide with real blood glucose value, therefore can be different at the time of
Different cave blocks is selected to carry out blood glucose measurement.
Fig. 3 shows the schematic diagram of partially effective detection zone in palm area.It should be noted that according to hair
The substantial amounts of experimental study of a person of good sense, has between the potential difference and blood glucose value in human body between block only few in number obvious
Proportionate relationship, and presented between the potential difference and blood glucose value such as on the region such as two-arm, shirtfront any effective
Linear ratio relation.Fig. 3 shows contact site of 4 effective monitoring points as one of electrode in palm area, separately
The human contact position of one electrode is not limited then, generally the thumb first segment finger belly of another hand.
Left hand cave point A, B, C and the D to be detected shown in Fig. 3 are cleaned first, and alcohol swab can be used to wipe or with fertile
Soap cleans, and just starts to measure after waiting drying.
With reference to Fig. 4, which show exemplary blood glucose measuring device.It should be noted that the present invention is not limited thereto,
Any blood glucose device that can realize measuring method of the present invention can use.With reference to figure 4, the exemplary blood glucose measuring device
Including housing 1, probe assembly (not shown) and operating circuit plate (not shown).The probe assembly is installed in housing 1.
The probe assembly has two electrodes 2,3, for contacting two different skin positions of human body, so as to measure two differences
Potential difference between skin site.There is clock module and microprocessor etc., for calculating current potential on the operating circuit plate
Difference, and the operation relation formula by prestoring calculates blood glucose value.In addition, the blood-sugar detecting instrument of the non-intrusion type further include it is aobvious
Display screen 4, loudspeaker 5 and switch 6.
In use, the unlatching power supply of switch 6 is pressed first, the pictures to be measured such as display screen 4 occurs.Then the right hand is held
The blood-sugar detecting instrument of the present invention, right hand thumb (other right hand fingers also can) presses live electrode 3 (reference point), then by another
Electrode 2 slaps the light press contacts of cave point (block) to be measured against left hand and is slightly recessed to skin, and survey occurs in display screen 4 at this time
Picture is tried, and the numerical value tested out occurs, which is the reference value and record that can be considered testee's blood glucose.If custom is left
Hand operates, then electrode 2 is slapped the light press contacts of cave point (block) to be measured against the right hand is slightly recessed to skin.
The blood glucose value and the graph of a relation of time that the blood glucose meter according to the present invention that Fig. 5 shows is detected, Fig. 6 show sieve formula
The blood glucose value of blood glucose meter and the line chart of time.Roche blood glucose meter in Fig. 6 refers to the Accu-Chek of Roche manufactures
Active blood glucose meters, have indicatively position, so the reference data as blood glucose meter of the present invention in blood glucose meter field.Observation figure
5 line chart according to the present invention, has the curve of different curve convergence sieve formula blood glucose meters in the different division of day and night, there is little bit different
And deviation, but with reference to the regulation of international standard EN ISO 15197 (2003), qualified blood glucose meter error is below 20%.Institute
Although, should be within permissible range with blood glucose meter of the present invention and some errors of sieve formula blood glucose meter.The institute in units of mmol/L
The formula of deduction is as follows：
The morning 7~9 point, preferably carry out blood glucose measurement, A block formula, blood glucose value=skin pricktest potential difference using A caves point (block)
The value range of × K1, K1 are 1.7~3.9.
, preferably carry out blood glucose measurement at 3 points in 9~afternoon in the morning using C caves point, C block formula, and blood glucose value=skin pricktest potential difference ×
The value range of K3, K3 are 0.5~2.4.
Afternoon 3~5 point, preferably using D caves point carry out blood glucose measurement, D block formula, blood glucose value=skin pricktest potential difference × K4,
The value range of K4 is 1.1~3.5.
Afternoon 5~9 point, preferably carry out blood glucose measurement, the value range of blood glucose value=skin pricktest potential difference × K3, K3 using C caves point
It is 0.5~2.4.
Afternoon 9~11 point, preferably carry out blood glucose measurement, the value range of blood glucose value=skin pricktest potential difference × K2, K2 using B caves point
It is 1.9~4.6.
In conclusion blood sugar measuring method according to the present invention, can not bring the situation of acupuncture treatment pain to testee
Under, obtain very accurately blood glucose value；The measuring method is extremely easily mastered at the same time, and need not use test paper, is saved big
Measure cost.
