CN104906336A - Application of antitussive pink powder for preparing rectal administration preparation - Google Patents
Application of antitussive pink powder for preparing rectal administration preparation Download PDFInfo
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- CN104906336A CN104906336A CN201510311716.8A CN201510311716A CN104906336A CN 104906336 A CN104906336 A CN 104906336A CN 201510311716 A CN201510311716 A CN 201510311716A CN 104906336 A CN104906336 A CN 104906336A
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Abstract
The invention belongs to the field of pharmaceutic preparations, and particularly relates to novel application of antitussive pink powder for preparing a rectal administration preparation. The rectal administration preparation prepared by antitussive pink powder has the advantages of being fast to absorb, capable of avoiding a first-pass effect, convenient to operate, free of pains, noninvasive, capable of being accepted particularly by child patients and directly acting on lesion tissue for certain diseases, quick in effect, capable of improving the bioavailability of drugs and the like according to different ages, different catheter depths and different dilution ratios, and an obvious therapeutic effect on infectious diseases is achieved.
Description
[technical field]
The invention belongs to field of pharmaceutical preparations, be specifically related to the novelty teabag of sharp monarch's cough-relieving pink powder for the preparation of rectally preparation.
[background technology]
Cough-relieving pink powder, square medicine early sees the treatise on Febrile Diseases of Zhang Zhongjing.For pertussis and refractory cough, the anti-tussive agents of measles and pneumonia infection.Its prescription is made up of Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Gypsum Fibrosum, Cinnabaris, Moschus, Herba Menthae, Borneolum Syntheticum, there is lung heat clearing, reduce phlegm, cough-relieving, sensible heat radiation, relieving convulsion effect.
At present, various clinical preparation has been derived with the medicine that Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Gypsum Fibrosum, Cinnabaris, Moschus, Herba Menthae, Borneolum Syntheticum are raw material, the such as dosage form such as powder, capsule
Pharmacodynamics test shows, and in cough-relieving pink powder preparation, Bulbus Fritillariae Cirrhosae is by the main component as various clinical cough-relieving product, can be used for treatment expectorant heat syndrome cough and breathes heavily, yellow thick card of coughing up phlegm; In the Rhizoma Pinelliae, alkaloid can directly suppress coughing centre to produce antitussive effect; Gypsum Fibrosum has the merit of heat-clearing and toxic substances removing, for lung-heat cough with asthma, and asthma; Tranquilizing cinnabar, QI invigorating, arresting convulsion; Herba Menthae can cure cold to generate heat and have sore throat, and headache, also can alleviate stomachache, spasm; Moschus antiinflammatory, analgesia, enhancing immunity; Borneolum Syntheticum has refreshment of having one's ideas straightened out, heat clearing away fall apart poison effect.Seven taste side's medicines are combined and are made cough-relieving pink powder pure Chinese medicinal preparation, have cough-relieving concurrently, reduce phlegm, lung heat clearing, the effect such as heat radiation.Confirm in clinical practice that it increases coughing centre, nervus centripetalis threshold value, improve irritative cough's sensor respiratory muscle, diaphram, tracheal smooth muscle, alleviate nasal decongestion, thus reduce thick sputum degree, accelerate ciliary movement, improve sputum running.Use without antagonism with Antibiotic combination.
Owing to can not avoid first pass effect completely, the bioavailability improving medicine is poor, and Clinical practice is comparatively frequent.The treatment of the cough that cough-relieving pink powder is widely used in not healing to acute/chronic bronchitis, bronchopneumonia, cough variant asthma, pertussis, chronic cough, measles and pneumonia infection etc. causes etc.
But existing powder, capsule still also exist the consuming time and inconvenient problem for the treatment of in clinical treatment, especially for child patient, more there is the not adaptive for the treatment of.
[summary of the invention]
To be solved by this invention is that cough-relieving pink powder oral administration relative bioavailability is low; Solve the problem of patient's oral administration and intravenously administrable difficulty, pediatric drugs weak tendency, oral, intravenously administrable is more difficult, infant, the first pin or the second stylus printer are not gone up, and child wails, the head of a family also can follow little crying, and very occurs physician-patient relationship tense or offending scene; Rectally operating technology lack of standardization so provide a kind of utilize cough-relieving pink powder to prepare rectally preparation novelty teabag and standard operation.
