CN104940841B - A kind of Chinese medicine composition and application thereof - Google Patents
A kind of Chinese medicine composition and application thereof Download PDFInfo
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Abstract
It is composed of the following components the present invention provides a kind of Chinese medicine composition：15 parts of semen brassicae, 15 parts of Chinese cassia tree, 30 parts of peppermint, 30 parts of borneol, 15 parts of trigone, 15 parts of curcuma zedoary, 30 parts of the rhizome of davallia, 15 parts of dragon's blood, 20 parts of safflower, 30 parts of bletilla, 15 parts of Rheum palmatum (processed with wine), 20 parts of radix scrophulariae, in terms of mass fraction.It safe and effective can prevent cerebral infarction, cerebral hemorrhage, cerebral arteriovenous malformation, inhibition and recession patient's carotid artery atherosclerosis block, level-one, secondary prevention important in inhibiting to cerebral apoplexy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, and application thereof and preparation method.
Background technology
The blood vessels accident serious threat human life and health such as cerebral infarction, cerebral hemorrhage, and artery sclerosis is cerebral infarction, brain
The main pathological basis of the cerebrovascular diseases such as bleeding.Rationally, systematically the treatments such as decompression, hypoglycemic, lipid-loweringing are current control arteries
The taken main means of hardening.Modern medicine removes statins for the stronger direct intervention measure of artery sclerosis specific aim
Use outside, method is less.The study found that even small arteriosclerosis plaque reverses, vascular events can also be greatly reduced.
Statins Lipid modulating is one of the level-one of cardiovascular and cerebrovascular diseases, the main policies of secondary prevention at present, but statins
It can cause the adverse reactions such as myalgia, rhabdomyolysis, hepatic disorder.
Current internal and international medical field has gradually recognized that traditional Chinese medicine is hard in treatment cerebral infarction, cerebral hemorrhage, cerebral artery
Change and the advantage and characteristic of carotid atherosclerosis etc., other than traditional decoction dosage form, Chinese patent drug dosage form, Chinese medicine
More and more preparation ways such as parenteral solution formulation constantly enter the sight of people.But the weight of Traditional Chinese Medicine " inner disease outer treat "
Component part " paste external application " therapy is wanted, using still few in the treatment of apoplexy relevant disease, blank is still located in correlative study.
Invention content
The object of the present invention is to provide a kind of Chinese medicine composition, can safe and effective prevention cerebral infarction, cerebral hemorrhage,
Cerebral arteriovenous malformation, inhibits and recession patient's carotid artery atherosclerosis block, level-one, secondary prevention to cerebral apoplexy have important
Meaning.
The purpose of the present invention is what is realized by following measures：
A kind of traditional Chinese medicine for external application, it is composed of the following components：15 parts of semen brassicae, 15 parts of Chinese cassia tree, 30 parts of peppermint, borneol 30
Part, 15 parts of trigone, 15 parts of curcuma zedoary, 30 parts of the rhizome of davallia, 15 parts of dragon's blood, 20 parts of safflower, 30 parts of bletilla, 15 parts of Rheum palmatum (processed with wine), radix scrophulariae 20
Part, in terms of mass fraction.The present invention realizes resolving sputum and leads to stagnant, and drug of breaking blood stasis to resolve lumps, promoting blood circulation is cured the wound, clearing heat and detoxicating, saprophytic removing.
Preferably, above-mentioned Chinese medicine composition is made external application paste and sticks agent.It is pasted on (neck Adam's apple at neck " Renying point "
Side, at nutator leading edge, carotid arterial pulse).
The above-mentioned agent preparation method that sticks includes the following steps：Chinese medicinal material is taken in proportion, it is ground to become fine powder and excessively 80
Mesh sieve is uniformly mixed；Heating makes vaseline and beeswax melt completely, then be slowly added into Chinese medicinal powder, uniform stirring, traditional Chinese medicine powder：It is all
Intellectual circle's weight ratio is 1:3, vaseline：Beeswax weight ratio is 15：1；50 DEG C of constant temperature infusions 1 hour, every 10 minutes during infusion
It need to stir once, medicinal powder is allowed to be merged with vaseline, infusion is completed postcooling and is made in curdled appearance.
