CN104887879B - Application of the Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis agents - Google Patents
Application of the Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis agents Download PDFInfo
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Abstract
The present invention relates to a kind of application of the hot 13 taste roc bird balls of Tibetan medicine Sa in preparation treatment osteoporosis agents, the technology prejudice of prior art application aspect is overcome, Sa 13 taste roc bird balls of heat are significantly improved effect to HOP index in the bone density, bone biomechanical index, urine of rat model and Biochemical Indices In Serum.Sa 13 taste roc bird balls of heat can be used for the treatment of osteoporosis, be used especially for the treatment of osteoporosis caused by estrogen lacks.
Description
Technical field
The present invention relates to a kind of application of the hot 13 taste roc bird balls of Tibetan medicine Sa in preparation treatment osteoporosis agents, belong to
In field of medicaments.
Background technique
Osteoporosis, that is, osteoporosis is the disease caused by many factors, with skeleton pain, is easy to fracture as spy
Sign.The factors such as it and age, hormone, heredity, nutrition intake and life style have close relationship, and pathogenesis is main
It is the increased activity of osteoclast, and osteoblast activity is inhibited, the infiltration rate of bone is more than to form speed, causes bone group
Organic matter and inorganic matter in knitting are reduced.It is reported that in 50 years old Chinese or more crowd, there are about 70,000,000 people to suffer from osteoporosis,
Middle women disease incidence is more than 30%, and with continuing to increase for the aged, osteoporosis will become increasingly severe publilc health
It threatens.
Sa 13 taste Peng Niaowanxi Tibetan proved recipes of heat, form as muscone, radix aucklandiae, Rhizoma Acori Calami, Aconitum Szechenyianum Gay, myrobalan, coral
Coral, pearl, cloves, nutmeg, agalloch eaglewood, magnetite, licorice root ointment, 13 taste medicinal material of limonite, have anti-inflammatory analgetic, and clearing and activating the channels and collaterals is waken up
Brain is had one's ideas straightened out effect.For apoplexy, facial paralysis caused by " white vein ", paralysis and numbness, vasculitis, tenosynovitis, extremities joint is not
Benefit, leprosy etc..
Although there are many major function of Sa 13 taste roc bird balls of heat, document, patent etc. do not find that it can be used for
The research for treating osteoporosis.
Summary of the invention
The present invention is achieved through the following technical solutions:
Application of the Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis agents.
Application of the component of Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis agents.
Application of the component of Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis agents, using hot 13 tastes of Sa
The extract of component or its component that roc bird ball goes desilver pearl to be coated
Preferably, osteoporosis of the present invention refers to osteoporosis caused by oestrogen deficiencies.
Preferably, application of the present invention, usage and dosage are a 5~6g, 3 times a day.
Sa 13 taste roc bird balls of heat are " Drug Standard of Ministry of Public Health of the Peoples Republic of Chinas: Tibetan medicine first [S] .1995
Version " in the nomenclature of drug recorded, standard No. WS3-BC-0330-95, market is commercially available.
The component of Sa 13 taste roc bird balls of heat: Moschus 7.5g, radix aucklandiae 500g, Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g, myrobalan
100g, coral 40g, pearl 25g, cloves 20g, nutmeg 75.5g, agalloch eaglewood 50g, magnetite 25g, licorice root ointment 40g, Yu
Grain stone 250g.
Preparation method: above 13 taste, in addition to Moschus, coral, pearl, licorice root ointment, remaining is ground into fine powder altogether, sieving.Coral is added
Coral, pearl fine powder mix.Add appropriate water pill with Moschus, licorice root ointment, then with silver-colored pearl coating, dry in the shade to get.
In the application for the treatment of field of the hot 13 taste roc bird balls of Sa, its widely known anti-inflammatory analgetic, clearing and activating the channels and collaterals, consciousness regaining
Effect.For apoplexy, facial paralysis caused by " white vein ", paralysis and numbness, vasculitis, tenosynovitis, extremities joint is unfavorable, leprosy
Deng.
