CN104922064B - A kind of nanoscale nutrient microemulsion and preparation method thereof for preventing and treating ketosis of dairy cows - Google Patents
A kind of nanoscale nutrient microemulsion and preparation method thereof for preventing and treating ketosis of dairy cows Download PDFInfo
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Abstract
The invention discloses a kind of nanoscale nutrient microemulsion for preventing and treating ketosis of dairy cows, the components including following parts by weight: 70~85 parts of propylene glycol, 3.5~6 parts of niacinamide, 0.05~0.45 part of vitamin A, 0.03~0.2 part of vitamine D3,0.02~0.1 part of vitamin E, 0.012~0.2 part of vitamin B2,1~10 part of surfactant, 0.05~0.2 part of antioxidant, 0.05~0.2 part of preservative, 14~20 parts of pure water.The mode that nano nutrient microemulsion of the invention is drunk water by using stomach-filling or directly is administered, drug can be made to mix well, no longer need to additionally add vitamins and other nutritious components, it is uneven to overcome Solid nutritional additive spice in the market, it is time-consuming and laborious, and absorb the disadvantages of effect is poor.
Description
Technical field
The present invention relates to veterinary additive technical fields, more specifically to a kind of nanoscale for preventing and treating ketosis of dairy cows
Nutrient microemulsion and preparation method thereof.
Background technique
Ketosis of dairy cows is one of commonly-occurring disease of high yield cow, is that body is caused to mobilize body fat by carbohydrate insufficient supply
Metabolism, causes ketoboidies in Contents in Cows largely to gather, and then causes a kind of disease that general metabolism obstacle causes body function imbalance.With
Blood, urine, cream in ketoboidies content increase, blood sugar concentration decline, digestive function disorder, weight loss, the output of milk decline, occasionally have
Nervous symptoms are characterized.This disease mostly occurs in after calving 10 days~60 days, and higher with the high yield cow disease incidence of 3~6 parity.
Ketoacidosis receives the attention of milk cow production, the ketoacidosis of clinical type as a kind of generally existing milk cow postpartum nutrition metabolic diseases
Since its symptom is obvious, can often be effectively treated, but sub-clinical ketosis or subclinical ketosis, since its disease symptom is unknown
It is aobvious, usually it is ignored.In recent years, with the continuous improvement of the development of dairy, especially milk yield, the disease incidence of ketosis of dairy cows
It rises year by year.Although ketoacidosis can cure, the lactation amount of milk cow can be made to decline, the reduction of breast matter amount, weight loss, breeding potential drop
It is low, aquaculture cost is increased, causes huge economic loss to milk cow production.
Cattle farm, which mostly uses greatly, at present gavages pure propylene glycol directly to prevent and treat ketosis of dairy cows, and niacinamide and vitamin by
In its solubility problem, it cannot be directly dissolved in propylene glycol, so can only additionally add.And milk cow nutritional additive in the market
Product is directly edible by spice mostly, but since required nutrient composition content is less, and when spice is not easy to mix, time-consuming to take
Power；And when milk cow breaks out disease, feed intake is reduced, and causes nutritional ingredient that cannot absorb in time.Therefore it cannot reach well
To the effect of prevention and treatment ketosis of dairy cows.
Summary of the invention
The technical problem to be solved in the present invention is that in view of the above drawbacks of the prior art, providing a kind of prevention and treatment milk cow ketone
The nanoscale nutrient microemulsion and preparation method thereof of disease.
The technical solution adopted by the present invention to solve the technical problems is: providing a kind of nanoscale battalion for preventing and treating ketosis of dairy cows
Microemulsion is supported, the component including following parts by weight:
The nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows of the present invention, wherein the nanoscale nutrient microemulsion
Partial size be less than 100nm.
The nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows of the present invention, wherein the surfactant is tween-
80, one of sldium lauryl sulfate, polyethylene glycol.
The nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows of the present invention, wherein the antioxidant is sulfurous acid
One of hydrogen sodium, ascorbic acid, butylated hydroxy anisole, propylgallate.
