CN104906563B - A kind of anti-bacterial, anti-itching composition and its preparation - Google Patents
A kind of anti-bacterial, anti-itching composition and its preparation Download PDFInfo
- Publication number
- CN104906563B CN104906563B CN201510354999.4A CN201510354999A CN104906563B CN 104906563 B CN104906563 B CN 104906563B CN 201510354999 A CN201510354999 A CN 201510354999A CN 104906563 B CN104906563 B CN 104906563B
- Authority
- CN
- China
- Prior art keywords
- glucose
- parts
- bacterial
- metal phthalocyanine
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 50
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims abstract description 51
- 229910052751 metal Inorganic materials 0.000 claims abstract description 50
- 239000002184 metal Substances 0.000 claims abstract description 50
- 239000003575 carbonaceous material Substances 0.000 claims abstract description 37
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 30
- 108010015776 Glucose oxidase Proteins 0.000 claims abstract description 25
- 239000004366 Glucose oxidase Substances 0.000 claims abstract description 25
- 229940116332 glucose oxidase Drugs 0.000 claims abstract description 25
- 235000019420 glucose oxidase Nutrition 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 15
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical group [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- IYZPEGVSBUNMBE-UHFFFAOYSA-N 2-[[5-[1-[3-[[carboxylatomethyl(carboxymethyl)azaniumyl]methyl]-4-hydroxy-5-methylphenyl]-3-oxo-2-benzofuran-1-yl]-2-hydroxy-3-methylphenyl]methyl-(carboxymethyl)azaniumyl]acetate Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3C(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 IYZPEGVSBUNMBE-UHFFFAOYSA-N 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 239000010941 cobalt Chemical group 0.000 claims description 3
- 229910017052 cobalt Inorganic materials 0.000 claims description 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical group [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 3
- 229910021389 graphene Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical group [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
- 229910052759 nickel Inorganic materials 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 abstract description 12
- 201000004624 Dermatitis Diseases 0.000 abstract description 6
- 230000001225 therapeutic effect Effects 0.000 abstract description 6
- 208000017520 skin disease Diseases 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 4
- 208000010668 atopic eczema Diseases 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000839 emulsion Substances 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 150000002825 nitriles Chemical class 0.000 abstract description 4
- 201000004647 tinea pedis Diseases 0.000 abstract description 4
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 3
- 206010000496 acne Diseases 0.000 abstract description 3
- 239000002260 anti-inflammatory agent Substances 0.000 abstract description 3
- 230000001741 anti-phlogistic effect Effects 0.000 abstract description 3
- 230000000840 anti-viral effect Effects 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 239000003899 bactericide agent Substances 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 241000219095 Vitis Species 0.000 description 7
- 235000009754 Vitis X bourquina Nutrition 0.000 description 7
- 235000012333 Vitis X labruscana Nutrition 0.000 description 7
- 235000014787 Vitis vinifera Nutrition 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 125000003051 glycosyloxy group Chemical group 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000003197 catalytic effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- KMHSUNDEGHRBNV-UHFFFAOYSA-N 2,4-dichloropyrimidine-5-carbonitrile Chemical compound ClC1=NC=C(C#N)C(Cl)=N1 KMHSUNDEGHRBNV-UHFFFAOYSA-N 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- -1 glycosyloxy β-D-Glucose Chemical compound 0.000 description 2
- 208000005687 scabies Diseases 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 0 CC**Cc(cc1)cc2c1C(*=C(*1*34*5)c6ccccc6C1=*1)=*3C2=*C(C)=C(C=C*(C=*)C=C2)C2=*5*=C2*4=C1c1ccc(**)cc21 Chemical compound CC**Cc(cc1)cc2c1C(*=C(*1*34*5)c6ccccc6C1=*1)=*3C2=*C(C)=C(C=C*(C=*)C=C2)C2=*5*=C2*4=C1c1ccc(**)cc21 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010014190 Eczema asteatotic Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013527 degreasing agent Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 230000003694 hair properties Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, glucose oxidase and β D glucose on the carbon material.Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, glucose oxidase, β D glucose and water on the carbon material.Anti-bacterial, anti-itching composition provided by the invention dissolves including the use of Shi Yishui, mixed, and is applied to affected part.Wherein, glucose oxidase can be catalyzed β D glucose and water reaction, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.The preparation of the present invention has a variety of antiviral, bactericidals, itching-relieving action, notable to the skin disease such as dermatitis, eczema, epifolliculitis, acne, tinea pedis, therapeutic effect caused by a variety of causes.Caused itch and inflammation also have remarkable result when simultaneously in the fields such as medical treatment, physics and chemistry, industry using emulsion agent, nitrile system, PVC product etc..