Above-mentioned Chinese medicine preparation is applied in prevention cerebral infarction, cerebral hemorrhage, cerebral arteriovenous malformation drug is prepared.
Above-mentioned Chinese medicine preparation is preparing the application in treating carotid artery atherosclerosis plaques drug.Carotid arteriosclerosis plaque
The mainly local essential resistance of turbid phlegm of the interpretation of the cause, onset and process of an illness that block is formed, phlegm and blood stasis and the solid caused muscle corruption arteries and veins wound of the evil glue of poison.Through clinical research
Chinese medicine composition of the present invention has apparent recession and inhibiting effect for carotid artery atherosclerosis plaques.
Advantageous effect
1. in the present invention, semen brassicae is good at " search and pick the outer phlegm of flesh side film "；" promoting blood circulation, manages and dredges deficiency Chinese cassia tree, and a surname leads hundred
Medicine "；Trigone " main Lao Pi Disorder lumps in the abdomen caking "；Curcuma zedoary " broken Xuan addictions cold air ", for " controlling the medicine for gathering all gas and most wanting "；The rhizome of davallia " kidney tonifying
Promoting blood circulation, continuous muscle are cured the wound "；Dragon's blood " promoting blood circulation to remove blood stasis, expelling pus and promoting granulation "；Safflower energy " promoting blood circulation Xiao Disorder, unobstructed blood vessels "；Rheum officinale " under
Hemostasis, blood close fever and chills , Po lumps in the chest and abdomen "；Radix scrophulariae is apt to " dissipating convulsive seizure due to phlegm-fire pent-up, disappear swollen ulcer drug "；Borneol " leads to all keys, dissipates stagnated fire, property
It walks without keeping, also can myogenic "；Peppermint " Chhnang rises floating, awakening consciousness "；And borneol, peppermint have exact promotion drug transdermal to inhale
The effect of receipts；Bletilla has " hold back gas, ooze phlegm, hemostasis, subduing inflammation, support is routed, removes dead flesh, clean purulence blood, holds in the palm new wonderful of old life ", bletilla
Contained colloid has tackness, can prevent moisture evaporation, plays the bonding aggregation efficacy of a drug and moisturizing softening skin, continues conducive to the efficacy of a drug
The effect penetrated deep into.All medicine compatibilities play resolving sputum and lead to stagnant, the benefits of drug of breaking blood stasis to resolve lumps, promoting blood circulation is cured the wound, clearing heat and detoxicating, saprophytic removing altogether.
2. external used medicine application method stimulation Renying point can be used in the present invention, existing drug has the stimulation at acupuncture point
The effect of drug in itself, a variety for the treatment of factors interact, complement one another, and play the effect being integrally superimposed jointly, and evade
Needle thorn risk, it is easily operated.
3. the invention avoids skin allergy and the strong medicinal material of irritation is easily caused, such as ground bettle, frankincense, myrrh, day
Southern Star etc., and the medicinal material that pharmacological property, effect is avoided to repeat, improve preparation security and clinical efficacy, reduce preparation cost.This
Invention is more rigorous, reasonable, science composition of prescription.
4. invention formulation can be widely applied in the treatment and prevention of various cerebrovascular diseases, it is provided with good prevention and makees
With.
Specific embodiment
It is further illustrated the present invention below by the mode of embodiment, does not therefore limit the present invention to the implementation
Among example range.
Embodiment 1
A kind of Chinese medicine preparation, formula are：Semen brassicae 15g, Chinese cassia tree 15g, peppermint 30g, borneol 30g, trigone 15g, curcuma zedoary
15g, rhizome of davallia 30g, dragon's blood 15g, safflower 20g, bletilla 30g, Rheum palmatum (processed with wine) 15g, radix scrophulariae 20g.