To better understand the essence of the present invention, the present invention further illustrates the hot 13 taste rocs of Sa by zoopery
The application of bird ball and its component in preparation treatment osteoporosis agents.
The present invention passes through pharmacological research discovery, femur, shin of the Sa 13 taste roc bird balls of heat to Osteoporotic Model rat
HOP index has certain curative effect in the bone density of bone, bone biomechanical index, Determination of Calcium in Serum, BGP index and urine, shows Sa heat
13 taste roc bird balls can be used for the treatment of osteoporosis (especially estrogen lacks caused osteoporosis).
Specific embodiment
Embodiment 1
Purposes of the Sa 13 taste roc bird balls of heat in preparation treatment osteoporosis, component: Moschus 7.5g, radix aucklandiae 500g,
Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g, myrobalan 100g, coral 40g, pearl 25g, cloves 20g, nutmeg 75.5g, agalloch eaglewood
50g, magnetite 25g, licorice root ointment 40g, limonite 250g.Preparation method: above 13 taste removes Moschus, coral, pearl, licorice root ointment
Outside, remaining is ground into fine powder altogether, sieving.Coral, pearl fine powder is added, mixes.Add appropriate water pill with Moschus, licorice root ointment, then uses
The coating of silver-colored pearl, dry in the shade to get.Its usage and dosage is a 5~6g, 3 times a day.
Embodiment 2
Sa 13 taste roc bird balls of heat treat the purposes in treatment oestrogen deficiencies initiation osteoporosis in preparation, component:
Moschus 7.5g, radix aucklandiae 500g, Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g, myrobalan 100g, coral 40g, pearl 25g, cloves
20g, nutmeg 75.5g, agalloch eaglewood 50g, magnetite 25g, licorice root ointment 40g, limonite 250g.Preparation method: above 13 taste removes
Moschus, coral, pearl, outside licorice root ointment, remaining is ground into fine powder altogether, sieving.Coral, pearl fine powder is added, mixes.With Moschus, sweet
Careless cream adds appropriate water pill, then with silver-colored pearl coating, dry in the shade to get.Its usage and dosage is a 5~6g, 3 times a day.
Embodiment 3
Purposes of the component of Sa 13 taste roc bird balls of heat in preparation osteoporosis, component: Moschus 7.5g, radix aucklandiae
500g, Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g, myrobalan 100g, coral 40g, pearl 25g, cloves 20g, nutmeg 75.5g,
Agalloch eaglewood 50g, magnetite 25g, licorice root ointment 40g, limonite 250g.Preparation method: above 13 taste removes Moschus, coral, pearl, Radix Glycyrrhizae
Outside cream, remaining is ground into fine powder altogether, sieving.Coral, pearl fine powder is added, mixes.Add appropriate water pill with Moschus, licorice root ointment, yin
It is dry to get.Its usage and dosage is a 5~6g, 3 times a day.
Embodiment 4
The component of Sa 13 taste roc bird balls of heat causes the purposes in osteoporosis, group in preparation treatment oestrogen deficiencies
Point: Moschus 7.5g, radix aucklandiae 500g, Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g, myrobalan 100g, coral 40g, pearl 25g, cloves
20g, nutmeg 75.5g, agalloch eaglewood 50g, magnetite 25g, licorice root ointment 40g, limonite 250g.Preparation method: above 13 taste removes
Moschus, coral, pearl, outside licorice root ointment, remaining is ground into fine powder altogether, sieving.Coral, pearl fine powder is added, mixes.With Moschus, sweet
Careless cream adds appropriate water pill, dry in the shade to get.Its usage and dosage is a 5~6g, 3 times a day.
Experimental example 5:
One, material
1, animal: SD rat, August age, Shandong Shandong rat feeding center provide (quality certification number SLXK2008002) animal
Rank: cleaning grade.
2, drug:
Nilestriol Tablets, Beijing Sihuan Pharmaceutical Co., Ltd's production, national drug standard H11020123,1mg/ piece, 10/
Box.
Sa 13 taste roc bird balls of heat, scold Tibetan medicine by Qinghai gold and provide, batch 20131109.
