CN105011946A - Method for measuring value of blood glucose - Google Patents

Method for measuring value of blood glucose Download PDF

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CN105011946A
CN105011946A CN 201510435515 CN201510435515A CN105011946A CN 105011946 A CN105011946 A CN 105011946A CN 201510435515 CN201510435515 CN 201510435515 CN 201510435515 A CN201510435515 A CN 201510435515A CN 105011946 A CN105011946 A CN 105011946A
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method
human
value
body
blood
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CN 201510435515
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CN105011946B (en )
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张宏才
李成功
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通普生物科技(北京)有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue

Abstract

The invention discloses a method for measuring value of blood glucose. The method includes the steps of firstly, contacting two positions of skin of the human body with two electrodes of a probe assembly respectively and calculating potential difference of the two different positions; secondly, according to linear proportional relation of the value of blood glucose and the potential difference, calculating the value of blood glucose of the human body under examination on the basis of the potential difference. As injection is replaced by calculation of the potential difference of the two positions of the human body under examination, suffering of the human body under examination due to injection is relieved greatly. Economic cost is saved greatly since test paper is omitted in application of the method.

Description

测量血糖值的方法 The method of measuring the blood sugar level

技术领域 FIELD

[0001] 本发明涉及一种测量血糖的方法,特别涉及一种无创伤的非侵入式测量血糖的方法。 [0001] The present invention relates to a method for measuring blood glucose, in particular, it relates to a non-invasive, non-invasive method for measuring blood glucose.

背景技术 Background technique

[0002] 血糖是糖尿病的一个比较重要的指标之一。 [0002] blood sugar is one of the more important indicators of diabetes. 糖尿病患必须终身控制血糖值并以及时血糖值作为服用或施打胰岛素控制的依据。 Lifelong diabetes must control the blood sugar level and blood sugar level and when applied as a basis for taking or insulin injections to control. 在1840年前后都是以粗糙的尿糖或繁琐的静脉血清测量血糖值作为依据,初期尿糖是以班氏液烧灼法测试,后被氧化酶试纸法取代。 In 1840 are cumbersome to rough urine or serum as a basis for venous blood glucose measurement, the initial urine is substituted Bancroft cauterization test solution, after oxidase test paper method. 由于尿糖出现得在血糖值超过180mg/dL(10mmol/dL),加上饮食性糖尿会严重造成误判,现在只在一些比较穷或医疗资源贫瘠地区还在广泛使用。 Since the urine must appear in the blood sugar level of more than 180mg / dL (10mmol / dL), plus dietary diabetes can cause serious miscarriage of justice, only now is still widely used in some relatively poor or marginal areas of medical resources. 而静脉血清更是不方便也不可能普及到糖尿病患者随时测试及时血糖用。 The vein serum is more convenient and can not spread to diabetic blood sugar test at any time by timely. 所以当时科学家们一直在研发一种最方便且适合居家自我测试及时血糖的仪器,终于在1956年,发明家弗雷利用尿糖试纸原理将葡萄糖氧化酶及过氧化氢分别涂抹在干式试纸上,开发出肉眼比色的第一个血糖值测试纸,不过就是还得多一道手续,必须用水洗去血液擦干,否则会持续反应造成误判。 So when scientists have been working on one of the most convenient and suitable for home self-testing of blood glucose timely instrument, and finally in 1956, inventor Fred urine test strips utilizing the principles of the glucose oxidase enzyme and hydrogen peroxide applied on dry paper respectively developed the naked eye colorimeter first blood glucose test strips, but is also much more one procedure, the blood must be washed off with water to dry, otherwise it will continue to cause false positive reactions.

[0003] 电化学技术应用在血糖检测仪始于1981年,美国Medisense雅培公司在1986年开发出第一台取代传统比色法,体积更小,更方便,反应时间更短的电化学式血糖笔开始了第四代血糖检测仪的发展,2001年开始到目前所有血糖检测仪都是采取电化学法。 [0003] Application of electrochemical detector in blood glucose began in 1981, US Abbott Medisense first developed in 1986 to replace the traditional colorimetric, smaller, more convenient, the reaction time is shorter electrochemical glucose Pen began the fourth generation development of blood glucose monitoring device, 2001 to all current blood glucose monitoring device is taken electrochemical method.

