CN104970806B - A kind of smart machine for cancer return real-time dynamic monitoring - Google Patents
A kind of smart machine for cancer return real-time dynamic monitoring Download PDFInfo
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- CN104970806B CN104970806B CN201510406730.6A CN201510406730A CN104970806B CN 104970806 B CN104970806 B CN 104970806B CN 201510406730 A CN201510406730 A CN 201510406730A CN 104970806 B CN104970806 B CN 104970806B
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 87
- 201000011510 cancer Diseases 0.000 title claims abstract description 78
- 238000012544 monitoring process Methods 0.000 title claims abstract description 31
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 48
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 48
- 239000008280 blood Substances 0.000 claims abstract description 41
- 210000004369 blood Anatomy 0.000 claims abstract description 41
- 238000004891 communication Methods 0.000 claims description 50
- 238000010438 heat treatment Methods 0.000 claims description 45
- 230000001939 inductive effect Effects 0.000 claims description 40
- 238000005057 refrigeration Methods 0.000 claims description 33
- 102000004506 Blood Proteins Human genes 0.000 claims description 32
- 108010017384 Blood Proteins Proteins 0.000 claims description 32
- 239000002070 nanowire Substances 0.000 claims description 26
- 230000005059 dormancy Effects 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000012545 processing Methods 0.000 claims description 13
- 239000007943 implant Substances 0.000 claims 1
- 238000012546 transfer Methods 0.000 abstract description 7
- 239000000439 tumor marker Substances 0.000 abstract description 4
- 239000003147 molecular marker Substances 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000011017 operating method Methods 0.000 description 5
- 230000001627 detrimental effect Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 102000027450 oncoproteins Human genes 0.000 description 3
- 108091008819 oncoproteins Proteins 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 210000000707 wrist Anatomy 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010061819 Disease recurrence Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Abstract
The invention discloses a kind of smart machine for cancer return real-time dynamic monitoring, the smart machine includes et al. Ke component and external component, tumor marker protein information in blood can be changed into the digital information that can be transmitted and external component is sent to by way of being wirelessly transferred by et al. Ke component, external component is analyzed the Protein Information of reception, notifies the user of implanted cancer return real-time monitoring system to note the danger of cancer return by way of presentation of information and alarm.The smart machine of the present invention can monitor the molecular marker albumen of cancer return/transfer in real time, in the danger of cancer return early stage i.e. detectable cancer return, the patient of cancer return is resulted in timely treatment.
Description
Technical field
The invention belongs to medical instruments field, it is related to a kind of smart machine, and in particular to it is real-time that one kind is used for cancer return
The smart machine of dynamic monitoring.
Background technology
The curative competence of current China cancer is also not fully up to expectations, and about 1/3 can be controlled in whole cancer patients
More, the chance of long term survival is obtained, but there is relapse and metastasis in the course of disease in the cancer patient for also having half or so.Cancer return is
Refer to the cancer being brought under control again on primary organ to occur, or cancer invades lymph vessels or body cavity from original site, moves
Elsewhere continued growth is moved on to, is formed and the same type of tumour of primary tumor.Some cancers can be in some months after treating first
Or recurred after several years.Therefore for cancer patient, the monitoring for carrying out postoperative recurrence transfer is very important.Cancer return
It is more early that the sign of transfer is found, it becomes possible to takes counter-measure in time, the effective possibility for suppressing cancer return transfer, prolongs
Long cancer patient postoperative life cycle.
The mode of current patient monitoring cancer return is mainly periodically to be checked to hospital, this mode for patient,
One is inconvenient, expends the time, two be to check not in time, it is possible to misses the possibility of early detection cancer return.For side
Just cancer patient can timely check oneself the recurrence of cancer, study a kind of equipment that can monitor cancer patient recurrence in real time
It is necessary.
The content of the invention
In order to solve the deficiencies in the prior art, dynamically supervised in real time for cancer return it is an object of the invention to provide one kind
The smart machine of survey, the smart machine is by monitoring monitoring of the level completion of oncoprotein matter in blood to cancer return.
The smart machine sets the threshold value of the level of oncoprotein matter in a blood, when the water for detecting oncoprotein matter in blood
When putting down up to or over the threshold value, the smart machine can then notify monitoring system wearer's cancer by way of sending alarm
Disease recurrence may have occurred and that cancer patient can be made a definite diagnosis to arrive hospital in time, the state of an illness is controlled early.