Sa 13 taste roc bird ball components of heat, the water pill being prepared according to the component of experimental example 3 and preparation method (are free of
Silver-colored pearl coating).
3, capital equipment: (1) serum alkaline phosphatase kit, serum calcium ion kit, serum inorganic phosphorus kit,
Urinary hydroxyproline, estradiol, osteocalcin kit (originating from Nanjing to build up);(2) Shanghai Hengping Science Instrument Co., Ltd. produces
FA2004 electronic analytical balance;(3) Japan produces Olympus optical microscopy;(4) the XR-36 type of U.S. Norland company production
Dynamic filtration dual energy X-ray absorptiometry diagnostic equipment；(5) INSTRON-1195 type universal testing machine.
Two, experimental method
1, Ovariectomy model mouse: 1% yellow Jackets 30mg/kg intraperitoneal anesthesia, sterile working take abdomen median incision,
Into abdominal cavity, bilateral ovaries are completely extractd, thoroughly after hemostasis, dividing two layers, successively suture muscle and skin, the ovary of excision are passed through
Pathology confirm;Sham-operation group notch is the same, into abdominal cavity after cut off each one section of left and right mesenterium, weight is substantially and two sides
Ovary is consistent, takes out bilateral ovaries and also receives after placing 1min in vitro, not removal ovary, hemostatic suture.Wound spreads penicillin powder,
Postoperative wound heals on schedule without infection.
2, animal packet and medication: the SD rat of modeling was randomly divided into ovariectomized group, Western medicine group, height in postoperative 90 days
1 group of dosage, 1 group of low dosage, 2 groups of high dose, 2 groups of low dosage, sham-operation group, totally 7 groups, every group 10.Ovariectomized group gives life
Salt water stomach-filling is managed, 20ml/kg weight, once a day, continuous 12 weeks, sham-operation group handled same model group.Western medicine group stomach-filling Neil
Female alcohol 12 weeks, 2 times a week, each 1.2mg/kg.(water decocts and is condensed into 15mg crude drug/ml the hot 13 taste roc bird balls of stomach-filling Sa
Liquid) 1 group of high dose (300mg/kg), 1 group of low dosage (100mg/kg), (water decocts simultaneously the hot 13 taste roc bird ball components of stomach-filling Sa
It is condensed into 15mg crude drug/ml liquid) 2 groups of high dose (300mg/kg), 2 groups of low dosage (100mg/kg), each stomach-filling 20ml/kg body
Weight, one time a day, continuous 12 weeks.In same environment free water, ingest 12 weeks, control appetite.
3, measuring method and index
(1) bone densitometry: 12 weekend of stomach-filling with 1% yellow Jackets 30mg/kg intraperitoneal anesthesia, four limbs exhibition after anesthesia
It opens and is flat on bone density diagnostic equipment platform, scan the whole body of each group rat, distinguished by toy software in computer system
Measure the bone density of femur, shin bone, precision 1.5%, accuracy 90%.
(2) bone biomechanical measures: right femur is taken out, with -20 DEG C of preservations of merging after physiological saline gauze package, when measurement
Taking-up is put into physiological saline, rewarming 3h is impregnated under room temperature (20 DEG C), using three point bending test method, using NSTRON-
1195 type universal testing machines (Britain) are tested, set right femur in span be 10mm bracket on, with the speed of 1mm/min
Degree pushes femur middle section, records load-deformation curve, and the internal-and external diameter for measuring femur middle section calculates femur cross sectional moment of inertia.Bone
Structural mechanics parameter: being directly obtained by load-deflection curve, maximum load (kg), elastic load (kg), maximum defluxion (mm),
Elastic deflection (mm).
(3) urinary hydroxyproline measures: 4d fasting and collecting respectively is urinated spare for 24 hours before experiment terminates, with sample alkali hydrolysis method
It measures urinary hydroxyproline (HOP).
(4) Biochemical Indices In Serum detects: empty stomach 14h, and femoral artery 7.0~8.0mL of blood sampling presses kit operating instruction respectively
Measure serum calcium ion, Phos, estradiol, osteocalcin (BGP), alkaline phosphatase (BALP).
