CN104921845A - Bone defect filler - Google Patents

Bone defect filler Download PDF

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Publication number
CN104921845A
CN104921845A CN201510387244.4A CN201510387244A CN104921845A CN 104921845 A CN104921845 A CN 104921845A CN 201510387244 A CN201510387244 A CN 201510387244A CN 104921845 A CN104921845 A CN 104921845A
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CN
China
Prior art keywords
implant
cranial defect
bone
implant according
described part
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510387244.4A
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Chinese (zh)
Inventor
朱健
徐龙伟
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Shanghai active biotechnology service center
Original Assignee
Jiangsu Okani Medical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Okani Medical Technology Co Ltd filed Critical Jiangsu Okani Medical Technology Co Ltd
Priority to CN201510387244.4A priority Critical patent/CN104921845A/en
Publication of CN104921845A publication Critical patent/CN104921845A/en
Priority to PCT/CN2015/000728 priority patent/WO2017004742A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a bone defect filler. The bone defect filler comprises a first part and a second part. The first part is a main bone filling part, and the second part is a part in direct contact with natural bone. The first part is made of biocompatible high molecular materials. The second part is made of biocompatible metal or biological ceramic. The first part is combined with the second part. The elastic modulus of the bone defect filler is matched with that of the natural bone, and the stress shielding problem is solved; as the main part of an internal implanted part in the bone defect filler is made of the high molecular materials, the metal corrosion problem and the irritability and toxicity problem possibly caused by the metal are solved; magnetic resonance imaging is not disturbed by the internal implanted part made of the biocompatible high molecular materials.