Preparation method is：Chinese medicinal material is taken in proportion, it is ground to be uniformly mixed as fine powder and the sieve of 80 mesh excessively；Prepare all scholars
Woods 750g, beeswax 50g, heat vaseline and beeswax melts, then be slowly added into traditional Chinese medicine powder completely, uniform stirring.50 DEG C of constant temperatures are endured
Boil 1 hour, during infusion stirring in every 10 minutes once medicinal powder is allowed to be merged with vaseline, after the completion of infusion, ointment is poured into point
In bottling, cooling is in spare after curdled appearance completely.
Application method：Appropriate paste (3g) is taken to be applied to blank acupoint plaster (specification：7cm × 6cm) center, it is pasted on bilateral
At Renying point.It is daily to stick primary, each application time 4h, 30 days courses for the treatment of.
Embodiment 2
1. clinical treatment object：60 patients are in January, 2013 to Pinggu District in December, 2014 hospital of traditional Chinese hospital encephalopathy needle
Moxibustion rehabilitation department out-patient.Man 32, female 28, age 45-72 Sui, be averaged (58.26 ± 7.17) year.It is by arteria carotis
Ultrasonic examination, carotid intimal medial thickness (IMT) >=1.0mm or discovery local intra-arterial atherosclerotic plaque former.
Diagnostic criteria：0.1cm≤IMT ＜ 0.15cm are Carotid Sclerosis, when IMT >=0.15mm and the inner membrance that thickens are to pipe
Intracavitary is protruded, then is formed for patch.
2. drug forms and usage
2.1 trial drug：Chinese medicine composition (being prepared by embodiment 1) of the present invention.
2.2 testing program：Test group itself cross-reference.
Appropriate paste (3g) is taken to be applied to blank acupoint plaster center, is pasted at bilateral Renying point.It is daily to stick once, often
Secondary application time 4h, 30 days courses for the treatment of.
3. observation index
Before treatment, treatment 1,2,3 month after U.S.'s philips HD11 colorful Doppler ultrasound diagnostic apparatus is respectively adopted
L12-5 linear array high frequency probes measure Carotid arterial IMT showed thickness, the maximum gauge of same patch, patch by fixed ultrasonic doctor
The indexs such as echo.Carotid arterial IMT showed measures：Fully exposure checks bilateral common carotid artery, along chest lock mamillary process muscle outer edge, is popped one's head in and examined with 7.5MHz
It is whole to survey arteria carotis, then measures respectively at carotid bifuracation, at proximal part 1.0cm and the Carotid arterial IMT showed of distal end 1.0cm is thick
Degree, takes the average value at 3；Carotid artery atherosclerosis plaques integration is each isolated athero- by two bilateral common carotid arteries respectively using Crous methods
The maximum gauge of patch be added as the patch total mark of the patient.
4. observation of curative effect
Compare carotid intimal medial thickness variation and carotid artery atherosclerosis plaques integration variation before and after the course for the treatment of.(result
It is shown in Table 1).
5. statistical method
Statistical procedures, measurement data mean ± standard deviation are carried out using SAS8.0 softwaresIt represents, treatment
It is front and rear itself to compare with paired t-test, P<0.05 is statistically significant for difference.
Table 1
6. conclusion (of pressure testing)
Before 1st course for the treatment of rear neck artery Internal-media thickness of traditional Chinese medicine composition for treating of the present invention and atheromatous plaque integration and treatment
It compares, though numerical value is reduced earlier above, no significant difference (P>0.05)；Arteria carotis when treating the 2nd, 3 course for the treatment of
Internal-media thickness and atheromatous plaque integration significantly reduce before relatively treating, and difference is statistically significant (P ＜ 0.05), and with
The increase for the treatment of course, curative effect are more notable.
