CN104888283A - Acupuncture needle with medical membrane and preparation method of acupuncture needle - Google Patents
Acupuncture needle with medical membrane and preparation method of acupuncture needle Download PDFInfo
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- CN104888283A CN104888283A CN201510324030.2A CN201510324030A CN104888283A CN 104888283 A CN104888283 A CN 104888283A CN 201510324030 A CN201510324030 A CN 201510324030A CN 104888283 A CN104888283 A CN 104888283A
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Abstract
The invention discloses an acupuncture needle with a medical membrane. The acupuncture needle comprises a needle body formed by metal substrates, wherein a graft polymer layer and a medical membrane layer are sequentially arranged on the surface of the needle body from inside to outside. The invention further provides a preparation method of the acupuncture needle, which is implemented through plasma surface treatment. The acupuncture needle with the medical membrane is prepared by adopting a low-temperature plasma polymer grafting method rather than a coating method, so that the novel acupuncture needle with salvianolate effective groups being fixed on the needle surface is achieved, the growth of effective groups of drugs on the metallic surface is successively realized, the purpose of perfectly combining acupuncture with acupoint fixed-point and controllable drug delivery is achieved, the acupuncture therapeutic effect is improved, and a broad market application prospect is achieved.
Description
Technical field
The present invention relates to medical supplies industry, be specifically related to a kind of acupuncture needle with medicine film and preparation method thereof.
Background technology
Acupuncture is an ancient medical science, has experienced various vicissitudes of life and stands erect in the woods of world medicine, demonstrates vitality and unique charm.Acupuncture comprises the skill of handling needles and moxibustion therapy.The skill of handling needles utilizes special needle set, by the optimal stimulation to meridional point, nurses one's health through gas to reach a kind of external treatment of disease preventing and treating.Moxibustion therapy is then, after being lighted by moxa, the meridional point of body surface carries out a kind of external treatment of burning or fire-cureing and curing the disease.
The development of acupuncture be unable to do without progress and the reform of acupuncture instrument.Acupuncture needle to acupuncture needle, acupuncture needle, then to stainless pin, acusector, magnetic needle, microwave and ultrasound therapeutic instrument etc., has enriched acupuncture and moxibustion therapy means by bronze pin.But current acupuncture needle can only carry out acupuncture of a point moxibustion mostly, medicine can not be made effectively to arrive acupuncture point deep layer, thus medicine can not be made to give full play to drug effect.
Therefore, patent CN200320112401.3 and patent CN200420120971.1 reports the acupuncture needle with medicine film.They are all adopt painting method, medicine is prepared as medicine film in acupuncture needle surface, is then brought in human body medicine to play its drug effect into by acupuncture.
Summary of the invention
Salvianolate is that what to extract from single medicinal material Radix Salviae Miltiorrhizae take Radix Salviae Miltiorrhizae acetate magnesium as the poly phenolic acid of Radix Salviae Miltiorrhizae salt compounds of main component, have invigorate blood circulation, blood stasis dispelling, the effect of promoting blood circulation and good clinical tolerability, compared with Chinese medicine Radix Salviae Miltiorrhizae, there is the advantages such as effective ingredient is clear and definite, quality is easily monitored, toxic and side effects is little, stable curative effect, be successfully applied to the treatment of various diseases.
Inventor finds, because salvianolate is primarily of 8 kinds of groups: Radix Salviae Miltiorrhizae acetate magnesium (MLB) 80%, all the other 20% be danshensu potassium, rosmarinic acid sodium, alkannic acid dipotassium, alkannic acid magnesium, Radix Salviae Miltiorrhizae acetic acid dipotassium, salvianolic acid G magnesium and different Radix Salviae Miltiorrhizae acetic acid dipotassium composition, finished medicines is powder, can be mixed with dipping graft copolymer solution with 15 ~ 30% ethanol waters.