For solving the problem, this programme is realized by following technological means:
A kind of cough-relieving pink powder of the present invention is for the preparation of the purposes of rectally preparation.It is characterized in that, the raw material of described cough-relieving pink powder consists of: Bulbus Fritillariae Cirrhosae 30 weight portion artificial Moschus 9 weight portion Borneolum Syntheticum 6 weight portion Herba Menthae 9 weight parts water Cinnabaris 6 weight portion Rhizoma Pinelliae Preparata 12 weight portion Gypsum Fibrosum Preparatum 30 weight portion
Cough-relieving pink powder of the present invention is prepared as follows: get described Bulbus Fritillariae Cirrhosae, artificial Moschus, Borneolum Syntheticum, Herba Menthae, Cinnabaris (water flies), the Rhizoma Pinelliae, Gypsum Fibrosum (forging) according to selected weight portion.Above seven tastes are except artificial Moschus, Borneolum Syntheticum, and Cinnabaris water flies into impalpable powder, and four tastes such as all the other Bulbus Fritillariae Cirrhosaes, Herba Menthae, Rhizoma Pinelliae (processed), Gypsum Fibrosum (forging) are ground into fine powder, and cross 100 mesh sieves, mean diameter is 163um, and specific surface area is 320C m
2during/g, compared with general medicine, the heavy 600mg of major part every, its specific surface area only has 12.5C m
2/ g.Mixed homogeneously with above four Chinese medicine material fine powder by Cinnabaris, by artificial Moschus and above-mentioned powder facing-up, Borneolum Syntheticum is with same method facing-up, and add 918 weight portion glucose powders, facing-up, sieves, mix homogeneously, makes 1020 weight portions, and point packaging, to obtain final product.
The day application dosage of rectally preparation described in such use of the present invention is 0.6g-1.8g.
Described in such use of the present invention, the concrete operation method of rectally is as follows:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution to 5 after heating to 10ml;
Step 3: suck with 10ml to 20ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus about 3cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows infant keep ventricumbent position (adult's left lateral position) 5min.
Through health volunteer use after 12 hours, it always drains 15 times that cumulant is large grain.
The normative choice of the concrete catheter depth of such use of the present invention is as follows:
| Age (year) | Within 2 years old | 2 to 7 | 7 to 15 | Adult |
| Catheter depth (cm) | 3 >=degree of depth≤5 | 4 >=degree of depth≤7 | 5 >=degree of depth≤8 | 5 >=degree of depth≤10 |
The normative choice of the concrete dosage of such use of the present invention is as follows:
Rectally refers to sends medicine into intestinal tube by anus, enters blood circulation by rectal mucosal rapid absorption by three approach.Play drug effect to treat the medication of whole body or local disease, be mainly used in the treatment of acute and chronic respiratory system disease, digestive system disease, diseases of urinary system and andropathy, gynaecopathia class, and there is good effect.
Cough-relieving pink powder rectally superiority: the first pass effect avoiding liver, improves bioavailability, prevents again medicine to the damage of liver, alleviate the burden of liver; The decomposition avoiding medicine to be subject to Digestive system destroys, and improves the bioavailability of medicine, prevents medicine from stimulating gastrointestinal; " misery that non insertion is taken medicine ", particularly suitable for the infant patient not easily accepting injection and oral administration; To the patient needing long term administration, prevent the organ injury that single channel administration causes, as sclerosis of blood vessels, muscle hardens, gastrointestinal damage, liver injury etc.; To stupor, vomiting oral patient can not be convenient to first aid;
Cough-relieving pink powder is in the drug absorption of rectum:
1) fat-soluble and degree of dissociation
Rectal mucosa is lipid membrane, medicine absorption is in the rectum absorbed by adipose membrane and micropore approach, cough-relieving pink powder meets first-order rate formula from the disappearance of rectum, and cough-relieving pink powder enters retrorectal pH value and changes to and can increase the proportional quantities of not dissociating shared by medicine, increases the absorption of medicine.
2) dissolubility of cough-relieving pink powder and particle diameter
The dissolubility of medicine is absorbed with certain influence, the medicine that dissolubility is little, because the secretory volume in rectum is less to rectum, medicine dissolution amount is few, absorbs also few, when medicine water solublity is larger, absorb and also increase, in the substrate of medicine insoluble and in outstanding dispersity time, its ionic size can affect absorption.
