CN104887832A - Traditional Chinese medicine for treatment of renal deficiency and blood stasis type diminished ovarian reserve function - Google Patents

Abstract

The invention belongs to the technical field of medication and particularly relates to a traditional Chinese medicine for treatment of a renal deficiency and blood stasis type diminished ovarian reserve function. The traditional Chinese medicine is prepared from traditional Chinese medicine raw materials comprising, by weight, 8-16 parts of eucommia ulmoides, 8-16 parts of teasel roots, 8-16 parts of herba epimedii, 2-4 parts of human placenta, 8-16 parts of colla corii asini, 8-16 parts of wolfberries, 8-16 parts of glossy privet fruit, 8-16 parts of safflower carthamus, 8-16 parts of peach kernels, 8-16 parts of roots of bidentate achyranthes, 8-16 parts of caulis spatholobi, 4-8 parts of rosa chinensis and 4-8 parts of liquorice. By the application of the traditional Chinese medicine for treatment of the renal deficiency and blood stasis type diminished ovarian reserve function, sex hormone levels can be remarkably removed, presentation of ovarian granulose cells of inhibin B protein and anti-mullerian hormone is up-regulated, the count of antrum ovarian follicle is increased, ovarian volume is enlarged, ovarian blood supply in improved, the ovarian reserve function is improved, clinical symptoms are improved, and a clinical curative effect is obvious.

Description

A kind of Chinese medicine for the treatment of kidney deficiency blood stasis type diminished ovarian reserve function

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of kidney deficiency blood stasis type diminished ovarian reserve function.

Background technology

Ovary reserve (Ovairan Reservation, OR) refers to the ability of ovarian cortex district ovarian follicular growth, growth, formation fertilizability follicle.Therefore the decline of reproductive function shows that the quality that the ovulum blast cell in cortical areas stores and quantity decline, and this is also the basic intension of diminished ovarian reserve function (Decreasing Ovarian Reservation, DOR).The DOR clinical manifestation initial stage there is no special, i.e. the shortening in the clinical manifestation of the earliest period of ovarian senescence mainly menstrual period, then occurs the menopause transition performances such as irregular, menostaxis in menstrual period.Major part patient early symptom is slight, easily ignores, and manyly when symptom is obvious has developed into premature ovarian failure (Premature Ovarian Failure, POF), thus bad old practices die hard.Domestic and international research display, approximately needs 1 ~ 6 year from DOR to ovarian function failure amenorrhea.So, earlier evaluations DOR, and treating in time, significant to prevention amenorrhea, infertile, POF etc.

The multiplex hormone replacement therapy of DOR doctor trained in Western medicine, and hormone can increase the disease incidence danger such as endometrial hyperplasia, carcinoma of endometrium, breast carcinoma, apoplexy, and contraindication is more, therefore finds Therapeutic Method safely and effectively particularly important.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of kidney deficiency blood stasis type diminished ovarian reserve function is provided, this Chinese medicine can obvious improvement hormonal readiness, raise the expression of gonad granulocyte inhibin B albumen, anti-gyneduct hormone, increase Antral follicles, increase Ovarian Volume, improve the confession of ovary blood, improve Ovary reserve, improve clinical symptoms, clinical efficacy is remarkable.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Cortex Eucommiae 8-16 part, Radix Dipsaci 8-16 part, Herba Epimedii 8-16 part, Placenta Hominis 2-4 part, Colla Corii Asini 8-16 part, Fructus Lycii 8-16 part, Fructus Ligustri Lucidi 8-16 part, Flos Carthami 8-16 part, Semen Persicae 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Caulis Spatholobi 8-16 part, Flos Rosae Chinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment kidney deficiency blood stasis type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Cortex Eucommiae 10-14 part, Radix Dipsaci 10-14 part, Herba Epimedii 10-14 part, Placenta Hominis 2.5-3.5 part, Colla Corii Asini 10-14 part, Fructus Lycii 10-14 part, Fructus Ligustri Lucidi 10-14 part, Flos Carthami 10-14 part, Semen Persicae 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Caulis Spatholobi 10-14 part, Flos Rosae Chinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment kidney deficiency blood stasis type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