During acupuncture treatment, acupuncture needle (acupuncture needle) can the dexterous certain depth arriving acupuncture point, if at the specific medicine of the surface combination of acupuncture needle, according to patient's body, age, disease character, acupuncture position difference, the difference of the acupuncture point depth is thrust with acupuncture needle, medicine is transported in human acupoint different aspects, different tissues structure, when heating acupuncture needle, temperature range (30 ~ 55 DEG C) the controllability release that pharmaceutical group adapts at human body, thus give full play to pin and medicament dual therapeutic effect, to improve clinical efficacy.But the material of acupuncture needle is metal material, is generally rustless steel, based on the characteristic of metallic molecule, its surface does not have the group that can be combined with medicine, and therefore medicine is difficult on its surface by effectively bind.Therefore, when adopting the method for coating to prepare its medicine film, in the process implementing acupuncture, due to insecure at the drug molecule of acupuncture needle surface binding, medicine does not usually reach acupuncture point place and just loses completely, thus cannot reach the object of the accurate administration in acupuncture point.
Therefore, need at present a kind of can the acupuncture needle and preparation method thereof of the effective group of effectively bind salvianolate.
For solving the problem, the invention provides a kind of acupuncture needle with medicine film, it comprises the needle body of metal base, and described needle body surface is also provided with graft polymer layer and medicine film layer from the inside to the outside successively; Described graft polymer layer prepares with the grafted monomers shown in plasma polymer layer and formula I;
Wherein, R
1for methyl or H, R
2for alkoxyl, hydroxyl, hydroxyalkyl, sulfonate substituent or amido;
The polymer layer monomer of described plasma polymer layer is selected from methane, ethane, propane, butane, ethylene, propylene or butylene;
Described medicine film layer is the pharmaceutical group layer that can be combined with described graft polymer layer.The described pharmaceutical group layer that can be combined with described graft polymer layer refers to the pharmaceutical group layer with following characteristics:
Pharmaceutical group in pharmaceutical group layer comprises the active substructure that can combine with the carbonyl in graft polymer layer, alkoxyl, hydroxyl, hydroxyalkyl, sulfonate substituent or amido isoreactivity group, and described active substructure comprises one or more hydroxyl, carboxyl, carbonyl, phenolic group etc.Therefore, those skilled in the art can know by inference according to general knowledge, and above-mentioned medicine film layer includes but not limited to that poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer, ginsenoside's group, astragaloside group layer and flavone group layer etc. have the pharmaceutical group layer of above-mentioned feature.
Further preferably, described pharmaceutical group layer is selected from poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer, ginsenoside's group, astragaloside group layer or flavone group layer.
Further preferably, described acupuncture needle is stainless filiform needle.
Further preferably, the needle length of the described needle body is 25-50mm, and diameter of needle body is 0.30-0.32mm.
Further preferably, described polymer layer monomer is selected from methane, and grafted monomers is selected from acrylic acid;
Or polymer layer monomer is selected from propane, and grafted monomers is selected from acrylic acid;
Or polymer layer monomer is selected from ethane, and grafted monomers is selected from methyl methacrylate;
Or polymer layer monomer is selected from ethylene, and grafted monomers is selected from methyl methacrylate.
Further preferably, described medicine film layer is poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer, and the quality of medicine film layer is 0.5-20mg, preferred 1-6mg.
Meanwhile, cannot the problem of effective fixed drug in order to solve existing metal needle acupuncture needle, present invention also offers a kind of using plasma surface treatment method and carry out the fixing method of salvianolate.
The method of the present invention by stainless filiform needle is contacted with multiple plasma organic gas, at the active group of acupuncture needle surface aggregate and grafting formation and good ester group, hydroxyl, carboxyl and the amino etc. of metal adhesive, can there is chemical bonding with salvia root polyphenol salt by aseptic dipping in above active group, thus grow with kind of the effective group of 8 in salvia root polyphenol salt securely and be attached to acupuncture needle surface.Further, the quantity of the poly phenolic acid of Radix Salviae Miltiorrhizae salt groups on acupuncture needle surface can also by controlling whole technical process to adjust.It should be noted that the poly phenolic acid of Radix Salviae Miltiorrhizae salt groups on acupuncture needle surface after acupuncture needle thrusts human body, can only realize slow release in the situation of heating (human body allowable temperature) in body fluid.Therefore, the multiple action of acupuncture when acupuncture needle of the present invention can give full play to acupuncture and moxibustion therapy, hot moxibustion and acupuncture point medicine feed is the desirable crystallization of Traditional Chinese Medicine acupuncture and modern science and technology
The technology used in the present invention comprises: the method first utilizing low temperature plasma surface clean, cleans acupuncture needle surface, removes the pollutant on its surface, to provide the surface of molecule level cleaning for follow-up step; Then, utilize the method for low temperature plasma polymerization, at acupuncture needle surface aggregate one deck alkanes polymer as transition zone.Being for improving the adhesion with matrix on the one hand, is the grafting for the ease of carrying out active group on transition zone on the other hand; Then, transition zone carries out plasma grafting, utilize the monomeric substance with double bond and ester group, hydroxyl, carboxyl or amino, after plasmarized, graft on the transition zone surface of acupuncture needle; Finally, the acupuncture needle after above step process be impregnated in poly phenolic acid of Radix Salviae Miltiorrhizae saline solution at a certain temperature, the group of the active group on acupuncture needle surface in salvianolate is combined, thus is firmly secured to acupuncture needle surface.
