CN104906563B - A kind of anti-bacterial, anti-itching composition and its preparation - Google Patents

A kind of anti-bacterial, anti-itching composition and its preparation Download PDF

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CN104906563B
CN104906563B CN201510354999.4A CN201510354999A CN104906563B CN 104906563 B CN104906563 B CN 104906563B CN 201510354999 A CN201510354999 A CN 201510354999A CN 104906563 B CN104906563 B CN 104906563B
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glucose
parts
bacterial
metal phthalocyanine
weight
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CN104906563A (en
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吕汪洋
王燕燕
陈文兴
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Zhejiang Sci Tech University ZSTU
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Zhejiang Sci Tech University ZSTU
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Abstract

The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, glucose oxidase and β D glucose on the carbon material.Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, glucose oxidase, β D glucose and water on the carbon material.Anti-bacterial, anti-itching composition provided by the invention dissolves including the use of Shi Yishui, mixed, and is applied to affected part.Wherein, glucose oxidase can be catalyzed β D glucose and water reaction, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.The preparation of the present invention has a variety of antiviral, bactericidals, itching-relieving action, notable to the skin disease such as dermatitis, eczema, epifolliculitis, acne, tinea pedis, therapeutic effect caused by a variety of causes.Caused itch and inflammation also have remarkable result when simultaneously in the fields such as medical treatment, physics and chemistry, industry using emulsion agent, nitrile system, PVC product etc..