Description

A kind of Cranial defect implant
Technical field
The invention belongs to field of medical technology, more specifically, relate to a kind of Cranial defect implant be made up of biocompatible polymer material and biocompatibility metal or bioceramic material compound.
Background technology
Cranial defect is very general in the patient of severe osteoporosis patient and serious skeleton deformity, in addition after artificial joint replacement first lost efficacy in patient because bone dissolves also ubiquity (Callaghan JJ, Liu SS, Phruetthiphat OA.The revision acetabulum--allograftand bone substitutes:vestigial organs for bone deficiency.Bone Joint J.2014Nov; 96-B (11Supple A): 70-2.doi:10.1302/0301-620X.96B11.34452).The reparation of Cranial defect generally has two kinds of methods, one, natural bone is as filling bone (Chun CH, Kim JW, Kim SH, Kim BG, Chun KC, Kim KM.Clinical and radiological results offemoral head structural allograft for severe bone defects in revision TKA--aminimum 8-year follow-up.Knee.2014Mar; 21 (2): 420-3.doi:10.1016/j.knee.2013.04.012), its two, artificial bone is as implant.The source of natural bone is more difficult, and the restriction especially in the source of Chinese homogeneous allogenic bone due to culture and regulation is more rare.Artificial bone generally forms the most general by bioceramic or metal bi-material.Bioceramic is generally by calcium phosphate, the compositions such as hydroxyapatite, although its self-bone grafting and biocompatibility excellence, but its bearing capacity is not good, so its clinical practice is confined to slight Cranial defect and non-bearing position (Egawa H1, Ho H, Huynh C, Hopper RH Jr, Engh CA Jr, Engh CA.A three-dimensional methodfor evaluating changes in acetabular osteolytic lesions in response totreatment.Clin Orthop Relat Res.2010Feb; 468 (2): 480-90.doi:10.1007/s11999-009-1050-0).Metal material particularly titanium or titanium alloy is generally applied to severe bone or needs the Cranial defect position of carrying, when particularly joint replacement needed to overhaul after losing efficacy, although mechanical performance and the bearing capacity of metal material are splendid, but its elastic modelling quantity and rigidity are far above natural bone, therefore relatively more serious (the Agarwal S of stress shielding problem, Azam A, Morgan-Jones R.Metal metaphyseal sleeves in revision total kneereplacement.Bone Joint J.2013Dec; 95-B (12): 1640-4.doi:10.1302/0301-620X.95B12.31190.).In addition, metal charge generally needs to be combined with metallic screw that to reach with natural bone fixing, metal to metal can produce wearing and tearing and corrosion when producing fine motion, thus release metal ions and metallic particles, untoward reaction (the Magone K1 of patient can be caused when excessive, Luckenbill D, Goswami T.Arch Orthop TraumaSurg.2015May; 135 (5): 683-95.doi:10.1007/s00402-015-2196-8.Epub2015Mar 21.Metal ions as inflammatory initiators of osteolysis).
Summary of the invention
For above-mentioned technical problem to be solved, the object of this invention is to provide a kind of Cranial defect implant be made up of biocompatible polymer material and biocompatibility metal or bioceramic material compound.
In order to realize foregoing invention, the present invention adopts following technical scheme:
A kind of Cranial defect implant, comprise Part I and Part II, wherein said Part I is main bone filling part; Described Part II is the part directly contacted with natural bone; Described Part I is made up of biocompatible polymer material; Described Part II is made up of biocompatibility metal or bioceramic material; Described Part I combines with described Part II.
Further, described biocompatible polymer material is one or more in polyether-ether-ketone and derivant, ultra-high molecular weight polyethylene and derivant thereof and politef and derivant thereof; Described biocompatibility metal material be vitallium, titanium or titanium alloy, tantalum or tantalum alloy, magnesium or magnesium alloy, rustless steel and zirconium-niobium alloy one or more; Described bioceramic material is hydroxyapatite.
Further, described Part I is combined by surface spraying or chemical deposition with described Part II.
Further, described Part II is made up of biocompatibility metal material, and described Part II is by machining or 3D printing shaping; Described Part I is combined by injection mo(u)lding with described Part II.
Further, the outer surface of described Part II is loose structure.
Further, described Cranial defect implant is the implant of the acetabular fossa for severe deformities or Cranial defect, and wherein said Part II is the nonreentrant surface part of described acetabular fossa implant, and described Part I is the remainder of described acetabular fossa implant.
Further, described acetabular fossa implant contains one or more screw hole.
Further, described implant is the hollow vertebral body of femoral hip prosthesis upper end for severe bone or knee joint femoral condyle or knee joint tibial upper end, wherein said Part II is the outer surface part of described vertebral body, and described Part I is the remainder of described vertebral body.
Further, described implant is the hollow pad of the knee joint femoral condyle for severe bone, and wherein said Part II is the maximum planes part of described hollow pad, and described Part I is the remainder of described hollow pad; Or described implant is the hollow pad of the knee joint tibial upper end for severe bone, wherein said Part II is time large planar section of described hollow pad, and described Part I is the remainder of described hollow pad.
Further, described hollow pad contains one or more screw hole.
Owing to adopting above technical scheme, beneficial effect of the present invention is:
1) elastic modelling quantity of Cranial defect implant provided by the invention and natural bone match, and alleviate stress shielding problem;
2) major part of the implants parts in Cranial defect implant provided by the invention is made up of macromolecular material, reduces allergy, toxicity problem that metal erosion and metal may cause;
3) the implants parts be made up of biocompatible polymer material in the present invention do not cause interference to NMR (Nuclear Magnetic Resonance)-imaging.
Accompanying drawing explanation
Fig. 1 is an embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the acetabular fossa implant of severe deformities or Cranial defect;
Fig. 2 is another embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the hollow vertebral body of the femoral hip prosthesis upper end of severe bone;
Fig. 3 is the another embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the hollow vertebral body of the knee joint femoral condyle of severe bone;
