CN104887879A - Application of Sare Shisanwei Pengniao pills to osteoporosis treatment medicine preparation - Google Patents
Application of Sare Shisanwei Pengniao pills to osteoporosis treatment medicine preparation Download PDFInfo
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Abstract
The invention relates to application of Tibetan medicine-Sare Shisanwei Pengniao pills to osteoporosis treatment medicine preparation. The application overcomes technology biases on the aspect of application in the prior art, and the Sare Shisanwei Pengniao pills play a remarkable improvement role in model rat bone density, a bone biomechanics index, an HOP index in urine and a serum biochemical index and can be used for osteoporosis treatment, particularly treating osteoporosis resulting from estrogen lack.
Description
Technical field
The present invention relates to the application of a kind of Tibetan medicine Sa heat 13 taste roc bird balls in preparation treatment osteoporosis agents, belong to field of medicaments.
Background technology
Osteoporosis and osteoporosis are the diseases caused by many factors, with skeleton pain, are easy to fracture for feature.The factor such as it and age, hormone, heredity, nutrition intake and life style has close relationship, the increased activity of its pathogenesis mainly osteoclast, and osteoblast activity is suppressed, the infiltration rate of bone exceedes formation speed, causes the Organic substance in osseous tissue and inorganic matter to reduce.It is reported, about have 7,000 ten thousand people to suffer from osteoporosis in China more than 50 years old crowd, wherein women's sickness rate is more than 30%, and along with continuing to increase of the aged, osteoporosis threatens becoming more and more serious publilc health.
Sa heat 13 taste Peng Niaowanxi Tibetan proved recipes, consist of artificial Moschus, the Radix Aucklandiae, Rhizoma Acori Calami, Radix aconiti szechenyiani, Fructus Chebulae, Corallium Japonicum Kishinouye, Margarita, Flos Caryophylli, Semen Myristicae, Lignum Aquilariae Resinatum, Magnetitum, GANGCAO GAO, limonite 13 taste medical material, there is anti-inflammatory analgetic, dredge the meridian passage, consciousness-restoring and orifice-opening effect.For apoplexy, the facial hemiparalysis that " aortic arch syndrome " causes, paralysis and numbness, vasculitis, tenosynovitis, extremities joint is unfavorable, leprosy etc.
Although the function of Sa heat 13 taste roc bird balls cures mainly a lot, the aspect such as document, patent does not all find that it can be used for treating the research of osteoporosis.
Summary of the invention
The present invention is achieved through the following technical solutions:
The application of Sa heat 13 taste roc bird balls in preparation treatment osteoporosis agents.
The application of component in preparation treatment osteoporosis agents of Sa heat 13 taste roc bird balls.
The application of component in preparation treatment osteoporosis agents of Sa heat 13 taste roc bird balls, adopts Sa heat 13 taste roc bird ball to remove the component of Vermilion coating or the extract of its component
Preferably, osteoporosis of the present invention, refers to the osteoporosis that oestrogen deficiencies causes.
Preferably, application of the present invention, its usage and dosage is a 5 ~ 6g, 3 times on the one.
Sa heat 13 taste roc bird balls are the nomenclature of drugs recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China: Tibetan medicine first [S] .1995 version ", and standard No. is WS3-BC-0330-95, and market can be purchased.
The component of Sa heat 13 taste roc bird balls: Moschus 7.5g, Radix Aucklandiae 500g, Rhizoma Acori Calami 65g, Radix aconiti szechenyiani 50g, Fructus Chebulae 100g, Corallium Japonicum Kishinouye 40g, Margarita 25g, Flos Caryophylli 20g, Semen Myristicae 75.5g, Lignum Aquilariae Resinatum 50g, Magnetitum 25g, GANGCAO GAO 40g, limonite 250g.
Method for making: above 13 tastes, except Moschus, Corallium Japonicum Kishinouye, Margarita, GANGCAO GAO, all the other are ground into fine powder altogether, sieve.Add Corallium Japonicum Kishinouye, Margarita fine powder, mixing.Add appropriate water pill by Moschus, GANGCAO GAO, then use Vermilion coating, dry in the shade, to obtain final product.