To achieve these goals, this invention takes following technical scheme：
A kind of smart machine for cancer return real-time dynamic monitoring, the smart machine includes et al. Ke component 1
With external component 2；The et al. Ke component 1 includes blood protein sensor 11, data processing module 12, the first radio communication
Module 13；The blood protein sensor 11 includes albumen trapping layer 111, binding signal inductive layer 112, heating module 113, system
Chill block 114, containment vessel 115；The albumen trapping layer 111 is sticked on binding signal inductive layer 112, the containment vessel 115
Being covered in the albumen trapping layer 111 is used to open the albumen trapping layer 111 with blood separating, the heating module 113
For by the transient heating of albumen sensor 11, to more than 56 DEG C, the refrigeration module 114 to be used for the egg that will have been heated
The temperature moment of white sensor 11 is reduced to physiological temp；The data processing module 12 includes input interface 121, microprocessor
122nd, output interface 123, reactor 124；The input interface 121 receives the electrochemistry that the blood protein sensor 11 is exported
It is simultaneously converted into after data signal and inputs the microprocessor 122 by signal, and the microprocessor 122 is assisted to data signal
The external component 2 is uploaded to via first wireless communication module 13 by the output interface 123 after view conversion；It is described
External component 2 includes data receiver 21, and the data receiver 21 includes controller 211, display 212, siren
213rd, the second wireless communication module 214；The controller 211 receives and analyzed the albumen letter that the et al. Ke component 1 is uploaded
Number, Protein Information is sent on the display 212 shown afterwards, the analysis program of the controller 211 sets a threshold
Value, when the level of albumen exceedes the threshold value, the controller 211 issues instructions to the siren 213, the siren
213 send alarm, notify wearer to note the danger of cancer return；Second wireless communication module 214 is by the controller
211 control command is passed on the reactor 124 in the et al. Ke component 1, and the reactor 124 controls the guarantor
The startup or dormancy that are turned on and off, control the heating module 113, the startup of the control refrigeration module 114 of protective case 115
Or dormancy.
Further, the external component 2 also includes intelligent mobile terminal equipment 22, and the data receiver 21 also includes
Tumor marker protein information is passed through the 3rd wireless communication module by the 3rd wireless communication module 215, the controller 211
215 are sent in the intelligent mobile terminal equipment 22.
The intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Further, the siren 213 is vibrator, notifies wearer to note the danger of cancer return by way of vibration
Danger.
Further, the siren 213 is photophore, notifies wearer to note the danger of cancer return by way of luminous
Danger.
Further, the albumen trapping layer 111 is by being constituted with the antibody that blood protein is specifically bound.
Further, the binding signal inductive layer 112 is made up of array of nanowire transistors.
The albumen trapping layer 111 and the combination of the binding signal inductive layer 112 of the present invention is by nano wire
Cover the antibody of last layer target protein in the surface of transistor.
The operation principle of the blood protein sensor 11 of the present invention is：When the tumor markers in blood-target egg
After antibody binding in white matter and the albumen trapping layer 111, with the nano-wire transistor on the binding signal inductive layer 112
The electron interaction of top layer movement, changes the electric conductivity of nano-wire transistor, front and rear by comparing target protein combination, receives
The difference of the electric conductivity of nanowire transistor, you can know the concentration information of target protein in blood.
The species of antibody in albumen trapping layer 111 of the present invention is determined according to the target protein of antibody capture.Meet
The target protein of condition is the mark of cancer return and transfer, i.e., by detecting that the concentration of target protein can determine whether that cancer is
No recurrence is shifted again.Every cancer return antibody corresponding with the marker protein of transfer is used equally for this hair
It is bright.
Further, first wireless communication module 13, second wireless communication module 214, the 3rd channel radio
Believe module 215 using any one in Bluetooth protocol or Zigbee protocol.
Further, any part that the data receiver 12 can be worn on cancer patient's body, preferably wears
In wrist.In addition, the data receiver 12 can not also be worn on a certain position of the body of cancer patient, but make
Used in vitro accessory.
Further, the controller 211 regularly realizes the control being turned on and off to the containment vessel 115, to heating
The control of startup or the dormancy of module 113, the control to startup or the dormancy of refrigeration module 114.The interval that control command is assigned
Time, regulation stepping was 2s in 1s to continuously adjustabe between 1800s.