The processing step of preparation method of the present invention is specific as follows: (1) prepares plasma polymer layer on acupuncture needle surface: on clean acupuncture needle surface, using hydrocarbon monomer as the monomer of plasma polymer layer, utilization waits daughter polymerization technique to prepare the acupuncture needle that surface has plasma polymer layer; Described hydrocarbon monomer is selected from methane, ethane, propane, butane, ethylene, propylene or butylene; (2) graft polymer layer is prepared: with monomer shown in formula I for grafted monomers raw material, the plasma polymer layer surface obtained in step (1), utilize plasma grafting technique to obtain acupuncture needle that surface has graft polymer layer; (3) medicine film layer is prepared at graft polymer layer surface impregnation: impregnated in drug solution by the acupuncture needle that step (2) obtains, flood complete post-drying and get final product.
Further preferably, in step (1), described acupuncture needle surface is the acupuncture needle surface through plasma clean activation, and the process conditions of wherein plasma clean activation are: working gas: high purity oxygen gas; Or the mist of oxygen and noble gas, oxygen and inert gas ratio are 1:0.5 ~ 4; Described noble gas is selected from argon, nitrogen or helium; Operating air pressure: 5-50Pa; Electric field supply frequency: 40KHz-80KHz or 13.56MHz; Processing time: 1-300 second.
Further preferably, in step (1), the process conditions of described plasma polymerization are: working gas: hydrocarbon monomer gas; Or the mol ratio of hydrocarbon monomer gas and noble gas argon or helium is 1:(1-5) mist; Operating air pressure: 5-50Pa; Supply frequency: 40KHz-80KHz or 13.56MHz; Processing time: 10-600 second.
Further preferably, in step (1), the process conditions of described plasma polymerization are: working gas: methane gas; Operating air pressure: 30Pa; Supply frequency: 40KHz; Processing time: 300 seconds;
Or, working gas: the mist of ethane and argon; Operating air pressure: 30Pa; Supply frequency: 13.56MHz; Processing time: 300 seconds;
Or, working gas: the mist of ethylene gas and helium; Operating air pressure: 30Pa; Supply frequency: 13.56MHz; Processing time: 400 seconds;
Or, working gas: the mist of propane gas and helium; Operating air pressure: 40Pa; Supply frequency: 80KHz; Processing time: 350 seconds.
Further preferably, in step (2), described grafted monomers is selected from acrylic or methacrylic acid methyl ester.
Further preferably, in step (2), the process conditions of described plasma grafting are: working gas: grafted monomers; Operating air pressure: 5-50Pa; Supply frequency: 20KHz-100KHz or 13.56MHz processing time: 10-600 second.
Further preferably, in the technique of described plasma clean, polymerization or grafting, vacuum is 15-30Pa.
Further preferably, described drug solution is prepared by poly phenolic acid of Radix Salviae Miltiorrhizae salt powder and 15-30% alcoholic solution, and wherein, the concentration of salvianolate is 2-6%.
Described drug solution also can be selected from ginsenoside and other Chinese medicine solution, can be used for the preparation of ginsenoside's medicine film pin and other Chinese medicine film pins.
Further preferably, in step (3), the process conditions of described dipping and oven dry are:
Dipping temperature: 60-80 DEG C;
Dip time: 3-60 minute;
Bake out temperature: 30-70 DEG C;
Drying time: 1-60 minute.
Further preferably, in step (4), the environment of described dipping is gnotobasis.