In the application for the treatment of field of Sa heat 13 taste roc bird balls, people know its anti-inflammatory analgetic, dredge the meridian passage, consciousness-restoring and orifice-opening effect.For apoplexy, the facial hemiparalysis that " aortic arch syndrome " causes, paralysis and numbness, vasculitis, tenosynovitis, extremities joint is unfavorable, leprosy etc.
In order to understand essence of the present invention better, the present invention further illustrates Sa heat 13 taste roc bird balls and the application of component in preparation treatment osteoporosis agents thereof by zoopery.
The present invention is found by pharmacological research, Sa heat 13 taste roc bird balls have certain curative effect to HOP index in the bone density of the femur of Osteoporotic Model rat, tibia, bone biomechanical index, Determination of Calcium in Serum, BGP index and urine, show that Sa heat 13 taste roc bird balls can be used for the treatment of osteoporosis (especially estrogen lacks the osteoporosis caused).
Detailed description of the invention
Embodiment 1
The purposes of Sa heat 13 taste roc bird balls in preparation treatment osteoporosis, component: Moschus 7.5g, Radix Aucklandiae 500g, Rhizoma Acori Calami 65g, Radix aconiti szechenyiani 50g, Fructus Chebulae 100g, Corallium Japonicum Kishinouye 40g, Margarita 25g, Flos Caryophylli 20g, Semen Myristicae 75.5g, Lignum Aquilariae Resinatum 50g, Magnetitum 25g, GANGCAO GAO 40g, limonite 250g.Method for making: above 13 tastes, except Moschus, Corallium Japonicum Kishinouye, Margarita, GANGCAO GAO, all the other are ground into fine powder altogether, sieve.Add Corallium Japonicum Kishinouye, Margarita fine powder, mixing.Add appropriate water pill by Moschus, GANGCAO GAO, then use Vermilion coating, dry in the shade, to obtain final product.Its usage and dosage is a 5 ~ 6g, 3 times on the one.
Embodiment 2
Sa heat 13 taste roc bird balls cause the purposes in osteoporosis at preparation treatment treatment oestrogen deficiencies, component: Moschus 7.5g, Radix Aucklandiae 500g, Rhizoma Acori Calami 65g, Radix aconiti szechenyiani 50g, Fructus Chebulae 100g, Corallium Japonicum Kishinouye 40g, Margarita 25g, Flos Caryophylli 20g, Semen Myristicae 75.5g, Lignum Aquilariae Resinatum 50g, Magnetitum 25g, GANGCAO GAO 40g, limonite 250g.Method for making: above 13 tastes, except Moschus, Corallium Japonicum Kishinouye, Margarita, GANGCAO GAO, all the other are ground into fine powder altogether, sieve.Add Corallium Japonicum Kishinouye, Margarita fine powder, mixing.Add appropriate water pill by Moschus, GANGCAO GAO, then use Vermilion coating, dry in the shade, to obtain final product.Its usage and dosage is a 5 ~ 6g, 3 times on the one.
Embodiment 3
The purposes of component in preparation osteoporosis of Sa heat 13 taste roc bird balls, component: Moschus 7.5g, Radix Aucklandiae 500g, Rhizoma Acori Calami 65g, Radix aconiti szechenyiani 50g, Fructus Chebulae 100g, Corallium Japonicum Kishinouye 40g, Margarita 25g, Flos Caryophylli 20g, Semen Myristicae 75.5g, Lignum Aquilariae Resinatum 50g, Magnetitum 25g, GANGCAO GAO 40g, limonite 250g.Method for making: above 13 tastes, except Moschus, Corallium Japonicum Kishinouye, Margarita, GANGCAO GAO, all the other are ground into fine powder altogether, sieve.Add Corallium Japonicum Kishinouye, Margarita fine powder, mixing.Add appropriate water pill by Moschus, GANGCAO GAO, dry in the shade, to obtain final product.Its usage and dosage is a 5 ~ 6g, 3 times on the one.