Description

A kind of anti-bacterial, anti-itching composition and its preparation
Technical field
The invention belongs to technical field of pharmaceuticals, more particularly to a kind of anti-bacterial, anti-itching composition and its preparation.
Background technology
Modern medicine study proves that pruitus is a kind of conscious pruitus and the skin disease without primary lesion.Face Systemic pruitus and limitation pruitus can be divided on bed, the latter is confined to anus and external genital more.Systemic skin Itch common cause is endocrinopathy and winter itch, and liver and kidney disease, malignant tumour and spiritual sexual factor can also cause scabies Itch, excessive cleaning skin causes skin degreaser drying and produces itch.Common sympton has violent itch:Whole body is found in, is battle array Hair property, gargalesthesia are violent, are often aggravated at night, influence to sleep.
The medicine for the treatment pruitus sold on the market at present is a lot, and mainly based on external used medicine, Chinese medicine, Western medicine are each There are an eternal lasting, but most medicines can only be directed to a certain specific skin disease and be treated, for having the other causes of disease or Different types of etiopathogenises Caused pruitus, therapeutic effect is poor, and treatment time is longer, can not fundamentally release what pruitus band gave people It is worried.
Metal phthalocyanine has many premium properties such as heat-resisting, light shine, acidproof alkaline stability, and its structure has following spy Sign:(1) aromatic series pi-electron is conjugated on whole phthalocyanine ring, and the flatness of height is presented in LARGE CONJUGATE MOLECULES, and catalytic reaction can be at this The axial location of plane occurs;(2) aromatic rings had both had the characteristic of electron donor, had the characteristic of electron acceptor again;(3) it is chemical Property is highly stable, its acidproof, alkaline-resisting, resistance to water logging, heat-resisting, fast light and resistance to various organic solvents.Features described above, make them full Intimate harsh requirement in foot catalytic process to catalyst, as catalyst in use, can catalytic activation oxygen, peroxidating The oxidation reaction of thing etc..
The content of the invention
Inventor, which studies, to be found, the structure of metal phthalocyanine makes it even more with inactive dimer is formed in the solution The trend of polymers, and the formation of dimer will reduce the active site of axial coordination, so as to cause catalytic efficiency to be greatly lowered.For Reduce the aggregation of metal phthalocyanine, reach the purpose for improving metal phthalocyanine catalytic efficiency, the present inventor by it is metal phthalocyanine loaded in On carbon material, and glucose oxidase and β-D-Glucose are introduced simultaneously, it is good, rapid-action and Small side effects to obtain therapeutic effect Sterilizing and itch-relieving composition.
The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, grape glycosyloxy on the carbon material Change enzyme and β-D-Glucose.
Preferably, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight grape glycosyloxy on the carbon material Change enzyme and 25~30 parts by weight β-D-Glucose.
Preferably, including 1 parts by weight load metal phthalocyanine, 0.2 parts by weight glucose oxidase and 25 on the carbon material Parts by weight β-D-Glucose.
Preferably, the carbon material is CNT or graphene.
Preferably, the metal phthalocyanine has the structure of formula 1:
Formula 1
Wherein:M is iron, cobalt, nickel or manganese, R1Or R2Or R3For-H ,-NH2-Cl、-F、-COOH、-NO2、-NHCOCH3、- NHSO3H、-SO3Any one in H.
Preferably, the metal phthalocyanine of the load on the carbon material is prepared in accordance with the following methods:
Carbon material is placed in metal phthalocyanine solution and flowed back.
Preferably, the reflux temperature is 50~100 DEG C, and the return time is 2~12h.
Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, grape glycosyloxy on the carbon material Change enzyme, β-D-Glucose and water.
Preferably, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight grape glycosyloxy on the carbon material Change enzyme, 25~30 parts by weight β-D-Glucose and 15~20 parts by weight water.
Preferably, including 1 parts by weight load metal phthalocyanine, 0.2 parts by weight glucose oxidase, 25 weights on the carbon material Measure part β-D-Glucose and 20 parts by weight water.
Compared with prior art, anti-bacterial, anti-itching composition provided by the invention includes:The metal phthalein of load on the carbon material Cyanines, glucose oxidase and β-D-Glucose, dissolved, mixed with water during use, being applied to affected part.Wherein, grape glycosyloxy β-D-Glucose and water reaction can be catalyzed by changing enzyme, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.This The preparation of invention has a variety of antiviral, bactericidals, itching-relieving action, to dermatitis caused by a variety of causes, eczema, epifolliculitis, The skin diseases such as acne, tinea pedis, therapeutic effect are notable.Simultaneously in the fields such as medical treatment, physics and chemistry, industry using emulsion agent, nitrile system, Caused itch and inflammation also have remarkable result during PVC product etc..
Embodiment
The invention provides a kind of anti-bacterial, anti-itching composition, including load metal phthalocyanine, grape glycosyloxy on the carbon material Change enzyme and β-D-Glucose.
One of preferred embodiment is, including 1~2 parts by weight load metal phthalocyanine on the carbon material, 0.2~ 0.4 parts by weight glucose oxidase and 25~30 parts by weight β-D-Glucose.
Other in which preferred embodiment is, including 1 parts by weight load metal phthalocyanine, 0.2 weight on the carbon material Measure part glucose oxidase and 25 parts by weight β-D-Glucose.
Anti-bacterial, anti-itching composition provided by the invention includes the metal phthalocyanine of load on the carbon material, wherein, carbon material is excellent Elect CNT or graphene as, metal phthalocyanine has the structure of formula 1:
Formula 1;
Wherein:M is iron, cobalt, nickel or manganese, and R is-H ,-NH2、-Cl、-F、-COOH、-NO2、-NHCOCH3、-NHSO3H、- SO3Any one in H.
After metal phthalocyanine loaded and carbon material, it forms following structure:
Formula 1
The metal phthalocyanine of the load on the carbon material can be prepared in accordance with the following methods:
Carbon material is placed in metal phthalocyanine solution and flowed back.
Carbon material is positioned in the solution of metal phthalocyanine and isoamyl nitrite and flowed back, is made metal phthalocyanine loaded in carbon materials On material.Wherein, the reflux temperature is 60-90 DEG C, and the return time is 12h.Metal phthalocyanine solution is preferably dimethyl Asia Sulfone (DMSO) solution.After backflow, carbon material is washed repeatedly with solvent to colourless, 80~100 DEG C of drying.Course of reaction It is as follows:
In the present invention, the load capacity of the metal phthalocyanine is 0.4% or so.