[0004] 第五代血糖检测仪主要特色是以微采血量及多部位采血为主,由美国在2001年推出Freestyle (自由式)血糖检测仪开了先河,目前成为侵入式血糖检测仪争相研发的目标。 [0004] The fifth-generation blood glucose monitoring device is based on the amount of the main features of micro blood and blood-based multi-site, launched by the United States in 2001 Freestyle (Freestyle) blood glucose monitoring device to open the first of its kind, it has now become invasive blood glucose monitoring device competing R & D objectives.

[0005] 所有的侵入式血糖检测方式不论采血量多少或多部位采血,都无法实质帮助糖尿病患者不用扎血,不用耗材的实际需求。 [0005] All invasive glucose detection system regardless of how much blood or parts of blood volume, the substance can not help people with diabetes do not have the blood tie, no supplies of actual demand. 所以目前研发都是走向非侵入式的血糖检测仪,目前世界各国的开发都集中在利用生化标示物(酶,抗体,类似物特异反应)联结传导物产生一种可检测的信号,如电流或电压,颜色或光强度及热信号来捕捉相对应的血糖值。 Therefore, the current trend is the development of non-invasive blood glucose monitoring device, the development of the world are focused on the use of biochemical markers (enzymes, antibodies, specifically reactive analogs) coupled to the conductive material to produce a detectable signal, such as current or voltage, light intensity or color and to capture the thermal signals corresponding to the blood glucose level. 例如:电化学传感器分为两类:体外传感器(皮肤表面的传感器)和可植入皮下的传感器,其工作原理为:测量与被分析物质浓度成比例变化的物理量。 For example: electrochemical sensor divided into two categories: in vitro sensor (skin surface sensor) and the sensor may be implanted subcutaneously, which working principle is: measuring the analyte concentration changes in proportion to a physical quantity. 不过电化学传感器只能在有限的范围内使用,还没能真正应用于临床。 However, electrochemical sensors can be used only within a limited range, not really for clinical application. 光学方面以傅立叶变换近红外光谱的(FT-NIR)疗法。 Optically Fourier Transform Near Infrared Spectroscopy (FT-NIR) therapy. 德国的Heise和美国的Arnold等人都做了大量工作,进行了深入研究。 Germany and the United States Arnold Heise, who have done a lot of work, conducted in-depth research. 测量方法分为透射谱和反色谱。 The method of measuring transmission spectra into and anti chromatography. 德国的Heise等首次用ATR(衰减全反射)技术测量了人体血浆和血液中的葡萄糖、蛋白质、胆固醇、尿素、尿酸和甘油三酯等组分的浓度。 Germany's Heise and so for the first time with ATR (attenuated total reflection) technique for measuring the concentration of human plasma and blood components glucose, protein, cholesterol, urea, uric acid and triglycerides.

[0006] 公开于该背景技术部分的信息仅仅旨在增加对本发明的总体背景的理解,而不应当被视为承认或以任何形式暗示该信息构成已为本领域一般技术人员所公知的现有技术。 [0006] disclosed in this Background section is only for enhancement of understanding of the information of the general background of the invention and should not be taken as an acknowledgment or any form of suggestion that this information forms known to those of ordinary skill in the known prior technology.

发明内容 SUMMARY

[0007] 本发明的目的在于提供随身一种非侵入式血糖值测量方法,可以免除病患每次扎血的痛苦与不便,也不需要使用试纸耗材,除了降低病患的支出负担,又能避免环境污染,减少环保问题。 [0007] The object of the present invention is to provide a non-invasive portable blood glucose level measuring method, each patient can remove the pain and inconvenience blood tie nor the use of paper supplies, in addition to reducing the burden of patients expenditure, but also to avoid environmental pollution, reduce environmental problems.

[0008] 为实现上述目的,本发明提供了一种测量血糖值的方法,其包括以下步骤:步骤一,将探针组件的两个电极分别接触人体皮肤表面的两个不同位置,计算出该两个不同位置之间的电位差;和步骤二,根据血糖值与电位差的线性比例关系式,通过所述电位差计算出待测人体的血糖值。 [0008] To achieve the above object, the present invention provides a method for measuring blood glucose level, which comprises the following steps: Step one, two electrodes are in contact probe assembly in two different positions of the body skin surface, the calculated a potential difference between two different positions; and step two, according to the blood sugar level and the potential difference proportional linear relationship, to calculate the blood glucose level measured by the human body potential difference.