Present invention also offers a kind of acupuncture needle with medicine film, it is the acupuncture needle obtained by above-mentioned preparation method.Its preparation process meets describing of aforementioned preparation process completely, and preparation technology parameter is also in the scope of above-mentioned technological parameter.
The acupuncture needle of band medicine film of the present invention, be different from painting method and prepare medicine film, but adopt the method for low temperature plasma polymerization grafting, prepare the new type acupuncture needle being fixed with poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer on acupuncture needle surface, overcome the problem that poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer effectively cannot be fixed on metal surface, successfully achieve the growth of the effective organic group of medicine on metal surface, the object of administration perfect adaptation of acupuncture and acupuncture point being fixed a point can be reached, improve therapeutic effect of acupuncture and moxibustion.
Acupuncture needle (filiform needle): be a kind of conventional acupuncture needle, be made with metal is that needle material person processed is the most frequently used with rustless steel.Stainless filiform needle has higher intensity and toughness, and the straight and upright sliding profit of needle body, can be heat-resisting and antirust, not easily corroded by chemical substance, therefore extensively adopted clinically at present.Also the acupuncture needle that makes of useful other metals, as acupuncture needle, acupuncture needle, though its conduction, heat transfer property are obviously better than stainless filiform needle, needle body is comparatively thick, and intensity, toughness are not as stainless pin, in addition expensive, generally clinically more seldom uses.
Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Accompanying drawing explanation
Fig. 1 is preparation technology's flow process of acupuncture needle of the present invention.
Detailed description of the invention
Instrument of the present invention and raw material all come from commercially available commodity.
Embodiment 1
1 cun, Huatuo's board (the long 25mm of the needle body)/No. 31 (diameter of needle body 0.30mm) stainless filiform needles that sample adopts Suzhou medical supplies company limited to produce, plasma clean, polymerization and grafting adopt Plasma Science and Technology Co., Ltd. Suzhou Hops to produce DT-03 type gas ions surface treatment instrument.
First, sample is laid on pallet, opens process chamber door, pallet is put between electrode, closing process chamber door.Start vacuum pump, to cavity evacuation, when vacuum reaches 15Pa, pass into purge gas, acupuncture needle surface is cleaned, remove the pollutant on its surface.The process conditions of plasma clean are: working gas: purity oxygen (steel cylinder gas); Operating air pressure: 30Pa; Supply frequency: 40KHz; Processing time: 120 seconds; When arriving the processing time, powered-down stopped reaction, closes purge gas, continues evacuation, when vacuum reaches 15Pa, passes into polymerizable gas, utilize the method for low temperature plasma polymerization, at acupuncture needle surface aggregate one deck alkanes polymer as transition zone.The process conditions of plasma polymerization are: working gas: methane gas (steel cylinder gas); Operating air pressure: 30Pa; Supply frequency: 40KHz; Processing time: 300 seconds; When arriving the processing time, powered-down stopped reaction, closes polymerizable gas, continues evacuation, when vacuum reaches 15Pa, passes into grafting gas, transition zone carries out plasma grafting.The process conditions of plasma grafting are: working gas: acrylic monomers (liquid boil-off gas); Operating air pressure: 35Pa; Supply frequency: 40KHz; Processing time: 300 seconds; When arriving the processing time, powered-down stopped reaction, closes grafting gas, stops evacuation, opens emptying gas and pour process chamber, after cavity internal and external pressure balance, closes purge valve, opens process chamber door, remove pallet, take out sample.
Acupuncture needle after above step process impregnated in poly phenolic acid of Radix Salviae Miltiorrhizae saline solution in aseptic environment, dip time 5 minutes, dipping temperature 40 DEG C, salvianolate solution preparation is: poly phenolic acid of Radix Salviae Miltiorrhizae salt powder (upper sea green paddy drugmaker)+20% ethanol water, poly phenolic acid of Radix Salviae Miltiorrhizae concentration of salt solution: 2%; Dried by acupuncture needle after having flooded, drying condition is: temperature 70 degree, drying time: 10 minutes.The mono-acupuncture needle of poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group quality 1mg/.
Embodiment 2
1.5 cun, Huatuo's board (the long 40mm of the needle body)/No. 31 (diameter of needle body 0.30mm) stainless filiform needles that sample adopts Suzhou medical supplies company limited to produce, the DT-03 type plasma surface treatment instrument that plasma clean, polymerization and grafting adopt Plasma Science and Technology Co., Ltd. Suzhou Hops to produce.