The Cortex Eucommiae 12 parts, Radix Dipsaci 12 parts, Herba Epimedii 12 parts, Placenta Hominis 3 parts, 12 parts, Colla Corii Asini, Fructus Lycii 12 parts, Fructus Ligustri Lucidi 12 parts, 12 parts, Flos Carthami, 12 parts, Semen Persicae, Radix Achyranthis Bidentatae 12 parts, Caulis Spatholobi 12 parts, Flos Rosae Chinensis 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of delayed menstrual cycle that kidney deficiency blood stasis type diminished ovarian reserve function causes, very few.

The usage and dosage of Chinese medicine of the present invention: be decocted in water for oral dose, every day potion, sooner or later sub-service.Menstruation starts every day one pair on the 5th day, and serveing on 14 days is a course for the treatment of.Be used in conjunction two menstrual cycle.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

Kidney deficiency blood stasis type is the clinical common pattern of syndrome of DOR.The pathogeny of DOR is main relevant with the pathological changes of kidney and blood.In kidney, cloudy gas belongs to " Kidney-Yin ", belongs to cloudy and is tangiblely called cloudy essence, being the material base of reproductive function, follicle maturity desired substance being originated sufficient, and in kidney, yang-energy can the metabolic activity of warm, exciting human, is the power that Follicular growth and ovum are discharged.Essence in kidney should be admittedly secret, if consumption is let out too or failed to supplement in time, the dysfunction of kidney governing reproduction, the material needed for Follicular growth and being short of power, follicle quantity reduces, and Oocyte quality declines, and causes DOR.Therefore, deficiency of kidney-QI, kidney essense loss are the Etiological pathogenesis of DOR.Women take blood as this, and disorder of QI and blood is the important pathogenesis of this onste, and blood stasis is many to be detained by blood circulating out of vessels, or blood operation is not freely formed.Blood stasis is the cause of disease, can form pathological product again, i.e. " blood stasis ", and promotion as warm in insufficiency of kidney-YANG is unable, the slow and hyperamization stasis of blood of blood.Stop in blood stasis, with the passing of time cementing with phlegm-damp, the stagnation of QI, make the touching difficulty of the state of an illness more.Stagnation of blood stasis in CHONG and REN meridians, uterus, fresh blood does not give birth to then menstruation difficulty extremely." treatise on blood trouble ": " blood in uterus, monthly one changes, and except old tissue regeneration promoting, old blood is blood stasis, and this blood does not go, just air resister ".Therefore blood stasis is also one of reason of DOR.The author thinks DOR clinically to suffer from a deficiency of the kidney, and blood stasis is pathogenesis basis.Blood stasis due to renal deficiency is one of primary disease pathogenesis.Blood stasis both can be by heat burn meridians, the stagnation of QI produces, and also can be caused by the golden sword such as operation, miscarriage damages.Congenital deficiency of kidney-QI, vital essence are not filled, menses is deficient or have a delicate constitution, exhaustion due to sexual indulgence fecund, kidney qi loss, essence and blood all can be made deficient, so that the weary source of executing, break its stream, punching of source is appointed to lose and is supported, and the sea of blood is hollow, and uterus Tibetan is rushed down not normal, and menses can not on time and extremely; Kidney yang virtual loss, promotes weak, can cause hematogenous blockage, accumulate in blood stasis, vessels of the uterus impatency and cause delayed period, through come puckery less, notably amenorrhea." medical science main story " cloud: " menstruation borrows executing of kidney water entirely, and kidney water is both weary, then menses day is with dry ".Kidney storing essence, essence can turn to blood, and blood can enter the essence and blood that kidney becomes kidney, and both mutual promotions are mutually promoted, and pathology has again and contacts closely.Suffer from a deficiency of the kidney and blood stasis usually influence each other.Kidney is the root of Kidney-Yin, Yuanyang, if deficiency of kidney-QI is agitated weak, the operation sluggishness of blood then easily causes the stasis of blood; Suffer from a deficiency of the kidney deficiency of YIN-blood, blood vessels do not fill, and sering also can be made unsmooth, hematogenous blockage and the hyperamization stasis of blood.As errors in Medicine Corrected is said: " vigour is both empty, can not reach in blood vessel, and blood vessel depletion of QI must stop and the stasis of blood ".Suffer from a deficiency of the kidney and can cause the stasis of blood, and venation block, hematogenous blockage, then easily hinder the supplementing nutrition of kidney essense, kidney qi change raw, change smart weary source and can increase the weight of again to suffer from a deficiency of the kidney, the two causal correlation.Waist is house of kidney, suffers from a deficiency of the kidney and flourishly can not support outer mansion, therefore lumbosacral aching pain; The kidney generating marrow and dominating bone to fill brain, kidney opening at ear, therefore then dizziness and tinnitus of suffering from a deficiency of the kidney; Uterus silt resistance, stagnation of QI and blood may bring about pain, therefore have through carrying out lower abdomen pain; Insufficiency of kidney-YANG decline of the fire from the gate of life, Reproductive Performance goes down then hyposexuality; Xerostomia is not for drink, and light red tongue or purple dark side have ecchymosis, and deep-thready pulse or heavy is the picture of blood stasis due to renal deficiency.