The operating method of the smart machine for cancer return real-time dynamic monitoring of the present invention：
(1) the et al. Ke component 1 is implanted into blood；
(2) issued an order by the controller 211 to the reactor 124 and be allowed to control opening for the containment vessel 115
Open, at this moment the albumen trapping layer 111 and contacting blood, target protein and antibody binding；
(3) after reaction certain time, issued an order by the controller 211 to the reactor 124 and be allowed to control institute
State heating module 113 to start, cause the albumen trapping layer 111 and the transient temperature of binding signal inductive layer 112 to reach 56
More than DEG C, now, combined antigen and antibody separation, afterwards, the controller 211 assigns life to the reactor 124
The order control containment vessel 115 is closed, and the albumen trapping layer 111 is isolated with blood, while the controller 211 is to described
Reactor 124 issues an order control refrigeration module 114 by the albumen trapping layer 111 and the binding signal inductive layer 112
Temperature is reduced to physiological temp, so as to complete one-time detection.
(4) wearer of smart machine of the invention is by observing the information and siren that the display 212 is shown
213 reaction knows whether to have occurred that cancer return is dangerous；
The heating module 113 causes the albumen trapping layer 111 and the binding signal inductive layer 112 to be increased to 56 DEG C
More than, this process is instantaneous, and only extremely short time is to start the refrigeration module 114 to complete to cool after heating
There is no any harmful influence in journey, therefore whole process to the composition in blood.
Preferably, the heating module 113 causes 112 liters of the albumen trapping layer 111 and the binding signal inductive layer
Height is to 56 DEG C.Because under the conditions of 56 DEG C, combined antigen-antibody separation, more than 56 DEG C can similarly realize with reference to anti-
The separation of original antibody.
The advantages of the present invention：
1st, the present invention is used for the smart machine of cancer return real-time dynamic monitoring by detecting the tumor markers in blood
Whether the level of albumen is recurred to judge that cancer patient is postoperative, and the diagnosis of molecular level be able to can be sent out in recurrence early stage
It is existing, effectively and timely to take corresponding treatment means to provide diagnostic base.
2nd, the smart machine for cancer return real-time dynamic monitoring of the invention can be realized monitors anywhere or anytime, reaches
To the purpose of real-time dynamic monitoring, cancer patient can be made easily timely to grasp the current intelligence of cancer return transfer.
3rd, the smart machine for cancer return real-time dynamic monitoring of the invention can be reused, and the smart machine leads to
Cross the temperature of control blood protein sensor to reach the purpose of antigen-antibody combination separation, it is to avoid often detect once needs afterwards
Again the operation of smart machine is implanted into.
Brief description of the drawings
A kind of structural representation of the smart machine for cancer return real-time dynamic monitoring of Fig. 1 display present invention；
A kind of structural representation of the smart machine for cancer return real-time dynamic monitoring of Fig. 2 display present invention；
Wherein, 1：Et al. Ke component；11：Blood protein sensor；111：Albumen trapping layer；112：Binding signal senses
Layer；113：Heating module；114：Refrigeration module；115：Containment vessel；12：Data processing module；121：Input interface, 122：Micro- place
Manage device, 123：Output interface；124：Reactor；13：First wireless communication module；2：External component；21：Data receiver；
211：Controller；212：Display；213：Siren；214：Second wireless communication module；215：3rd wireless communication module；
22：Intelligent mobile terminal equipment.
Embodiment
Below in conjunction with specific embodiment, the present invention is furture elucidated.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.
A kind of smart machine for cancer return real-time dynamic monitoring of embodiment 1
A kind of smart machine for cancer return real-time dynamic monitoring, smart machine includes et al. Ke component 1 and body
Outer component 2；Et al. Ke component 1 includes blood protein sensor 11, data processing module 12, the first wireless communication module 13；
Blood protein sensor 11 include albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114,
Containment vessel 115；Albumen trapping layer 111 is sticked on binding signal inductive layer 112, and containment vessel 115 is covered in albumen trapping layer 111
Upper to be used to open albumen trapping layer 111 and blood separating, heating module 113 is used for the transient heating of albumen sensor 11 to 56 DEG C
More than, refrigeration module 114 is used to the temperature moment of the albumen sensor 11 heated being reduced to physiological temp；Data processing mould
Block 12 includes input interface 121, microprocessor 122, output interface 123, reactor 124；Input interface 121 receives blood protein
It is simultaneously converted into input microprocessor 122 after data signal, the logarithm of microprocessor 122 by the electrochemical signals of the output of sensor 11
Word signal carries out after protocol conversion being uploaded to external component 2 via the first wireless communication module 13 by output interface 123；In vitro
Component 2 includes data receiver 21, and data receiver 21 includes controller 211, display 212, siren 213, second
Wireless communication module 214；Controller 211 receives and analyzes the protein signal of the upload of et al. Ke component 1, afterwards by Protein Information
It is sent in display 212 and shows, the analysis program of controller 211 sets a threshold value, when the level of albumen exceedes the threshold value,
Controller 211 issues instructions to siren 213, and siren 213 sends alarm, notifies wearer to note the danger of cancer return；
Second wireless communication module 214 passes to the control command of controller 211 on the reactor 124 in et al. Ke component 1, reaction
Device 124 controls the startup or dormancy that are turned on and off, control heating module 113 of containment vessel 115, controls refrigeration module 114
Start or dormancy.