[0009] 优选地,上述技术方案中,还包括步骤三,其记录执行所述步骤一的时刻;其中在不同时刻下,血糖值与电位差具有不同的线性比例关系式,根据所记录的时刻,选择相对应的血糖值与电位差的线性比例关系式,从而计算出待测人体的血糖值。 [0009] Preferably, the above-described aspect, further comprising the step of three, recording time of the execution of a step; wherein at different times, blood glucose level with a potential difference having different linear proportional relationship, based on the time recorded , a blood glucose level corresponding to the selection of the potential difference between the linear proportional relationship, thereby calculating the blood glucose level of the human body to be measured.

[0010] 优选地,上述技术方案中,在不同的时刻选择不同位置的人体皮肤表面进行电位差测量。 [0010] Preferably, the above-described aspect, select a different location at different times of human skin surface potential difference measurements.

[0011 ] 优选地,上述技术方案中,所述两个电极分别为第一电极和第二电极,该第一电极接触的皮肤表面位置选自:虎口区靠近大拇指的部位、无名指的第二指关节的中间部位、手掌自然伸开状态下大拇指纵向中心轴线的延长线和食指纵向中心轴线的延长线的交汇部位、或者小拇指下方的手掌和手背连接段的中间部位。 [0011] Preferably, the above technical solution, the two electrodes of the first and second electrodes, the first electrode contact position of the surface of the skin is selected from: tiger's mouth zone near the thumb portion, a second ring means an intermediate portion of the joint, the palm thumb naturally stretched state in the intersections of the longitudinal extension line of the center axis of the extension line of the longitudinal central axis and the index finger, little finger or palm and back of the hand below the middle of the connection section.

[0012] 优选地,上述技术方案中,所述第二电极接触的皮肤表面位置为大拇指的第一节(最上面一节)的指肚中部。 [0012] Preferably, the above technical solution, the skin surface position of the second electrode is in contact with the thumb of the first (uppermost one) of the middle finger belly.

[0013] 与现有技术相比,本发明具有如下有益效果:由于无需扎针,仅仅需要测人体不同皮肤位置之间的电位差,大大减少了受试对象的扎针痛苦。 [0013] Compared with the prior art, the present invention has the following advantages: Since no acupuncture treatment, only need to measure the potential between the different human skin location difference, greatly reducing the pain of a subject needling. 此外,由于不需要使用试纸,大大节省了经济成本。 In addition, since the use of paper, saving the economic costs.

附图说明 BRIEF DESCRIPTION

[0014] 图1是根据本发明的测量血糖值的方法的流程图。 [0014] FIG. 1 is a flowchart of a method of measuring blood glucose level of the present invention.

[0015] 图2是根据本发明的测量血糖值的方法的另一流程图。 [0015] FIG 2 is a flowchart illustrating another method of measuring blood glucose level of the present invention.

[0016]图3是根据本发明的手掌区域的触摸部位的示意图。 [0016] FIG. 3 is a schematic diagram of a part of the palm area of ​​the touch of the present invention.

[0017] 图4是实现本发明的血糖测量方法的示例性测量装置的示意图。 [0017] 4 is a schematic diagram of an exemplary measuring device of FIG achieve blood glucose measuring method according to the present invention.

[0018]图5是根据本发明的穴点(区块)皮肤电位差与血糖值之间的折线图。 [0018] FIG. 5 is a line graph between (blocks) of the skin potential difference between the blood glucose level according to the present invention acupoints.

[0019] 图6是罗式血糖仪的血糖值和时间的关系的折线图。 [0019] FIG 6 is a relationship between Lo glucose meter and the blood glucose level time line chart.

具体实施方式 detailed description

[0020] 下面结合附图,对本发明的具体实施方式进行详细描述,但应当理解本发明的保护范围并不受具体实施方式的限制。 [0020] below with the accompanying drawings, specific embodiments of the present invention will be described in detail, it should be understood that the scope of the present invention is not limited to the specific embodiments.

[0021] 除非另有其它明确表示,否则在整个说明书和权利要求书中,术语“包括”或其变换如“包含”或“包括有”等等将被理解为包括所陈述的元件或组成部分,而并未排除其它元件或其它组成部分。 [0021] Unless otherwise expressly indicated otherwise, throughout the specification and claims, the terms "including" or a conversion such as "comprises" or "comprising" and the like will be understood to include the recited elements or components of , and does not exclude other elements or other components.