Description
Technical field
The invention belongs to technical field of pharmaceuticals, more particularly to a kind of anti-bacterial, anti-itching composition and its preparation.
Background technology
Modern medicine study proves that pruitus is a kind of conscious pruitus and the skin disease without primary lesion.Face
Systemic pruitus and limitation pruitus can be divided on bed, the latter is confined to anus and external genital more.Systemic skin
Itch common cause is endocrinopathy and winter itch, and liver and kidney disease, malignant tumour and spiritual sexual factor can also cause scabies
Itch, excessive cleaning skin causes skin degreaser drying and produces itch.Common sympton has violent itch：Whole body is found in, is battle array
Hair property, gargalesthesia are violent, are often aggravated at night, influence to sleep.
The medicine for the treatment pruitus sold on the market at present is a lot, and mainly based on external used medicine, Chinese medicine, Western medicine are each
There are an eternal lasting, but most medicines can only be directed to a certain specific skin disease and be treated, for having the other causes of disease or Different types of etiopathogenises
Caused pruitus, therapeutic effect is poor, and treatment time is longer, can not fundamentally release what pruitus band gave people
It is worried.
Metal phthalocyanine has many premium properties such as heat-resisting, light shine, acidproof alkaline stability, and its structure has following spy
Sign：(1) aromatic series pi-electron is conjugated on whole phthalocyanine ring, and the flatness of height is presented in LARGE CONJUGATE MOLECULES, and catalytic reaction can be at this
The axial location of plane occurs；(2) aromatic rings had both had the characteristic of electron donor, had the characteristic of electron acceptor again；(3) it is chemical
Property is highly stable, its acidproof, alkaline-resisting, resistance to water logging, heat-resisting, fast light and resistance to various organic solvents.Features described above, make them full
Intimate harsh requirement in foot catalytic process to catalyst, as catalyst in use, can catalytic activation oxygen, peroxidating
The oxidation reaction of thing etc..
The content of the invention
Inventor, which studies, to be found, the structure of metal phthalocyanine makes it even more with inactive dimer is formed in the solution
The trend of polymers, and the formation of dimer will reduce the active site of axial coordination, so as to cause catalytic efficiency to be greatly lowered.For
Reduce the aggregation of metal phthalocyanine, reach the purpose for improving metal phthalocyanine catalytic efficiency, the present inventor by it is metal phthalocyanine loaded in
On carbon material, and glucose oxidase and β-D-Glucose are introduced simultaneously, it is good, rapid-action and Small side effects to obtain therapeutic effect
Sterilizing and itch-relieving composition.
The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, grape glycosyloxy on the carbon material
Change enzyme and β-D-Glucose.
Preferably, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight grape glycosyloxy on the carbon material
Change enzyme and 25~30 parts by weight β-D-Glucose.
Preferably, including 1 parts by weight load metal phthalocyanine, 0.2 parts by weight glucose oxidase and 25 on the carbon material
Parts by weight β-D-Glucose.
Preferably, the carbon material is CNT or graphene.
Preferably, the metal phthalocyanine has the structure of formula 1：
Formula 1
Wherein：M is iron, cobalt, nickel or manganese, R1Or R2Or R3For-H ,-NH2、-Cl、-F、-COOH、-NO2、-NHCOCH3、-
NHSO3H、-SO3Any one in H.
Preferably, the metal phthalocyanine of the load on the carbon material is prepared in accordance with the following methods：
Carbon material is placed in metal phthalocyanine solution and flowed back.