Experimental example 3
1. clinical treatment object：60 Acute Cerebral Infarction patients are in December, -2014 in January, 2012 in our hospital's encephalopathy
The patient that acupuncture rehabilitation lesion is hospitalized, is divided into observation group and control group by table of random number.Observation group 30, male 18, female
Property 12,42~70 years old age, average (61.33 ± 4.52) year；Course of disease 3-48 hours, average course of disease (17.16 ± 5.89) are small
When；Circulation infarction (PACI) 24 before part, posterior circulation ischemia are adhered to separately by Oxfordshire's Community Stroke research parting (OCSP)
(POCI) 3, lacunar infarction (LACI) 3；Complication with diabetes 23, high blood pressure 26, hyperlipidemia 19.Control group
30, male 16, women 14,43~67 years old age, average (60.26 ± 3.87) year, course of disease 5-45 hours, average course of disease
(16.65 ± 3.81) hour；PACI24, POCI2, LACI4 are adhered to separately by OCSP；Complication with diabetes 22, high blood pressure
27, hyperlipidemia 20.Two groups of patient's general information comparing differences are not statistically significant (P ＞ 0.05), are comparable.
Diagnostic criteria：It was proposed with reference to Chinese Neuscience meeting, Chinese neurosurgery association in 1996《All kinds of cerebrovasculars
Medical diagnosis on disease main points》Diagnosis：(1) Acute onset；(2) focal neurologic impairment, minority are comprehensive neurologic impairment；
(3) more than sings and symptoms last for hours；(4) brain CT or MRI Cerebral hemorrhages and other lesions；(5) brain CT or MRI have duty
Appoint infarct lesion.
2. drug forms and test method
2.1 trial drug：Chinese medicine composition (being prepared by embodiment 1) of the present invention.
2.2 testing program：The completely random check experiment of test group and control group.
Control group：All 30 patients all in accordance with《Chinese cerebrovascular disease guideline of prevention and treatment》Instruct decompression, hypoglycemic, lipid-loweringing, drop
Fine, platelet aggregation-against and Neuroprotective Therapy in Treating Acute according to the specific state of an illness of patient, ensure nutrition intake, keep respiratory passage unblocked, close
Manage anti-infective therapy etc..
Treatment group：Add on the basis of control group treatment and use pharmaceutical composition of the present invention.Appropriate paste (3g) is taken to be applied to blank
Acupoint plaster center, is pasted at bilateral Renying point.It is daily to stick primary, each application time 4h, 30 days courses for the treatment of.
3. observation index
(1) neurological deficits score (NIHSS)：Before treatment and 30 days after treatment, score using NIHSS
Measure neurologic impairment state.(2) daily life active ability (ADL) scores：Before treatment and 30 days after treatment, adopt
Disabled degree or daily life dependence are measured with Barthel indexes (BI).
4. observation of curative effect
With reference to national 4th cerebrovascular disease academic conference in 1996 by《Cerebral Apoplexy Nerve Function defect degree
Standards of grading》Carry out efficacy determination：It is divided into according to NIHSS scorings reduction degree：Basic healings, marked improvement, progress and in vain
Or four grades such as deterioration.Scoring reduction (%)=(scoring of being admitted to hospital-is scored) for 14 days after treatment/scoring × 100% of being admitted to hospital.Substantially
It cures：Scoring reduces 91%~100%, can resume work or manage household affairs；Marked improvement：Scoring reduces 46%~90%, portion
Divide and take care of oneself；Progress：Scoring reduces l8%~45%；Invalid or deterioration：Scoring reduces below l7% or increases.
5. statistical method
It is analyzed using SAS8.0 statistical softwares.Measurement data mean ± standard deviationIt represents, before treatment
Itself compare afterwards with paired t-test, comparison among groups use two groups of independent samples t tests after treatment；Enumeration data rate or composition
Than representing, comparison among groups use X2It examines.It is statistically significant for difference with P ＜ 0.05.
5.1 two groups of pretherapy and post-treatment neurological deficits scores compare and (are shown in Table 2).
The pretherapy and post-treatment neurological deficits score (NIHSS) of 2 two groups of table comparison (Point)
With before group treatment compared with itself, equal P ＜ 0.001；Compare before two groups of treatments：T=1.01, p=0.31, no statistics
Learn difference；Compare after two groups of treatments：T=2.32, p=0.02, it is statistically significant.
The comparison of 5.2 two groups of pretherapy and post-treatment activity of daily living scorings:(being shown in Table 3)
The scoring of 3 two groups of table pretherapy and post-treatment daily life active ability (ADL) comparison (Point)
Compare before two groups of treatments：T=0.29, p=0.77 no difference of science of statistics compare after two groups of treatments：T=2.38, p=
0.0449, it is statistically significant.