[0022] 需要说明的是,在以下的详细描述中步骤一、步骤二、步骤三等等仅仅是为了表示不同的步骤,并非表示本发明的血糖值测量方法的顺序,本领域技术人员可以根据实际情况变换这些步骤顺序,并不影响本发明的实质。 [0022] Incidentally, in the following detailed description of the steps of a step two, step three, etc. merely to represent different steps, not a sequence of blood glucose measurement method of the present invention, those skilled in the art can converting the actual order of steps, it does not affect the essence of the present invention.

[0023] 许多实验证明生物体不仅可以导电,而且在新陈代谢过程中还可以产生生物电。 [0023] Many experiments show that the organism can not only conductive, but also in the metabolic process can also produce bioelectricity. 这种生物电可以通过组织的电解质,呈导电形式投射到皮肤表面,形成皮肤电现象。 This bioelectrical tissue through the electrolyte, was projected onto the skin in the form of a conductive surface to form a skin electrical phenomena. 穴位(区块)是生物电流的触点,经络是传输电流的通道(生物电波)。 Point (block) is bioelectrical contact, the meridian current transmission channel (bio wave). 当生理病变对应于相关的穴位(区块),电位就发生变化,激发生物电流产生电磁波,然后传到全身的经络,传到中枢神经形成刺激,对病变部位进行调整。 When the lesion corresponding to the physiological relevant points (block), the potential change occurs, a biological excitation current generating electromagnetic waves, then to the body meridian, is formed reached central nervous system stimulation, adjustment of the lesion.

[0024] 本发明的血糖检测方法是依据中国临床医学诊断与经络学中提及有关糖尿病,尿糖,血糖等相关的穴点(区块),测试受检者的皮肤穴点(区块)与皮肤参考点之间的电位差(也就是电压差),然后透过数据分析找出近似公式搭配测试时间,再换算成血糖值供待测对象参考之用。 [0024] blood glucose testing method of the present invention is mentioned about diabetes, urine, blood glucose and other relevant acupoints (block) based on clinical diagnosis and China meridian, the skin of test subjects - points (block) between the skin and the point of reference potential difference (i.e. voltage difference), then through the analyzed data to identify the approximate formula with a test time, and then converted into the blood glucose level for the reference object to be measured. 优选地,经络学提出的观点是,人体在不同的时辰,走不同的经脉,所以本发明测试时也会随着时辰选择不同的部位进行测量,并使用较合适的公式去计算血糖值。 Preferably, the meridian view is presented, in a different human hour, along different meridians, the present invention will be carried out to select the hour when tested with different parts of the measurement, and the formula used to calculate more appropriate blood glucose level.

[0025] 需要说明的是,在本发明的一方面当中,本发明的血糖检测方法并不需要测量人体不同皮肤位置的具体的电压值,而仅仅需要测量出二者之间的电压差(电位差)即可。 [0025] Incidentally, in an aspect of the present invention, among the blood sugar detection method of the present invention does not require measurement of the particular voltage values ​​of the different positions of human skin, but only needs to measure the voltage difference between the two (potential poor) can be. 通过电位差的值和血糖值之间的线性比例关系计算出血糖值,而不像很多现有技术那样,预先存储血糖值与电压/电阻之间的映射关系表,从而测出某些电子信号参数来进行血糖值的查找,这种方式准确率很低,因为实际上人体绝大部分的区块的电信号与血糖值压根没有任何关系。 Calculated by the linear relationship between the potential difference ratio value of blood glucose level and the blood glucose level, unlike many of the prior art, pre-stores a mapping table between the blood glucose level and the voltage / resistance to measure certain electrical signals parameters to find the blood sugar level, this way accuracy rate is very low, because in fact most of the blocks of the human body and the blood sugar level electrical signals are fundamentally nothing to do.

[0026] 如图1所示,在根据本发明的血糖值测量方法的一个实施例当中,首先,将探针组件的两个电极分别接触人体皮肤表面的两个不同位置,这两个电极的一端与人体皮肤接触(两个电极接触的皮肤位置不相同),另一端与电位差测量仪相连接,这样计算出该两个不同位置之间的电位差。 Two different locations [0026] As shown, in accordance with a blood glucose measuring method according to the present embodiment of the invention which, first, two electrodes are in contact probe assembly 1 shown in the human skin surface, two electrodes One end brought into contact with human skin (skin contact positions of the two electrodes are not the same), and the other end is connected to a potential difference measuring instrument, so that the calculated potential difference between the difference between two different positions. 接着,根据血糖值与电位差的线性比例关系式,通过所述电位差计算出待测人体的血糖值。 Next, the potential difference between the blood glucose level is linearly proportional relationship, to calculate the blood glucose level measured by the human body potential difference.