It is of the present invention prevention and treatment ketosis of dairy cows nanoscale nutrient microemulsion, wherein the preservative be sodium benzoate,
One of benzoic acid, potassium sorbate, sorbic acid, dehydroactic acid sodium, calcium propionate, sodium Diacetate.
The present invention also provides a kind of preparation methods such as the above-mentioned nanoscale nutrient microemulsion for preventing and treating ketosis of dairy cows, including
Following steps:
(1) surfactant is weighed by formula ratio to be placed in container, the vitamin A, vitamine D3 and dimension of formula ratio is added
Raw element E, mixes, and stirring obtains oily phase；
(2) niacinamide, vitamin B2, antioxidant, preservative are weighed by formula ratio to be placed in container, formula ratio is added
Pure water, stirring, dissolves it sufficiently, obtains water phase；
(3) oil made from step (1) is mutually slowly added into water phase made from step (2), it is stirring while adding, it is sufficiently mixed
To get living solution after closing uniformly；
(4) propylene glycol of formula ratio is slowly added in the living solution made from step (3), it is stirring while adding, to solution
Clarification is gradually become to get the nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows by muddiness.
Preparation method of the present invention, the surfactant are Tween-80, in sldium lauryl sulfate, polyethylene glycol
One kind.
Preparation method of the present invention, the antioxidant are sodium hydrogensulfite, ascorbic acid, butylhydroxy fennel
One of ether, propylgallate.
Preparation method of the present invention, the preservative are sodium benzoate, benzoic acid, potassium sorbate, sorbic acid, dehydrogenation
One of sodium acetate, calcium propionate, sodium Diacetate.
The nanoscale nutrient microemulsion and preparation method thereof for implementing prevention and treatment ketosis of dairy cows of the invention, has below beneficial to effect
Fruit:
(1) present invention provides a kind of nano nutrient microemulsion for gavaging suitable for milk cow or directly drinking water, directly by nicotinoyl
The nano nutrient microemulsion that degree of scatter is high, stability is good is made in the nutritional ingredients such as amine and multivitamin and mixed with propylene glycol；
(2) mode that nano nutrient microemulsion of the invention is drunk water by using stomach-filling or directly is administered, and can make drug
It mixes well, no longer needs to additionally add vitamins and other nutritious components, overcome Solid nutritional additive spice unevenness in the market, take
When it is laborious, and absorb effect it is poor the disadvantages of；
(3) nano nutrient microemulsion of the invention not only simplifies traditional administration mode, and greatly reduces milk cow ketone
The generation of disease, is also significantly increased to milk cow milk production；Wherein generation of the ingredients such as propylene glycol, niacinamide to ketosis of dairy cows is reduced
With remarkable result, vitamin A, vitamine D3, vitamin E, vitamin B2 as the daily indispensable nutritional ingredient of milk cow,
There is remarkable result to promote the growth and development of milk cow, improve production performance etc.；
(4) nano nutrient microemulsion particle size range of the invention in 100nm hereinafter, since partial size is small, effective component
Diffusion velocity greatly improves, and improves bioavilability, so as to save a large amount of additive raw materials.
Specific embodiment
A kind of nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows of the invention, the component including following parts by weight:
Wherein, propylene glycol has raw sugared effect, is rapidly absorbed into cow rumen rear portion and is converted into glucose, separately
A part is absorbed after cud intracellular metabolite is propionate.Early in the fifties in 19th century, propylene glycol has been used to treatment milk cow ketone
Disease.Studies have shown that propylene glycol can reduce the probability of ketosis of dairy cows generation, while it also can increase milk crop and improving egg in milk
The content of white matter, it is particularly evident in early period nursing period.
Niacinamide is a kind of anti-lipidolysis and antiketogenetic substance, and having, which reduces body fat, decomposes, and reduces the β-in blood
The ability of ketoboidies and free fatty acid in hydroxybutyric acid, blood, and significantly improve the output of milk.
Vitamin is micronutrient important needed for Cow product process, not only influences the growth and development of milk cow,
Production performance and health to milk cow also have an impact.Existing research shows to add 150,000~250,000 units in dairy cow diet daily
Vitamin A can reduce the disease incidence of recessive mastitis and clinical mammitis；Vitamine D3 can alleviate Diseases of Cow and exempt from
Epidemic disease globulin and immunocyte；Vitamin E is fed, milk production of cow can be made to have raising trend.