Siren 213 is vibrator, notifies wearer to note the danger of cancer return by way of vibration.
Albumen trapping layer 111 is by being constituted with the antibody that blood protein is specifically bound.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
Albumen trapping layer 111 and the combination of binding signal inductive layer 112 are to be covered with the surface of nano-wire transistor
The antibody of one layer of target protein.
The operation principle of blood protein sensor 11 is：When tumor markers-target protein in blood is caught with albumen
Obtain after the antibody binding on layer 111, the electronics phase interaction with the nano-wire transistor top layer movement on binding signal inductive layer 112
With, change the electric conductivity of nano-wire transistor, it is front and rear by comparing target protein combination, the electric conductivity of nano-wire transistor
Difference, you can know the concentration information of target protein in blood.
First wireless communication module 13, the second wireless communication module 214 use Bluetooth protocol.
Any part that data receiver 12 can be worn on cancer patient's body, for example, be worn in wrist.
Controller 211 regularly realizes the control being turned on and off to the containment vessel 115, opening to heating module 113
The control of dynamic or dormancy, the control to startup or the dormancy of refrigeration module 114.The interval time that control command is assigned in 1s extremely
Continuously adjustabe between 1800s, regulation stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be increased to more than 56 DEG C, this mistake
Journey is instantaneous, and only extremely short time is to start refrigeration module 114 to complete in temperature-fall period, therefore whole process after heating
There is no any detrimental effect to the composition in blood.
Operating method for the smart machine of cancer return real-time dynamic monitoring：
(1) et al. Ke component 1 is implanted into blood；
(2) issued an order by controller 211 to reactor 124 and be allowed to the unlatching for controlling containment vessel 115, at this moment albumen is caught
Obtain layer 111 and contacting blood, target protein and antibody binding；
(3) after reaction certain time, issued an order by controller 211 to reactor 124 and be allowed to control heating module 113
Start, cause albumen trapping layer 111 and the transient temperature of binding signal inductive layer 112 to reach 56 DEG C, now, combined antigen
Separated with antibody, afterwards, controller 211 is issued an order to reactor 124 controls containment vessel 115 to close, and makes albumen trapping layer 111
Isolate with blood, while controller 211 is issued an order to reactor 124 controls refrigeration module 114 by albumen trapping layer 111 and knot
The temperature for closing induction of signal layer 112 is reduced to physiological temp, so as to complete one-time detection；
(4) wearer of the smart machine by observe display 212 show information and siren 213 reaction come
Know whether to have occurred that cancer return is dangerous.
A kind of smart machine for cancer return real-time dynamic monitoring of embodiment 2
A kind of smart machine for cancer return real-time dynamic monitoring, smart machine includes et al. Ke component 1 and body
Outer component 2；Et al. Ke component 1 includes blood protein sensor 11, data processing module 12, the first wireless communication module 13；
Blood protein sensor 11 include albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114,
Containment vessel 115；Albumen trapping layer 111 is sticked on binding signal inductive layer 112, and containment vessel 115 is covered in albumen trapping layer 111
Upper to be used to open albumen trapping layer 111 and blood separating, heating module 113 is used for the transient heating of albumen sensor 11 to 56 DEG C
More than, refrigeration module 114 is used to the temperature moment of the albumen sensor 11 heated being reduced to physiological temp；Data processing mould
Block 12 includes input interface 121, microprocessor 122, output interface 123, reactor 124；Input interface 121 receives blood protein
It is simultaneously converted into input microprocessor 122 after data signal, the logarithm of microprocessor 122 by the electrochemical signals of the output of sensor 11
Word signal carries out after protocol conversion being uploaded to external component 2 via the first wireless communication module 13 by output interface 123；In vitro
Component 2 includes data receiver 21, and data receiver 21 includes controller 211, display 212, siren 213, second
Wireless communication module 214；Controller 211 receives and analyzes the protein signal of the upload of et al. Ke component 1, afterwards by Protein Information
It is sent on display 212 and shows, the analysis program of controller 211 sets a threshold value, when the level of albumen exceedes the threshold value
When, controller 211 issues instructions to siren 213, and siren 213 sends alarm, notifies wearer to note the danger of cancer return
Danger；Second wireless communication module 214 passes to the control command of controller 211 on the reactor 124 in et al. Ke component 1,
The startup or dormancy that are turned on and off, control heating module 113 of the control containment vessel 115 of reactor 124, control refrigeration module
114 startup or dormancy.