[0027] 如图2所示,根据另一个实施方式,还包括记录执行所述接触步骤的时刻。 [0027] 2, according to another embodiment, further comprising performing recording time of the contacting step. 发明人已经发现,在不同时刻下,血糖值与电位差具有不同的线性比例关系式,因此根据所记录的时刻,选择相对应的血糖值与电位差的线性比例关系式,从而计算出待测人体的血糖值。 The inventors have found that, at different times, blood glucose level with a potential difference having a different linear proportional relationship, so based on the time recorded, the blood glucose level corresponding to the selection of the potential difference between the linear proportional relationship, thereby calculating the measured the body's blood sugar level.

[0028] 优选地,发明人还发现,在不同的时刻,其中一个电极接触不同的穴块,另一个电极的接触位置不做限制,仅需要两个电极接触位置不同即可(关于人体对称的位置认为是相同位置),这样计算出的血糖值可以与真实的血糖值更好的吻合,因此可以在不同的时刻选择不同的穴块进行血糖测量。 [0028] Preferably, the inventors have found that, at different times, wherein a different electrode contact hole blocks, the contact position of the other electrode is not limited, and requires only two different positions to the contact electrodes (symmetric about the body position that is the same position), thus calculated blood glucose level and the actual blood glucose level may be a better fit, and thus can select different blocks blood glucose measurement points at different times.

[0029]图3显示了手掌区域中部分有效的检测区域的示意图。 [0029] FIG. 3 shows a schematic partially effective in the palm area of ​​the detection region. 在此需要说明的是,根据发明人大量的实验研究,人体内仅有为数不多的区块之间的电位差与血糖值之间有比较明显的比例关系,而比如两臂、前胸等区域上的电位差与血糖值之间并没有呈现任何的有效的线性比例关系。 It should be noted here that a large number of experimental studies in accordance with the invention, there is obvious difference between the potential and the proportional relation between the blood glucose level in the human body is only a few blocks, such as the arms, chest, etc. and the potential difference between the blood glucose level does not exhibit any area of ​​efficient linear proportional relationship. 图3显示了手掌区域中4个有效的监测点作为其中一个电极的接触部位,另一个电极的人体接触部位则不做限制,一般为另一只手的拇指第一节指肚。 Figure 3 shows the four active monitoring points in the palm region as one of the electrodes of the contact portion, the body contact portion is not limited in the other electrode, typically the thumb of the other hand the first belly.

[0030] 首先清洁图3所示的要检测的左手穴点A、B、C和D,可以使用酒精棉擦拭或是用肥皂清洗,等干燥后才开始测量。 [0030] First, FIG cleaning left acupoints to be detected A, B, C, and D shown in Figure 3, can be wiped with alcohol or the cotton washed with soap, and other dry before measurement starts.

[0031] 结合图4,其显示了示例性的血糖测量装置。 [0031] in conjunction with FIG. 4, which shows an example of the blood sugar measuring device. 需要说明的是,本发明并不以此为限,任何能够实现本发明测量方法的血糖装置均可以使用。 Incidentally, the present invention is not limited thereto, any method of measuring blood sugar the device can be realized according to the present invention may be used. 参考图4,该示例性的血糖测量装置包括壳体1、探针组件(图中未示)和工作电路板(图中未示)。 Referring to Figure 4, the exemplary blood glucose measuring device comprises a probe assembly (not shown) and the operation circuit board housing (not shown). 所述探针组件安装在壳体I内。 The probe assembly mounted within the housing I. 该探针组件具有两个电极2、3,以用于接触人体的两个不同皮肤位置,从而测量该两个不同皮肤位置之间的电位差。 The probe assembly having two electrodes 2 and 3, for contacting the skin in two different positions of the body, so as to measure the potential between the two different skin location difference. 所述工作电路板上具有时钟模块和微处理器等,以用于计算电位差,并通过预先存储的运算关系式计算出血糖值。 The operation circuit board having a microprocessor and a clock module, for calculating the potential difference, and calculates the blood glucose level by calculating the relational expression stored in advance. 此外,该非侵入式的血糖检测仪还包括显示屏4、喇叭5和开关6。 In addition, the non-invasive blood glucose monitoring device further includes a display 4, a speaker 5 and a switch 6.

