CN113749828A - Personalized proximal fusion femoral stem and manufacturing method thereof - Google Patents
Personalized proximal fusion femoral stem and manufacturing method thereof Download PDFInfo
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- CN113749828A CN113749828A CN202010497053.4A CN202010497053A CN113749828A CN 113749828 A CN113749828 A CN 113749828A CN 202010497053 A CN202010497053 A CN 202010497053A CN 113749828 A CN113749828 A CN 113749828A
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- 230000004927 fusion Effects 0.000 title claims abstract description 56
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 26
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 44
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- 230000000996 additive effect Effects 0.000 claims abstract description 15
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- 238000000034 method Methods 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 7
- 230000001054 cortical effect Effects 0.000 claims description 4
- 238000007639 printing Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 230000000735 allogeneic effect Effects 0.000 claims description 3
- 230000037182 bone density Effects 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims description 3
- 238000002591 computed tomography Methods 0.000 claims description 3
- 238000005242 forging Methods 0.000 claims description 3
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- 239000002245 particle Substances 0.000 claims description 2
- 238000013461 design Methods 0.000 abstract description 3
- 238000003754 machining Methods 0.000 abstract description 3
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- 239000002639 bone cement Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 210000000629 knee joint Anatomy 0.000 description 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 210000004197 pelvis Anatomy 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
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- 210000003625 skull Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3662—Femoral shafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Geometry (AREA)
- Manufacturing & Machinery (AREA)
- Prostheses (AREA)
Abstract
The invention provides a personalized proximal fusion femoral stem and a manufacturing method thereof. The personalized proximal fusion femoral stem comprises a femoral stem main body and a fusion body used for matching and filling bone defects, wherein the fusion body is integrally formed on the femoral stem main body in an additive manufacturing mode. The proximal end fuses the femoral stem main part of femoral stem and fuses the body structure as an organic whole, has avoided traditional product because of the friction wear that the assembly leads to, the cooperation is too tight or too loose, the problem that the stress sheltered from, and the matching precision is high, and the suitability is good, and is short consuming time from the design to the parts machining completion.
Description
Technical Field
The invention relates to the field of biomedical treatment, in particular to a personalized proximal fusion femoral stem and a manufacturing method thereof.
Background
The artificial hip joint replacement operation is a more common surgical operation before ten years, over time, the early implanted artificial prosthesis has more and more failures due to various reasons and enters a revision operation period, revision of the femoral side often has proximal femoral bone defects of different degrees, a large amount of cancellous bone in a medullary cavity is lost and cortical bone defects are accompanied, a large medullary cavity is formed, when filling and fixing are carried out by bone cement, the micro-locking effect between the bone cement and the bone is reduced, and the possibility of early loosening is increased. For example, the S-ROM assembled femoral stem prosthesis proposed by DePuy corporation of the united states is one of representative types of the novel stem bodies, and a typical structure of the assembled femoral stem prosthesis is to add a filling sleeve for filling the proximal medullary cavity of the femur on the outer side of the proximal end of the femoral stem. However, bone cell degenerative atrophy caused by osteolysis due to chips of articular surface materials falling off after long-term abrasion is still unavoidable, so that separation and loosening of the interface gap between the femoral stem prosthesis and the bone still can cause final failure of the stem body implantation, and how to maintain long-term stability of the implanted prosthesis in the femoral medullary cavity is still a subject of continuous research in various aspects.
Therefore, there is a need to provide a proximal fused femoral stem and a method for making the same to overcome the drawbacks of the prior art.
Disclosure of Invention
The invention aims to provide a personalized proximal fusion femoral stem with high stability after implantation and a manufacturing method thereof.
In order to achieve the purpose, the invention provides a personalized proximal fusion femoral stem, which comprises a femoral stem main body and a fusion body used for matching and filling a bone defect, wherein the fusion body is integrally formed on the femoral stem main body in an additive manufacturing mode.
Further, the fusion is a three-dimensional pore structure with interconnected interiors.
Further, the fusion has a rough surface.
Further, the femoral stem body is formed through a forging or casting machining process.
Further, the femoral stem body is formed by an additive manufacturing process.
Furthermore, the femoral stem main body and the fusion body are made of titanium alloy.
Furthermore, bone grafting holes for filling autologous and allogeneic crushed bone particles are arranged on the fusion body.
In order to achieve the purpose, the invention provides a method for manufacturing a personalized proximal fusion femoral stem, which comprises the following steps: acquiring computed tomography data of a diseased bone of a patient, and performing medical image processing and three-dimensional model reconstruction by using industrial software; molding a femoral stem body; determining the shape and size of the fusion body according to the bone defect condition of the diseased bone of the patient; and printing the fused body outside the femoral stem main body integrally in an additive manufacturing mode.