Siren 213 is photophore, notifies wearer to note the danger of cancer return by way of luminous.
Albumen trapping layer 111 is by being constituted with the antibody that blood protein is specifically bound.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
Albumen trapping layer 111 and the combination of binding signal inductive layer 112 are to be covered with the surface of nano-wire transistor
The antibody of one layer of target protein.
The operation principle of blood protein sensor 11 is：When tumor markers-target protein in blood is caught with albumen
Obtain after the antibody binding on layer 111, the electronics phase interaction with the nano-wire transistor top layer movement on binding signal inductive layer 112
With, change the electric conductivity of nano-wire transistor, it is front and rear by comparing target protein combination, the electric conductivity of nano-wire transistor
Difference, you can know the concentration information of target protein in blood.
First wireless communication module 13, the second wireless communication module 214 use Zigbee protocol.
Data receiver 12 is used as in vitro accessory.
Controller 211 regularly realizes the control being turned on and off to the containment vessel 115, opening to heating module 113
The control of dynamic or dormancy, the control to startup or the dormancy of refrigeration module 114.The interval time that control command is assigned in 1s extremely
Continuously adjustabe between 1800s, regulation stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be increased to more than 56 DEG C, this mistake
Journey is instantaneous, and only extremely short time is to start refrigeration module 114 to complete in temperature-fall period, therefore whole process after heating
There is no any detrimental effect to the composition in blood.
Operating method for the smart machine of cancer return real-time dynamic monitoring：
(1) et al. Ke component 1 is implanted into blood；
(2) issued an order by controller 211 to reactor 124 and be allowed to the unlatching for controlling containment vessel 115, at this moment albumen is caught
Obtain layer 111 and contacting blood, target protein and antibody binding；
(3) after reaction certain time, issued an order by controller 211 to reactor 124 and be allowed to control heating module 113
Start, cause albumen trapping layer 111 and the transient temperature of binding signal inductive layer 112 to reach 56 DEG C, now, combined antigen
Separated with antibody, afterwards, controller 211 is issued an order to reactor 124 controls containment vessel 115 to close, and makes albumen trapping layer 111
Isolate with blood, while controller 211 is issued an order to reactor 124 controls refrigeration module 114 by albumen trapping layer 111 and knot
The temperature for closing induction of signal layer 112 is reduced to physiological temp, so as to complete one-time detection；
(4) wearer of the smart machine by observe display 212 show information and siren 213 reaction come
Know whether to have occurred that cancer return is dangerous.
A kind of smart machine for cancer return real-time dynamic monitoring of embodiment 3
A kind of smart machine for cancer return real-time dynamic monitoring, smart machine includes et al. Ke component 1 and body
Outer component 2；Et al. Ke component 1 includes blood protein sensor 11, data processing module 12, the first wireless communication module 13；
Blood protein sensor 11 include albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114,
Containment vessel 115；Albumen trapping layer 111 is sticked on binding signal inductive layer 112, and containment vessel 115 is covered in albumen trapping layer 111
Upper to be used to open albumen trapping layer 111 and blood separating, heating module 113 is used for the transient heating of albumen sensor 11 to 56 DEG C
More than, refrigeration module 114 is used to the temperature moment of the albumen sensor 11 heated being reduced to physiological temp；Data processing mould
Block 12 includes input interface 121, microprocessor 122, output interface 123, reactor 124；Input interface 121 receives blood protein
It is simultaneously converted into input microprocessor 122 after data signal, the logarithm of microprocessor 122 by the electrochemical signals of the output of sensor 11
Word signal carries out after protocol conversion being uploaded to external component 2 via the first wireless communication module 13 by output interface 123；In vitro
Component 2 includes data receiver 21, and data receiver 21 includes controller 211, display 212, siren 213, second
Wireless communication module 214；Controller 211 receives and analyzes the protein signal of the upload of et al. Ke component 1, afterwards by Protein Information
It is sent on display 212 and shows, the analysis program of controller 211 sets a threshold value, when the level of albumen exceedes the threshold value
When, controller 211 issues instructions to siren 213, and siren 213 sends alarm, notifies wearer to note the danger of cancer return
Danger；Second wireless communication module 214 passes to the control command of controller 211 on the reactor 124 in et al. Ke component 1,
The startup or dormancy that are turned on and off, control heating module 113 of the control containment vessel 115 of reactor 124, control refrigeration module
114 startup or dormancy.
