CN104897827A - Preparative type fraction collector avoiding sample loss - Google Patents
Preparative type fraction collector avoiding sample loss Download PDFInfo
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- CN104897827A CN104897827A CN201510335132.4A CN201510335132A CN104897827A CN 104897827 A CN104897827 A CN 104897827A CN 201510335132 A CN201510335132 A CN 201510335132A CN 104897827 A CN104897827 A CN 104897827A
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Abstract
The invention discloses a preparative type fraction collector avoiding sample loss. The preparative type fraction collector comprises a fixed support, a moving arm assembly, a collecting device and a control unit, wherein the moving arm assembly is connected onto the fixed support; the collecting device is mounted on the moving arm assembly and comprises a collection liquid temporary storage device, a liquid inlet pipeline part and a collecting pipeline part, an inlet of the liquid inlet pipeline part is communicated with a liquid medium outlet of a separation column, an outlet of the liquid inlet pipeline part is communicated with an inlet of the collection liquid temporary storage device, an outlet of the collection liquid temporary storage device is communicated with an inlet of the collecting pipeline part, an outlet of the collecting pipeline part is used for allowing liquid media to flow into corresponding collecting containers, and a switching valve is further arranged at the collecting pipeline part; a control output end of the control unit is connected with a control signal input end of the moving arm assembly and is connected with a control signal input end of the switching valve. According to the preparative type fraction collector avoiding the sample loss, the phenomenon of fraction leakage during collecting container switching can be avoided, so that the sample loss ratio is reduced.
Description
Technical field
The present invention relates to a kind of preparative fraction collector avoiding sample loss, for the collection of target compound after chromatographic resolution.
Background technology
At present, fraction collector is the servicing unit of liquid chromatograph, mainly for the preparation of with enrichment pure component.When needs provide standard pure sample or to certain component do identify further time, usually collect required component with fraction collector in separating column exit, namely the mobile phase in removing cut obtains pure component.The signal that gatherer can flow out by chromatographic peak, cuts with craft or automatic control mode.Current development trend is the robotization realizing sample introduction and fraction collection, can carry out continuous print operation and separation repeatedly like this.
Fraction collector is generally divided into two classes, the first kind is that collection container is with general rectangular array, cut dispensing head is disposed on two dimensional surface or on all three dimension scales, thus distributes the liquid to each collection container selectively, realizes the collection of different fractions.First kind gatherer is collectively referred to as " X-Y gatherer ".Equations of The Second Kind is that collection container is arranged on annular rotary table, and fraction collector generally operates by rotating the combination of rotating disk with rotation installation and with the arm of dispensing head of installing the collection realizing cut.Equations of The Second Kind gatherer is collectively referred to as " turntable collectors ".
No matter be the fraction collector of that type, between each independent collection container, all there is certain distance.Therefore, when cut dispensing head switches to subsequent vessel from a collection container, likely there is spilling, especially under mobile phase liquid substantially continuous print situation of institute's dispense liquid.In addition, fraction collector on market generally requires that whole collection container rack piles collection container, whether a certain collection container position of chromatograph None-identified places collection container, only manually intervening by user prevents fraction collector from carrying out fraction collection in the position without collection container, avoids causing target compound or mobile phase to leak.Simultaneously, according to the general operation needs of chromatographic resolution, the collection container rack holding target compound needs temporarily to preserve or turnover, preserve or turnover process in generally mark and identify collection container rack and sample message with the form of artificial/hand labeled or label, but the mode efficiency of this hand labeled is low and easily make a mistake.Therefore, a kind of preparative fraction collector avoiding sample loss, effectively identification collection container position and the convenient identification collection container rack of energy and sample message is needed.
Summary of the invention
Technical matters to be solved by this invention is the defect overcoming prior art, provides a kind of preparative fraction collector avoiding sample loss, and what it can avoid when switching collection container cut spills phenomenon, thus reduces the loss percentage of sample.