Embodiment 4
The component of Sa heat 13 taste roc bird balls causes the purposes in osteoporosis, component: Moschus 7.5g, Radix Aucklandiae 500g at preparation treatment oestrogen deficiencies, Rhizoma Acori Calami 65g, Radix aconiti szechenyiani 50g, Fructus Chebulae 100g, Corallium Japonicum Kishinouye 40g, Margarita 25g, Flos Caryophylli 20g, Semen Myristicae 75.5g, Lignum Aquilariae Resinatum 50g, Magnetitum 25g, GANGCAO GAO 40g, limonite 250g.Method for making: above 13 tastes, except Moschus, Corallium Japonicum Kishinouye, Margarita, GANGCAO GAO, all the other are ground into fine powder altogether, sieve.Add Corallium Japonicum Kishinouye, Margarita fine powder, mixing.Add appropriate water pill by Moschus, GANGCAO GAO, dry in the shade, to obtain final product.Its usage and dosage is a 5 ~ 6g, 3 times on the one.
Experimental example 5:
One, material
1, animal: SD rat, at 8 monthly ages, anti-rat feeding center, Shandong, Shandong provides (quality certification SLXK2008002) animal rank: cleaning grade.
2, medicine:
Nilestriol Tablets, Beijing Sihuan Pharmaceutical Co., Ltd produces, No. H11020123, the accurate word of traditional Chinese medicines, 1mg/ sheet, 10/box.
Sa heat 13 taste roc bird balls, scolding Tibetan medicine by Qinghai gold provides, and batches 20131109.
Sa heat 13 taste roc bird ball components, the water pill prepared according to component and the method for making of experimental example 3 (namely not containing Vermilion coating).
3, capital equipment: (1) serum alkaline phosphatase test kit, serum calcium ion test kit, serum inorganic phosphorus test kit, urinary hydroxyproline, estradiol, Bone Gla protein test kit (all originating from Nanjing to build up); (2) Shanghai Hengping Science Instrument Co., Ltd. produces FA2004 electronic analytical balance; (3) Japan produces Olympus optical microscope; (4) the XR-36 type dynamic filtration dual energy X-ray absorptiometry diagnostic apparatus of U.S. Norland company production; (5) INSTRON-1195 type universal testing machine.
Two, experimental technique
1, Ovariectomy model Mus: 1% pentobarbital sodium 30mg/kg intraperitoneal anesthesia, sterile working, gets abdominal part median incision, enters abdominal cavity, complete excision bilateral ovaries, thoroughly after hemostasis, point two-layer suture muscles successively and skin, the ovary of excision all confirms through pathology; Sham operated rats otch is the same, excises each one section of left and right mesentery after entering abdominal cavity, and its weight is basic consistent with both sides ovary, takes out bilateral ovaries and also receives after external placement 1min, not removal ovary, hemostatic suture.Wound spreads penicillin powder, and postoperative wound, without infection, heals on schedule.
2, animal grouping and medication: the SD rat of modeling was divided into ovariectomized group, Western medicine group, high dose 1 group, low dosage 1 group at random in postoperative 90 days, high dose 2 groups, low dosage 2 groups, sham operated rats, totally 7 groups, often organizes 10.Ovariectomized group gives normal saline gavage, 20ml/kg body weight, once a day, continuous 12 weeks, the same model group of sham operated rats process.Western medicine group gavage nilestriol 12 weeks, 2 times weekly, each 1.2mg/kg.Gavage Sa heat 13 taste roc bird balls (soak by water is also condensed into 15mg crude drug/ml liquid) high dose 1 group (300mg/kg), low dosage 1 group (100mg/kg), gavage Sa heat 13 taste roc bird ball components (soak by water is also condensed into 15mg crude drug/ml liquid) high dose 2 groups (300mg/kg), low dosage 2 groups (100mg/kg), each gavage 20ml/kg body weight, every day 1 time, continuous 12 weeks.Freely drink water in same environment, ingest 12 weeks, control appetite.
3, assay method and index
(1) bone densitometry: gavage 12 weekend is with 1% pentobarbital sodium 30mg/kg intraperitoneal anesthesia, after anesthesia, extremity launch to be flat on bone density diagnostic apparatus platform, scan the whole body of each group of rat, the bone density of femur, tibia is measured respectively by toy software in computer system, precision 1.5%, accuracy 90%.
(2) bone biomechanical measures: take out right femur, with normal saline gauze parcel rearmounted enter-20 DEG C of preservations, take out during mensuration and put into normal saline, rewarming 3h is soaked under room temperature (20 DEG C), adopt three point bending test method, application NSTRON-1195 type universal testing machine (Britain) is tested, put on support that right femur is 10mm in span, femur stage casing is pressed down with the speed of 1mm/min, record load-deflection curve, and the internal-and external diameter measuring femur stage casing calculates femur cross sectional moment of inertia.Bone structure mechanics parameter: directly obtained by load-deflection curve, maximum load (kg), elastic load (kg), maximum defluxion (mm), elastic deflection (mm).