[0032] 使用中,首先按动开关6开启电源,显示屏4会出现等待测量的画面。 [0032] In use, firstly press the power switch 6 is turned on, the display 4 will be waiting for the measurement screen. 然后右手拿着本发明的血糖检测仪,右手大拇指(其他右手指头亦可)按住电极3 (参考点),接着将另一个电极2对着左手掌待测的穴点(区块)轻压接触至皮肤略微凹陷即可,此时显示屏4会出现测试画面,并会出现测试出的数值,该数值即可视为受测者血糖的参考值并记录。 Then the right hand of the blood glucose monitoring device of the present invention, the right hand thumb (other fingers also Right) hold the electrode 3 (reference point), then the other electrode 2 facing the left hand pocket point tested (blocks) light press-contact to the skin can be slightly concave, then the display screen 4 appears the test, and the test values ​​occur, this value can be regarded as a reference value and the test subject's blood glucose record. 如果习惯左手操作,则将电极2对着右手掌待测的穴点(区块)轻压接触至皮肤略微凹陷。 If left-handed operation, then the electrode 2 against the palm - points tested (block) is gently pressed into contact with the skin slightly concave.

[0033] 图5显示了根据本发明的血糖仪所检测的血糖值和时间的关系图,图6显示了罗式血糖仪的血糖值与时间的折线图。 [0033] FIG. 5 shows a graph of blood glucose level and time of the blood glucose meter according to the present invention, in accordance with the detected, Figure 6 shows a line graph of blood glucose level and time of Lo glucose meter. 图6中的罗氏血糖仪指的是Roche制造的Accu-ChekActive血糖仪,在血糖仪领域具有指标性地位,所以做为本发明血糖仪的参考基准。 Roche in FIG. 6 refers to a blood glucose meter manufactured by Roche Accu-ChekActive blood glucose meter, an index of the position in the field of the blood glucose meter, the blood glucose meter according to the present invention so as reference base. 观察图5的根据本发明的折线图,在不同的时辰有不同的曲线趋近罗式血糖仪的曲线,有些许差异和偏离,但是参照国际标准EN ISO 15197(2003)的规定,合格的血糖仪误差在20%以下。 The observed line graph in FIG. 5 of the present invention, in a different hour have different curves approach the curve Lo glucose meter, and deviates slightly different, but the reference to the provisions of international standards EN ISO 15197 (2003), qualified glucose of error 20% or less. 所以本发明血糖仪虽然与罗式血糖仪有些误差,但是应在容许范围之内。 Therefore, although the blood glucose meter according to the present invention, some errors Lo glucose meter, it will be within the allowable range. 以mmol/L为单位所推断的公式如下: In mmol / L units inferred the following formula:

[0034] 上午7〜9点,宜采用A穴点(区块)进行血糖测量,A区块公式,血糖值=皮肤电位差XK1,Kl的范围值是1.7〜3.9。 [0034] Morning 7~9 point, point A point should be adopted (block) for blood glucose measurements, block A formula, blood glucose level = XK1 skin potential difference, the range of values ​​of Kl is 1.7~3.9.

[0035] 上午9〜下午3点,宜采用C穴点进行血糖测量,C区块公式,血糖值=皮肤电位差XK3,K3的范围值是0.5〜2.4。 [0035] 15:00 a.m. 9~, point C should be used for blood glucose measurement point, C block formula, blood glucose level = skin potential difference XK3, the range value K3 is 0.5~2.4.

[0036] 下午3〜5点,宜采用D穴点进行血糖测量,D区块公式,血糖值=皮肤电位差XK4,K4的范围值是1.1〜3.5。 [0036] ~ 5 o'clock in the afternoon, should be adopted point blood glucose measurement points D, D block formula, blood glucose level = skin potential difference XK4, range of values ​​K4 is 1.1~3.5.

[0037] 下午5〜9点,宜采用C穴点进行血糖测量,血糖值=皮肤电位差XK3,K3的范围值是0.5〜2.4。 [0037] Afternoon 5~9 point, point C should be adopted point blood glucose measurement, blood glucose level = skin potential difference XK3, the range value K3 is 0.5~2.4.

