CN104910189B - 一种盐酸头孢甲肟的工业结晶方法 - Google Patents
一种盐酸头孢甲肟的工业结晶方法 Download PDFInfo
- Publication number
- CN104910189B CN104910189B CN201510332606.XA CN201510332606A CN104910189B CN 104910189 B CN104910189 B CN 104910189B CN 201510332606 A CN201510332606 A CN 201510332606A CN 104910189 B CN104910189 B CN 104910189B
- Authority
- CN
- China
- Prior art keywords
- cefmenoxime hemihydrochloride
- pressure
- temperature
- crystallization
- cefmenoxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
检测项 | 高度H | 半径r | 休止角θ |
第一次 | 40mm | 74.2mm | 28.3° |
第二次 | 40mm | 74.7mm | 28.2° |
第三次 | 40mm | 75.4mm | 28.0° |
平均值 | 40mm | 74.8mm | 28.2° |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510332606.XA CN104910189B (zh) | 2015-06-16 | 2015-06-16 | 一种盐酸头孢甲肟的工业结晶方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510332606.XA CN104910189B (zh) | 2015-06-16 | 2015-06-16 | 一种盐酸头孢甲肟的工业结晶方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104910189A CN104910189A (zh) | 2015-09-16 |
CN104910189B true CN104910189B (zh) | 2016-01-20 |
Family
ID=54079679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510332606.XA Active CN104910189B (zh) | 2015-06-16 | 2015-06-16 | 一种盐酸头孢甲肟的工业结晶方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104910189B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4581166A (en) * | 1983-05-19 | 1986-04-08 | Fried. Krupp Gesellschaft Mit Beschrankter Haftung | Method for isolating and purifying antibiotics |
CN102329329A (zh) * | 2011-07-15 | 2012-01-25 | 海南灵康制药有限公司 | 盐酸头孢甲肟化合物的新制法 |
-
2015
- 2015-06-16 CN CN201510332606.XA patent/CN104910189B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4581166A (en) * | 1983-05-19 | 1986-04-08 | Fried. Krupp Gesellschaft Mit Beschrankter Haftung | Method for isolating and purifying antibiotics |
CN102329329A (zh) * | 2011-07-15 | 2012-01-25 | 海南灵康制药有限公司 | 盐酸头孢甲肟化合物的新制法 |
Non-Patent Citations (2)
Title |
---|
Evaluation of separation and purification processes in the antibiotic industry;Bienkowski, Paul R.等;《Applied Biochemistry and Biotechnology》;19881231;第18卷;261-273页 * |
超临界流体萃取原理及应用;于娜娜等;《化工中间体》;20111231(第8期);38-43页 * |
Also Published As
Publication number | Publication date |
---|---|
CN104910189A (zh) | 2015-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102516096B (zh) | 一种盐酸氨溴索化合物的精制法 | |
CN105153124B (zh) | 一种坎地沙坦酯的制备方法 | |
EP2559696B1 (en) | Purification method of azacyclohexapeptide or its salt | |
CN103864819B (zh) | 一种头孢他啶化合物及其药物组合物 | |
CN112870979B (zh) | 一种β-烟酰胺单核苷酸的分离纯化方法 | |
CN104961749B (zh) | 一种头孢呋辛钠的新型工业结晶方法及其制剂 | |
CN102875574A (zh) | 头孢曲松钠晶型及其制备方法 | |
CN101584671A (zh) | 一种头孢西酮钠药物粉针剂以及头孢西酮钠原料药的合成方法 | |
CN105377840A (zh) | 一种二氮杂环庚烷化合物的盐及其晶型与无定型物 | |
CN102206218B (zh) | 一种高纯度培美曲塞二钠的纯化方法 | |
CN103951562A (zh) | 一种绿原酸晶型及其制备方法 | |
TWI488862B (zh) | Separation and Purification of Cyclohexyl Compounds and Their Salts | |
CN104910189B (zh) | 一种盐酸头孢甲肟的工业结晶方法 | |
CN104926833B (zh) | 一种头孢硫脒的新型工业结晶方法及其制剂 | |
CN106916142A (zh) | 一种制备高纯度德拉沙星的方法 | |
CN104892637B (zh) | 一种头孢孟多酯钠的新型工业结晶方法及其制剂 | |
CN106336411B (zh) | Cdk4/6抑制剂帕博西尼高纯度原料药的制备工艺及用途 | |
CN103601737B (zh) | 一种盐酸头孢替安的制备方法 | |
CN102391259A (zh) | 一种硝呋太尔化合物及其制法 | |
CN102391326B (zh) | 一种盐酸克林霉素棕榈酸酯化合物及其制法 | |
CN105622635B (zh) | 一种减少过敏反应的头孢唑肟钠新晶型及其制剂 | |
CN108033948A (zh) | 一种德拉沙星及其中间体的制备 | |
CN102329328A (zh) | 一种纯化头孢唑肟钠化合物的新方法 | |
CN101613360B (zh) | 一种头孢噻肟的制备方法 | |
CN105503852A (zh) | 噻唑甲酰胺氮氧化物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Tao Linggang Inventor after: Hao Hongxun Inventor before: Tao Linggang |
|
COR | Change of bibliographic data | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150917 Address after: 570216 Hainan Province, Haikou city Jinpan Industrial Development Zone Industrial Village No. 3-6 building Applicant after: Hainan Lingkang Pharmaceutical Co., Ltd. Applicant after: Tianjin University Address before: 570216 Hainan Province, Haikou city Jinpan Industrial Development Zone Industrial Village No. 3-6 building Applicant before: Hainan Lingkang Pharmaceutical Co., Ltd. |
|
CB03 | Change of inventor or designer information |
Inventor after: Tao Linggang Inventor after: Hao Hongxun Inventor after: Wang Jingkang Inventor before: Tao Linggang Inventor before: Hao Hongxun |
|
COR | Change of bibliographic data | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Tao Linggang Inventor after: Hao Hongxun Inventor after: Wang Jingkang Inventor after: Li Chunli Inventor after: Wang Honghai Inventor before: Tao Linggang Inventor before: Hao Hongxun Inventor before: Wang Jingkang |
|
COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160329 Address after: 570216 Hainan Province, Haikou city Jinpan Industrial Development Zone Industrial Village No. 3-6 building Patentee after: Hainan Lingkang Pharmaceutical Co., Ltd. Patentee after: Tianjin University Patentee after: Hebei University of Technology Address before: 570216 Hainan Province, Haikou city Jinpan Industrial Development Zone Industrial Village No. 3-6 building Patentee before: Hainan Lingkang Pharmaceutical Co., Ltd. Patentee before: Tianjin University |