All data are handled through spss17.0 software statistics, and comparison among groups t is examined.
Three, experimental result
1, the comparison that bone density is changed: compared with sham-operation group, under ovariectomized group rat femur, shin bone bone density are significant
It drops (P < 0.05), illustrates osteoporosis experimental animal modeling success.It is close for femur bone compared with ovariectomized group after 12w is administered
Degree, Western medicine group, high dose group and low dose group are extremely significant sex differernce (P < 0.01), the bone density for shin bone, Western medicine group
It is significant difference (P < 0.05) with low dose group, high dose group is extremely significant sex differernce (P < 0.01).It is shown in Table 1.
2, the influence to femur bone biomechanical index: compared with sham-operation group, ovariectomized group Rat Right femur bone biology
Mechanical index peak load, elastic load and maximum defluxion are remarkably decreased (P < 0.05), and elastic deflection decline is obvious.Administration
After 12w, compared with ovariectomized group, for peak load, Western medicine group, low dose group are significant difference (P < 0.05), and high agent
Amount group is extremely significant sex differernce (P < 0.01)；For maximum defluxion and elastic load, Western medicine group and high dose group are conspicuousness
Difference (P < 0.05), and low dose group has improvement trend but there was no significant difference (P > 0.05).It is shown in Table 2.
3, the influence to Ovariectomized rats urinary hydroxyproline and Biochemical Indices In Serum: compared with sham-operation group, removal ovary
Group rat bone Biochemical Indices In Serum and urinary hydroxyproline content are remarkably decreased (P < 0.05), and osteoporosis rat is prompted bone occur
Form reduced pathological change.After 12w is administered, compared with ovariectomized group, for HOP, Western medicine group and high dose group are significant
Sex differernce (P < 0.05), and low dose group has improvement trend but there was no significant difference (P > 0.05)；For Biochemical Indices In Serum,
Western medicine group shows as extremely significant sex differernce (P < 0.01) serum paraoxonase and BGP, and Western medicine group is for blood calcium, BALP and HOP and height
Dosage group is consistent, is significant difference (P < 0.05), and low dose group has improvement trend but nothing for HOP and Biochemical Indices In Serum
Significant difference (P > 0.05).It is shown in Table 3.
Table 1, the influence to Ovariectomized rats bone density
| Group | N | Femur BMD | Shin bone BMD |
| Sham-operation group | 10 | 0.218±0.008 | 0.191±0.013 |
| Ovariectomized group | 10 | 0.175±0.006# | 0.171±0.008# |
| Western medicine group | 10 | 0.211±0.011** | 0.189±0.013* |
| 1 group of low dosage | 10 | 0.201±0.008** | 0.182±0.015* |
| 1 group of high dose | 10 | 0.208±0.015** | 0.195±0.010** |
| 2 groups of low dosage | 10 | 0.205±0.007** | 0.183±0.016* |
| 2 groups of high dose | 10 | 0.213±0.013** | 0.196±0.011** |
Note: compared with sham-operation group, # p < 0.05；The * p < 0.05 compared with ovariectomized group, * * p < 0.01.
Table 2, the influence to Ovariectomized rats femur bone biomechanical
Note: compared with sham-operation group, # p < 0.05；The * p < 0.05 compared with ovariectomized group, * * p < 0.01.
Table 3, the influence (x ± s) to Ovariectomized rats urinary hydroxyproline and Biochemical Indices In Serum
Note: compared with sham-operation group, # p < 0.05；The * p < 0.05 compared with ovariectomized group, * * p < 0.01.