In order to solve the problems of the technologies described above, technical scheme of the present invention is: a kind of preparative fraction collector avoiding sample loss, and it comprises:
Fixed support;
Transfer arm assembly, described transfer arm assembly is connected on fixed support;
Gathering-device, described gathering-device is arranged on transfer arm assembly, described gathering-device comprises collects liquid buffer, water influent pipeline part and collecting part, the import of described water influent pipeline part is used for exporting with the liquid medium of separating column being connected, the outlet of described water influent pipeline part is connected with the import of collecting liquid buffer, the outlet of described collection liquid buffer is connected with the import of collecting part, the outlet of collecting part is used for trickle medium in collection container, and described collecting part is also provided with switch valve;
Control assembly, the control output end of described control assembly is connected with the control signal input end of transfer arm assembly, to be controlled the action of transfer arm assembly manually or automatically by control assembly, the control output end of described control assembly is also connected with the control signal input end of switch valve, so that by the action of control assembly gauge tap valve manually or automatically.
The further technical matters to be solved of the present invention is: effectively prevent the frequent starting of chromatogram pump and avoid the waste of sample liquids better, the preparative fraction collector of sample loss is avoided also to comprise waste-solution line, described water influent pipeline part has multiport valve, water influent pipeline and fluid pipeline, the outlet of water influent pipeline is connected with an import of multiport valve, the import of fluid pipeline is connected with an outlet of multiport valve, another of the import of waste-solution line and multiport valve exports and is connected, the outlet of fluid pipeline is connected with the import of collecting liquid buffer, the control signal input end of described multiport valve is connected with the control output end of control assembly, to be controlled the action of multiport valve by control assembly.
More even time further in order to make distillate flow out, not easily make to produce larger liquid fluctuating in collection liquid buffer, the exit of described water influent pipeline part is provided with shower nozzle.
Liquid stream further in order to enable shower nozzle spray rinses the inwall collecting liquid buffer, thus the sample crystallization that removal inwall may be formed, described shower nozzle has funnelform spout.
Further in order to keep suitable pressure by collection liquid buffer, making distillate easily flow into and discharge, described collection liquid buffer is provided with pressure compensation mouth.
Further, described transfer arm assembly has power source, and the control output end of described control assembly is connected with the control signal input end of power source, to control power source by control assembly, thus controls the action of transfer arm assembly.
Further, the preparative fraction collector of sample loss is avoided also to comprise collection container rack, described collection container rack is provided with collection container chassis or has the collection container receptacle body of multiple collection container jack, collection container chassis or collection container receptacle body are for placing described collection container.
Further provide a kind of concrete structure of control assembly the information of collection container in collection container rack can be learnt easily, described control assembly has master control borad and collection container rack control panel, described collection container rack control panel is arranged on described collection container rack, and this collection container rack control panel transmits with master control borad two-way signaling and is connected.
Further in order to can the position of automatic recognition collecting container, and reach and do not need all to pile collection container at collection container rack, partly can place the requirement of collection container, effectively prevent the wasting phenomenon without collecting the sample liquids caused during collection container, described collection container rack is also provided with collection container recognition device, and collection container recognition device is corresponding with collection container, so that collection container recognition device is for gathering the collection container status information in collection container chassis or collection container jack, the described control output end of collection container recognition device is connected with the signal input part of control assembly, so that control assembly controls the action of transfer arm assembly according to the collection container status information received.
Further in order to show the information such as model, sample message, duty of current collection container, avoid the preparative fraction collector of sample loss also to include display module, described display module is connected with control assembly.
Further in order to electric energy can be provided to collection container rack, the preparative fraction collector of sample loss is avoided also to include power autonomous module and/or external power source interface.
After have employed technique scheme, the present invention has following beneficial effect:
1, the present invention can avoid switch collection container time cut spill phenomenon, thus reduce the loss percentage of sample: because the transfer arm of transfer arm assembly is moving in the process of another collection container from a collection container, the interval region of meeting between collection container, in order to ensure distillate can not to be overflowed, the outlet of collecting part moves in the interval time of another collection container from a collection container, the outlet at bottom collecting liquid buffer will be closed by switch valve, and the distillate that at this moment water influent pipeline part is discharged can accumulate in collection liquid buffer; When the transfer arm of transfer arm assembly complete gathering-device is moved to another collection container top from a collection container top time, switch valve is opened, and the distillate in collection liquid buffer is discharged.