The prescription mechanism of Chinese medicine of the present invention is as follows:

Prescription is as follows:

Monarch drug: the Cortex Eucommiae, Radix Dipsaci merit, with invigorating the liver and kidney, adjust punching to appoint for monarch.

Ministerial drug: Herba Epimedii, Placenta Hominis, Colla Corii Asini, Fructus Lycii, Fructus Ligustri Lucidi merit with invigorating the liver and kidney, nourishing YIN and supplementing blood.

Adjuvant drug: Flos Carthami, Semen Persicae, Radix Achyranthis Bidentatae, Caulis Spatholobi, Flos Rosae Chinensis merit are with promoting blood flow to regulate menstruation, and wherein Flos Rosae Chinensis is good at dispersing the stagnated live-QI to relieve the stagnation of QI, adjust smooth QI and blood, availablely controls the stagnation of liver-QI symptoms such as the irritable that with the passing of time female irregular menstruation cause.

Make medicine: Radix Glycyrrhizae for making, coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, in line with " through this in kidney ", the principle " going out all kidneys through water ", the kidney invigorating matches with all medicines of invigorating blood circulation, complement each other, play the effect of invigorating kidney, promoting blood circulation altogether, the delayed menstrual cycle for the treatment of kidney deficiency blood stasis type diminished ovarian reserve function, very few, make its YIN and YANG in a relative equilibrium, essence and blood is all prosperous, QI and blood is logical to be adjusted, then menstruation self-regulated, can obvious improvement hormonal readiness, raise gonad granulocyte inhibin B albumen, the expression of anti-gyneduct hormone, increase Antral follicles, increase Ovarian Volume, improve ovary blood to supply, improve Ovary reserve, improve clinical symptoms, clinical efficacy is remarkable, be worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Cortex Eucommiae 12g, Radix Dipsaci 12g, Herba Epimedii 12g, Placenta Hominis 3g, Colla Corii Asini 12g, Fructus Lycii 12g, Fructus Ligustri Lucidi 12g, Flos Carthami 12g, Semen Persicae 12g, Radix Achyranthis Bidentatae 12g, Caulis Spatholobi 12g, Flos Rosae Chinensis 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Cortex Eucommiae 10g, Radix Dipsaci 14g, Herba Epimedii 10g, Placenta Hominis 2.5g, Colla Corii Asini 14g, Fructus Lycii 10g, Fructus Ligustri Lucidi 14g, Flos Carthami 10g, Semen Persicae 14g, Radix Achyranthis Bidentatae 10g, Caulis Spatholobi 14g, Flos Rosae Chinensis 5g, Radix Glycyrrhizae 7g.