External component 2 also includes intelligent mobile terminal equipment 22, and data receiver 21 also includes the 3rd radio communication mold
Tumor marker protein information is sent to intelligent mobile terminal by block 215, controller 211 by the 3rd wireless communication module 215
In equipment 22.Intelligent mobile terminal equipment 22 carries out remote storage and analysis to Protein Information.
Intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Data receiver 12 can be worn on any part of cancer patient's body, for example wrist.
First wireless communication module 13, the second wireless communication module 214, the 3rd wireless communication module 215 are assisted using bluetooth
View.
Siren 213 is vibrator, notifies wearer to note the danger of cancer return by way of vibration.
Albumen trapping layer 111 is by being constituted with the antibody that blood protein is specifically bound.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
Albumen trapping layer 111 and the combination of binding signal inductive layer 112 are to be covered with the surface of nano-wire transistor
The antibody of one layer of target protein.
The operation principle of blood protein sensor 11 is：When tumor markers-target protein in blood is caught with albumen
Obtain after the antibody binding on layer 111, the electronics phase interaction with the nano-wire transistor top layer movement on binding signal inductive layer 112
With, change the electric conductivity of nano-wire transistor, it is front and rear by comparing target protein combination, the electric conductivity of nano-wire transistor
Difference, you can know the concentration information of target protein in blood.
Controller 211 regularly realizes the control being turned on and off to the containment vessel 115, opening to heating module 113
The control of dynamic or dormancy, the control to startup or the dormancy of refrigeration module 114.The interval time that control command is assigned in 1s extremely
Continuously adjustabe between 1800s, regulation stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be increased to more than 56 DEG C, this mistake
Journey is instantaneous, and only extremely short time is to start refrigeration module 114 to complete in temperature-fall period, therefore whole process after heating
There is no any detrimental effect to the composition in blood.
Operating method for the smart machine of cancer return real-time dynamic monitoring：
(1) et al. Ke component 1 is implanted into blood；
(2) issued an order by controller 211 to reactor 124 and be allowed to the unlatching for controlling containment vessel 115, at this moment albumen is caught
Obtain layer 111 and contacting blood, target protein and antibody binding；
(3) after reaction certain time, issued an order by controller 211 to reactor 124 and be allowed to control heating module 113
Start, cause albumen trapping layer 111 and the transient temperature of binding signal inductive layer 112 to reach 56 DEG C, now, combined antigen
Separated with antibody, afterwards, controller 211 is issued an order to reactor 124 controls containment vessel 115 to close, and makes albumen trapping layer 111
Isolate with blood, while controller 211 is issued an order to reactor 124 controls refrigeration module 114 by albumen trapping layer 111 and knot
The temperature for closing induction of signal layer 112 is reduced to physiological temp, so as to complete one-time detection；
(4) wearer of the smart machine by observe information that display 212 or intelligent terminal 22 are shown with
And the reaction of siren 213 knows whether to have occurred that cancer return is dangerous.