Preferably, the reflux temperature is 50~100 DEG C, and the return time is 2~12h.
Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, grape glycosyloxy on the carbon material
Change enzyme, β-D-Glucose and water.
Preferably, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight grape glycosyloxy on the carbon material
Change enzyme, 25~30 parts by weight β-D-Glucose and 15~20 parts by weight water.
Preferably, including 1 parts by weight load metal phthalocyanine, 0.2 parts by weight glucose oxidase, 25 weights on the carbon material
Measure part β-D-Glucose and 20 parts by weight water.
Compared with prior art, anti-bacterial, anti-itching composition provided by the invention includes：The metal phthalein of load on the carbon material
Cyanines, glucose oxidase and β-D-Glucose, dissolved, mixed with water during use, being applied to affected part.Wherein, grape glycosyloxy
β-D-Glucose and water reaction can be catalyzed by changing enzyme, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.This
The preparation of invention has a variety of antiviral, bactericidals, itching-relieving action, to dermatitis caused by a variety of causes, eczema, epifolliculitis,
The skin diseases such as acne, tinea pedis, therapeutic effect are notable.Simultaneously in the fields such as medical treatment, physics and chemistry, industry using emulsion agent, nitrile system,
Caused itch and inflammation also have remarkable result during PVC product etc..
Embodiment
The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, grape glycosyloxy on the carbon material
Change enzyme and β-D-Glucose.
One of preferred embodiment is, including 1~2 parts by weight load metal phthalocyanine on the carbon material, 0.2~
0.4 parts by weight glucose oxidase and 25~30 parts by weight β-D-Glucose.
Other in which preferred embodiment is, including 1 parts by weight load metal phthalocyanine, 0.2 weight on the carbon material
Measure part glucose oxidase and 25 parts by weight β-D-Glucose.
Anti-bacterial, anti-itching composition provided by the invention includes the metal phthalocyanine of load on the carbon material, wherein, carbon material is excellent
Elect CNT or graphene as, metal phthalocyanine has the structure of formula 1：
Formula 1；
Wherein：M is iron, cobalt, nickel or manganese, and R is-H ,-NH2、-Cl、-F、-COOH、-NO2、-NHCOCH3、-NHSO3H、-
SO3Any one in H.
After metal phthalocyanine loaded and carbon material, it forms following structure：
Formula 1
The metal phthalocyanine of the load on the carbon material can be prepared in accordance with the following methods：
Carbon material is placed in metal phthalocyanine solution and flowed back.
Carbon material is positioned in the solution of metal phthalocyanine and isoamyl nitrite and flowed back, is made metal phthalocyanine loaded in carbon materials
On material.Wherein, the reflux temperature is 60-90 DEG C, and the return time is 12h.Metal phthalocyanine solution is preferably dimethyl Asia
Sulfone (DMSO) solution.After backflow, carbon material is washed repeatedly with solvent to colourless, 80~100 DEG C of drying.Course of reaction
It is as follows：
In the present invention, the load capacity of the metal phthalocyanine is 0.4% or so.
The present invention mixes metal phthalocyanine, glucose oxidase and β-D-Glucose loaded on the carbon material i.e. available
Anti-bacterial, anti-itching composition.
Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, grape glycosyloxy on the carbon material
Change enzyme, β-D-Glucose and water.
In a preferred embodiment, including 1~2 parts by weight load metal phthalocyanine on the carbon material, 0.2~
0.4 parts by weight glucose oxidase, 25~30 parts by weight β-D-Glucose and 15~20 parts by weight water.
In another preferred embodiment, including 1 parts by weight load metal phthalocyanine on the carbon material, 0.2 weight
Part glucose oxidase, 25 parts by weight β-D-Glucose and 20 parts by weight water.
Anti-bacterial, anti-itching composition or anti-bacterial, anti-itching preparation provided by the invention use in accordance with the following methods：
First carbon based metal phthalocyanine powder, glucose oxidase powder, β-D-Glucose powder are poured into water, mixed, stands 10 points
Clock；
Affected part is cleaned again, one layer of the preparation of the present invention is smeared to affected part, should not be too thick, Bao Yuehao is got over, soon may be used
With antipruritic.