[0038] 下午9〜11点,宜采用B穴点进行血糖测量,血糖值=皮肤电位差ΧΚ2,Κ2的范围值是1.9〜4.6。 [0038] Afternoon 9~11 point, point B should be adopted point blood glucose measurement, blood glucose level = skin potential difference ΧΚ2, Κ2 range of values ​​is 1.9~4.6.

[0039] 综上所述,根据本发明的血糖测量方法,能够在不给受测者带来扎针痛苦的情况下,获得十分精准的血糖值;同时该测量方法十分容易掌握,且不需要使用试纸,节省了大量成本。 [0039] As described above, blood glucose measuring method according to the present invention, it is possible not to bring needling painful condition test subject, the blood glucose level is obtained very accurate; Meanwhile, the measuring method is very easy to grasp, and does not require the use of paper, saves a lot of cost.

[0040] 前述对本发明的具体示例性实施方案的描述是为了说明和例证的目的。 [0040] The foregoing description of specific exemplary embodiments of the present invention for purposes of illustration and explanation. 这些描述并非想将本发明限定为所公开的精确形式,并且很显然,根据上述教导,可以进行很多改变和变化。 They are not intended to limit the invention to the precise form disclosed, and obviously, of the above teachings, many modifications and variations may be made. 对示例性实施例进行选择和描述的目的在于解释本发明的特定原理及其实际应用,从而使得本领域的技术人员能够实现并利用本发明的各种不同的示例性实施方案以及各种不同的选择和改变。 Exemplary embodiments were chosen and described to explain certain principles of the object of the present invention and its practical application, thereby enabling others skilled in the art to make and utilize various exemplary embodiments of the present invention and various select and change. 本发明的范围意在由权利要求书及其等同形式所限定。 The scope of the present invention is intended by the appended claims and their equivalents as defined.

Claims (5)

  1. 1.一种测量血糖值的方法,其特征在于,包括以下步骤: 步骤一,将探针组件的两个电极分别接触人体皮肤表面的两个不同位置,计算出该两个不同位置之间的电位差;和步骤二,根据血糖值与电位差的线性比例关系式,通过所述电位差计算出待测人体的血糖值。 1. A method for measuring blood glucose level, which is characterized in that it comprises the following steps: Step one, two electrodes are in contact probe assembly in two different positions of the body skin surface, is calculated between the two different locations potential difference; two step, blood sugar level and the potential difference proportional linear relationship, to calculate the blood glucose level measured by the human body potential difference.
  2. 2.根据权利要求1所述的方法,其特征在于,还包括以下步骤: 步骤三,记录执行所述步骤一的时刻; 其中在不同时刻下,血糖值与电位差具有不同的线性比例关系式,根据所记录的时刻,选择相对应的血糖值与电位差的线性比例关系式,从而计算出待测人体的血糖值。 2. The method according to claim 1, characterized by further comprising the following steps: Step three, the step of performing a recording time; wherein at different times, blood glucose level with a potential difference having different linear proportional relationship the time of the recorded blood glucose level corresponding to the selection of the potential difference between the linear proportional relationship, thereby calculating the blood glucose level of the human body to be measured.
  3. 3.根据权利要求2所述的方法,其特征在于,还包括: 在不同的时刻选择人体不同区块的皮肤表面进行电位差测量。 3. The method according to claim 2, characterized in that, further comprising: selecting a different skin surface of the human body blocks the potential difference measured at different times.
  4. 4.根据权利要求1至3中任意一项所述的方法,其特征在于,所述两个电极分别为第一电极和第二电极,该第一电极接触的皮肤表面位置选自:虎口区靠近大拇指的部位、无名指的第二指关节的中间部位、手掌自然伸开状态下大拇指纵向中心轴线的延长线和食指纵向中心轴线的延长线的交汇部位、或者小拇指下方的手掌和手背连接段的中间部位。 4. The method according to any one of claims 1 to 3, characterized in that the two first electrodes and second electrodes, the first electrode contact position of the surface of the skin is selected from: tiger's mouth area site near the thumb, the middle finger portion of the second finger joint, palm thumb naturally stretched state in the intersections of the central extension line of the longitudinal axis of the extension line of the longitudinal central axis and the index finger, the palm or the back of the hand below the little finger and is connected the middle of the section.
  5. 5.根据权利要求4所述的方法,其特征在于,所述第二电极接触的皮肤表面位置为大拇指的第一节的指肚中部。 The method according to claim 4, characterized in that the position of the skin surface of the second electrode is in contact with the thumb of the first middle finger pad.
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