The method of the invention is prepared rectally preparation with existing cough-relieving pink powder and is carried out clinical administration, utilize and carry out rectally with the diverse route of administration of prior art, with existing oral administration, intravenous injection, intramuscular injection is compared this rectally preparation and is had absorption soon, avoid first pass effect, easy to operate, safety is high, no pain, hurtless measure, be easy to accept for child patient especially, pathological tissues is directly acted on for part disease, soon effective, improve the features such as drug bioavailability, for the cough that all kinds of reason causes, particularly refractory cough shape has outstanding therapeutic effect.
Experimental example
Concrete operations mode and effect that the rectally preparation prepared containing cough-relieving pink powder of the present invention is described is observed by following clinical practice case operation and result.Wherein, each medicine mentioned in following case is commercially available product.
Case content:
Data and diagnosis: infant 2 years old, generate heat 39.2 DEG C, cough watery nasal discharge one day, auscultation pulmonary, without rale, respiratory harshness, is diagnosed as upper respiratory tract infection.
Experimental group is treated: normal saline 5ml is placed in 10ml beaker, is heated to 38 DEG C; Cough-relieving pink powder 0.6g enters in normal saline and fully dissolves, and continues to add aminophenazone 2ml, dexamethasone 2mg, keeps temperature 38 DEG C; Suck above-mentioned medicinal liquid 7ml with 20ml disposable syringe, suck 3ml air simultaneously; Rectal catheter connects syringe, makes slowly to insert anus 5cm place with lubricator; Medicinal liquid in syringe is slowly pushed relief children's and keep 10min administration position.Operation like this 2 times/day, simultaneously oral QINGRE JIEDU KOUFUYE, cefradine for suspension.Treat infant recovery from illness after two days.
Treatment of control group: with the embodiment of the present invention 1 cough-relieving pink powder 0.6g, aminophenazone 2ml, dexamethasone 2mg, intramuscular injection, 1 day 2 times, oral QINGRE JIEDU KOUFUYE, cefradine for suspension, 1 day 2 times.Administration is after 2 days, and pharyngalgia is alleviated not obvious, uses rectally instead.
Cold cough
Data and diagnosis: after 67 routine patients suffer from cold, occur cough (wherein 20 examples within 2 years old, 2 to 7 years old 21 examples, 7 to 15 years old 13 examples, adult 13 example), the frequent dry cough of 63 example (wherein 25 examples within 2 years old, 2 to 7 years old 14 examples, 7 to 15 years old 11 examples, adult 13 example), 12 examples cough up white slimy expectorant (wherein 7 to 15 years old 5 example, adult 7 example), 91 routine infants cough up clear yellow viscous expectorant (wherein 32 examples within 2 years old, 2 to 7 years old 17 examples, 7 to 15 years old 27 examples, adult 15 example), there are low grade fever (wherein 58 examples within 2 years old in 121 examples, 2 to 7 years old 29 examples, 7 to 15 years old 13 examples, adult 21 example).
Get 50ml sodium chloride, the disposable dilution of cough-relieving pink powder 10 bags (6g) is dissolved, as thermostatic water tank, use solution 5ml/ time, be heated to 38 DEG C; Cough-relieving pink powder 6g enters in normal saline and fully dissolves, and continues to add aminophenazone 20ml, dexamethasone 20mg, keeps temperature 38 DEG C; Suck above-mentioned medicinal liquid 7ml with 10ml disposable syringe, suck 3ml air simultaneously; Rectal catheter connects syringe, makes slowly to insert anus (seeing the following form) with lubricator;
| Age (year) | Within 2 years old | 2 to 7 | 7 to 15 | Adult |
| Catheter depth (cm) | 3 >=degree of depth≤5 | 4 >=degree of depth≤7 | 5 >=degree of depth≤8 | 5 >=degree of depth≤10 |
Medicinal liquid in syringe is slowly pushed relief patient and keep 10min administration position.Operation like this 2 times/day, is aided with Herba Houttuyniae and Herba Houttuyniae and Flos Lonicerae injection 2mL according to the administration of Neulized inhalation mode, 1 day 2 times.Administration, after 2.5 days, is fully recovered.
Visible, be of the present inventionly prepared with cough-relieving pink powder the scheme that rectally preparation carries out administration, compared to prior art cough-relieving pink powder, to infectious disease, there is more outstanding therapeutic effect, and it is more extensive to be suitable for patients
[detailed description of the invention]
Embodiment 1
The cough-relieving pink powder rectally preparation described in the present embodiment with patient's infectious disease in treatment 2 years old is made up of following methods:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution after heating to 5ml; 2.5ml/ time, 2 times/day
Step 3: suck with 10ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus 3.5cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows patient keep ventricumbent position 5min.