Embodiment 3

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Cortex Eucommiae 14g, Radix Dipsaci 10g, Herba Epimedii 14g, Placenta Hominis 3.5g, Colla Corii Asini 10g, Fructus Lycii 14g, Fructus Ligustri Lucidi 10g, Flos Carthami 14g, Semen Persicae 10g, Radix Achyranthis Bidentatae 14g, Caulis Spatholobi 10g, Flos Rosae Chinensis 7g, Radix Glycyrrhizae 5g.

Embodiment 4

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Cortex Eucommiae 8g, Radix Dipsaci 16g, Herba Epimedii 8g, Placenta Hominis 4g, Colla Corii Asini 16g, Fructus Lycii 8g, Fructus Ligustri Lucidi 16g, Flos Carthami 8g, Semen Persicae 16g, Radix Achyranthis Bidentatae 8g, Caulis Spatholobi 16g, Flos Rosae Chinensis 4g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, each crude drug weight proportion is as follows:

Cortex Eucommiae 16g, Radix Dipsaci 8g, Herba Epimedii 16g, Placenta Hominis 2g, Colla Corii Asini 8g, Fructus Lycii 16g, Fructus Ligustri Lucidi 8g, Flos Carthami 16g, Semen Persicae 8g, Radix Achyranthis Bidentatae 16g, Caulis Spatholobi 8g, Flos Rosae Chinensis 8g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to treatment kidney deficiency blood stasis type diminished ovarian reserve function Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose the delayed menstrual cycle of kidney deficiency blood stasis type diminished ovarian reserve function, very few patient 100 example.

1.1.1 diagnostic criteria

Western medicine diagnose standard:

Draft with reference to " practical gynecologic endocrinology (the 2nd edition) ", " obstetrics and gynecology (the 7th edition) " and " obstetrical and gynecological disease Diagnosis and differential diaggnosis (the 2nd edition) ".(1) patient has normal menstruation or childbearing history, obviously gradually occurs infrequent menstruation, simultaneously can with irritable, hectic fever sweating, the class such as soreness of the waist and knees, hyposexuality perimenopausal symptom.(2) 10mIU/mL< follicle-stimulating growth hormone (FSH) < 40mIU/mL; Or FSH/ interstitialcellstimulating hormone (ICSH) (LH) > 3.6; Above-mentionedly meet wherein one.

Tcm diagnosis standard

(1) traditional Chinese medical science differential diagnosis of diseases standard

Draft with reference to the diagnostic criteria of menoxenia in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002.

Delayed menstrual cycle: wrong latter more than 7 days of menstrual cycle, even 3 ~ 5 months a line, menstrual blood volume is normal, needs to occur more than two menstrual cycle continuously.

Hypomenorrhea: refer to that menstrual cycle is normal, menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, there are more than two menstrual cycle continuously.It is generally acknowledged Hypomenorrhea in 20ml be hypomenorrhea.

(2) Standards of Chinese Medical Syndrome Differentiation

Draft with reference to the CM syndrome differentiation criterion of nephrasthenia syndrome, syndrome of blood stasis in menoxenia in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002.

Main symptom: 1. menstruation delay 2. Hypomenorrhea 3. color secretly have block.

Secondary disease: 1. lumbosacral aching pain 2. dizziness and tinnitus 3. hectic fever sweating 4. hyposexuality.

Tongue arteries and veins: light red tongue or purple dark side have ecchymosis, deep-thready pulse or heavy.

1., 2. primary symptom at least possesses one, and possesses 3. simultaneously, secondary disease 1. ~ 4. in one, in conjunction with tongue arteries and veins can dialectical for blood stasis due to renal deficiency demonstrate,prove.

1.1.2 include case standard in

1. age >20 year and <40 year.

2. primary disease Western medicine diagnose standard and tcm diagnosis standard person is met.

3. do not merge and use other medicines therapist.

4. urine pregnancy test is negative.