5.3 two groups of curative effects compare and (are shown in Table 4).
4 two groups of curative effects of table compare
X2=6.85, P=0.0446, two a group total effective rate have significant difference.
6. conclusion (of pressure testing)
This observation result is shown on cerebral infarction basis of conventional therapy, is added and is used pharmaceutical composition combination therapy of the present invention, to brain
The recovery of infarct patients during acute stage nervous function has the effect of preferable, improves the treated effect of acute cerebral infarction.
Experimental example 4
1. clinical treatment object：60 patients with cerebral hemorrhage are in December, -2014 in January, 2012 in our hospital's encephalopathy acupuncture health
The patient that multiple lesion is hospitalized, turns out to be hypertensive cerebral hemorrhage, amount of bleeding is in 3-33mL through head CT.Wherein man 27, female 33
Example；It is age 45-68 Sui, 62.68 years old average；Basal ganglia area hemorrhage 48, thalamus hemorrhage 2, cerebellar hemorrhage 3, frontal lobe 2,
4, top, hemorrhage of brain stem 1；Course of disease 3-72 hours, average course of disease (17.35 ± 9.76) hour.By 60 patient's completely randoms
It is divided into treatment group and each 30 of control group, two groups of general information compare, no significant difference (P ＞ 0.05), have comparable
Property.
Diagnostic criteria：Reference《Clinical practice》In the standard in relation to cerebral hemorrhage draft：(1) it is most to suffer from for 50 years old or more hypertension
Person, activity or it is excited when real so morbidity；(2) occur blood pressure raising, headache, vomiting, the disturbance of consciousness and hemiplegia, mistake suddenly
The focal neurologic defect symptom such as language, disease are fast；(3) the visible intracerebral high density area of CT examination.
2. drug forms and test method
2.1 trial drug：Chinese medicine composition (being prepared by embodiment 1) of the present invention.
2.2 testing program：The completely random check experiment of test group and control group.
Control group：All 30 patients all in accordance with《Chinese cerebrovascular disease guideline of prevention and treatment》Guiding treatment.Including general treatment,
Intensive Care Therapy not move patient arbitrarily, ensure nutrition intake, keep respiratory passage unblocked, reasonable anti-infective therapy etc..According to trouble
Cranium pressure, reasonable blood pressure lowering, hypoglycemic, reducing blood lipid, positive treatment complication etc. drop in the specific state of an illness of person in time.
Treatment group：Add on the basis of control group treatment and use pharmaceutical composition of the present invention.Appropriate paste (3g) is taken to be applied to blank
Acupoint plaster center, is pasted at bilateral Renying point.It is daily to stick primary, each application time 4h, 30 days courses for the treatment of.
3. observation index
(1) neurological deficits score (NIHSS)：Before treatment and 30 days after treatment, comment using NIHSS
It is fixed.(2) variation of patient's cerebral hemorrhage amount, absorption of hematoma is observed, hemorrhagic focus disappears to fully absorb in iconography, absorption of hemorrhage
More than 50% is most of absorption, and absorption of hemorrhage is less than 50% to partially absorb.
4. observation of curative effect
With reference to national 4th cerebrovascular disease academic conference in 1996 by《Cerebral Apoplexy Nerve Function defect degree
Standards of grading》Carry out efficacy determination：It is divided into according to NIHSS scorings reduction degree：Basic healings, marked improvement, progress and in vain
Or four grades such as deterioration.Scoring reduction (%)=(scoring of being admitted to hospital-is scored) for 14 days after treatment/scoring × 100% of being admitted to hospital.Substantially
It cures：Scoring reduces 91%~100%, can resume work or manage household affairs；Marked improvement：Scoring reduces 46%~90%, portion
Divide and take care of oneself；Progress：Scoring reduces l8%~45%；Invalid or deterioration：Scoring reduces below l7% or increases.