Wherein, the partial size of the nanoscale nutrient microemulsion is less than 100nm, which has low viscosity, stabilization, absorption fast
The advantages that fast.
The surfactant is one of Tween-80, sldium lauryl sulfate, polyethylene glycol.The antioxidant is
One of sodium hydrogensulfite, ascorbic acid, butylated hydroxy anisole, propylgallate.The preservative be sodium benzoate,
One of benzoic acid, potassium sorbate, sorbic acid, dehydroactic acid sodium, calcium propionate, sodium Diacetate.
The present invention also provides a kind of preparation methods such as the above-mentioned nanoscale nutrient microemulsion for preventing and treating ketosis of dairy cows, including
Following steps:
Wherein, the surfactant is one of Tween-80, sldium lauryl sulfate, polyethylene glycol.It is described anti-oxidant
Agent is one of sodium hydrogensulfite, ascorbic acid, butylated hydroxy anisole, propylgallate.The preservative is benzene first
One of sour sodium, benzoic acid, potassium sorbate, sorbic acid, dehydroactic acid sodium, calcium propionate, sodium Diacetate.
In the following, being described further in conjunction with specific embodiment to the present invention:
Embodiment 1
Following raw material based on parts by weight: 70~85 parts of propylene glycol, 3.5~6 parts of niacinamide, vitamin A is taken respectively
0.05~0.45 part, 0.03~0.2 part of vitamine D3,0.02~0.1 part of vitamin E, 0.012~0.2 part of vitamin B2,
1~10 part of surfactant, 0.05~0.2 part of antioxidant, 0.05~0.2 part of preservative, 14~20 parts of pure water.Specifically match
Than being shown in Table 1.
The proportion table of 1 embodiment 1-5 of table
Above-mentioned raw materials, which are followed these steps preparation, prevents the nano nutrient microemulsion of ketosis of dairy cows, successively includes following step
It is rapid:
(1) surfactant is weighed by formula ratio to be placed in container, the vitamin A, vitamine D3 and dimension of formula ratio is added
Raw element E, mixes, and stirring obtains oily phase；
(2) niacinamide, vitamin B2, antioxidant, preservative are weighed by formula ratio to be placed in container, formula ratio is added
Pure water, stirring, dissolves it sufficiently, obtains water phase；
(3) oil made from step (1) is mutually slowly added into water phase made from step (2), it is stirring while adding, it is sufficiently mixed
To get living solution after closing uniformly；
(4) propylene glycol of formula ratio is slowly added in the living solution made from step (3), it is stirring while adding, to solution
Clarification is gradually become to get the nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows by muddiness.
In the following, to the stability and validity of the nano nutrient microemulsion prepared in the above embodiments for preventing ketosis of dairy cows
It is investigated.
1. stability test
Ordinary temperature stability is carried out to nano nutrient microemulsion obtained in embodiment 1 and accelerated stability is investigated, as a result such as
Shown in table 1.
1 nano nutrient microemulsion study on the stability of table
As seen from Table 1, in nanometer micro emulsion in 25 DEG C of preservations, each component content is stablized.And in 40 DEG C of preservations, dimension life
Plain A explanation is rapid, therefore this product should be saved be protected from light shady place.
2. efficiency assay
Seven groups are randomly divided into milking cow by 280, every group 40, sets control group 1, control group 2 and embodiment 1-5 respectively
Group.Wherein, control group 1, i.e., after childbirth daily every cow head do not take any drug；Control group 2, i.e., open after childbirth
Begin daily every to gavage propylene glycol 300ml；Embodiment 1-5 group, i.e., after childbirth daily every gavage invented nanometer
Nutrient microemulsion 300ml is used in conjunction 7 days, and in the disease incidence of postpartum 7 days detection ketosis of dairy cows, the results are shown in Table 2.
The comparative test of 2 nano nutrient micro emulsion of table prevention and treatment ketosis of dairy cows
As seen from Table 2, after taking invented nano nutrient microemulsion, the disease incidence of ketosis of dairy cows is remarkably decreased,
The invention has good control efficiency to milk cow postpartum ketoacidosis.