5. patient willingness participates in this research and actively can coordinate further consultation, completes clinical observers.

1.1.3 Excluded cases standard

1. age >40 year or <20 year.

2. hormone medicine therapist is applied in 3 months.

3. genitals organic disease person is associated with.

4. the severe primary disease patients such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are merged.

5. the premature ovarian failure that causes of bilateral ovaries or Unilateral oophorectomy.

6. psychotic.

7. not by regulation medication, curative effect cannot be judged, or the not congruent judgement person that affects the treatment of data.

8. polycystic ovary syndrome is got rid of.

9. previously menorrhagia is got rid of

The case standard 1.1.4 come off

1. the bad person of compliance.

2. occur that adverse events should not proceed this clinical trial person.

3. experimenter exits voluntarily.

1.2 method

1.2.1 Therapeutic Method

Adopt the Chinese medicine of the treatment kidney deficiency blood stasis type diminished ovarian reserve function of the embodiment of the present invention 1, prescription: Cortex Eucommiae 12g, Radix Dipsaci 12g, Herba Epimedii 12g, Placenta Hominis 3g, Colla Corii Asini 12g, Fructus Lycii 12g, Fructus Ligustri Lucidi 12g, Flos Carthami 12g, Semen Persicae 12g, Radix Achyranthis Bidentatae 12g, Caulis Spatholobi 12g, Flos Rosae Chinensis 6g, Radix Glycyrrhizae 6g.Be decocted in water for oral dose, every day potion, sooner or later sub-service.Menstruation starts every day one pair on the 5th day, and serveing on 14 days is a course for the treatment of.Be used in conjunction two menstrual cycle.

1.2.2 observation index

Lab index: serum FSH, LH, FSH/LH, estradiol (E2) level are with chemiluminescence determination.Inhibin B(INHB), AMH (AMH) adopts elisa (ELISA) detection method.(menstruation 2nd ~ 3 days)

Vagina supersonic inspection: observe basic Antral follicles (Antral Follicle Count, AFC) peak systolic velocity (the Peak Systolic Velocity obtained under blood flow parameter chromatic colour Doppler (Color Doppler) condition that (follicle of diameter 2 ~ 10mm), flat Ovarian Volume, ovarian stromal blood flow are used, PSV), pulsatility index (Pulsatility In-Dex, PI), drag index (Resistance Index, RI).

TCM syndrome integration: instruct with reference to the scalar quantization index of nephrasthenia syndrome, syndrome of blood stasis in menoxenia in " new Chinese medicine guideline of clinical investigations " that new-century textbooks " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China are promulgated for 2002 and draft.

Main symptom: menstruation is delayed: 0 point of menstrual cycle is normal; 2 points of postponed menstruation l ~ 2 week; 4 points of postponed menstruations 2 ~ 3 weeks; 6 points of postponed menstruation >3 weeks; Hypomenorrhea: 0 point of menstrual blood loss (MBL) integration ﹥ 25 points; 2 points of 20 points of <MBL integration≤25 point; 4 points of 15 points of <MBL integration≤20 point; 6 points of 10 points of <MBL integration≤15 point; Color secretly has block: 0 color separation is red in clot; 2 points of blood secretly occasionally have clot; 4 points of blood secretly have clot; 6 points of blood purples secretly have more clot;

Secondary card: lumbosacral aching pain: 0 point of nothing; 1 point cuts in and out; 2 points of sustainable existences; 3 points for walking; Dizziness and tinnitus: 0 point of nothing; 1 point of idol has generation; 2 points happen occasionally; 3 points frequently occur; Hectic fever sweating: 0 point of amphidromic febrile perspiration goes out; 1 point of random thoughts hectic fever antiperspirant goes out; 2 points of frequent hectic fever antiperspirant go out; 3 points of lasting hectic fever antiperspirant go out; Hyposexuality: 0 point normal; 1 point of hyposexuality, 1 week 1 time; 2 points of hyposexualitys, first quarter moon 1 time; 3 points of hyposexualitys are without active claimer; Light red tongue or purple dark side have ecchymosis: note (﹢).Deep-thready pulse or heavy: note (﹢).Severity extent syndrome integral is slight: 8 ~ 16 points, moderate: 17 ~ 25, severe: >=26 points.

