CN104984096A

CN104984096A - Medicine for treating epilepsia

Info

Publication number: CN104984096A
Application number: CN201510464579.1A
Authority: CN
Inventors: 苘辉斌; 毕传平
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-22
Filing date: 2015-07-22
Publication date: 2015-10-21

Abstract

The invention relates to the field of pharmaceutical formulations, in particular to medicine for treating epilepsia. The medicine is characterized by comprising, by weight, 10%-15% of calcined dens draconis, 7%-10% of calcined chlorite schist, 8%-10% of fruits of polygonum orientale, 1%-3% of bidens frondosa, 6%-10% of schisandra glaucescens diels, 7%-12% of gastrodia elata, 6%-9% of sophora fruit, 4%-7% of cortex lycii radicis, 2%-5% of semen brassicae, 3%-6% of inula flower, 3%-5% of eclipta, 2%-4% of hematoxylon, 4%-7% of tuber fleeceflower stem, 6%-10% of spina date seeds, 2%-6% of pubescent holly root and 3%-6% of saruma henryi. The calcined dens draconis and the calcined chlorite schist are dried in single packages and then ground, water is added to residual bulk drugs for immersion, residues are removed after decocting, filter liquor is obtained, and the calcined dens draconis and the calcined chlorite schist which are ground in single packages are placed and evenly mixed. The medicine has the effects of tranquilizing and allaying excitement, coordinating internal organs, invigorating the spleen and supplementing qi, use is convenient, the absorption effect is good, no harmful or toxic and side effects are generated, and the extremely good relieving and treating effects are achieved for epilepsia.

Description

Be used for the treatment of the medicine of epilepsy

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of medicine being used for the treatment of epilepsy.

Background technology

As everyone knows, epilepsy is chronic recurrent of short duration brain function imbalance syndrome, causes repeatedly epilepsy outbreak for feature with brain neuron paradoxical discharge.Epilepsy is one of nervous system common disease, and prevalence is only second to apoplexy.The sickness rate of epilepsy is relevant with the age.Within it is generally acknowledged 1 years old, prevalence is the highest, is secondly to reduce gradually for 1 ~ 10 years old later.The ratio of China men and women is 1.15: 1 ~ 1.7: 1.

Epileptics, because of extremely complicated, can divide idiopathy, symptomatic epilepsy and essential epilepsy three major types, and there is the factor of multiple impact morbidity.Idiopathy, certain special age bracket onset of being everlasting, has Characteristic clinical and EEG, diagnoses clearer and more definite; Symptomatic epilepsy affects structure or function etc. by central nervous system pathological change, as chromosomal abnormality, focal or diffusivity brain diseases, and caused by some systemic disease.Essential epilepsy is more common, and clinical manifestation prompting symptomatic epilepsy, but does not find the clear and definite cause of disease, can in special age bracket onset, without specific clinical and EEG.

The clinical manifestation of epilepsy has the outbreak of generalized tonic-clonic outbreak (grand mal), simplicial subdivision, petit mal (petit mal) and status epilepticus.

Epilepsy is that a kind of disease patient of repeated relapsing abnormal state of mind understands loss of consciousness, very then holds down, syncope, tonic seizure, slobbering, shouts strangely in the eyes turning upwards or mouth, reviving when moving, is a kind of common nervous system chronic paroxysmal disease, and treatment is complicated and the course for the treatment of is long.At present clinically use western medicine epilepsy, but most antiepileptic exists toxic and side effects, compliance is poor, directly affects the quality of life of patient more, to be not easy to by patient and family members accept.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, a kind of medicine being used for the treatment of epilepsy is provided, there is tranquillizing and allaying excitement, coordinate effect of internal organs, invigorating the spleen and benefiting QI, easy to use, good absorbing effect, without bad and toxic and side effects, to epileptic condition, there is fabulous alleviation and therapeutic effect, be suitable for the clinical treatment of epilepsy and applying of nursing.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of medicine being used for the treatment of epilepsy, it is characterized in that being made up of the crude drug of following percentage by weight: calcined DENS DRACONIS 10 ~ 15%, forge Lapis Chloriti 7 ~ 10%, Fructus Polygoni Orientalis 8 ~ 10%, large Herba Bidentis Tripartitae 1 ~ 3%, Kingsoft Fructus Schisandrae Chinensis 6 ~ 10%, Rhizoma Gastrodiae 7 ~ 12%, Chinese scholartree 6 ~ 9%, Cortex Lycii 4 ~ 7%, Semen Sinapis Albae 2 ~ 5%, Flos Inulae 3 ~ 6%, Herba Ecliptae 3 ~ 5%, Lignum Sappan 2 ~ 4%, Caulis Polygoni Multiflori 4 ~ 7%, Semen Ziziphi Spinosae 6 ~ 10%, Radix Ilicis Pubescentis 2 ~ 6%, Herba Asari 3 ~ 6%, calcined DENS DRACONIS and forge Lapis Chloriti list bag dry after grind into powder, remaining crude drug is soaked, to remove slag after decocting to obtain filtrate, put into calcined DENS DRACONIS that Dan Bao grinds into powder again and forge Lapis Chloriti mixing.