5. statistical method
It is analyzed using SAS8.0 statistical softwares.Measurement data mean ± standard deviationIt represents, before treatment
Itself compare afterwards with paired t-test, comparison among groups use two groups of independent samples t tests after treatment；Enumeration data rate or composition
Than representing, comparison among groups use X2It examines.It is statistically significant for difference with P ＜ 0.05.
5.1 two groups of pretherapy and post-treatment hemotoncus changes compare and (are shown in Table 1).
1 two groups of hemotoncus changes of table are compared (example, %)
X2=4.58, P=0.0147, two a group hemotoncus change have significant difference.
5.2 two groups of curative effects compare and (are shown in Table 2).
2 two groups of curative effects of table compare
X2=5.37, P=0.0481, two a group total effective rate have significant difference.
6. conclusion (of pressure testing)
This observation result is shown on cerebral hemorrhage basis of conventional therapy, is added and is used pharmaceutical composition combination therapy of the present invention, for
Reduction of patient clinical symptoms promote absorption of hematoma and improve limbs disturbance etc. effect affirmative, effectively reduce disability
Degree, significantly improves quality of life, and without obvious adverse reaction, securely and reliably.
Claims (2)
1. a kind of be used to treat carotid artery atherosclerosis plaques, cerebral infarction and the Chinese medicine composition of cerebral hemorrhage, the Chinese medicine group
It closes object and sticks agent for external application paste, which is characterized in that is composed of the following components：15 parts of semen brassicae, 15 parts of Chinese cassia tree, 30 parts of peppermint,
30 parts of borneol, 15 parts of trigone, 15 parts of curcuma zedoary, 30 parts of the rhizome of davallia, 15 parts of dragon's blood, 20 parts of safflower, 30 parts of bletilla, 15 parts of Rheum palmatum (processed with wine),
20 parts of radix scrophulariae, in terms of mass fraction.
2. a kind of preparation method of Chinese medicine composition, which is characterized in that include the following steps：Chinese medicine medicine is taken in following components ratio
Material, 15 parts of semen brassicae, 15 parts of Chinese cassia tree, 30 parts of peppermint, 30 parts of borneol, 15 parts of trigone, 15 parts of curcuma zedoary, 30 parts of the rhizome of davallia, dragon's blood 15
Part, 20 parts of safflower, 30 parts of bletilla, 15 parts of Rheum palmatum (processed with wine), 20 parts of radix scrophulariae, in terms of mass fraction；By the Chinese medicinal material it is ground into
It is uniformly mixed for fine powder and the sieve of 80 mesh excessively；Heating makes vaseline and beeswax melt completely, then be slowly added into Chinese medicinal powder, uniformly stirs
It mixes, the Chinese medicinal powder：The vaseline weight ratio is 1:3, the vaseline：The beeswax weight ratio is 15：1；50 DEG C fixed
Warm infusion 1 hour need to stir once, medicinal powder is allowed to be merged with vaseline for every 10 minutes during infusion, and infusion completes postcooling and is in
Curdled appearance is made.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600358A (en) * | 2004-02-25 | 2005-03-30 | 李世杰 | Combination of medication for curing hyperlipemia, arteriosclerosis, coronary heart disease and fatty liver |
| US7456225B1 (en) * | 2007-06-14 | 2008-11-25 | Golden Biotechnology Corporation | Liver protection compounds of the cyclohexenone type from Antrodia camphorata |
-
2015
- 2015-07-16 CN CN201510418615.0A patent/CN104940841B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600358A (en) * | 2004-02-25 | 2005-03-30 | 李世杰 | Combination of medication for curing hyperlipemia, arteriosclerosis, coronary heart disease and fatty liver |
| US7456225B1 (en) * | 2007-06-14 | 2008-11-25 | Golden Biotechnology Corporation | Liver protection compounds of the cyclohexenone type from Antrodia camphorata |
Non-Patent Citations (1)
| Title |
|---|
| "自拟颈斑消贴膏贴敷人迎穴对颈动脉粥样硬化斑块的影响";申斌等;《中医药导报》;20131231;第19卷(第12期);第88-90页，尤其是第88页左栏第1段，第89页左栏第2段和最后1段，右栏第1段 * |
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