First sample is laid on pallet, opens process chamber door, pallet is put between electrode, closing process chamber door.Start vacuum pump, to cavity evacuation, when vacuum reaches 15Pa, pass into purge gas, acupuncture needle surface is cleaned, remove the pollutant on its surface.The process conditions of plasma clean are: the method utilizing low temperature plasma surface clean, clean acupuncture needle surface, remove the pollutant on its surface.The process conditions of plasma clean are: working gas: oxygen and argon (steel cylinder gas), oxygen/argon (flow-rate ratio)=1:2; Operating air pressure: 40Pa; Supply frequency: 13.56MHz; Processing time: 120 seconds; When arriving the processing time, powered-down stopped reaction, closes purge gas, continue evacuation, when vacuum reaches 15Pa, pass into the mist of polymerizable gas and argon, utilize the method for low temperature plasma polymerization, at acupuncture needle surface aggregate one deck alkanes polymer as transition zone.The process conditions of plasma polymerization are: working gas is ethane gas and argon gaseous mixture (steel cylinder gas); Ethane gas: argon=1:3 (mol ratio); Operating air pressure: 45Pa; Supply frequency: 13.56MHz; Processing time: 300 seconds; When arriving the processing time, powered-down stopped reaction, closes polymerizable gas, continues evacuation, when vacuum reaches 15Pa, passes into grafting gas, transition zone carries out plasma grafting.The process conditions of plasma grafting are: working gas: methyl methacrylate monomer (liquid boil-off gas); Operating air pressure: 35Pa; Supply frequency: 13.56MHz; Processing time: 300 seconds; When arriving the processing time, powered-down stopped reaction, closes grafting gas, stops evacuation, opens emptying gas and pour process chamber, after cavity internal and external pressure balance, closes purge valve, opens process chamber door, take out pallet, take out sample.
Acupuncture needle after above step process impregnated in the poly phenolic acid of Radix Salviae Miltiorrhizae saline solution of ultraviolet disinfection, dip time 10 minutes, dipping temperature 45 DEG C, salvianolate solution preparation is: poly phenolic acid of Radix Salviae Miltiorrhizae salt powder (upper sea green paddy drugmaker)+25% ethanol water, poly phenolic acid of Radix Salviae Miltiorrhizae concentration of salt solution: 4%; Finally, the acupuncture needle after dipping is dried, and drying condition is: temperature 70 degree, drying time: 10 minutes.Poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group quality: the mono-acupuncture needle of 4mg/.
Embodiment 3
Huatuo's board 2 cun of (50mm)/No. 30 (diameter 0.32mm) stainless filiform needle that sample adopts Suzhou medical supplies company limited to produce, the DT-03 type plasma surface treatment instrument that plasma treatment adopts Plasma Science and Technology Co., Ltd. Suzhou Hops to produce.
First sample is laid on pallet, opens process chamber door, pallet is put between electrode, closing process chamber door.Start vacuum pump, to cavity evacuation, when vacuum reaches 20Pa, pass into purge gas, acupuncture needle surface is cleaned, remove the pollutant on its surface.The process conditions of plasma clean are: the method utilizing low temperature plasma surface clean, clean acupuncture needle surface, remove the pollutant on its surface.The process conditions of plasma clean are: working gas: oxygen and argon (steel cylinder gas), oxygen/argon (flow-rate ratio)=1:0.5; Operating air pressure: 30Pa; Supply frequency: 50KHz; Processing time: 60 seconds; When arriving the processing time, powered-down stopped reaction, closes purge gas.Continue subsequently to keep vacuum at 20Pa, opening power, passes into polymerizable gas, utilizes the method for low temperature plasma polymerization, at acupuncture needle surface aggregate one deck olefin polymer as transition zone.The process conditions of plasma polymerization are: working gas: ethylene gas and helium mix gas (steel cylinder gas), ethylene gas: helium ratio=1:1 (mol ratio); Operating air pressure: 35Pa; Supply frequency: 13.56MHz; Processing time: 400 seconds; When arriving the processing time, powered-down stopped reaction, closes polymerizable gas, continues evacuation, when vacuum reaches 15Pa, passes into grafting gas, transition zone carries out plasma grafting.The process conditions of plasma grafting are: working gas: methyl methacrylate monomer (liquid boil-off gas); Operating air pressure: 45Pa; Supply frequency: 13.56MHz; Processing time: 300 seconds; ; When arriving the processing time, powered-down stopped reaction, closes grafting gas, stops evacuation, opens emptying gas and pour process chamber, after cavity internal and external pressure balance, closes purge valve, opens process chamber door, remove pallet, take out sample.