Further, according to a relation function between the gray value and the bone density of the image and the difference between the mechanical property and the porosity of the cortical bone and the cancellous bone, the fusion body is set to be a three-dimensional pore structure with the interior communicated with each other through industrial software.
Further, the three-dimensional model is reconstructed and replaced by the following steps of determining the shapes and the sizes of the femoral stem body and the fused body according to the diseased bone condition of the patient, and printing the femoral stem body and the fused body in an additive manufacturing mode.
The femoral stem main body and the fusion body of the proximal fusion femoral stem are of an integral structure, so that the problems of friction wear, over-tight or over-loose fit and stress shielding caused by assembly of a traditional product are solved, the matching precision is high, the adaptability is excellent, and the time from design to part processing is short.
Drawings
Fig. 1 is a schematic view of a first embodiment of a personalized proximal fused femoral stem of the present invention.
Fig. 2 is a schematic view of other angles of the first embodiment of the personalized proximal fused femoral stem of the present invention.
Fig. 3 is a schematic view of a second embodiment of a personalized proximal fused femoral stem of the present invention.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
Referring to fig. 1 to 3, the proximal fusion femoral stem 100 of the present invention is used to fill a bone defect. In the present invention, the proximal fused femoral stem 100 is not only suitable for supporting and repairing defects of acetabulum, knee joint, skull, maxillofacial region and pelvis of spine, but also suitable for repairing defects of trunk bone and limb bone in human skeletal system, filling and repairing bone, and in addition, can be combined with artificial joint to produce artificial joint replacement and revision prosthesis suitable for various severe deformities, so as to realize functions of bone healing, bone repair acceleration and the like.
Referring to fig. 1 and 2, a personalized proximal fusion femoral stem 100 is shown comprising a femoral stem body 1 and a fusion 2 for matching to fill a bone defect. The fusion body 2 is integrally formed on the femoral stem body 1 by means of additive manufacturing.
That is, the molding material is melted at a high temperature during the additive manufacturing process, and is bonded to the outer surface of the femoral stem body 1 to be integrally molded. Femoral stem main part 1 and fusion 2 structure as an organic whole have avoided traditional product because of the friction wear that the assembly leads to, the cooperation is too tight or too loose, the problem that the stress sheltered from, and the matching precision is high, and the suitability is good, and is short consuming time from the design to the parts machining completion.
In the invention, the fusion body 2 is a three-dimensional pore structure with mutually communicated interiors and has a rough surface, so that the integration of the postoperative bone and the prosthesis is facilitated, the service life of the prosthesis is prolonged, and the revision rate of the postoperative prosthesis is reduced.
The fusion body 2 of the proximal fusion femoral stem 100 is provided with a hydroxyapatite coating on the outer surface contacting with the bone, and has the function of inducing the growth of bone cells. The hydroxyapatite coating can be formed by a conventional plasma spraying method or an electrochemical deposition method and a sintering method.
The femoral stem body 1 may be formed by forging or casting, and the above-mentioned processes are well known in the art and will not be further described herein.
In other embodiments, the femoral stem body 1 and the fusion 2 are both formed by an additive manufacturing process. The femoral stem main body 1 and the fusion body 2 are made of titanium alloy, so that the femoral stem has good biocompatibility.
Referring to fig. 3, in the second embodiment, the fusion body 2 is provided with bone grafting holes 3 for filling autologous and allogeneic bone fragments, and after the bone grafting holes are surgically implanted, the bone tissues infiltrate and grow into three-dimensional meshes, and are fused with the bone fragments filled in the bone grafting holes 3 to grow into a whole, so that the proximal fusion femoral stem 100 and the bone are effectively prevented from loosening.
The manufacturing method of the personalized proximal fusion femoral stem 100 comprises the following steps:
acquiring computed tomography data of a diseased bone of a patient, and performing medical image processing and three-dimensional model reconstruction by using industrial software;
molding a femoral stem body 1;
determining the shape and size of the fusion body 2 according to the bone defect condition of the diseased bone of the patient;
the fused body 2 is integrally printed outside the femoral stem body 1 by means of additive manufacturing.
In other embodiments, after the three-dimensional model is reconstructed, the shapes and the sizes of the femoral stem body 1 and the fusion body 2 can be determined according to the diseased bone condition of the patient, and the femoral stem body 1 and the fusion body 2 can be printed out at one time by means of additive manufacturing.
Further, according to a relation function between the gray value of the image and the bone density and the difference between the mechanical properties and the porosity of the cortical bone and the cancellous bone, the fusion body 2 is set to be a three-dimensional pore structure with the interiors communicated with each other through industrial software. The metal additive manufacturing technology is adopted for manufacturing, and the structural form and porosity of pores can be accurately controlled.
Therefore, the above description is only a preferred embodiment of the present invention, and should not be taken as limiting the scope of the present invention, i.e. all the simple equivalent changes and modifications made by the claims and the content of the present specification should be included in the scope of the present invention.