Embodiment 2
The cough-relieving pink powder rectally preparation described in the present embodiment with treatment 2 to 7 years old patient infection's property diseases is made up of following methods:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution after heating to 7ml; 7ml/ time, 2 times/day
Step 3: suck with 10ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus 5cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows patient keep ventricumbent position 5min.
Embodiment 3
The cough-relieving pink powder rectally preparation described in the present embodiment with treatment 7 to 15 years old patient infection's property diseases is made up of following methods:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution after heating to 10ml; 10ml/ time, 2 times/day
Step 3: suck with 10ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus 6cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows patient keep ventricumbent position 5min.
Embodiment 4
The cough-relieving pink powder rectally preparation described in the present embodiment with treatment more than 15 years old patient infection's property disease is made up of following methods:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution after heating to 30ml; 30ml/ time, 2 times/day
Step 3: suck with 30ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus 8cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows patient keep ventricumbent position 5min.
Embodiment 5
The cough-relieving pink powder rectally preparation described in the present embodiment with treatment patient infection's property disease is made up of following methods:
Step one: 50ml normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 6g with the normal saline dilution after heating to 50ml; 5ml/ time, 2 times/day
Step 3: suck with 10ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus 3.5 to 8cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows patient keep ventricumbent position 5min.
Obvious above-mentioned example is only used to described purposes is clearly described, and the restriction not to embodiment.For the technical staff in described field, other multi-form change or variations can also be made on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And the apparent change of amplifying out thus or variation are still among the protection domain of the invention.
Claims (4)
1. cough-relieving pink powder is for the preparation of a purposes for rectally preparation, it is characterized in that operational approach
Described in such use of the present invention, the concrete operation method of rectally is as follows:
Step one: normal saline is heated to 35 DEG C to 40 DEG C (winter remains on 38 DEG C to 41 DEG C);
Step 2: cough-relieving pink powder 0.6g with the normal saline dilution to 5 after heating to 10ml;
Step 3: suck with 10ml to 20ml disposable syringe, and stay 3ml air, be connected with rectal catheter with disposable syringe, anus about 3cm is inserted from anus towards umbilicus direction in rectal catheter top, sense (by anorectal ring) of pitching stops advancing afterwards, by angle that is 68 ° identical with anus rectum drift angle for conduit biased forwards, then rectum need be inserted;
Step 4: slowly pushed by the medicinal liquid in syringe, allows infant keep ventricumbent position (adult's left lateral position) 5min.
2. purposes according to right 1, is characterized in that, the normative choice of catheter depth is as follows:
3. purposes and catheter depth according to right 1 and 2, is characterized in that, after dilution, the normative choice of dosage is as follows:
4. the purposes according to claim 1,2,3, the wiping pipe degree of depth and dosage, is characterized in that, the day application dosage 0.6g to 1.8g of described rectally preparation.
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| CN201510311716.8A CN104906336A (en) | 2015-06-09 | 2015-06-09 | Application of antitussive pink powder for preparing rectal administration preparation |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86105639A (en) * | 1985-08-05 | 1987-02-25 | 弗·哈夫曼-拉罗切有限公司 | The preparation method of rectally dosage form |
| US20060121137A1 (en) * | 2004-12-07 | 2006-06-08 | Hartle Diane K | Muscadine grape pomace in the treatment of intestinal inflammation |
-
2015
- 2015-06-09 CN CN201510311716.8A patent/CN104906336A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86105639A (en) * | 1985-08-05 | 1987-02-25 | 弗·哈夫曼-拉罗切有限公司 | The preparation method of rectally dosage form |
| US20060121137A1 (en) * | 2004-12-07 | 2006-06-08 | Hartle Diane K | Muscadine grape pomace in the treatment of intestinal inflammation |
Non-Patent Citations (2)
| Title |
|---|
| 丽君医学推广部: "止咳桃花散直肠给药病例分享", 《HTTPS://WENKU.BAIDU.COM/VIEW/ E4EFBFFBA32D7375A517809E.HTML》 * |
| 宝笙索尼专卖: "止咳桃花散直肠给药资料", 《HTTPS://WENKU.BAIDU.COM/VIEW/AF229A68B52ACFC788EBC948.HTML》 * |
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