CN104984390A - 一种真皮组织修复材料及其制备方法 - Google Patents
一种真皮组织修复材料及其制备方法 Download PDFInfo
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- CN104984390A CN104984390A CN201510352562.7A CN201510352562A CN104984390A CN 104984390 A CN104984390 A CN 104984390A CN 201510352562 A CN201510352562 A CN 201510352562A CN 104984390 A CN104984390 A CN 104984390A
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- dermal tissue
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- tissue repair
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- 239000000463 material Substances 0.000 title claims abstract description 49
- 230000002500 effect on skin Effects 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 102000008186 Collagen Human genes 0.000 claims abstract description 35
- 108010035532 Collagen Proteins 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008367 deionised water Substances 0.000 claims abstract description 22
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 22
- 239000000835 fiber Substances 0.000 claims abstract description 22
- 229920001436 collagen Polymers 0.000 claims abstract description 21
- 210000004177 elastic tissue Anatomy 0.000 claims abstract description 20
- 108010081750 Reticulin Proteins 0.000 claims abstract description 17
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 15
- 229920001661 Chitosan Polymers 0.000 claims abstract description 15
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 15
- 102000011782 Keratins Human genes 0.000 claims abstract description 8
- 108010076876 Keratins Proteins 0.000 claims abstract description 8
- 239000002131 composite material Substances 0.000 claims description 42
- 239000002002 slurry Substances 0.000 claims description 42
- 230000017423 tissue regeneration Effects 0.000 claims description 29
- 239000013078 crystal Substances 0.000 claims description 21
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 14
- 239000008187 granular material Substances 0.000 claims description 14
- 108010067306 Fibronectins Proteins 0.000 claims description 11
- 102000016359 Fibronectins Human genes 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 7
- 102100037362 Fibronectin Human genes 0.000 claims description 3
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 claims description 3
- 102100040487 Keratin, type I cytoskeletal 13 Human genes 0.000 claims description 3
- 102100032704 Keratin, type I cytoskeletal 24 Human genes 0.000 claims description 3
- 101710183646 Keratin, type I cytoskeletal 24 Proteins 0.000 claims description 3
- 108010065070 Keratin-13 Proteins 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- 102000001621 Mucoproteins Human genes 0.000 abstract 1
- 108010093825 Mucoproteins Proteins 0.000 abstract 1
- 239000000383 hazardous chemical Substances 0.000 abstract 1
- 231100000206 health hazard Toxicity 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 10
- 210000002615 epidermis Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000002808 connective tissue Anatomy 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001608 connective tissue cell Anatomy 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 210000001365 lymphatic vessel Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 102100023127 Keratin, type I cuticular Ha2 Human genes 0.000 description 1
- 101710150712 Keratin, type I cuticular Ha2 Proteins 0.000 description 1
- 238000005267 amalgamation Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 210000004905 finger nail Anatomy 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
Abstract
Description
pH值 | 含水量/% | 修复周期 | 与人体真皮组织融合情况 | |
实施例1 | 6.5 | 32 | 8天 | 较佳 |
实施例2 | 7 | 34 | 4天 | 完全融合 |
实施例3 | 7 | 36 | 6天 | 完全融合 |
Claims (7)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510352562.7A CN104984390B (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料及其制备方法 |
CN201810074599.1A CN108079372A (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料的制备方法 |
Applications Claiming Priority (1)
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CN201510352562.7A CN104984390B (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料及其制备方法 |
Related Child Applications (1)
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CN201810074599.1A Division CN108079372A (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104984390A true CN104984390A (zh) | 2015-10-21 |
CN104984390B CN104984390B (zh) | 2018-02-02 |
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CN201810074599.1A Withdrawn CN108079372A (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料的制备方法 |