It will be apparent to those skilled in the art that can make various other according to the above description of the technical scheme and ideas
Corresponding change and deformation, and all these changes and deformation all should belong to the protection scope of the claims in the present invention
Within.
Claims (1)
1. a kind of preparation method for the nanoscale nutrient microemulsion for preventing and treating ketosis of dairy cows, which is characterized in that the prevention and treatment ketosis of dairy cows
Nanoscale nutrient microemulsion be composed of the following parts by weight:
70~85 parts of propylene glycol
3.5~6 parts of niacinamide
0.05~0.45 part of vitamin A
0.03~0.2 part of vitamine D3
0.02~0.1 part of vitamin E
0.012~0.2 part of vitamin B2
1~10 part of surfactant
0.05~0.2 part of antioxidant
0.05~0.2 part of preservative
14~20 parts of pure water；
The partial size of the nanoscale nutrient microemulsion is less than 100nm；
The surfactant is one of Tween-80, sldium lauryl sulfate, polyethylene glycol；
The antioxidant is one of sodium hydrogensulfite, ascorbic acid, butylated hydroxy anisole, propylgallate；
The preservative is sodium benzoate, in benzoic acid, potassium sorbate, sorbic acid, dehydroactic acid sodium, calcium propionate, sodium Diacetate
One kind；
It is specific the preparation method is as follows:
(1) surfactant is weighed by formula ratio to be placed in container, the vitamin A, vitamine D3 and vitamin of formula ratio is added
E is mixed, and stirring obtains oily phase；
(2) niacinamide, vitamin B2, antioxidant, preservative are weighed by formula ratio to be placed in container, the pure of formula ratio is added
Water, stirring, dissolves it sufficiently, obtains water phase；
(3) oil made from step (1) is mutually slowly added into water phase made from step (2), it is stirring while adding, it is sufficiently mixed
To get living solution after even；
(4) propylene glycol of formula ratio is slowly added in the living solution made from step (3), it is stirring while adding, to solution by muddy
It is turbid to gradually become clarification to get the nanoscale nutrient microemulsion of prevention and treatment ketosis of dairy cows.
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| CN106806374B (en) * | 2016-12-23 | 2018-04-24 | 刘春海 | A kind of composition for preventing and treating perinatal period ruminant ketoacidosis and fatty liver |
| CN111228298A (en) * | 2020-01-15 | 2020-06-05 | 开封嘉骏生物科技有限公司 | Medicine for preventing and treating cattle and sheep flaccid paralysis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958464A (en) * | 1996-02-08 | 1999-09-28 | Register; Jack W. | Veterinary pharmaceutical composition |
| CN101766261A (en) * | 2010-01-11 | 2010-07-07 | 广东大华农动物保健品股份有限公司 | Nano nutrient microemulsion and preparation method thereof |
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| JPS5525163B2 (en) * | 1972-06-06 | 1980-07-04 | ||
| HU191245B (en) * | 1984-01-06 | 1987-01-28 | Egis Gyogyszergyar,Hu | Process for the production of stbale pharmaceutical preparation against ketosis |
| CN102326680B (en) * | 2011-07-01 | 2013-04-10 | 上海光明荷斯坦牧业有限公司 | Dairy cow postpartum nutrition enhancer premix and preparation method and application thereof |
| US9861587B2 (en) * | 2011-09-08 | 2018-01-09 | Rp Feed Components, Llc | Composition and method for treating ketosis in cows |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958464A (en) * | 1996-02-08 | 1999-09-28 | Register; Jack W. | Veterinary pharmaceutical composition |
| CN101766261A (en) * | 2010-01-11 | 2010-07-07 | 广东大华农动物保健品股份有限公司 | Nano nutrient microemulsion and preparation method thereof |
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Effective date of registration: 20160616 Address after: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Applicant after: GUANGDONG WENS DAHUANONG BIOTECHNOLOGY CO., LTD. Address before: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Applicant before: Guangdong Dahuanong Animal Health Products Co., Ltd. Applicant before: Zhaoqing Dahuanong Biological Pharmaceutical Co., Ltd. |
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