The invention has the beneficial effects as follows, have tranquillizing and allaying excitement, coordinate effect of internal organs, invigorating the spleen and benefiting QI, easy to use, good absorbing effect, without bad and toxic and side effects, to epileptic condition, there is fabulous alleviation and therapeutic effect, be suitable for the clinical treatment of epilepsy and applying of nursing.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopt calcined DENS DRACONIS, forge Lapis Chloriti, Fructus Polygoni Orientalis, large Herba Bidentis Tripartitae, Kingsoft Fructus Schisandrae Chinensis, Rhizoma Gastrodiae, Chinese scholartree, Cortex Lycii, Semen Sinapis Albae, Flos Inulae, Herba Ecliptae, Lignum Sappan, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ilicis Pubescentis, Herba Asari be that crude drug is prepared from.Its component (% by weight) is often paid medicine and is calcined DENS DRACONIS 12, forges Lapis Chloriti 9, Fructus Polygoni Orientalis 9, large Herba Bidentis Tripartitae 2, Kingsoft Fructus Schisandrae Chinensis 9, Rhizoma Gastrodiae 10, Chinese scholartree 9, Cortex Lycii 6, Semen Sinapis Albae 4, Flos Inulae 4, Herba Ecliptae 3, Lignum Sappan 3, Caulis Polygoni Multiflori 5, Semen Ziziphi Spinosae 8, Radix Ilicis Pubescentis 3, Herba Asari 4.Getting above-mentioned 16 taste Chinese herbal medicine gross weights is 200 grams, calcined DENS DRACONIS and forge Lapis Chloriti list bag dry after grind into powder, 14 remaining taste crude drug at room temperature add water to about 1000ml, soak 4 ~ 5 hours, then boiling slow fire with high heat decocts to about 90 ~ 100 minutes, remove slag to obtain filtrate about 300ml, medicinal residues add water 200 ~ 300ml again, decoct about 30 minutes, remove slag to obtain filtrate 100ml, altogether to obtain about 400ml medicine juice, then put into calcined DENS DRACONIS that Dan Bao grinds into powder and forge Lapis Chloriti mixing i.e. this bright decoction obtained, load in sterile glass vials, seal bottle cap is for subsequent use.Every day, potion, divided 2 empty stomaches oral, each serving 200ml.

The main infantile convulsion of calcined DENS DRACONIS of the present invention, demented, severe palpitation, insomnia and dreamful sleep, fever of the body is vexed; Forging Lapis Chloriti, to control pertinacious phlegm cementing, cough with dyspnea dyspnea with rapid respiration, and epilepsy is gone mad, irritated uncomfortable in chest, convulsion with spasms; Fructus Polygoni Orientalis has loose blood eliminating mass, removing food stagnancy pain relieving, inducing diuresis to remove edema function; Large Herba Bidentis Tripartitae cures mainly: body void is weak, night sweat, spitting of blood, infantile malnutrition, dysentery; Kingsoft Fructus Schisandrae Chinensis expelling wind and activating blood circulation; Dissipating blood stasis for subsidence of swelling.Main air pain of dampness syndrome, impairment caused by overstrain takes off power, goiter; Rhizoma Gastrodiae endogenous wind stopping, arresting convulsion.Control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom; Chinese scholartree cooling blood for hemostasis, liver heat removing and eyesight improving; Cortex Lycii removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat; Semen Sinapis Albae warming spleen and stomach for dispelling cold, promoting the circulation of QI eliminating phlegm, the meridian dredging, detumescence poison; Flos Inulae sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum; Herba Ecliptae inducing diuresis for treating stranguria syndrome, parasite killing, antipruritic.For pyretic stranguria, oliguria with reddish urine, drenches the puckery pain of drop; Lignum Sappan blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain; Caulis Polygoni Multiflori controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies; The main trusted subordinate's cold and heat of Semen Ziziphi Spinosae, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen; Radix Ilicis Pubescentis cures mainly heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral.Main anemopyretic cold, dyspnea and cough due to lung-heat, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia; Herba Asari XIAOFENG SAN gas expelling summer-heat, inducing diuresis for treating stranguria syndrome goes to amass.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.