Claims (10)
1. A personalized proximal fusion femoral stem, comprising: the femoral stem fusion body is integrally formed on the femoral stem main body in an additive manufacturing mode.
2. The personalized proximal fusion femoral stem of claim 1, wherein: the fusion is a three-dimensional pore structure with interconnected interiors.
3. The personalized proximal fusion femoral stem of claim 2, wherein: the fusion has a rough surface.
4. The personalized proximal fusion femoral stem of claim 1, wherein: the femoral stem body is formed by forging or casting.
5. The personalized proximal fusion femoral stem of claim 1, wherein: the femoral stem body is formed through an additive manufacturing process.
6. The personalized proximal fusion femoral stem of claim 5, wherein: the femoral stem main body and the fusion body are made of titanium alloy.
7. The personalized proximal fusion femoral stem of claim 1, wherein: bone grafting holes for filling autologous and allogeneic crushed bone particles are formed in the fusion body.
8. A method for manufacturing a personalized proximal fusion femoral stem is characterized in that: the method comprises the following steps:
acquiring computed tomography data of a diseased bone of a patient, and performing medical image processing and three-dimensional model reconstruction by using industrial software;
molding a femoral stem body;
determining the shape and size of the fusion body according to the bone defect condition of the diseased bone of the patient;
and printing the fused body outside the femoral stem main body integrally in an additive manufacturing mode.
9. The method of manufacturing a personalized proximal fusion femoral stem of claim 8, wherein: and setting the fusion body into a three-dimensional pore structure with the interior communicated with each other through industrial software according to a relation function between the gray value of the image and the bone density and the difference between the mechanical properties and the porosity of the cortical bone and the cancellous bone.
10. The method of manufacturing a personalized proximal fusion femoral stem of claim 8, wherein: and replacing the three-dimensional model after reconstruction with the following steps of determining the shapes and the sizes of the femoral stem main body and the fusion body according to the diseased bone condition of the patient, and printing the femoral stem main body and the fusion body in an additive manufacturing mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010497053.4A CN113749828A (en) | 2020-06-04 | 2020-06-04 | Personalized proximal fusion femoral stem and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010497053.4A CN113749828A (en) | 2020-06-04 | 2020-06-04 | Personalized proximal fusion femoral stem and manufacturing method thereof |
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| CN113749828A true CN113749828A (en) | 2021-12-07 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU950341A1 (en) * | 1980-10-15 | 1982-08-15 | Ленинградский Государственный Ордена Ленина Институт Усовершенствования Врачей Им.С.М.Кирова | Method of making endoprosthesis of femur proximal part |
| CN102188297A (en) * | 2010-03-12 | 2011-09-21 | 北京爱康宜诚医疗器材股份有限公司 | Near-end fusion filling sleeve combined thighbone stem |
| CN105078619A (en) * | 2015-06-26 | 2015-11-25 | 北京市春立正达医疗器械股份有限公司 | Femoral prosthesis and using method |
| CN108294849A (en) * | 2018-03-14 | 2018-07-20 | 华南理工大学 | A kind of personalized type femoral bone end prosthesis and manufacturing method of variable modulus |
| CN110840626A (en) * | 2019-11-05 | 2020-02-28 | 吉林大学 | Femoral stem prosthesis design method |
| CN212755998U (en) * | 2020-06-04 | 2021-03-23 | 上海昕健医疗技术有限公司 | Personalized proximal fusion femoral stem |
-
2020
- 2020-06-04 CN CN202010497053.4A patent/CN113749828A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU950341A1 (en) * | 1980-10-15 | 1982-08-15 | Ленинградский Государственный Ордена Ленина Институт Усовершенствования Врачей Им.С.М.Кирова | Method of making endoprosthesis of femur proximal part |
| CN102188297A (en) * | 2010-03-12 | 2011-09-21 | 北京爱康宜诚医疗器材股份有限公司 | Near-end fusion filling sleeve combined thighbone stem |
| CN105078619A (en) * | 2015-06-26 | 2015-11-25 | 北京市春立正达医疗器械股份有限公司 | Femoral prosthesis and using method |
| CN108294849A (en) * | 2018-03-14 | 2018-07-20 | 华南理工大学 | A kind of personalized type femoral bone end prosthesis and manufacturing method of variable modulus |
| CN110840626A (en) * | 2019-11-05 | 2020-02-28 | 吉林大学 | Femoral stem prosthesis design method |
| CN212755998U (en) * | 2020-06-04 | 2021-03-23 | 上海昕健医疗技术有限公司 | Personalized proximal fusion femoral stem |
Non-Patent Citations (1)
| Title |
|---|
| 邹建新等: "《钒钛功能材料》", 31 March 2019, pages: 31 - 32 * |
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