Acupuncture needle after above step process impregnated in poly phenolic acid of Radix Salviae Miltiorrhizae saline solution in aseptic environment, dip time 18 minutes, dipping temperature 50 DEG C, salvianolate solution preparation is: poly phenolic acid of Radix Salviae Miltiorrhizae salt powder (upper sea green paddy drugmaker)+20% ethanol water, poly phenolic acid of Radix Salviae Miltiorrhizae concentration of salt solution: 3%; Finally, the acupuncture needle after dipping is dried, and drying condition is: temperature 70 degree, drying time: 10 minutes.Poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group quality: the mono-acupuncture needle of 6mg/.
Embodiment 4:
1.5 cun, Huatuo's board (the long 40mm of the needle body)/No. 31 (diameter of needle body 0.30mm) stainless filiform needles that sample adopts Suzhou medical supplies company limited to produce, the DT-03 type plasma surface treatment instrument that plasma treatment adopts Plasma Science and Technology Co., Ltd. Suzhou Hops to produce.
First sample is laid on pallet, opens process chamber door, pallet is put between electrode, closing process chamber door.Start vacuum pump, to cavity evacuation, when vacuum reaches 30Pa, pass into purge gas, acupuncture needle surface is cleaned, remove the pollutant on its surface.The process conditions of plasma clean are: the method utilizing low temperature plasma surface clean, clean acupuncture needle surface, remove the pollutant on its surface.The process conditions of plasma clean are: working gas: oxygen and argon (steel cylinder gas), oxygen/argon (flow-rate ratio)=1:3; Operating air pressure: 35Pa; Supply frequency: 80KHz; Processing time: 30 seconds; When arriving the processing time, powered-down stopped reaction, closes purge gas.Continue subsequently to keep vacuum at 30Pa, opening power, passes into polymerizable gas, utilizes the method for low temperature plasma polymerization, at acupuncture needle surface aggregate one deck alkanes polymer as transition zone.The process conditions of plasma polymerization are: working gas: propane gas and helium mix gas (steel cylinder gas), propane flammable gas: helium=1:4 (mol ratio); Operating air pressure: 40Pa; Supply frequency: 80KHz; Processing time: 350 seconds; When arriving the processing time, powered-down stopped reaction, closes polymerizable gas, passes into grafting gas, transition zone carries out plasma grafting.The process conditions of plasma grafting are: working gas: acrylic monomers (liquid boil-off gas); Operating air pressure: 35Pa; Supply frequency: 13.56MHz; Processing time: 300 seconds; When arriving the processing time, powered-down stopped reaction, closes grafting gas, stops evacuation, opens emptying gas and pour process chamber, after cavity internal and external pressure balance, closes purge valve, opens process chamber door, remove pallet, take out sample.
Acupuncture needle after above step process impregnated in poly phenolic acid of Radix Salviae Miltiorrhizae saline solution in aseptic environment, dip time 8 minutes, dipping temperature 45 DEG C, salvianolate solution preparation is: poly phenolic acid of Radix Salviae Miltiorrhizae salt powder (upper sea green paddy drugmaker)+25% ethanol water, poly phenolic acid of Radix Salviae Miltiorrhizae concentration of salt solution: 2%; Finally, the acupuncture needle after dipping is dried, and drying condition is: temperature 80 DEG C, 15 minutes time.Poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group quality: the mono-acupuncture needle of 2mg/.
In sum, the form of using plasma of the present invention polymerization and grafting process is at the active group of metal needle acupuncture needle surface grafting and good hydroxyl, carboxyl and the amino etc. of metal adhesive, can there is chemical bonding with salvia root polyphenol salt by aseptic dipping in this active group, thus grow with kind of the effective group of 8 in salvia root polyphenol salt securely and be attached to acupuncture needle surface.In addition, the quantity of acupuncture needle surface poly phenolic acid of Radix Salviae Miltiorrhizae salt groups by controlling whole technical process to adjust, can be applicable to different clinical demands.Therefore, the multiple action of acupuncture when acupuncture needle of the present invention can give full play to acupuncture and moxibustion therapy, hot moxibustion and acupuncture point medicine feed, is the desirable crystallization of Traditional Chinese Medicine acupuncture and modern science and technology, has wide market application foreground.