Clinical data:

1, case selection:

The routine clinical observation of epileptic 300 selecting my institute to make a definite diagnosis, patient is divided into two groups at random, treatment group 150 example, wherein male 70 example, women 80 example, 13 ~ 72 years old age, 42 years old mean age, the course of disease 2 months ~ 5 years, average 3 years; Matched group 150 example, wherein male 77 example, women 73 example, 15 ~ 68 years old age, 40 years old mean age, the course of disease 3 months ~ 4.5 years, average 2.7 years; The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.

2, medicament selection:

Treatment group patient takes the embodiment of the present invention one medicine, every day potion, point 2 empty stomaches are oral, and each serving 200ml, within 20 days, be 1 course for the treatment of, 4 ~ 6 courses for the treatment of can fully recover.

Matched group takes epilepsy medicine (Dianxianning) sheet, oral, one time 2 ~ 4,3 times on the one.

3, efficacy determination:

(1) cure: tic of the limbs, upward adverse flow of QI raucous breath, plagiocephaly, the transference cure such as to have a dizzy spell; Breathe smooth and easy, health is fully recovered.

(2) effective: above-mentioned symptom is alleviated to some extent, breathes smooth and easy, health is fully recovered.

(3) invalid: disease is unchanged.

4, result:

Take in the treatment group of medicine of the present invention, cure 108 examples, effective 27 examples, invalid 15 examples, cure rate 72%, total effective rate 90%.

90 examples are cured, effective 41 examples, invalid 19 examples, cure rate 60%, total effective rate 87.3% in matched group.

Model case is illustrated:

1, Bai, man, 21 years old.Patient is interrupted extremity and repeatedly twitches, middle generation confusion of sleeping because pressure is excessive, and companion's tic of the limbs, closes order, and mouth is spat saliva, allophone in mouth, lip pastiness, spontaneous remission after continuing a few minutes, dizzy weak after alleviating, and once takes multi-medicament, without positive effect.Then to our hospital, be diagnosed as epilepsy.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, the symptom such as tic of the limbs, palpitation and short breath is obviously alleviated, and continues to take 2 courses for the treatment of, and laboratory indexes is all normal, and physical recovery is healthy.Follow up a case by regular visits to and do not recur so far.

2, grandson, man, 31 years old.The headache of patient's intermittence, tic are for many years.Several times, each convulsion about 5 minutes, companioned with headache of spitting out white foams during outbreak is felt sick, gnathospasma, syncope, clear-headed after acupuncture Renzhong acupoint in annual outbreak.Bring out because of headache due to common cold in the recent period, opisthotonus, spits out white foams, sensation of oppression over the chest with shortness of breath.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom is obviously alleviated, and after continuing to take 2 courses for the treatment of, health is fully recovered, and breathes smooth and easy, and laboratory indexes is all normal, follows up a case by regular visits to and does not recur so far.

3, poplar, man, 42 years old.Patient suffers from epilepsy for many years, recklessly runs verbal garbage during outbreak, and kneel sleeping variable, the recent state of an illness increases the weight of gradually, hits the person everywhere, ruins thing.Once crossed various medicine, effect is all not good.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, and after continuing to take 4 courses for the treatment of, transference cure, indices is normal, and physical recovery is healthy.

4, Huang, man, 35 years old.Patient suffers from epilepsy for many years, and outbreak is frequent in recent years, and the persistent period lengthens, and on average monthly falls ill, and short then week outbreak once.After recommending to take 3 courses for the treatment of of Chinese medicine preparation of the present invention by doctor, symptom is obviously alleviated, and continues to take this 2 courses for the treatment of, and transference cure, livelihood restoration is normal.

Claims

1. one kind is used for the treatment of the medicine of epilepsy, it is characterized in that being made up of the crude drug of following percentage by weight: calcined DENS DRACONIS 10 ~ 15%, forge Lapis Chloriti 7 ~ 10%, Fructus Polygoni Orientalis 8 ~ 10%, large Herba Bidentis Tripartitae 1 ~ 3%, Kingsoft Fructus Schisandrae Chinensis 6 ~ 10%, Rhizoma Gastrodiae 7 ~ 12%, Chinese scholartree 6 ~ 9%, Cortex Lycii 4 ~ 7%, Semen Sinapis Albae 2 ~ 5%, Flos Inulae 3 ~ 6%, Herba Ecliptae 3 ~ 5%, Lignum Sappan 2 ~ 4%, Caulis Polygoni Multiflori 4 ~ 7%, Semen Ziziphi Spinosae 6 ~ 10%, Radix Ilicis Pubescentis 2 ~ 6%, Herba Asari 3 ~ 6%, calcined DENS DRACONIS and forge Lapis Chloriti list bag dry after grind into powder, remaining crude drug is soaked, to remove slag after decocting to obtain filtrate, put into calcined DENS DRACONIS that Dan Bao grinds into powder again and forge Lapis Chloriti mixing.