(3) urinary hydroxyproline measures: experiment terminates front 4d fasting and collect 24h respectively to urinate for subsequent use, measures urinary hydroxyproline (HOP) with sample alkali hydrolysis method.
(4) Biochemical Indices In Serum detects: 14h on an empty stomach, and femoral artery blood sampling 7.0 ~ 8.0mL, presses test kit operating instruction respectively and measure serum calcium ion, Phos, estradiol, Bone Gla protein (BGP), alkali phosphatase (BALP).
All data, through the process of spss17.0 software statistics, compare t inspection between group.
Three, experimental result
1, to the comparison that bone density changes: compare with sham operated rats, ovariectomized group rat femur, tibial bone density significantly decline (P<0.05), osteoporosis laboratory animal modeling success is described.After administration 12w, compare with ovariectomized group, for femoral bmd, Western medicine group, high dose group and low dose group are pole significant difference (P<0.01), bone density for tibia, Western medicine group and low dose group are significant difference (P<0.05), and high dose group is pole significant difference (P<0.01).In table 1.
2, on the impact of femur bone biomechanical index: compare with sham operated rats, ovariectomized group Rat Right femur bone biomechanical index peak load, elastic load and maximum defluxion all significantly decline (P<0.05), and elastic deflection declines obviously.After administration 12w, compare with ovariectomized group, for peak load, Western medicine group, low dose group are significant difference (P<0.05), and high dose group is pole significant difference (P<0.01); For maximum defluxion and elastic load, Western medicine group and high dose group are significant difference (P<0.05), and low dose group is improved trend but there was no significant difference (P > 0.05).In table 2.
3, on the impact of Ovariectomized rats urinary hydroxyproline and Biochemical Indices In Serum: compare with sham operated rats, ovariectomized group rat bone Biochemical Indices In Serum and urinary hydroxyproline content significantly decline (P<0.05), and the pathological change that bone formation reduces has appearred in prompting osteoporosis rat.After administration 12w, compare with ovariectomized group, for HOP, Western medicine group and high dose group are significant difference (P<0.05), and low dose group is improved trend but there was no significant difference (P > 0.05); For Biochemical Indices In Serum, Western medicine group shows as pole significant difference (P<0.01) for serum paraoxonase and BGP, Western medicine group is consistent with high dose group for blood calcium, BALP with HOP, for significant difference (P<0.05), and low dose group is improved trend for HOP and Biochemical Indices In Serum but there was no significant difference (P > 0.05).In table 3.
Table 1, impact on Ovariectomized rats bone density
| Group | N | Femur BMD | Tibia BMD |
| Sham operated rats | 10 | 0.218±0.008 | 0.191±0.013 |
| Ovariectomized group | 10 | 0.175±0.006# | 0.171±0.008# |
| Western medicine group | 10 | 0.211±0.011** | 0.189±0.013* |
| Low dosage 1 group | 10 | 0.201±0.008** | 0.182±0.015* |
| High dose 1 group | 10 | 0.208±0.015** | 0.195±0.010** |
| Low dosage 2 groups | 10 | 0.205±0.007** | 0.183±0.016* |
| High dose 2 groups | 10 | 0.213±0.013** | 0.196±0.011** |
Note: compare with sham operated rats, # p < 0.05; * p < 0.05, * * p < 0.01 is compared with ovariectomized group.
Table 2, impact on Ovariectomized rats femur bone biomechanical
Note: compare with sham operated rats, # p < 0.05; * p < 0.05, * * p < 0.01 is compared with ovariectomized group.
Table 3, impact (x ± s) on Ovariectomized rats urinary hydroxyproline and Biochemical Indices In Serum
Note: compare with sham operated rats, # p < 0.05; * p < 0.05, * * p < 0.01 is compared with ovariectomized group.