1.2.3 tcm syndrome curative effect determinate standard

Relevant criterion with reference to " new Chinese medicine guideline of clinical investigations " is drafted.Computing formula (nimodipine method): integration × 100% before therapeutic index (n)=(before treatment the rear integration of integration-treatment)/treatment.

1. cure: menstruation recovers normal through amount, cycle; Clinical symptom disappearance or substantially disappear, maintains more than 3 menstrual cycle.N >=95%; 2. effective: menstruation is close normal through amount, cycle; Clinical symptoms is obviously improved, and continues more than 3 menstrual cycle.95% > n >=70%; 3. effective: menstruation increases to some extent through amount, and delayed menstrual cycle person shortens the postponed menstruation time to some extent, but menstrual cycle is abnormal; Clinical symptoms all take a favorable turn but fails lasting 3 menstrual cycle.70% > n >=30%; 4. invalid: menstruation through amount, the cycle is without improvement; Clinical symptoms is all not improved, even increase the weight of.n＜30％

1.2.4 regulating menstruation observation of curative effect

Menstrual blood loss (Menstrual Blood, MBL) measures: MBL is assessed in application menstrual blood loss figure (Pictprial Blood Loss Assessment Chart, PBAC).After each sanitary towel of menstruation each time menstrual period before and after patient treatment finishes using, all put into plastic bag voluntarily by patient and deposit, MBL press to PBAC method is marked, record simultaneously.Again by reclassifying in person, marking, record, adjust after the sanitary towel left in plastic bag is collected.

Degree of staining with blood according to PBAC Mei Zhang sanitary towel is divided into:

Slight: to stain 1/3 of area≤whole sanitary towel area with blood, comment 1 point;

Moderate: stain that area accounts for whole sanitary towel area with blood 1/3 ~ 3/5, comments 5 points;

Severe: staining area with blood is whole sanitary towel substantially, comments 20 points.

The clot size scoring of losing:

Lose clot <1 unit coin, be little clot, comment 1 point;

Lose clot >=1 yuan coin, be large clot, comment 5 points;

Every patient per MBL Integral Transformation of passing through becomes TCM symptom score standard:

MBL integration≤10 point, symptom integral meter 12 points;

10 points of <MBL integration≤15 point, symptom integral meter 6 points;

15 points of <MBL integration≤20 point, symptom integral meter 4 points;

20 points of <MBL integration≤25 point, symptom integral meter 2 points;

MBL integration ﹥ 25 points, symptom integral meter 0 point.

Note: the scoring of PBAC method with the corresponding relation of MBL is: 1ml blood can comment to obtain 1.25 points, and namely the size of score value is 1.25 times of blood volume.Then 100 points of persons, blood volume is 80ml; Blood volume is 20ml person, can comment to obtain 25 points.

1.2.5 regulating menstruation efficacy assessment standard

1. cure: recover normal (quite through amount about 30 ~ 80 milliliters) through amount after treatment, drug withdrawal 3 menstrual cycle do not recur.

2. effective: after treatment through amount comparatively treatment before increase and more than.

3. effective: to improve before amount comparatively treatment after treatment.

4. invalid: unchanged through measuring after treatment.

1.2.6 statistical method

Adopt SPSS18.0 version statistics software to process, measurement data represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 between group.

2. result

TCM syndrome integration curative effect before and after 2.1 treatments

Treat rear and drug withdrawal TCM syndrome integration obviously reduction before all comparatively treating after three months, difference has statistical significance (P<0.05); After treatment and drug withdrawal comparing difference not statistically significant (P>0.05) after three months.