It is foregoing to the present invention specific exemplary embodiment description be in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to the above instruction, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explain that the certain principles of the present invention and its reality should
With so that those skilled in the art can realize and utilize the present invention a variety of exemplaries and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (3)
- A kind of 1. method for measuring blood glucose value, it is characterised in that comprise the following steps：Two electrodes of probe assembly, are contacted two diverse locations of human skin surface by step 1 respectively, calculate this two Potential difference between a diverse location；Step 2, according to blood glucose value and linear ratio relation's formula of potential difference, human body to be measured is calculated by the potential difference meter Blood glucose value；AndStep 3, at the time of record performs the step 1；Wherein under at different moments, blood glucose value has different linear ratio relation's formulas from potential difference, according to it is recorded at the time of, Linear ratio relation's formula of corresponding blood glucose value and potential difference is selected, so as to calculate the blood glucose value of human body to be measured；AndThe skin surface of human body different blocks is selected to carry out potential difference measurement wherein different at the time of.
- 2. according to the method described in claim 1, it is characterized in that, described two electrodes are respectively first electrode and the second electricity Pole, the skin surface site of first electrode contact are selected from：Tiger's jaw area is close to the position of thumb, the second nameless articulations digitorum manus Middle part, the extended line of thumb longitudinal center axis and prolonging for forefinger longitudinal center axis under palm nature extended state The middle part of palm and the back of the hand linkage section below the intersection part or little finger of long line.
- 3. according to the method described in claim 2, it is characterized in that, the skin surface site of second electrode contact is big thumb In the middle part of the finger belly of the first segment of finger.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510435515.9A CN105011946B (en) | 2015-07-22 | 2015-07-22 | The method for measuring blood glucose value |
| PCT/CN2015/090233 WO2017012190A1 (en) | 2015-07-22 | 2015-09-22 | Blood sugar level measurement method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510435515.9A CN105011946B (en) | 2015-07-22 | 2015-07-22 | The method for measuring blood glucose value |
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| CN105011946A CN105011946A (en) | 2015-11-04 |
| CN105011946B true CN105011946B (en) | 2018-05-04 |
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| WO (1) | WO2017012190A1 (en) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6841389B2 (en) * | 2001-02-05 | 2005-01-11 | Glucosens, Inc. | Method of determining concentration of glucose in blood |
| ES2582185T3 (en) * | 2004-02-05 | 2016-09-09 | Dermal Devices Inc. | Apparatus for measuring blood glucose using impedance measurements of subdermal body tissue |
| WO2005086725A2 (en) * | 2004-03-06 | 2005-09-22 | Calisto Medical, Inc. | Methods and devices for non-invasively measuring quantitative information of substances in living organisms |
| US20100130883A1 (en) * | 2005-12-16 | 2010-05-27 | Carpenter Scott E | In-Vivo Non-Invasive Bioelectric Impedance Analysis of Glucose-Mediated Changes in Tissue |
| US20070299617A1 (en) * | 2006-06-27 | 2007-12-27 | Willis John P | Biofouling self-compensating biosensor |
| WO2009033625A1 (en) * | 2007-09-07 | 2009-03-19 | Flore, Ingo | Medical measuring device for bioelectrical impedance measurement |
| US8812097B2 (en) * | 2012-02-06 | 2014-08-19 | Honeywell International Inc. | Neurologically based non-invasive blood glucose concentration system and method |
| CN102727215A (en) * | 2012-06-08 | 2012-10-17 | 林建中 | Blood collection-free blood sugar measurement instrument and testing method |
| CN104188662A (en) * | 2014-08-22 | 2014-12-10 | 林建中 | Blood-sampling-free type blood sugar monitoring device and use method thereof |
| CN104983423B (en) * | 2015-07-22 | 2018-05-15 | 通普生物科技（北京）有限公司 | Multifunctional health detector |
| CN104983430B (en) * | 2015-07-22 | 2018-10-02 | 通普生物科技（北京）有限公司 | The blood-sugar detecting instrument of non-intrusion type |
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2015
- 2015-07-22 CN CN201510435515.9A patent/CN105011946B/en active Active
- 2015-09-22 WO PCT/CN2015/090233 patent/WO2017012190A1/en active Application Filing
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| CN105011946A (en) | 2015-11-04 |
| WO2017012190A1 (en) | 2017-01-26 |
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