2, the present invention effectively prevent the frequent starting of chromatogram pump and avoids the phenomenon of waste of sample liquids better, liquid chromatograph duty has two kinds of situations, fraction collection state and non-fraction collection state, when liquid chromatograph is in non-fraction collection state, on multiport valve, water influent pipeline is connected with waste-solution line, and the path of closing between water influent pipeline and fluid pipeline, the distillate of discharging in such separating column can flow out from waste-solution line; When liquid chromatograph is in fraction collection state, the path between water influent pipeline and fluid pipeline connected by multiport valve, and close the path of water influent pipeline and waste-solution line, the distillate of discharging in such separating column can enter collection container through collecting liquid buffer, the present invention is when switching to next collection container from a collection container, do not need to stop chromatogram pump or the direct removal waste fluid of sample, thus effectively prevent the frequent starting of chromatogram pump and the waste of sample liquids;
3, present invention achieves the position of automatic recognition collecting container, parameter and status information, do not require that collection container rack is all piled, effectively preventing without collecting the waste causing sample liquids during collection container; To keep in or turnover period can the information such as the user profile of convenient identification collection container rack and sample message collecting sample.
Accompanying drawing explanation
Fig. 1 is the structural representation avoiding the preparative fraction collector of sample loss of the present invention;
Fig. 2 is the partial enlarged drawing in Fig. 1;
Fig. 3 is fluid pipeline of the present invention and the connection diagram of collecting liquid buffer.
Embodiment
In order to make content of the present invention more easily be clearly understood, below according to specific embodiment also by reference to the accompanying drawings, the present invention is further detailed explanation.
As shown in Figures 1 to 3, a kind of preparative fraction collector avoiding sample loss, it comprises:
Fixed support 1;
Transfer arm assembly 2, transfer arm assembly 2 is connected on fixed support 1; This transfer arm assembly 2 can be set to be applied on the fraction collector of grid type and (also claim X-Y fraction collector), also can be set to be applied on the fraction collector of rotating disc type, by arranging corresponding mode of motion, namely above-mentioned technique effect can be reached;
Gathering-device, described gathering-device is arranged on transfer arm assembly 2, gathering-device comprises collects liquid buffer 17, water influent pipeline part and collecting part 8, the import of water influent pipeline part is used for exporting with the liquid medium of separating column being connected, the outlet of described water influent pipeline part is connected with the import of collecting liquid buffer 17, the outlet of collecting liquid buffer 17 is connected with the import of collecting part 8, the outlet of collecting part 8 is used for trickle medium in collection container 9, and collecting part 8 is also provided with switch valve 7; Control assembly, the control output end of control assembly is connected with the control signal input end of transfer arm assembly 2, to be controlled the action of transfer arm assembly 2 manually or automatically by control assembly, the control output end of described control assembly is also connected with the control signal input end of switch valve 7, by the action of control assembly gauge tap valve 7 manually or automatically, thus to open or close the path of collecting part 8.
As shown in Figure 1, the preparative fraction collector of sample loss is avoided also to comprise waste-solution line 5, water influent pipeline part has multiport valve 4, water influent pipeline 3 and fluid pipeline 28, the outlet of water influent pipeline 3 is connected with an import of multiport valve 4, the import of fluid pipeline 28 is connected with an outlet of multiport valve 4, another of the import of waste-solution line 5 and multiport valve 4 exports and is connected, the outlet of fluid pipeline 28 is connected with the import of collecting liquid buffer 17, the control signal input end of multiport valve 4 is connected with the control output end of control assembly, to be controlled the action of multiport valve 4 by control assembly, action control is as follows: control multiport valve 4 by control assembly and make multiport valve 4 connect the path between water influent pipeline 3 and fluid pipeline 28 and the path between closedown water influent pipeline 3 and waste-solution line 5, or the path making multiport valve 4 connect the path between water influent pipeline 3 and waste-solution line 5 and close between water influent pipeline 3 and fluid pipeline 28.
As shown in Figure 1, the exit of water influent pipeline part is provided with shower nozzle 18, and shower nozzle 18 has funnelform spout.
As shown in Figure 3, collect on liquid buffer 17 and be provided with pressure compensation mouth 6, generally can adopt and offer an evacuated tube on collection liquid buffer 17 top and reach this object, also can be realized by pressurization, evacuator.
Transfer arm assembly 2 has power source, and the control output end of control assembly is connected with the control signal input end of power source, to control power source by control assembly, thus controls the action of transfer arm assembly 2.