The present invention mixes metal phthalocyanine, glucose oxidase and β-D-Glucose loaded on the carbon material i.e. available Anti-bacterial, anti-itching composition.
Present invention also offers a kind of anti-bacterial, anti-itching preparation, including load metal phthalocyanine, grape glycosyloxy on the carbon material Change enzyme, β-D-Glucose and water.
In a preferred embodiment, including 1~2 parts by weight load metal phthalocyanine on the carbon material, 0.2~ 0.4 parts by weight glucose oxidase, 25~30 parts by weight β-D-Glucose and 15~20 parts by weight water.
In another preferred embodiment, including 1 parts by weight load metal phthalocyanine on the carbon material, 0.2 weight Part glucose oxidase, 25 parts by weight β-D-Glucose and 20 parts by weight water.
Anti-bacterial, anti-itching composition or anti-bacterial, anti-itching preparation provided by the invention use in accordance with the following methods:
First carbon based metal phthalocyanine powder, glucose oxidase powder, β-D-Glucose powder are poured into water, mixed, stands 10 points Clock;
Affected part is cleaned again, one layer of the preparation of the present invention is smeared to affected part, should not be too thick, Bao Yuehao is got over, soon may be used With antipruritic.
In anti-bacterial, anti-itching composition or anti-bacterial, anti-itching preparation provided by the invention, glucose oxidase can be catalyzed β-D- grapes Sugar and water are reacted, then the effect of bactericidal antiphlogistic is generated in the presence of carbon based metal phthalocyanine.The preparation of the present invention has a variety of Antiviral, bactericidal, itching-relieving action, to the skin disease such as dermatitis, eczema, epifolliculitis, acne, tinea pedis caused by a variety of causes, Therapeutic effect is notable.It is caused when simultaneously to using emulsion agent, nitrile system, PVC product etc. in the fields such as medical treatment, physics and chemistry, industry Itch and inflammation also have remarkable result.
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment Only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area The every other embodiment that art personnel are obtained under the premise of creative work is not made, belong to the model that the present invention protects Enclose.
Embodiment 1
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts:1 part of carbon based metal phthalocyanine, glucose oxidase 0.2 part, 20 parts of β-D-Glucose, 20 parts of pure water.
CNT is positioned in 100 DEG C of iron-phthalocyanine solution and flowed back 10 hours, the carbon that taking-up is loaded with iron-phthalocyanine is received Mitron, wash, last 100 DEG C drying colourless to solution, obtained carbon based metal phthalocyanine repeatedly with solvent;Then by carbon based metal phthalein Cyanines, glucose oxidase, β-D-Glucose mixing, mix thoroughly, are reloaded into bag.
Application method:The carbon based metal phthalocyanine powder in bag, glucose oxidase powder, β-D-Glucose powder are first poured into 20 parts In water, mix, stand 10 minutes.Affected part is cleaned again, one layer of the preparation of the present invention is smeared to affected part, should not be too thick, it is thinner It is better, soon can be with antipruritic.
Embodiment 2:
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts:2 parts of carbon based metal phthalocyanine, glucose oxidase 0.3 part, 25 parts of β-D-Glucose, 20 parts of pure water.
Preparation method is the same as embodiment 1.With embodiment 1 during use.
Embodiment 3:
Anti-bacterial, anti-itching preparation, it is formulated by the raw material of following weight parts:1 part of carbon based metal phthalocyanine, glucose oxidase 0.2 part, 25 parts of β-D-Glucose, 20 parts of pure water.
Preparation method is the same as embodiment 1.With embodiment 1 during use.
Multiple model cases are now enumerated, to illustrate the therapeutic effect of carbon based metal phthalocyanine anti-bacterial, anti-itching preparation of the present invention And action speed.
Case one:Lin, 64 years old, suffer from allergic dermatitis, have the red point of itch at trick, through obtained by above-described embodiment 1 Anti-bacterial, anti-itching preparation, affected part is 1 times a day smeared, same day scratchiness substantially mitigates, and 3 days points red less than itch are most of to be eliminated, and 6 Can is cured after it, is never recurred over the past half year.
Case two:Zhang, 13 years old, whole body was very itched, and had small erythema, went multiple hospitals treatment invalid, and do not find allergy What source is, using the anti-bacterial, anti-itching preparation obtained by the embodiment of the present invention 2, treatment is smeared fully recovers twice, does not recur so far.
Case three:Field, 10 years old, annual spring was because pollen hypersensitivity whole body is itched, whole skin is scratched by hand.Use the present invention Anti-bacterial, anti-itching preparation for treating obtained by embodiment 3, spread after preparation less than 45 minutes, whole body is just no longer itched.
Case four:Liu, 41 years old, the diameter of double-legged heart length grew 4 cm sclerderm tinea pedis, and both legs GrandTech, which itches, feels bad, Skin many places are scratched, and are cured using the preparation of the embodiment of the present invention 1, not recurred so far three times.
Case five:Chen, 5 years old, annual summer mosquito was more, is itched very much unbearably after mosquito bite, spreads the embodiment of the present invention 2 Preparation after itch and eliminate after 30 seconds.
Case six:Slowly certain, 32 years old, caused four limbs itch is infected with ulcer on the shank, the preparation through the embodiment of the present invention 3 is controlled Treat, smear within 1st 1 and be inferior to affected part, pruritis all eliminates after 5 days, is cured after 7 days.
Case seven:Just certain, 28 years old, is engaged in physics and chemistry industry, the scabies caused by commonly using emulsion agent, nitrile system, PVC product etc. Itch and inflammation, use after the product of the embodiment of the present invention 2 that scratchiness disappears after 5 minutes.
Case eight:Zhao, 56 years old, with erythroderma, the preparation through above-described embodiment 1 once a day smeared affected part, 1 day Scratchiness substantially mitigates afterwards, starts to heal at 3 days rear peelings, all symptom eliminates after 7 days.
Finally it should be noted that:The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations;To the greatest extent The present invention is described in detail with reference to the foregoing embodiments for pipe, it will be understood by those within the art that:It is still Technical scheme described in foregoing embodiments can be modified, or which part technical characteristic is equally replaced Change;And these modifications or replacement, the essence of appropriate technical solution is departed from the essence of various embodiments of the present invention technical scheme God and scope.