A kind of smart machine for cancer return real-time dynamic monitoring of embodiment 4
A kind of smart machine for cancer return real-time dynamic monitoring, smart machine includes et al. Ke component 1 and body
Outer component 2；Et al. Ke component 1 includes blood protein sensor 11, data processing module 12, the first wireless communication module 13；
Blood protein sensor 11 include albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114,
Containment vessel 115；Albumen trapping layer 111 is sticked on binding signal inductive layer 112, and containment vessel 115 is covered in albumen trapping layer 111
Upper to be used to open albumen trapping layer 111 and blood separating, heating module 113 is used for the transient heating of albumen sensor 11 to 56 DEG C
More than, refrigeration module 114 is used to the temperature moment of the albumen sensor 11 heated being reduced to physiological temp；Data processing mould
Block 12 includes input interface 121, microprocessor 122, output interface 123, reactor 124；Input interface 121 receives blood protein
It is simultaneously converted into input microprocessor 122 after data signal, the logarithm of microprocessor 122 by the electrochemical signals of the output of sensor 11
Word signal carries out after protocol conversion being uploaded to external component 2 via the first wireless communication module 13 by output interface 123；In vitro
Component 2 includes data receiver 21, and data receiver 21 includes controller 211, display 212, siren 213, second
Wireless communication module 214；Controller 211 receives and analyzes the protein signal of the upload of et al. Ke component 1, afterwards by Protein Information
It is sent on display 212 and shows, the analysis program of controller 211 sets a threshold value, when the level of albumen exceedes the threshold value
When, controller 211 issues instructions to siren 213, and siren 213 sends alarm, notifies wearer to note the danger of cancer return
Danger；Second wireless communication module 214 passes to the control command of controller 211 on the reactor 124 in et al. Ke component 1,
The startup or dormancy that are turned on and off, control heating module 113 of the control containment vessel 115 of reactor 124, control refrigeration module
114 startup or dormancy.
External component 2 also includes intelligent mobile terminal equipment 22, and data receiver 21 also includes the 3rd radio communication mold
Tumor marker protein information is sent to intelligent mobile terminal by block 215, controller 211 by the 3rd wireless communication module 215
In equipment 22.Intelligent mobile terminal equipment 22 carries out remote storage and analysis to Protein Information.
Intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Data receiver 12 is used as in vitro accessory.
First wireless communication module 13, the second wireless communication module 214, the 3rd wireless communication module 215 use ZigBee
Agreement.
Siren 213 is photophore, notifies wearer to note the danger of cancer return by way of luminous.
Albumen trapping layer 111 is by being constituted with the antibody that blood protein is specifically bound.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
Albumen trapping layer 111 and the combination of binding signal inductive layer 112 are to be covered with the surface of nano-wire transistor
The antibody of one layer of target protein.
The operation principle of blood protein sensor 11 is：When tumor markers-target protein in blood is caught with albumen
Obtain after the antibody binding on layer 111, the electronics phase interaction with the nano-wire transistor top layer movement on binding signal inductive layer 112
With, change the electric conductivity of nano-wire transistor, it is front and rear by comparing target protein combination, the electric conductivity of nano-wire transistor
Difference, you can know the concentration information of target protein in blood.
Controller 211 regularly realizes the control being turned on and off to the containment vessel 115, opening to heating module 113
The control of dynamic or dormancy, the control to startup or the dormancy of refrigeration module 114.The interval time that control command is assigned in 1s extremely
Continuously adjustabe between 1800s, regulation stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be increased to more than 56 DEG C, this mistake
Journey is instantaneous, and only extremely short time is to start refrigeration module 114 to complete in temperature-fall period, therefore whole process after heating
There is no any detrimental effect to the composition in blood.
Operating method for the smart machine of cancer return real-time dynamic monitoring：
(1) et al. Ke component 1 is implanted into blood；
(2) issued an order by controller 211 to reactor 124 and be allowed to the unlatching for controlling containment vessel 115, at this moment albumen is caught
Obtain layer 111 and contacting blood, target protein and antibody binding；
(3) after reaction certain time, issued an order by controller 211 to reactor 124 and be allowed to control heating module 113
Start, cause albumen trapping layer 111 and the transient temperature of binding signal inductive layer 112 to reach 56 DEG C, now, combined antigen
Separated with antibody, afterwards, controller 211 is issued an order to reactor 124 controls containment vessel 115 to close, and makes albumen trapping layer 111
Isolate with blood, while controller 211 is issued an order to reactor 124 controls refrigeration module 114 by albumen trapping layer 111 and knot