CN201510352562.7A Active CN104984390B (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料及其制备方法 |
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CN201810074599.1A Withdrawn CN108079372A (zh) | 2015-06-24 | 2015-06-24 | 一种真皮组织修复材料的制备方法 |
Country Status (1)
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CN (2) | CN108079372A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3492073A4 (en) * | 2016-07-27 | 2020-03-25 | Ritapharma, Co., Ltd. | ORAL SLIME APPLICATION MATERIAL AND METHOD FOR THE PRODUCTION THEREOF |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1785444A (zh) * | 2005-12-07 | 2006-06-14 | 浙江大学 | 胶原-壳聚糖和硅橡胶双层皮肤再生支架及其制备方法 |
WO2010082138A2 (en) * | 2009-01-16 | 2010-07-22 | Geistlich Pharma Ag | Method and membrane for tissue regeneration |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9808783A (pt) * | 1997-05-13 | 2000-08-01 | Weyerhaeuser Co | Compósito absorvente, artigo absorvente, e, processo de preparação de um compósito absorvente |
CN101507834A (zh) * | 2008-07-14 | 2009-08-19 | 昆明理工大学 | 可降解皮肤组织工程支架材料及其制备的方法 |
CN101884602A (zh) * | 2010-03-03 | 2010-11-17 | 孙杰 | 一种皮肤美容修复抗衰除皱的化妆品制剂 |
CN102178617B (zh) * | 2011-05-09 | 2012-10-10 | 刘佩华 | 具有皮肤修复和养护功能的蛋白质护肤品 |
-
2015
- 2015-06-24 CN CN201810074599.1A patent/CN108079372A/zh not_active Withdrawn
- 2015-06-24 CN CN201510352562.7A patent/CN104984390B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1785444A (zh) * | 2005-12-07 | 2006-06-14 | 浙江大学 | 胶原-壳聚糖和硅橡胶双层皮肤再生支架及其制备方法 |
WO2010082138A2 (en) * | 2009-01-16 | 2010-07-22 | Geistlich Pharma Ag | Method and membrane for tissue regeneration |
Non-Patent Citations (2)
Title |
---|
刘卉 编著: "《化妆品应用基础 人物形象设计系列》", 31 January 2011, 中国轻工业出版社 * |
金岩 主编: "《组织工程学原理与技术》", 30 June 2004, 第四军医大学出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3492073A4 (en) * | 2016-07-27 | 2020-03-25 | Ritapharma, Co., Ltd. | ORAL SLIME APPLICATION MATERIAL AND METHOD FOR THE PRODUCTION THEREOF |
US10842741B2 (en) | 2016-07-27 | 2020-11-24 | Ritapharma, Co., Ltd. | Oral mucosa application material and method for producing same therefor |
Also Published As
Publication number | Publication date |
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CN108079372A (zh) | 2018-05-29 |
CN104984390B (zh) | 2018-02-02 |
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Inventor after: Wang Dong Inventor after: Guan Xiumei Inventor after: Mao Yufeng Inventor after: Sang Chen Inventor after: Li Xiaolong Inventor after: Wang Zhenggang Inventor before: Lv Shaobo Inventor before: Li Zhuocai Inventor before: Li Suyang |
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Effective date of registration: 20180906 Address after: 635100 2 group of Gao He village, Bai Ba Township, Dazhu County, Sichuan Patentee after: Zhou Qianqian Address before: 225300 6 Yongan Road, Yongan Town, Gao Gang, Jiangsu Province Patentee before: Taizhou Guangming Electronic Material Co., Ltd. |
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Address after: 225324 North of Kechuang Pioneering Avenue, Gaogang District, Taizhou City, Jiangsu Province Patentee after: Zhou Qianqian Address before: 635100 2 group of Gao He village, Bai Ba Township, Dazhu County, Sichuan Patentee before: Zhou Qianqian |
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Address after: 635100 Gaohe Village Group 2, Baiba Township, Dazhu County, Dazhou City, Sichuan Province Patentee after: Zhou Qianqian Address before: 225324 North of Kechuang Pioneering Avenue, Gaogang District, Taizhou City, Jiangsu Province Patentee before: Zhou Qianqian |
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Address after: 236000 Room 101, unit 1, building 4, Yijing, Xiyuan, Renmin Road, Yingshang County, Fuyang City, Anhui Province Patentee after: Zhou Qianqian Address before: 635100 group 2, Gaohe village, baiba Township, Dazhu County, Dazhou City, Sichuan Province Patentee before: Zhou Qianqian |
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Address after: 635100 group 2, Gaohe village, baiba Township, Dazhu County, Dazhou City, Sichuan Province Patentee after: Zhou Qianqian Address before: 236000 Room 101, unit 1, building 4, Yijing, Xiyuan, Renmin Road, Yingshang County, Fuyang City, Anhui Province Patentee before: Zhou Qianqian |
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Effective date of registration: 20201014 Address after: No. 201, Xinsheng street, Wangbao Town, Qidong City, Nantong City, Jiangsu Province, 226000 Patentee after: Qidong ouchang New Material Co., Ltd Address before: 635100 group 2, Gaohe village, baiba Township, Dazhu County, Dazhou City, Sichuan Province Patentee before: Zhou Qianqian |