Fig. 4 is the another embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the hollow vertebral body of the knee joint tibial upper end of severe bone;
Fig. 5 is the another embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the hollow pad of the knee joint femoral condyle of severe bone;
Fig. 6 is the another embodiment of Cranial defect implant provided by the invention, and wherein Cranial defect implant is the hollow pad of the knee joint tibial upper end of severe bone.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is described in further detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
A kind of Cranial defect implant provided by the invention, comprises Part I and Part II, and wherein Part I is main bone filling part; Part II is the part directly contacted with natural bone; Part I is made up of biocompatible polymer material; Part II is made up of biocompatibility metal or bioceramic material; Part I combines with described Part II.
In technique scheme, biocompatible polymer material is one or more in polyether-ether-ketone (PEEK) and derivant, ultra-high molecular weight polyethylene (UHMWPE) and derivant thereof and politef (PTFE) and derivant thereof; Biocompatibility metal material be vitallium, titanium or titanium alloy, tantalum or tantalum alloy, magnesium or magnesium alloy, rustless steel and zirconium-niobium alloy one or more; Bioceramic material is hydroxyapatite.
In technique scheme, biocompatible polymer material preferred, polyethers ether ketone (PEEK), biocompatibility metal material is preferably titanium or titanium alloy.
Polyether-ether-ketone (PEEK) is widely used in, in the clinical practice of orthopaedics inner matter, comprising spinal fusion device, spinal column fixing rod etc. as the macromolecular material of a kind of high strength and high-biocompatibility.The elastic modelling quantity of PEEK between cortical bone and spongy bone, compared to metal material, the inner matter be made up of PEEK to the latent stress occlusion issue of natural bone much smaller than metal material.In addition, the inner matter be made up of PEEK does not have imaging interference problem to NMR (Nuclear Magnetic Resonance)-imaging (MRI), and the combination between metallic screw does not exist and corrodes particularly galvanic corrosion problems.Therefore, PEEK possesses the most of advantage as artificial bone implant.But in promotion bone lengthening, compared to bioceramic or metal material, PEEK does not have advantage, combines form the concept of composite as artificial bone implant so the present invention proposes PEEK (Part I) with bioceramic or metal material (Part II).
In technique scheme, combination between PEEK (Part I) and bioceramic or metal material (Part II) can be realized by the method for surface spraying, the method on the surface or chemical deposition that such as hydroxyapatite are coated onto PEEK (Part I) by plasma spray deposits to the surface of PEEK (Part I), or the method on the surface or chemistry that metal material are sprayed to PEEK (Part I) deposits to the surface of PEEK (Part I).In addition, when Part II is made up of biocompatibility metal, combination between PEEK (Part I) and metal (Part II) also can be realized by the method for injection moulding, print as by machining or 3D the metallic member (Part II) first manufacturing composite filled thing, then realize the PEEK part molding of (Part I) and the combination with metallic member (Part II) by injection moulding.
In technique scheme, the outer surface of Part II is loose structure.
As shown in figures 1 to 6, the specific embodiment of Cranial defect implant provided by the invention, wherein Part I is preferably made up of polyether-ether-ketone (PEEK).
As shown in Figure 1, Fig. 1 shows the implant be composited by PEEK and bioceramic or metal material of the acetabular fossa of severe deformities acetabular fossa or Cranial defect and required reparation thereof.In this embodiment, the nonreentrant surface of this concrete implant is made up of bioceramic or metal material, and remainder is made up of PEEK.In addition, this concrete implant contains one or more screw hole.
As shown in Figure 2, Fig. 2 shows the hollow vertebral body of implant be composited by PEEK and bioceramic or metal material of the femoral hip prosthesis upper end of severe bone and required reparation thereof.In this embodiment, the outer surface of this vertebral body is made up of bioceramic or metal material, and remainder is made up of PEEK.
As shown in Figure 3, Fig. 3 shows the hollow vertebral body of implant be composited by PEEK and bioceramic or metal material of the knee joint femoral condyle of severe bone and required reparation thereof.In this embodiment, the outer surface of this vertebral body is made up of bioceramic or metal material, and remainder is made up of PEEK.
As shown in Figure 4, Fig. 4 shows the hollow vertebral body of implant be composited by PEEK and bioceramic or metal material of the knee joint tibial upper end of severe bone and required reparation thereof.In this embodiment, the outer surface of this vertebral body is made up of bioceramic or metal material, and remainder is made up of PEEK.
As shown in Figure 5, Fig. 5 shows the hollow pad of implant be composited by PEEK and bioceramic or metal material of the knee joint femoral condyle of severe bone and required reparation thereof.In this embodiment, the maximum planes part from bio pottery of this hollow pad or metal material are formed, and remainder is made up of PEEK.In addition, this hollow pad contains one or more screw hole.
As shown in Figure 6, Fig. 6 shows the hollow pad of implant be composited by PEEK and bioceramic or metal material of the knee joint tibial upper end of severe bone and required reparation thereof.In this embodiment, time large planar section of this hollow pad is made up of bioceramic or metal material, and remainder is made up of PEEK.In addition, this hollow pad contains one or more screw hole.
As can be seen here, elastic modelling quantity and the natural bone of the PEEK in Cranial defect implant provided by the invention match, and alleviate stress shielding problem; The major part of the implants parts in Cranial defect implant provided by the invention is made up of macromolecular material, reduces allergy, toxicity problem that metal erosion and metal may cause; The implants parts be made up of biocompatible polymer material in the present invention do not cause interference to NMR (Nuclear Magnetic Resonance)-imaging.
The foregoing is only preferred embodiment of the present invention, be not used for limiting practical range of the present invention; If do not depart from the spirit and scope of the present invention, the present invention is modified or equivalent to replace, in the middle of the protection domain that all should be encompassed in the claims in the present invention.