Claims (8)

1. a kind of anti-bacterial, anti-itching composition, to load metal phthalocyanine, glucose oxidase and β-D-Glucose on the carbon material, Including metal phthalocyanine, 0.2~0.4 parts by weight glucose oxidase and 25~30 weight load of 1~2 parts by weight on the carbon material Part β-D-Glucose.
2. anti-bacterial, anti-itching composition according to claim 1, it is characterised in that including the load of 1 parts by weight on the carbon material Metal phthalocyanine, 0.2 parts by weight glucose oxidase and 25 parts by weight β-D-Glucose.
3. anti-bacterial, anti-itching composition according to claim 1 or 2, it is characterised in that the carbon material be CNT or Graphene.
4. anti-bacterial, anti-itching composition according to claim 3, it is characterised in that the metal phthalocyanine has the structure of formula 1:
Wherein:M is iron, cobalt, nickel or manganese, R1Or R2Or R3For-H ,-NH2、-Cl、-F、-COOH、-NO2、-NHCOCH3、- NHSO3H、-SO3Any one in H.
5. anti-bacterial, anti-itching composition according to claim 4, it is characterised in that the metal phthalein of the load on the carbon material Cyanines are prepared in accordance with the following methods:
Carbon material is placed in metal phthalocyanine solution and flowed back.
6. anti-bacterial, anti-itching composition according to claim 5, it is characterised in that the reflux temperature is 50~100 DEG C, institute It is 2~12h to state return time.
7. a kind of anti-bacterial, anti-itching preparation, for load metal phthalocyanine on the carbon material, glucose oxidase, β-D-Glucose and Water, including 1~2 parts by weight load metal phthalocyanine, 0.2~0.4 parts by weight glucose oxidase, 25~30 weights on the carbon material Measure part β-D-Glucose and 15~20 parts by weight water.
8. anti-bacterial, anti-itching preparation according to claim 7, it is characterised in that including the load of 1 parts by weight on the carbon material Metal phthalocyanine, 0.2 parts by weight glucose oxidase, 25 parts by weight β-D-Glucose and 20 parts by weight water.
CN201510354999.4A 2015-06-25 2015-06-25 A kind of anti-bacterial, anti-itching composition and its preparation Active CN104906563B (en)

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