Claims (16)
1. the acupuncture needle with medicine film, is characterized in that: it comprises the needle body of metal base, and described needle body surface is also provided with graft polymer layer and medicine film layer from the inside to the outside successively;
Described graft polymer layer prepares with the grafted monomers shown in plasma polymer layer and formula I;
Wherein, R
1for methyl or H, R
2for alkoxyl, hydroxyl, hydroxyalkyl, sulfonate substituent or amido;
The polymer layer monomer of described plasma polymer layer is selected from methane, ethane, propane, butane, ethylene, propylene or butylene;
Described medicine film layer is the pharmaceutical group layer that can be combined with described graft polymer layer.
2. acupuncture needle according to claim 1, is characterized in that: described acupuncture needle is stainless filiform needle.
3. acupuncture needle according to claim 1 and 2, is characterized in that: described needle length is 25-50mm, and diameter is 0.28-0.32mm.
4. acupuncture needle according to claim 1 and 2, is characterized in that:
Described polymer layer monomer is selected from methane, and grafted monomers is selected from acrylic acid;
Or polymer layer monomer is selected from propane, and grafted monomers is selected from acrylic acid;
Or polymer layer monomer is selected from ethane, and grafted monomers is selected from methyl methacrylate;
Or polymer layer monomer is selected from ethylene, and grafted monomers is selected from methyl methacrylate.
5. acupuncture needle according to claim 4, is characterized in that: described medicine film layer is poly phenolic acid of Radix Salviae Miltiorrhizae salt groups group layer, and the quality of medicine film layer is 0.5-20mg.
6. prepare a method for the arbitrary described acupuncture needle of claim 1-5, it is characterized in that: comprise the following steps:
(1) prepare plasma polymer layer on acupuncture needle surface: on clean acupuncture needle surface, using hydrocarbon monomer as the monomer of plasma polymer layer, utilization waits daughter polymerization technique to prepare the acupuncture needle that surface has plasma polymer layer; Described hydrocarbon monomer is selected from methane, ethane, propane, butane, ethylene, propylene or butylene;
(2) graft polymer layer is prepared: with monomer shown in formula I for grafted monomers raw material, the plasma polymer layer surface obtained in step (1), utilize plasma grafting technique to obtain acupuncture needle that surface has graft polymer layer;
(3) medicine film layer is prepared at graft polymer layer surface impregnation: impregnated in drug solution by the acupuncture needle that step (2) obtains, flood complete post-drying and get final product.
7. preparation method according to claim 6, is characterized in that: in step (1), and described acupuncture needle surface is the acupuncture needle surface through plasma clean activation, and the process conditions of wherein plasma clean activation are:
Working gas: high purity oxygen gas; Or the mist of oxygen and noble gas, oxygen and inert gas ratio are 1:0.5 ~ 4; Described noble gas is selected from argon, nitrogen or helium;
Operating air pressure: 5-50Pa;
Electric field supply frequency: 40KHz-80KHz or 13.56MHz;
Processing time: 1-300 second.
8. preparation method according to claim 6, is characterized in that: in step (1), and the process conditions of described plasma polymerization are:
Working gas: hydrocarbon monomer gas; Or the mol ratio of hydrocarbon monomer gas and noble gas argon or helium is 1:(1-5) mist;
Operating air pressure: 5-50Pa;
Supply frequency: 40KHz-80KHz or 13.56MHz;
Processing time: 10-600 second.
9. preparation method according to claim 8, is characterized in that: in step (1), and the process conditions of described plasma polymerization are:
Working gas: methane gas;
Operating air pressure: 30Pa;
Supply frequency: 40KHz;
Processing time: 300 seconds;
Or, working gas: the mist of ethane and argon;
Operating air pressure: 30Pa;
Supply frequency: 13.56MHz;
Processing time: 300 seconds;
Or, working gas: the mist of ethylene gas and helium;
Operating air pressure: 30Pa;
Supply frequency: 13.56MHz;
Processing time: 400 seconds;
Or, working gas: the mist of propane gas and helium;
Operating air pressure: 40Pa;
Supply frequency: 80KHz;
Processing time: 350 seconds.
