CN104902959A - Irak抑制剂和其用途 - Google Patents

Irak抑制剂和其用途 Download PDF

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Publication number
CN104902959A
CN104902959A CN201380036906.2A CN201380036906A CN104902959A CN 104902959 A CN104902959 A CN 104902959A CN 201380036906 A CN201380036906 A CN 201380036906A CN 104902959 A CN104902959 A CN 104902959A
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China
Prior art keywords
compound
disease
cancer
ring
irak
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Pending
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CN201380036906.2A
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English (en)
Chinese (zh)
Inventor
杰拉尔丁·C·哈里曼
罗纳德·T·韦斯特
唐娜·L·罗梅罗
克雷格·E·马斯
肖奈希·罗宾逊
杰里米·罗伯特·格林伍德
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Nimbus Iris Inc
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Nimbus Iris Inc
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Publication of CN104902959A publication Critical patent/CN104902959A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
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CN201380036906.2A 2012-07-11 2013-07-11 Irak抑制剂和其用途 Pending CN104902959A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261670380P 2012-07-11 2012-07-11
US61/670,380 2012-07-11
US201261682622P 2012-08-13 2012-08-13
US61/682,622 2012-08-13
PCT/US2013/050113 WO2014011906A2 (en) 2012-07-11 2013-07-11 Irak inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CN104902959A true CN104902959A (zh) 2015-09-09

Family

ID=49914493

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380036906.2A Pending CN104902959A (zh) 2012-07-11 2013-07-11 Irak抑制剂和其用途

Country Status (10)

Country Link
US (2) US9067948B2 (enExample)
EP (1) EP2872518A4 (enExample)
JP (1) JP2015528801A (enExample)
CN (1) CN104902959A (enExample)
AU (1) AU2013290080A1 (enExample)
BR (1) BR112015000561A2 (enExample)
CA (1) CA2878040A1 (enExample)
HK (1) HK1210732A1 (enExample)
IN (1) IN2015DN00127A (enExample)
WO (1) WO2014011906A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428768A (zh) * 2015-03-09 2017-12-01 安斯泰来制药株式会社 二环式吡啶化合物

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US8703941B2 (en) 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
BR112014017021A8 (pt) 2012-01-10 2017-07-04 Nimbus Iris Inc inibidores de irak e usos dos mesmos
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
IN2015DN00127A (enExample) 2012-07-11 2015-05-29 Nimbus Iris Inc
CA2890911A1 (en) 2013-01-10 2014-07-17 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
KR20160092991A (ko) 2013-09-27 2016-08-05 님버스 아이리스 인코포레이티드 Irak 억제제 및 이의 용도
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
WO2019060742A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc AGENTS FOR DEGRADING PROTEINS AND USES THEREOF
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
KR20210024543A (ko) * 2018-06-25 2021-03-05 치아타이 티안큉 파마수티컬 그룹 주식회사 IRAK4 억제제로서의 이소티아졸로[5,4-d]피리미딘 화합물
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
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