In anti-bacterial, anti-itching composition or anti-bacterial, anti-itching preparation provided by the invention, glucose oxidase can be catalyzed β-D- grapes
Sugar and water are reacted, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.The preparation of the present invention has a variety of
Antiviral, bactericidal, itching-relieving action, to the skin disease such as dermatitis, eczema, epifolliculitis, acne, tinea pedis caused by a variety of causes,
Therapeutic effect is notable.It is caused when simultaneously to using emulsion agent, nitrile system, PVC product etc. in the fields such as medical treatment, physics and chemistry, industry
Itch and inflammation also have remarkable result.
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belong to the model that the present invention protects
Enclose.
Embodiment 1
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts：1 part of carbon based metal phthalocyanine, glucose oxidase
0.2 part, 20 parts of β-D-Glucose, 20 parts of pure water.
CNT is positioned in 100 DEG C of iron-phthalocyanine solution and flowed back 10 hours, the carbon that taking-up is loaded with iron-phthalocyanine is received
Mitron, wash, last 100 DEG C drying colourless to solution, obtained carbon based metal phthalocyanine repeatedly with solvent；Then by carbon based metal phthalein
Cyanines, glucose oxidase, β-D-Glucose mixing, mix thoroughly, are reloaded into bag.
Application method：The carbon based metal phthalocyanine powder in bag, glucose oxidase powder, β-D-Glucose powder are first poured into 20 parts
In water, mix, stand 10 minutes.Affected part is cleaned again, one layer of the preparation of the present invention is smeared to affected part, should not be too thick, it is thinner
It is better, soon can be with antipruritic.
Embodiment 2：
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts：2 parts of carbon based metal phthalocyanine, glucose oxidase
0.3 part, 25 parts of β-D-Glucose, 20 parts of pure water.
Preparation method is the same as embodiment 1.With embodiment 1 during use.
Embodiment 3：
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts：1 part of carbon based metal phthalocyanine, glucose oxidase
0.2 part, 25 parts of β-D-Glucose, 20 parts of pure water.
Preparation method is the same as embodiment 1.With embodiment 1 during use.
Multiple model cases are now enumerated, to illustrate the therapeutic effect of carbon based metal phthalocyanine anti-bacterial, anti-itching preparation of the present invention
And action speed.
Case one：Lin, 64 years old, suffer from allergic dermatitis, have the red point of itch at trick, through obtained by above-described embodiment 1
Anti-bacterial, anti-itching preparation, affected part is 1 times a day smeared, same day scratchiness substantially mitigates, and 3 days points red less than itch are most of to be eliminated, and 6
Can is cured after it, is never recurred over the past half year.
Case two：Zhang, 13 years old, whole body was very itched, and had small erythema, went multiple hospitals treatment invalid, and do not find allergy
What source is, using the anti-bacterial, anti-itching preparation obtained by the embodiment of the present invention 2, treatment is smeared fully recovers twice, does not recur so far.
Case three：Field, 10 years old, annual spring was because pollen hypersensitivity whole body is itched, whole skin is scratched by hand.Use the present invention
Anti-bacterial, anti-itching preparation for treating obtained by embodiment 3, spread after preparation less than 45 minutes, whole body is just no longer itched.
Case four：Liu, 41 years old, the diameter of double-legged heart length grew 4 cm sclerderm tinea pedis, and both legs GrandTech, which itches, feels bad,
Skin many places are scratched, and are cured using the preparation of the embodiment of the present invention 1, not recurred so far three times.
Case five：Chen, 5 years old, annual summer mosquito was more, is itched very much unbearably after mosquito bite, spreads the embodiment of the present invention 2
Preparation after itch and eliminate after 30 seconds.
Case six：Slowly certain, 32 years old, caused four limbs itch is infected with ulcer on the shank, the preparation through the embodiment of the present invention 3 is controlled
Treat, smear within 1st 1 and be inferior to affected part, pruritis all eliminates after 5 days, is cured after 7 days.