10. preparation method according to claim 6, is characterized in that: in step (2), and described grafted monomers is selected from acrylic or methacrylic acid methyl ester.
11. preparation methoies according to arbitrary one of claim 6-10, it is characterized in that: in step (2), the process conditions of described plasma grafting are:
Working gas: grafted monomers;
Operating air pressure: 5-50Pa;
Supply frequency: 20KHz-100KHz or 13.56MHz;
Processing time: 10-600 second.
12. preparation methoies according to arbitrary one of claim 6-10, is characterized in that: in the technique of described plasma clean, polymerization or grafting, and vacuum is 15-30Pa.
13. preparation methoies according to claim 6, is characterized in that: described drug solution is prepared by poly phenolic acid of Radix Salviae Miltiorrhizae salt powder and 15-30% alcoholic solution, and wherein, the concentration of salvianolate is 2-6%.
14. preparation methoies according to claim 6 or 13, it is characterized in that: in step (3), the process conditions of described dipping and oven dry are:
Dipping temperature: 60-80 DEG C;
Dip time: 3-60 minute;
Bake out temperature: 30-70 DEG C;
Drying time: 1-60 minute.
15. preparation methoies according to claim 7, is characterized in that: in step (3), and the environment of described dipping is gnotobasis.
16. 1 kinds of acupuncture needles with medicine film, is characterized in that: it is obtained by the preparation method described in arbitrary one of claim 7-16.
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| CN201510324030.2A CN104888283A (en) | 2015-06-12 | 2015-06-12 | Acupuncture needle with medical membrane and preparation method of acupuncture needle |
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| CN (1) | CN104888283A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922791A (en) * | 2015-05-26 | 2015-09-23 | 上海交通大学 | Noninvasive acupuncture patch and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87102738A (en) * | 1987-04-15 | 1988-12-21 | 北京工业学院 | Macromolecular substance is the plasma polymerization of monomer source |
| CN1422607A (en) * | 2001-12-07 | 2003-06-11 | 李永熙 | Needle with coating for muscle stimulation treatment device |
| CN1488462A (en) * | 2003-08-20 | 2004-04-14 | 东华大学 | Nano particle surface physicochemical structure cutting and coating method |
| CN1893822A (en) * | 2003-11-17 | 2007-01-10 | 生物之门股份公司 | Antimicrobial composite material |
| CN103328686A (en) * | 2010-11-16 | 2013-09-25 | 凯普卓尼克技术公司 | Metal coating of objects using plasma polymerisation |
| CN203802801U (en) * | 2014-01-29 | 2014-09-03 | 上海润知生物科技有限公司 | Thumbtack needle for acupuncture |
-
2015
- 2015-06-12 CN CN201510324030.2A patent/CN104888283A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87102738A (en) * | 1987-04-15 | 1988-12-21 | 北京工业学院 | Macromolecular substance is the plasma polymerization of monomer source |
| CN1422607A (en) * | 2001-12-07 | 2003-06-11 | 李永熙 | Needle with coating for muscle stimulation treatment device |
| CN1488462A (en) * | 2003-08-20 | 2004-04-14 | 东华大学 | Nano particle surface physicochemical structure cutting and coating method |
| CN1893822A (en) * | 2003-11-17 | 2007-01-10 | 生物之门股份公司 | Antimicrobial composite material |
| CN103328686A (en) * | 2010-11-16 | 2013-09-25 | 凯普卓尼克技术公司 | Metal coating of objects using plasma polymerisation |
| CN203802801U (en) * | 2014-01-29 | 2014-09-03 | 上海润知生物科技有限公司 | Thumbtack needle for acupuncture |
Non-Patent Citations (1)
| Title |
|---|
| 杨武保、蔡泽勇、赵震、其鲁: "等离子体辅助甲烷聚合物制备及分析", 《核聚变与等离子体物理》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922791A (en) * | 2015-05-26 | 2015-09-23 | 上海交通大学 | Noninvasive acupuncture patch and preparation method thereof |
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Application publication date: 20150909 |