CN105010360A - 一种胶霉毒素乳油制剂 - Google Patents
一种胶霉毒素乳油制剂 Download PDFInfo
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- CN105010360A CN105010360A CN201510433888.2A CN201510433888A CN105010360A CN 105010360 A CN105010360 A CN 105010360A CN 201510433888 A CN201510433888 A CN 201510433888A CN 105010360 A CN105010360 A CN 105010360A
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- gliotoxin
- cream preparation
- missible oil
- emulsifier
- stir
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- FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 title claims abstract description 82
- FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 title claims abstract description 82
- 229940103893 gliotoxin Drugs 0.000 title claims abstract description 82
- 229930190252 gliotoxin Natural products 0.000 title claims abstract description 82
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 34
- 239000002994 raw material Substances 0.000 claims abstract description 22
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims abstract description 18
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims abstract description 18
- 229940073769 methyl oleate Drugs 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000006184 cosolvent Substances 0.000 claims abstract description 10
- 239000006071 cream Substances 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 29
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 11
- 210000000481 breast Anatomy 0.000 claims description 9
- 239000003945 anionic surfactant Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- -1 alkyl phenol Chemical compound 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 6
- 230000005494 condensation Effects 0.000 claims description 6
- OWYSSKOUATWAAO-UHFFFAOYSA-N C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 Chemical compound C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 OWYSSKOUATWAAO-UHFFFAOYSA-N 0.000 claims description 5
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 5
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003905 agrochemical Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000222291 Passalora fulva Species 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241001330975 Magnaporthe oryzae Species 0.000 description 2
- 206010035148 Plague Diseases 0.000 description 2
- 241000234314 Zingiber Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000010148 water-pollination Effects 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
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- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007785 strong electrolyte Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
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Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510433888.2A CN105010360B (zh) | 2015-07-22 | 2015-07-22 | 一种胶霉毒素乳油制剂 |
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CN201510433888.2A CN105010360B (zh) | 2015-07-22 | 2015-07-22 | 一种胶霉毒素乳油制剂 |
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CN105010360A true CN105010360A (zh) | 2015-11-04 |
CN105010360B CN105010360B (zh) | 2017-04-19 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105494369A (zh) * | 2015-12-02 | 2016-04-20 | 京博农化科技股份有限公司 | 一种含胶霉菌素的组合物 |
CN106818793A (zh) * | 2017-01-03 | 2017-06-13 | 广东省微生物研究所(广东省微生物分析检测中心) | 两种胶霉毒素在制备生物农药中的应用 |
CN107711857A (zh) * | 2017-09-30 | 2018-02-23 | 京博农化科技股份有限公司 | 一种含胶霉菌素和环酰菌胺的杀菌组合物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1215433A (zh) * | 1996-12-02 | 1999-04-28 | 味之素株式会社 | 胶霉毒素衍生物及由它制成的抗癌药 |
JP2002053414A (ja) * | 2000-08-11 | 2002-02-19 | Idemitsu Kosan Co Ltd | 土壌病虫害防除剤および土壌病虫害防除法 |
CN101606517A (zh) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | 一种农药乳油制剂 |
-
2015
- 2015-07-22 CN CN201510433888.2A patent/CN105010360B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1215433A (zh) * | 1996-12-02 | 1999-04-28 | 味之素株式会社 | 胶霉毒素衍生物及由它制成的抗癌药 |
JP2002053414A (ja) * | 2000-08-11 | 2002-02-19 | Idemitsu Kosan Co Ltd | 土壌病虫害防除剤および土壌病虫害防除法 |
CN101606517A (zh) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | 一种农药乳油制剂 |
Non-Patent Citations (1)
Title |
---|
刘路宁 等: ""绿木霉菌株TY009 防治纹枯病等水稻主要真菌病害的潜力"", 《中国农业科学》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105494369A (zh) * | 2015-12-02 | 2016-04-20 | 京博农化科技股份有限公司 | 一种含胶霉菌素的组合物 |
CN106818793A (zh) * | 2017-01-03 | 2017-06-13 | 广东省微生物研究所(广东省微生物分析检测中心) | 两种胶霉毒素在制备生物农药中的应用 |
CN107711857A (zh) * | 2017-09-30 | 2018-02-23 | 京博农化科技股份有限公司 | 一种含胶霉菌素和环酰菌胺的杀菌组合物 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Gelamycin emulsifiable concentrate preparation Effective date of registration: 20211123 Granted publication date: 20170419 Pledgee: SHANDONG CHAMBROAD PETROCHEMICALS Co.,Ltd. Pledgor: CHAMBROAD CHEMICAL INDUSTRY RESEARCH INSTITUTE Co.,Ltd. Registration number: Y2021980013118 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220905 Granted publication date: 20170419 Pledgee: SHANDONG CHAMBROAD PETROCHEMICALS Co.,Ltd. Pledgor: CHAMBROAD CHEMICAL INDUSTRY RESEARCH INSTITUTE Co.,Ltd. Registration number: Y2021980013118 |
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TR01 | Transfer of patent right |
Effective date of registration: 20240521 Address after: 256500 Boxing Economic Development Zone, Shandong, Binzhou Patentee after: Shandong Jingbo Agrochemical Technology Co.,Ltd. Country or region after: China Address before: 256500 Boxing Economic Development Zone, Shandong, Binzhou Patentee before: CHAMBROAD CHEMICAL INDUSTRY RESEARCH INSTITUTE Co.,Ltd. Country or region before: China |