Case seven：Just certain, 28 years old, is engaged in physics and chemistry industry, the scabies caused by commonly using emulsion agent, nitrile system, PVC product etc.
Itch and inflammation, use after the product of the embodiment of the present invention 2 that scratchiness disappears after 5 minutes.
Case eight：Zhao, 56 years old, with erythroderma, the preparation through above-described embodiment 1 once a day smeared affected part, 1 day
Scratchiness substantially mitigates afterwards, starts to heal at 3 days rear peelings, all symptom eliminates after 7 days.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to the foregoing embodiments for pipe, it will be understood by those within the art that：It is still
Technical scheme described in foregoing embodiments can be modified, or which part technical characteristic is equally replaced
Change；And these modifications or replacement, the essence of appropriate technical solution is departed from the essence of various embodiments of the present invention technical scheme
God and scope.
Claims (8)
1. a kind of anti-bacterial, anti-itching composition, to load metal phthalocyanine, glucose oxidase and β-D-Glucose on the carbon material,
Including metal phthalocyanine, 0.2~0.4 parts by weight glucose oxidase and 25~30 weight load of 1~2 parts by weight on the carbon material
Part β-D-Glucose.
2. anti-bacterial, anti-itching composition according to claim 1, it is characterised in that including the load of 1 parts by weight on the carbon material
Metal phthalocyanine, 0.2 parts by weight glucose oxidase and 25 parts by weight β-D-Glucose.
3. anti-bacterial, anti-itching composition according to claim 1 or 2, it is characterised in that the carbon material be CNT or
Graphene.
4. anti-bacterial, anti-itching composition according to claim 3, it is characterised in that the metal phthalocyanine has the structure of formula 1：
Wherein：M is iron, cobalt, nickel or manganese, R1Or R2Or R3For-H ,-NH2、-Cl、-F、-COOH、-NO2、-NHCOCH3、-
NHSO3H、-SO3Any one in H.
5. anti-bacterial, anti-itching composition according to claim 4, it is characterised in that the metal phthalein of the load on the carbon material
Cyanines are prepared in accordance with the following methods：
Carbon material is placed in metal phthalocyanine solution and flowed back.
6. anti-bacterial, anti-itching composition according to claim 5, it is characterised in that the reflux temperature is 50~100 DEG C, institute
It is 2~12h to state return time.
7. a kind of anti-bacterial, anti-itching preparation, for load metal phthalocyanine on the carbon material, glucose oxidase, β-D-Glucose and
Water, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight glucose oxidase, 25~30 weights on the carbon material
Measure part β-D-Glucose and 15~20 parts by weight water.
8. anti-bacterial, anti-itching preparation according to claim 7, it is characterised in that including the load of 1 parts by weight on the carbon material
Metal phthalocyanine, 0.2 parts by weight glucose oxidase, 25 parts by weight β-D-Glucose and 20 parts by weight water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510354999.4A CN104906563B (en) | 2015-06-25 | 2015-06-25 | A kind of anti-bacterial, anti-itching composition and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510354999.4A CN104906563B (en) | 2015-06-25 | 2015-06-25 | A kind of anti-bacterial, anti-itching composition and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104906563A CN104906563A (en) | 2015-09-16 |
| CN104906563B true CN104906563B (en) | 2018-01-05 |
Family
ID=54076277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510354999.4A Active CN104906563B (en) | 2015-06-25 | 2015-06-25 | A kind of anti-bacterial, anti-itching composition and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104906563B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111481605A (en) * | 2020-05-14 | 2020-08-04 | 李素花 | Foot bath liquid for preventing diabetic foot and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101576484A (en) * | 2009-06-08 | 2009-11-11 | 浙江理工大学 | Reagent and method for detecting concentration of hydrogen peroxide |