Table 3, the influence to Ovariectomized rats HOP and Biochemical Indices In Serum
| Group | N | Calcium mmol/l | Phosphorus mmol/l | BGP(ng/ml) | BALP(U/dl) | HOP(mml·g/Cr) |
| Sham-operation group | 10 | 2.28±0.10 | 1.64±0.09 | 1.94±0.63 | 42.39±10.63 | 0.329±0.058 |
| Ovariectomized group | 10 | 2.01±0.11 | 1.21±0.09# | 2.79±0.50# | 25.79±9.80# | 0.147±0.034# |
| Western medicine group | 10 | 2.34±0.08* | 1.71±0.10** | 1.86±0.65** | 36.02±9.36* | 0.253±0.049* |
| 1 group of low dosage | 10 | 2.14±0.09 | 1.41±0.12 | 2.35±0.46 | 33.45±10.38 | 0.196±0.066 |
| 1 group of high dose | 10 | 2.32±0.11* | 1.62±0.14* | 2.19±0.41* | 38.49±7.84* | 0.308±0.058* |
| 2 groups of low dosage | 10 | 2.25±0.07 | 1.43±0.10 | 2.41±0.40 | 33.48±10.39 | 0.238±0.021 |
| 2 groups of high dose | 10 | 2.38±0.12* | 1.62±0.11* | 2.21±0.36* | 38.49±7.31* | 0.312±0.026* |
Note: compared with sham-operation group, # p < 0.05；The * p < 0.05 compared with ovariectomized group, * * p < 0.01.
Four, conclusion
Femur, the shin of Sa heat 13 taste roc bird ball low dose groups and high dose group for removal ovary osteoporosis model rat
The bone density of bone is significantly improved effect, and function and effect are suitable with estradiol；For the maximum in bone biomechanical index
Load has significantly more improvement, and the statistics effect of high dose group is extremely significant sex differernce (P < 0.01)；Maximum is scratched
Degree and elastic load, low dose group has improvement trend and there was no significant difference, and high dose group has significant difference (P < 0.05)；
For HOP index in Determination of Calcium in Serum, BGP index and urine, high dose group is suitable with Western medicine group effect, is significant difference (P <
0.05), for phosphorus, BGP index, high dose group is significant difference (P < 0.05), and Western medicine group is extremely significant sex differernce (P <
0.01).The above results show to can be used for osteoporosis by the hot 13 taste roc bird balls of Sa that (sclerotin caused by especially estrogen lacks is dredged
Pine) treatment.
Sa 13 taste roc bird balls of heat can also be with the Drug combination of other treatment osteoporosis, such as bone peptide piece, Ah
One of human relations phosphonate, calcitonin, calcium agent and vitamin D are a variety of.
Claims (1)
1. Sa 13 taste roc bird balls of heat cause the purposes of the drug of osteoporosis in preparation treatment oestrogen deficiencies, feature exists
In: the composition of the bulk pharmaceutical chemicals of Sa 13 taste roc bird balls of heat is as follows: Moschus 7.5g, radix aucklandiae 500g, Rhizoma Acori Calami 65g, Aconitum Szechenyianum Gay 50g,
Myrobalan 100g, coral 40g, pearl 25g, cloves 20g, nutmeg 75.5g, agalloch eaglewood 50g, magnetite 25g, licorice root ointment 40g, limonite
250g, the preparation method of Sa 13 taste roc bird balls of heat: above 13 taste, in addition to Moschus, coral, pearl, licorice root ointment, remaining is ground into carefully altogether
Powder, sieving, be added coral, pearl fine powder, mix, add appropriate water pill with Moschus, licorice root ointment, dry in the shade to get.
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Non-Patent Citations (3)
| Title |
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| 珍珠层，一种具有潜力的天然骨修复材料;黄千里等;《中国材料进展》;20131031;第32卷(第10期);第591-630页 |
| 珍珠的药理作用及临床应用;黄青萍等;《时珍国医国药》;20000630;第11卷(第6期);第565页左栏2.7 |
| 补钙新天地;罗江等;《医药经济报》;20031205;第A08版右栏第2段 |
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Address after: 250101 Shandong Province Jinan Hi-tech Zone Comprehensive Bonded Zone No. 1 North Section of Gangxing No. 3 Road Jinan Yaogu R&D Platform Area No. 3 Floor 8001 Applicant after: Jinhe Tibetan medicine (Shandong) Health Industry Co., Ltd. Address before: 250101 room 501-506, Shun Feng Road, Ji'nan hi tech Zone, Shandong, 501-506 Applicant before: Shandong Jin He drug development research company limited |
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