Due in actual use, size or the structure of the collection container 9 adopted can be distinguished to some extent, and the structure of collection container rack 20, putting in order etc. of collection container 9 also has difference, therefore, if need to allow this device can realize the fraction collection of more robotization, broaden application scope, as shown in Figure 1, the preparative fraction collector of sample loss is avoided also to comprise collection container rack 20, collection container rack 20 is provided with collection container chassis or there is the collection container receptacle body of multiple collection container jack 11, collection container chassis or collection container receptacle body are for placing described collection container 9.
Control assembly has master control borad 22 and collection container rack control panel, and described collection container rack control panel is arranged on described collection container rack 20, and this collection container rack control panel transmits with master control borad 22 two-way signaling and is connected.Collection container rack 20 is also provided with collection container recognition device 14, and collection container recognition device 14 and collection container 9 corresponding, so that collection container recognition device 14 is for gathering the collection container status information in collection container chassis or collection container jack 11, the described control output end of collection container recognition device 14 is connected with the signal input part of control assembly, so that control assembly controls the action of transfer arm assembly 2 according to the collection container status information received.The effect of collection container recognition device 14 in collection container jack 11 or in collection container chassis, whether is placed with collection container 9 for induction, and collection container status information is passed to control assembly, control assembly is when controlling transfer arm assembly 2, multiport valve 4, switch valve 7, situation about can place according to collection container 9 carries out suitable adjustment, such as, when not being placed with collection container 9 in collection container jack 11, the transfer arm of transfer arm assembly 2 can avoid the region of not placing collection container 9 automatically.Collection container recognition device 14 can be the recognition device that triggers or respond to based on contact or cordless, such as thin film switch, by compressing switch, the one of action response switch etc.Collection container rack 20 is made up of collection container support body 10 and/or collection container rack base 13.In addition, collection container rack control panel can also comprise the function of outside input, namely user inputs the information such as model, size of collection container 9 on collection container rack control panel, these information are sent to master control borad 22, like this, control assembly just can adjust the frequency of collection container switching according to the volume of collection container 9, the time namely stopped above collection container 9, make the cut adding suitable volumes in collection container 9.
As shown in Figure 1, avoid the preparative fraction collector of sample loss also to include display module 12, described display module 12 is connected with control assembly, so that display module 12 shows collection container information, cut information, sample message etc.Display module 12 can be arranged on collection container rack 20.
Wherein, the master control borad 22 of control assembly can be internally-arranged type, also can be externally positioned type, and externally positioned type is for example the master control borad 22 of liquid chromatograph, built-in for example itself master control borad 22.
As shown in Figure 1, avoid the preparative fraction collector of sample loss also to include power autonomous module and/or external power source interface, described power autonomous module is rechargeable battery 16 or dry cell.Power autonomous module and/or external power source interface, can be arranged on collection container rack 20, and the effect of rechargeable battery 16 is that collection container rack 20 is not when external power interface accesses external power supply, provides electric energy to collection container rack 20.When collection container rack 20 is positioned over fixed support 1 inside, complete the charging action to rechargeable battery 16.When collection container rack 20 to be taken from during fraction collector by user, rechargeable battery 16 still can retain the corresponding information of collection container rack 20 correspondence for a long time, such as user profile, sample message, cut information etc. that collection container is corresponding.The signal output part of described power autonomous module can be connected with the master control borad in control assembly or collection container rack control panel, the state of display rechargeable battery.
In general, this fraction collector can carry out the operation of robotization by such step:
First, open liquid chromatograph, now liquid chromatograph is in the non-fraction collection stage according to separation case, and the flow direction of multiport valve 4 is now set as flowing out from water influent pipeline 3 to waste-solution line 5 by control assembly;
Then, when occurring the cut needing to collect in liquid chromatograph, according to the volumescope of pre-set flow velocity and pipeline, control assembly calculates when required cut can arrive collection liquid buffer 17 place; If desired, transfer arm assembly 2 is arranged at collection container 9 top by control assembly, carries out the preparation receiving cut;
When distillate flow reached to the moment of collecting liquid buffer 17, the flow direction of multiport valve 4 is now set as flowing out from water influent pipeline 3 to fluid pipeline 28 by control assembly, the opening of control assembly maintained switch valve 7 simultaneously, enters into collection container 9 after making cut pass through to collect liquid buffer 17;
The volume of collection container 9 can be pre-set in control assembly, the time of filling needed for one bottle of collection container can be calculated again according to pre-set flow velocity, when the corresponding time arrives, control assembly makes switch valve 7 close, and mobile transfer arm assembly 2 moves to next collection container place, period, cut temporarily stores in collection liquid buffer 17; When reaching above next collection container, control assembly makes switch valve 7 open, be cached in the cut collected in liquid buffer 17 and enter into this collection container, when control assembly obtains filling the time needed for this collection container according to the volume of collection container and pre-set flow velocity, continue to repeat above-mentioned steps, fraction collection is carried out to next collection container again;
Finally, after liquid chromatograph detects that all fraction collections complete, the flow direction of multiport valve 4 is set as flowing out from water influent pipeline 3 to waste-solution line 5 by control assembly.