| CN103721747A (en) * | 2013-12-13 | 2014-04-16 | 浙江理工大学 | Catalytic carbon fibers and preparation method |
| CN104607247A (en) * | 2015-01-03 | 2015-05-13 | 浙江理工大学 | High-activity catalytic carbon fiber material and preparation method thereof |
-
2015
- 2015-06-25 CN CN201510354999.4A patent/CN104906563B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101576484A (en) * | 2009-06-08 | 2009-11-11 | 浙江理工大学 | Reagent and method for detecting concentration of hydrogen peroxide |
| CN103721747A (en) * | 2013-12-13 | 2014-04-16 | 浙江理工大学 | Catalytic carbon fibers and preparation method |
| CN104607247A (en) * | 2015-01-03 | 2015-05-13 | 浙江理工大学 | High-activity catalytic carbon fiber material and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 碳纳米纤维增强钴酞菁催化氧化染料的性能研究;李楠等;《中国科学》;20130620;第43卷(第6期);摘要，第774页右栏倒数第3行-第775页左栏倒数第1行，第775页右栏倒数第5行-第776页左栏第7行 * |
| 葡萄糖/葡萄糖氧化酶抗菌纸及抗菌性研究;虢杰等;《食品工业科技》;20110101;第32卷(第01期);摘要，第124页右栏倒数第3行-第125页左栏第12行，结果与讨论 * |
| 葡萄糖氧化酶的应用和检测方法研究进展;肖志明等;《科技与实践》;20140925;第50卷(第18期);摘要，3 作用机理，4 葡萄糖氧化酶的应用 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104906563A (en) | 2015-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Xi et al. | Light-enhanced sponge-like carbon nanozyme used for synergetic antibacterial therapy | |
| CN102350298A (en) | Multifunctional composite absorbing material for purifying water and preparation method thereof | |
| EP2351568A3 (en) | Uses of dpp-iv inhibitors | |
| Lu et al. | A photo‐responsive hollow manganese/carbon hybrid nanosphere for wound disinfection and healing | |
| CN102240388B (en) | Ginger extract and preparation method and applications thereof | |
| CN104906563B (en) | A kind of anti-bacterial, anti-itching composition and its preparation | |
| CN106653261B (en) | A kind of preparation method of graphene/carbon point/magnetic composite | |
| WO2011127829A1 (en) | Use of carbon nanoparticles as externl applied medicament for treating hemorrhoid | |
| CN106075000A (en) | A kind of Chinese medicine ointment for treating hemorrhoid and preparation method thereof | |
| CN103702785A (en) | Novel nano gold and process for preparation | |
| CN104256651B (en) | Improve composition and method of making the same and the application of male's sexual | |
| Nasir et al. | The effect of silver nanoparticles on braf gene expression | |
| CN104367905B (en) | It is a kind of to be used to treat Chinese and Western compound ointment agent of fungal dermatopathy and preparation method thereof | |
| Zhou et al. | A perylene diimide probe for NIR-II fluorescence imaging guided photothermal and type I/type II photodynamic synergistic therapy | |
| CN109876007B (en) | Ozone antibacterial and disinfecting gel and preparation method thereof | |
| CN100998673B (en) | Compound cream containing fluconazole and Radix scutellariae and its preparing method | |
| CN102716486B (en) | Slowly-releasing anticancer drug composition and application thereof | |
| CN101352432B (en) | Technique of preparing nano vitamin E emulsion | |
| CN103520211B (en) | A kind of compound florfenicol injection and preparation method thereof and application | |
| CN106334144A (en) | External use medicine for treating skin diseases | |
| CN105622655A (en) | Rare earth-luteolin-imidazole ternary complex and preparation method thereof | |
| CN104906173A (en) | Antibacterial itching relieving preparation and preparation method thereof | |
| CN1327870C (en) | Exterior-applied medicine for treating dermatopathy | |
| CN108096368A (en) | A kind of antibacterial cream of skin for treating recalcitrant dermal disease and preparation method thereof | |
| CN102258567B (en) | Externally-applied Chinese medicinal paste for treating psoriasis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150916 Assignee: Zhejiang Sci-Tech University Shangyu Industrial Technology Research Institute Co., Ltd. Assignor: Zhejiang University of Technology Contract record no.: X2019330000038 Denomination of invention: Antibacterial itching relieving composition and preparation thereof Granted publication date: 20180105 License type: Common License Record date: 20191108 |
|
| EE01 | Entry into force of recordation of patent licensing contract |