Table 3, impact on Ovariectomized rats HOP and Biochemical Indices In Serum
| Group | N | Calcium mmol/l | Phosphorus mmol/l | BGP(ng/ml) | BALP(U/dl) | HOP(mml·g/Cr) |
| Sham operated rats | 10 | 2.28±0.10 | 1.64±0.09 | 1.94±0.63 | 42.39±10.63 | 0.329±0.058 |
| Ovariectomized group | 10 | 2.01±0.11 | 1.21±0.09# | 2.79±0.50# | 25.79±9.80# | 0.147±0.034# |
| Western medicine group | 10 | 2.34±0.08* | 1.71±0.10** | 1.86±0.65** | 36.02±9.36* | 0.253±0.049* |
| Low dosage 1 group | 10 | 2.14±0.09 | 1.41±0.12 | 2.35±0.46 | 33.45±10.38 | 0.196±0.066 |
| High dose 1 group | 10 | 2.32±0.11* | 1.62±0.14* | 2.19±0.41* | 38.49±7.84* | 0.308±0.058* |
| Low dosage 2 groups | 10 | 2.25±0.07 | 1.43±0.10 | 2.41±0.40 | 33.48±10.39 | 0.238±0.021 |
| High dose 2 groups | 10 | 2.38±0.12* | 1.62±0.11* | 2.21±0.36* | 38.49±7.31* | 0.312±0.026* |
Note: compare with sham operated rats, # p < 0.05; * p < 0.05, * * p < 0.01 is compared with ovariectomized group.
Four, conclusion
Sa heat 13 taste roc bird ball low dose group and high dose group are all significantly improved effect for the femur of removal ovary osteoporosis model rat, the bone density of tibia, and action effect is suitable with estradiol; Peak load in bone biomechanical index is had and improves more significantly, and the statistics effect of high dose group is pole significant difference (P < 0.01); For maximum defluxion and elastic load, low dose group is improved trend and there was no significant difference, and high dose group has significant difference (P < 0.05); For HOP index in Determination of Calcium in Serum, BGP index and urine, high dose group is suitable with Western medicine group effect, be significant difference (P < 0.05), for phosphorus, BGP index, high dose group is significant difference (P < 0.05), and Western medicine group is pole significant difference (P < 0.01).The above results shows, Sa heat 13 taste roc bird balls can be used for the treatment of osteoporosis (especially estrogen lacks the osteoporosis caused).
Sa heat 13 taste roc bird balls also can with the Drug combination of other treatment osteoporosis, such as, in bone peptide sheet, alendronate, calcitonin, calcium preparation and vitamin D one or more.
Claims (6)
1. the application of Sa heat 13 taste roc bird balls in preparation treatment osteoporosis agents.
2. the application of Sa heat according to claim 1 13 taste roc bird balls in preparation treatment osteoporosis agents, it is characterized in that, its usage and dosage is a 5 ~ 6g, 3 times on the one.
3. the application of Sa heat according to claim 1 13 taste roc bird balls in preparation treatment osteoporosis agents, is characterized in that, adopts Sa heat 13 taste roc bird ball to remove the component of Vermilion coating or the extract of its component.
4. the application of Sa heat according to claim 1 13 taste roc bird balls in preparation treatment osteoporosis agents, it is characterized in that, described osteoporosis is the osteoporosis that estrogen deficiency causes.
5., according to the application of the Sa of claim 1-4 heat 13 taste roc bird balls in preparation treatment osteoporosis agents, it is characterized in that, Sa heat 13 taste roc bird balls be used alone or with the Drug combination of other treatment osteoporosis.
6. the application of Sa heat according to claim 5 13 taste roc bird balls in preparation treatment osteoporosis agents, it is characterized in that, the medicine of other treatment osteoporosis be selected from bone peptide sheet, alendronate, calcitonin, calcium preparation and vitamin D one or more.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796612A (en) * | 2016-05-18 | 2016-07-27 | 庄信修 | Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis |
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2015
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Non-Patent Citations (4)
| Title |
|---|
| 索朗顿珠: "《藏汗合璧常用藏成药实用手册》", 31 December 2006, 民族出版社 * |
| 罗江等: "补钙新天地", 《医药经济报》 * |
| 黄千里等: "珍珠层，一种具有潜力的天然骨修复材料", 《中国材料进展》 * |
| 黄青萍等: "珍珠的药理作用及临床应用", 《时珍国医国药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796612A (en) * | 2016-05-18 | 2016-07-27 | 庄信修 | Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis |
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