So far, a circulation is completed.
Above-described specific embodiment; technical matters, technical scheme and beneficial effect that the present invention solves are further described; be understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. avoid a preparative fraction collector for sample loss, it is characterized in that, it comprises:
Fixed support (1);
Transfer arm assembly (2), described transfer arm assembly (2) is connected on fixed support (1);
Gathering-device, described gathering-device is arranged on transfer arm assembly (2), described gathering-device comprises collects liquid buffer (17), water influent pipeline part and collecting part (8), the import of described water influent pipeline part is used for exporting with the liquid medium of separating column being connected, the outlet of described water influent pipeline part is connected with the import of collecting liquid buffer (17), the outlet of described collection liquid buffer (17) is connected with the import of collecting part (8), the outlet of collecting part (8) is used for trickle medium in collection container (9), described collecting part (8) is also provided with switch valve (7),
Control assembly, the control output end of described control assembly is connected with the control signal input end of transfer arm assembly (2), to be controlled the action of transfer arm assembly (2) manually or automatically by control assembly, the control output end of described control assembly is also connected with the control signal input end of switch valve (7), so that by the action of control assembly gauge tap valve (7) manually or automatically.
2. the preparative fraction collector avoiding sample loss according to claim 1, it is characterized in that: also comprise waste-solution line (5), described water influent pipeline part has multiport valve (4), water influent pipeline (3) and fluid pipeline (28), the outlet of water influent pipeline (3) is connected with an import of multiport valve (4), the import of fluid pipeline (28) is connected with an outlet of multiport valve (4), another of the import of waste-solution line (5) and multiport valve (4) exports and is connected, the outlet of fluid pipeline (28) is connected with the import of collecting liquid buffer (17), the control signal input end of described multiport valve (4) is connected with the control output end of control assembly, to be controlled the action of multiport valve (4) by control assembly.
3. the preparative fraction collector avoiding sample loss according to claim 1 and 2, is characterized in that: the exit of described water influent pipeline part is provided with shower nozzle (18).
4. the preparative fraction collector avoiding sample loss according to claim 1, is characterized in that: described collection liquid buffer (17) is provided with pressure compensation mouth (6).
5. the preparative fraction collector avoiding sample loss according to claim 1, it is characterized in that: described transfer arm assembly (2) has power source, the control output end of described control assembly is connected with the control signal input end of power source, to control power source by control assembly, thus control the action of transfer arm assembly (2).
6. the preparative fraction collector avoiding sample loss according to claim 1, it is characterized in that: also comprise collection container rack (20), described collection container rack (20) is provided with collection container chassis or has the collection container receptacle body of multiple collection container jack (11), collection container chassis or collection container receptacle body are for placing described collection container (9).
7. the preparative fraction collector avoiding sample loss according to claim 6, it is characterized in that: described control assembly has master control borad (22) and collection container rack control panel, described collection container rack control panel is arranged on described collection container rack (20), and this collection container rack control panel transmits with master control borad (22) two-way signaling and is connected.
8. the preparative fraction collector avoiding sample loss according to claim 6 or 7, it is characterized in that: described collection container rack (20) is also provided with collection container recognition device (14), and collection container recognition device (14) and collection container (9) corresponding, so that collection container recognition device (14) is for gathering the collection container status information in collection container chassis or collection container jack (11), the control output end of described collection container recognition device (14) is connected with the signal input part of control assembly, so that control assembly controls the action of transfer arm assembly (2) according to the collection container status information received.
9. the preparative fraction collector avoiding sample loss according to claim 1 or 6 or 7, is characterized in that: also include display module (12), and described display module (12) is connected with control assembly.
10. the preparative fraction collector avoiding sample loss according to claim 1 or 6 or 7, is characterized in that: also include power autonomous module and/or external power source interface.
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