Claims (10)

1. a Cranial defect implant, is characterized in that, comprises Part I and Part II, and wherein said Part I is main bone filling part; Described Part II is the part directly contacted with natural bone; Described Part I is made up of biocompatible polymer material; Described Part II is made up of biocompatibility metal or bioceramic material; Described Part I combines with described Part II.
2. Cranial defect implant according to claim 1, is characterized in that, described biocompatible polymer material is one or more in polyether-ether-ketone and derivant, ultra-high molecular weight polyethylene and derivant thereof and politef and derivant thereof; Described biocompatibility metal material be vitallium, titanium or titanium alloy, tantalum or tantalum alloy, magnesium or magnesium alloy, rustless steel and zirconium-niobium alloy one or more; Described bioceramic material is hydroxyapatite.
3. Cranial defect implant according to claim 1 and 2, is characterized in that, described Part I is combined by surface spraying or chemical deposition with described Part II.
4. Cranial defect implant according to claim 1, is characterized in that, described Part II is made up of biocompatibility metal material, and described Part II is by machining or 3D printing shaping; Described Part I is combined by injection mo(u)lding with described Part II.
5. Cranial defect implant according to claim 1, is characterized in that, the outer surface of described Part II is loose structure.
6. Cranial defect implant according to claim 1 and 2, it is characterized in that, described Cranial defect implant is the implant of the acetabular fossa for severe deformities or Cranial defect, wherein said Part II is the nonreentrant surface part of described acetabular fossa implant, and described Part I is the remainder of described acetabular fossa implant.
7. Cranial defect implant according to claim 6, is characterized in that, described acetabular fossa implant contains one or more screw hole.
8. Cranial defect implant according to claim 1 and 2, it is characterized in that, described implant is the hollow vertebral body of femoral hip prosthesis upper end for severe bone or knee joint femoral condyle or knee joint tibial upper end, wherein said Part II is the outer surface part of described vertebral body, and described Part I is the remainder of described vertebral body.
9. Cranial defect implant according to claim 1 and 2, it is characterized in that, described implant is the hollow pad of the knee joint femoral condyle for severe bone, wherein said Part II is the maximum planes part of described hollow pad, and described Part I is the remainder of described hollow pad; Or described implant is the hollow pad of the knee joint tibial upper end for severe bone, wherein said Part II is time large planar section of described hollow pad, and described Part I is the remainder of described hollow pad.
10. Cranial defect implant according to claim 9, is characterized in that, described hollow pad contains one or more screw hole.
CN201510387244.4A 2015-07-03 2015-07-03 Bone defect filler Pending CN104921845A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510387244.4A CN104921845A (en) 2015-07-03 2015-07-03 Bone defect filler
PCT/CN2015/000728 WO2017004742A1 (en) 2015-07-03 2015-10-28 Bone defect filler

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WO (1) WO2017004742A1 (en)

Cited By (7)

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CN105749355A (en) * 2016-04-22 2016-07-13 江苏奥康尼医疗科技发展有限公司 Orthopedic plant endoprosthesis
CN106580523A (en) * 2016-11-30 2017-04-26 北京爱康宜诚医疗器材有限公司 Femoral condyle front bone defect filling prosthesis
CN107260369A (en) * 2017-06-15 2017-10-20 西安交通大学 It is a kind of to be used for the personalized biological type cushion block of Cranial defect in total knee arthroplasty
CN108618837A (en) * 2018-05-30 2018-10-09 上海交通大学医学院附属第九人民医院 Individuation bone defect filling metal internal fixation device, preparation method and the usage
US10195816B2 (en) 2014-12-01 2019-02-05 Industrial Technology Research Institute Metal/polymer composite material and method for fabricating the same
CN109875729A (en) * 2019-03-05 2019-06-14 福建医科大学附属第一医院 A kind of single condyle displacement femoral prosthesis and its application method equipped with metal filling block
CN114788900A (en) * 2022-03-16 2022-07-26 西安卓恰新材料科技有限公司 Human body implant material and preparation method thereof

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CN107260369A (en) * 2017-06-15 2017-10-20 西安交通大学 It is a kind of to be used for the personalized biological type cushion block of Cranial defect in total knee arthroplasty
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CN109875729A (en) * 2019-03-05 2019-06-14 福建医科大学附属第一医院 A kind of single condyle displacement femoral prosthesis and its application method equipped with metal filling block
CN114788900A (en) * 2022-03-16 2022-07-26 西安卓恰新材料科技有限公司 Human body implant material and preparation method thereof

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