Front and back TCM syndrome integration curative effect treated by table 1

Number of cases	Before treatment	After treatment	Drug withdrawal is after three months
				100	22.31±2.57	7.36±1.02	8.12±1.08

100 routine patient's TCM syndrome curative effects: cure: 32 examples (32.0%), effective 54 examples (54.0%), effective 12 examples (12.0%), invalid 2 examples (2.0%), cure rate 32.0%, total obvious effective rate 86.0%, total effective rate 98.0%.

2.2 regulating menstruation curative effects

100 routine patient's regulating menstruation curative effects: cure 35 examples (35.0%), effective 45 examples (45.0%), effective 17 examples (17.0%), invalid 3 examples (3.0%), cure rate 35.0%, total obvious effective rate 80.0%, total effective rate 97.0%.

Lab index change before and after 2.3 treatments

After treatment, plasma FSH, LH, FSH/LH, E2, INHB, AMH level are obviously improved before all comparatively treating, and difference has statistical significance (P<0.05).The results are shown in Table 2.

Front and back lab index change treated by table 2

FSH(mIU/ml)

LH(mIU/ml)

FSH/LH

E2(mIU/ml)

INHB(mIU/ml)

AMH(mIU/ml)

Before treatment

18.45±3.25

10.36±2.46

2.78±1.05

24.37±5.48

80.26±11.28

3.02±1.37

After treatment

5.47±2.13

3.23±1.20

1.04±0.78

43.72±8.44

134.37±20.36

5.46±1.25

The observation that before and after 2.4 treatments, female B is super

After treatment, bilateral basis Antral follicles, Ovarian Volume, ovary PSV, ovary PI, ovary RI obviously improve before all comparatively treating, and difference has statistical significance (P<0.05).The results are shown in Table 3.

Table 3 is treated front and back female B and is surpassed results change before treating

Left side Antral follicles

Right side Antral follicles

Left ovary volume

Right ovary volume

Left ovary PSV

Right ovary PSV

Left ovary PI

Right ovary PI

Left ovary RI

Right ovary RI

Before treatment

2.53±1.03

2.46±1.05

4.36±1.28

4.22±1.27

9.03±3.30

9.08±3.28

1.65±0.82

1.67±0.88

0.78±0.12

0.76±0.15

After treatment

6.79±2.31

7.12±2.18

7.25±2.17

7.03±2.19

15.39±4.37

15.46±4.35

1.07±0.46

1.03±0.42

0.35±0.03

0.36±0.05

Claims (3)

1. treat a Chinese medicine for kidney deficiency blood stasis type diminished ovarian reserve function, be made up of the raw material of Chinese medicine medicine of following weight portion:

Cortex Eucommiae 8-16 part, Radix Dipsaci 8-16 part, Herba Epimedii 8-16 part, Placenta Hominis 2-4 part, Colla Corii Asini 8-16 part, Fructus Lycii 8-16 part, Fructus Ligustri Lucidi 8-16 part, Flos Carthami 8-16 part, Semen Persicae 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Caulis Spatholobi 8-16 part, Flos Rosae Chinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of kidney deficiency blood stasis type diminished ovarian reserve function according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Cortex Eucommiae 10-14 part, Radix Dipsaci 10-14 part, Herba Epimedii 10-14 part, Placenta Hominis 2.5-3.5 part, Colla Corii Asini 10-14 part, Fructus Lycii 10-14 part, Fructus Ligustri Lucidi 10-14 part, Flos Carthami 10-14 part, Semen Persicae 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Caulis Spatholobi 10-14 part, Flos Rosae Chinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of treatment kidney deficiency blood stasis type diminished ovarian reserve function according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

The Cortex Eucommiae 12 parts, Radix Dipsaci 12 parts, Herba Epimedii 12 parts, Placenta Hominis 3 parts, 12 parts, Colla Corii Asini, Fructus Lycii 12 parts, Fructus Ligustri Lucidi 12 parts, 12 parts, Flos Carthami, 12 parts, Semen Persicae, Radix Achyranthis Bidentatae 12 parts, Caulis Spatholobi 12 parts, Flos Rosae Chinensis 6 parts, 6 parts, Radix Glycyrrhizae.