The temperature for closing induction of signal layer 112 is reduced to physiological temp, so as to complete one-time detection；
(4) wearer of the smart machine by observe display 212 show information and siren 213 reaction come
Know whether to have occurred that cancer return is dangerous.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (7)
1. a kind of smart machine for cancer return real-time dynamic monitoring, it is characterised in that the smart machine includes internal
Implant assembly (1) and external component (2)；The et al. Ke component (1) includes blood protein sensor (11), data processing mould
Block (12), the first wireless communication module (13)；The blood protein sensor (11) includes albumen trapping layer (111), with reference to letter
Number inductive layer (112), heating module (113), refrigeration module (114), containment vessel (115)；Albumen trapping layer (111) adhesion
On binding signal inductive layer (112), the containment vessel (115), which is covered on the albumen trapping layer (111), to be used for by described in
Albumen trapping layer (111) is opened with blood separating, and the heating module (113) was used for blood protein sensor (11) moment
More than 56 DEG C are heated to, the refrigeration module (114) is used for the temperature wink for the blood protein sensor (11) that will have been heated
Between be reduced to physiological temp；The data processing module (12) includes input interface (121), microprocessor (122), output interface
(123), reactor (124)；The input interface (121) receives the electrochemical signals of blood protein sensor (11) output
And it is converted into after data signal inputs the microprocessor (122), the microprocessor (122) is assisted to data signal
The external component is uploaded to via first wireless communication module (13) by the output interface (123) after view conversion
(2)；The external component (2) include data receiver (21), the data receiver (21) include controller (211),
Display (212), siren (213), the second wireless communication module (214)；The controller (211) receives and analyzes the body
The protein signal of component (1) upload is implanted into, Protein Information is sent on the display (212) shown afterwards, the control
The analysis program of device (211) processed sets a threshold value, and when the level of albumen exceedes the threshold value, the controller (211) sends
Instruct and give the siren (213), the siren (213) sends alarm, notifies wearer to note the danger of cancer return；Institute
The second wireless communication module (214) is stated to pass to the control command of the controller (211) in the et al. Ke component (1)
On the reactor (124), the reactor (124) controls being turned on and off, controlling the heating for the containment vessel (115)
Startup or dormancy, the startup or dormancy of the control refrigeration module (114) of module (113).
2. smart machine according to claim 1, it is characterised in that it is whole that the external component (2) also includes intelligent mobile
End equipment (22), the data receiver (21) also includes the 3rd wireless communication module (215), and the controller (211) will
Protein Information is sent in the intelligent mobile terminal equipment (22) by the 3rd wireless communication module (215).
3. smart machine according to claim 1 or 2, it is characterised in that the siren (213) is vibrator, is passed through
The mode of vibration notifies wearer to note the danger of cancer return.
4. smart machine according to claim 1 or 2, it is characterised in that the siren (213) is photophore, is passed through
Luminous mode notifies wearer to note the danger of cancer return.
5. smart machine according to claim 1 or 2, it is characterised in that the albumen trapping layer (111) be by with blood
The antibody that protein-specific is combined is constituted.
6. smart machine according to claim 1 or 2, it is characterised in that the binding signal inductive layer (112) includes receiving
Nanowire transistor array.
7. smart machine according to claim 2, it is characterised in that first wireless communication module (13), described
Two wireless communication modules (214), the 3rd wireless communication module (215) are using any in Bluetooth protocol or Zigbee protocol
It is a kind of.
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| ES2316193T3 (en) * | 1998-09-30 | 2009-04-01 | Sicel Technologies, Inc. | PROCEDURES, SYSTEMS AND IMPLANTABLE DEVICES ASSOCIATED FOR DYNAMIC MONITORING OF TUMORS. |
| WO2004075032A2 (en) * | 2003-02-19 | 2004-09-02 | Sicel Technologies Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| US20090209031A1 (en) * | 2006-01-26 | 2009-08-20 | Tyco Healthcare Group Lp | Medical device package |
| GB0606998D0 (en) * | 2006-04-06 | 2006-05-17 | Oxford Biosensors Ltd | Lipoprotein sensor |
| CN201005704Y (en) * | 2007-02-15 | 2008-01-16 | 包头奥普德电子科技有限公司 | Body interplanted biochemistry parameter automatic monitoring system |
| CN101358982B (en) * | 2007-08-01 | 2012-01-04 | 中国科学院电子学研究所 | Saccharification hemoglobin immune sensor based on field effect tube |
| EP2095762B1 (en) * | 2008-02-26 | 2011-05-11 | Biostems Ltd. | Device for in vivo micro-invasive investigation comprising a metal guide |
| EP3249399A1 (en) * | 2011-09-22 | 2017-11-29 | Memorial Sloan-Kettering Cancer Center | Detecting ovarian cancer |
| CN204813901U (en) * | 2015-07-12 | 2015-12-02 | 北京泱深生物信息技术有限公司 | A smart machine for monitoring of cancer recurring real time kinematic |
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