CN104936611A - 用于癌症的免疫规划和治疗的选择性糖苷酶方案 - Google Patents
用于癌症的免疫规划和治疗的选择性糖苷酶方案 Download PDFInfo
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- CN104936611A CN104936611A CN201480005012.1A CN201480005012A CN104936611A CN 104936611 A CN104936611 A CN 104936611A CN 201480005012 A CN201480005012 A CN 201480005012A CN 104936611 A CN104936611 A CN 104936611A
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| PCT/US2014/011995 WO2014113641A1 (en) | 2013-01-18 | 2014-01-17 | Selective glycosidase regimen for immune programming and treatment of cancer |
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Cited By (2)
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| CN111494613A (zh) * | 2019-01-31 | 2020-08-07 | 香港中文大学 | 结肠直肠癌的治疗性和预防性处理 |
| CN111500715A (zh) * | 2019-01-31 | 2020-08-07 | 北京大学 | 用于预测结直肠癌术后复发与转移的检测组合物、检测装置、检测试剂盒及应用 |
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| JP6673696B2 (ja) | 2012-09-28 | 2020-03-25 | クライン，エリス | 感染症治療用グリコシダーゼレジメン |
| WO2016162867A1 (en) * | 2015-04-08 | 2016-10-13 | Efranat Ltd. | Combination therapy of macrophage activating factor and pd-1 signaling inhibitors |
| CN105256036B (zh) * | 2015-10-26 | 2019-02-12 | 中国人民解放军第二军医大学 | 一种检测血清中lncARSR的试剂盒及其在检测肾癌舒尼替尼耐药中的应用 |
| JP7462560B2 (ja) | 2018-01-03 | 2024-04-05 | パレオン ファーマシューティカルズ インコーポレイテッド | 組換えヒトシアリダーゼ、シアリダーゼ融合タンパク質およびそれらの使用方法 |
| MX2022000032A (es) * | 2019-07-03 | 2022-06-15 | Palleon Pharmaceuticals Inc | Sialidasas recombinantes y métodos de utilización de las mismas. |
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| US20010036455A1 (en) * | 2000-04-07 | 2001-11-01 | Kline Ellis L. | Methods and compositions for treating neoplasms |
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| US4071408A (en) | 1976-11-01 | 1978-01-31 | Research Corporation | Neuraminidase |
| DE3302160A1 (de) | 1983-01-22 | 1984-07-26 | Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell | Betaetigbare dosiereinrichtung |
| DE3315334A1 (de) | 1983-04-28 | 1984-10-31 | Pfeiffer Erich Gmbh & Co Kg | Zerstaeuber- oder dosierpumpe |
| DE3715301A1 (de) | 1987-05-08 | 1988-11-24 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| DE3722470A1 (de) | 1987-07-08 | 1989-01-19 | Pfeiffer Erich Gmbh & Co Kg | Handbetaetigbare austragvorrichtung fuer medien |
| US5326749A (en) | 1989-11-20 | 1994-07-05 | Nobuto Yamamoto | Macrophage activating factor from vitamin D binding protein |
| IT1252228B (it) | 1991-12-17 | 1995-06-05 | T Associated Bio Technologies | Procedimento per la produzione di neuraminidasi |
| US6562588B2 (en) | 1993-05-17 | 2003-05-13 | Genentech, Inc. | Sialidase and recombinant cell lines |
| US5985859A (en) | 1994-04-14 | 1999-11-16 | The University Of Alabama | Methods of inhibiting bacterial sialidase |
| US6410269B1 (en) * | 1995-06-07 | 2002-06-25 | Nobuto Yamamoto | Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis |
| DE19525734A1 (de) | 1995-07-14 | 1997-01-16 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für fließfähige Medien, insbesondere für den Austrag in nur einem Hub |
| DE10146815B4 (de) | 2001-09-18 | 2005-05-04 | Ing. Erich Pfeiffer Gmbh | Spender für Medien |
| US7201296B2 (en) | 2001-09-21 | 2007-04-10 | Ing. Erich Pfeiffer Gmbh | Dosing device with a pumping device |
| DE10164452A1 (de) | 2001-12-21 | 2003-07-03 | Pfeiffer Erich Gmbh & Co Kg | Spender für Medien |
| US7081340B2 (en) | 2002-03-13 | 2006-07-25 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| CA3061769C (en) | 2003-06-24 | 2021-10-26 | Genomic Health, Inc. | Methods of predicting the likelihood of long-term survival of a human patient with node-negative, estrogen receptor (er) positive, invasive ductal breast cancer without the recurrence of breast cancer |
| ES2905579T3 (es) | 2003-07-10 | 2022-04-11 | Genomic Health Inc | Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama |
| US7892752B2 (en) * | 2005-04-26 | 2011-02-22 | Dwek Raymond A | Glycosylation markers for cancer diagnosing and monitoring |
| US20110038856A1 (en) * | 2006-11-02 | 2011-02-17 | Seattle Genetics, Inc. | Methods of treating neoplastic, autoimmune and inflammatory diseases |
| CA2676686C (en) | 2007-02-20 | 2015-12-15 | Dsm Ip Assets B.V. | Novel sialidase |
| CA2692417C (en) * | 2007-07-03 | 2017-03-21 | Children's Hospital & Research Center At Oakland | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting |
| AU2009246009A1 (en) | 2008-05-14 | 2009-11-19 | University Health Network | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
| US20110238322A1 (en) | 2008-11-03 | 2011-09-29 | Precision Therapeutics, Inc. | Methods of simulating chemotherapy for a patient |
| US20100331210A1 (en) | 2009-05-29 | 2010-12-30 | Precision Therapeutics, Inc. | Methods and systems for evaluating the sensitivity or resistance of tumor specimens to chemotherapeutic agents |
| CA2771900A1 (en) * | 2009-08-22 | 2011-03-10 | Charles Knezevich | Tumoricidal, bactericidal, or viricidal macrophage activation |
| HRP20161147T1 (hr) * | 2011-09-14 | 2016-11-18 | Saisei Mirai Clinic | Farmaceutski sastav i postupak njegove proizvodnje |
-
2014
- 2014-01-17 US US14/760,809 patent/US20150352193A1/en not_active Abandoned
- 2014-01-17 CN CN201480005012.1A patent/CN104936611A/zh active Pending
- 2014-01-17 CA CA2896899A patent/CA2896899A1/en not_active Abandoned
- 2014-01-17 KR KR1020157018524A patent/KR20150107738A/ko not_active Ceased
- 2014-01-17 JP JP2015553844A patent/JP2016505043A/ja active Pending
- 2014-01-17 MX MX2015009260A patent/MX2015009260A/es unknown
- 2014-01-17 EP EP14740546.8A patent/EP2945644A4/en not_active Withdrawn
- 2014-01-17 AU AU2014207429A patent/AU2014207429B2/en not_active Ceased
- 2014-01-17 WO PCT/US2014/011995 patent/WO2014113641A1/en not_active Ceased
- 2014-01-17 EP EP19162169.7A patent/EP3563864A1/en not_active Withdrawn
-
2019
- 2019-02-01 AU AU2019200688A patent/AU2019200688B2/en not_active Ceased
- 2019-03-14 US US16/353,168 patent/US20190201503A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010036455A1 (en) * | 2000-04-07 | 2001-11-01 | Kline Ellis L. | Methods and compositions for treating neoplasms |
Non-Patent Citations (2)
| Title |
|---|
| KATHLEEN F.ARCARO ET AL.: ""β-Galactosidase and α-Mannosidase Inhibit Formation of Multicellular Nodules in Breast Cancer Cell Cultures"", 《ANTICANCER RESEACH》 * |
| KIMBERLY M. ANDERSON ET AL.: ""A Clostridial endo-β-galactosidase that cleaves both blood group A and B glycotopes"", 《THE JOURNAL OF BIOLOGIAL CHEMISTRY》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494613A (zh) * | 2019-01-31 | 2020-08-07 | 香港中文大学 | 结肠直肠癌的治疗性和预防性处理 |
| CN111500715A (zh) * | 2019-01-31 | 2020-08-07 | 北京大学 | 用于预测结直肠癌术后复发与转移的检测组合物、检测装置、检测试剂盒及应用 |
| CN111500715B (zh) * | 2019-01-31 | 2022-03-11 | 北京大学 | 用于预测结直肠癌术后复发与转移的检测组合物、检测装置、检测试剂盒及应用 |
| US11554145B2 (en) | 2019-01-31 | 2023-01-17 | The Chinese University Of Hong Kong | Therapeutic and prophylactic treatment for colorectal cancer |
| US12478649B2 (en) | 2019-01-31 | 2025-11-25 | The Chinese University Of Hong Kong | Therapeutic and prophylactic treatment for colorectal cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2945644A1 (en) | 2015-11-25 |
| CA2896899A1 (en) | 2014-07-24 |
| EP2945644A4 (en) | 2016-10-26 |
| MX2015009260A (es) | 2015-10-15 |
| JP2016505043A (ja) | 2016-02-18 |
| EP3563864A1 (en) | 2019-11-06 |
| WO2014113641A1 (en) | 2014-07-24 |
| US20150352193A1 (en) | 2015-12-10 |
| KR20150107738A (ko) | 2015-09-23 |
| AU2014207429A1 (en) | 2015-07-02 |
| US20190201503A1 (en) | 2019-07-04 |
| AU2019200688B2 (en) | 2020-08-06 |
| AU2014207429B2 (en) | 2018-11-01 |
| AU2019200688A1 (en) | 2019-02-21 |
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Application publication date: 20150923 |