CN104887819A - Calculus bovis Shangqing tablet and preparation method thereof - Google Patents

Abstract

The invention discloses a calculus bovis Shangqing tablet and a preparation method thereof. The calculus bovis Shangqing tablet comprises the following components in parts by weight: 2 parts of calculus bovis artifactus, 25-35 parts of mint, 35-45 parts of chrysanthemum, 12-18 parts of herba schizonepetae, 12-18 parts of angelica dahurica, 12-18 parts of ligusticum wallichii, 45-55 parts of cape jasmine, 12-18 parts of coptis chinensis, 8-12 parts of cortex phellodendri chinensis, 45-55 parts of scutellaria baicalensis, 75-85 parts of rheum officinale, 45-55 parts of fructus forsythia, 12-18 parts of radix paeoniae rubra, 45-55 parts of angelica sinensis, 60-65 parts of rehmannia glutinosa, 12-18 parts of platycodon grandiflorum, 8-12 parts of liquorice, 75-85 parts of plaster, 8-12 parts of borneol, 240-245 parts of starch, 1-2 parts of magnesium stearate, and 7-9 parts of a film coating premixed agent. The calculus bovis Shangqing tablet prepared has a good efficacy, takes effect fast, and is stable in performance.

Description

Niuhuang Shangqing Tablets and preparation method thereof

Technical field

The present invention relates to drug world, particularly relate to Niuhuang Shangqing Tablets and preparation method thereof.

Background technology

Niuhuang Shangqing Tablets, clearing away heat-fire, loose wind pain relieving.On dominance of heat in the interior, wind-fire, attack that caused headache is dizzy, conjunctival congestion tinnitus, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain, constipation due to dry stool.

Wherein, Calculus Bovis is the principal agent in prescription, and Calculus Bovis has resolving heat and reducing pathogenic fire removing toxic substances, effect that removing heat from the heart to restore the consciousness is calmed the nerves, and is the flourishing caused headache and dizziness for the treatment of part of the body cavity above the diaphragm housing the heart and lungs hyperactivity of fire or heart-fire, the principal agent of irritated insomnia.Existing Niuhuang Shangqing Tablets, due to the difference of each component content, causes its effect not obvious, and unstable.

Therefore, prior art has yet to be improved and developed.

Summary of the invention

In view of above-mentioned the deficiencies in the prior art, the object of the present invention is to provide Niuhuang Shangqing Tablets and preparation method thereof, be intended to solve the not obvious and problem of instability of existing Niuhuang Shangqing Tablets effect.

Technical scheme of the present invention is as follows:

Niuhuang Shangqing Tablets, wherein, by mass parts, comprising:

Artificial Calculus Bovis 2 parts;

Herba Menthae 25 ~ 35 parts;

Flos Chrysanthemi 35 ~ 45 parts;

Herba Schizonepetae 12 ~ 18 parts;

The Radix Angelicae Dahuricae 12 ~ 18 parts;

Rhizoma Chuanxiong 12 ~ 18 parts;

Fructus Gardeniae 45 ~ 55 parts;

Rhizoma Coptidis 12 ~ 18 parts;

Cortex Phellodendri 8 ~ 12 parts;

Radix Scutellariae 45 ~ 55 parts;

Radix Et Rhizoma Rhei 75 ~ 85 parts;

Fructus Forsythiae 45 ~ 55 parts;

Radix Paeoniae Rubra 12 ~ 18 parts;

Radix Angelicae Sinensis 45 ~ 55 parts;

Radix Rehmanniae 60 ~ 65 parts;

Radix Platycodonis 12 ~ 18 parts;

8 ~ 12 parts, Radix Glycyrrhizae;

75 ~ 85 parts, Gypsum Fibrosum;

Borneolum Syntheticum 8 ~ 12 parts;

Starch 240 ~ 245 parts;

Magnesium stearate 1 ~ 2 part;

Film coating pre-mix dose 7 ~ 9 parts.

Described Niuhuang Shangqing Tablets, wherein, by mass parts, comprising:

Artificial Calculus Bovis 2 parts;

Herba Menthae 30 parts;

Flos Chrysanthemi 40 parts;

Herba Schizonepetae 16 parts;

The Radix Angelicae Dahuricae 16 parts;

Rhizoma Chuanxiong 16 parts;

Fructus Gardeniae 50 parts;

Rhizoma Coptidis 16 parts;

Cortex Phellodendri 10 parts;

Radix Scutellariae 50 parts;

Radix Et Rhizoma Rhei 80 parts;

Fructus Forsythiae 50 parts;

Radix Paeoniae Rubra 16 parts;

Radix Angelicae Sinensis 50 parts;

Radix Rehmanniae 64 parts;

Radix Platycodonis 16 parts;

10 parts, Radix Glycyrrhizae;

80 parts, Gypsum Fibrosum;

Borneolum Syntheticum 10 parts;

Starch 241 parts;

Magnesium stearate 1.25 parts;

Film coating pre-mix dose 7.95 parts.

A preparation method for Niuhuang Shangqing Tablets as above, wherein, comprises step:

A, Radix Et Rhizoma Rhei and Rhizoma Coptidis co-grinding are obtained medicated powder, cross 100 mesh sieves, then the medicated powder sieved is carried out the fine powder that sterilization treatment obtains Radix Et Rhizoma Rhei and Rhizoma Coptidis, for subsequent use;

B, add in the first Chinese medicine extracting tank by Fructus Forsythiae, Herba Schizonepetae and Herba Menthae, that injects 6 times of medical material weight drank water logging after 1 hour, heating distillating extracting oil, when volatile oil no longer slips out, collected volatile oil, for subsequent use; Medicinal residues decoct with water 2 hours, leaching medicinal liquid; Medicinal liquid is added in the first vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

C, Radix Scutellariae, Fructus Gardeniae, Radix Platycodonis, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Gypsum Fibrosum and Radix Glycyrrhizae are added the second Chinese medicine extracting tank, the drinking water injecting 6 times of medical material weight soaks 1 hour, then extraction 2 hours is decocted, what medicinal residues added 4 times of medical material weight drinks water boiling and extraction 2 hours, merges twice decoction and extracts the medicinal liquid obtained; Medicinal liquid is added in the second vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

D, Cortex Phellodendri, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ground into medicated powder, medicated powder is added 70% ethanol of 2 times of medical material weight, place and within 4 hours, make its abundant moistening expansion, then load in percolate pot, 70% ethanol is slowly added from the side of percolate pot, until solvent exceeds medical material face 10 ~ 20cm, flood and carry out percolation after 24 hours:

With 70% ethanol for solvent carries out percolation, percolation speed is per kilogram medical material collection percolate per minute 5ml, remain during percolation that solvent exceeds medical material face 10 ~ 20cm, percolation is stopped when percolation to percolate is medical material about 6 times of weight, percolate normal pressure is reclaimed ethanol extremely without alcohol taste, the percolate reclaimed after ethanol is for subsequent use;

E, Flos Chrysanthemi is put into the 3rd Chinese medicine extracting tank, add the drinking water of 6 times of medical material weight, be heated to 70 DEG C ~ 80 DEG C, then stop heating, soak 2 hours, leaching medicinal liquid, medicinal residues add the drinking water of 4 times of medical material weight, are heated to 70 DEG C ~ 80 DEG C, then stop heating, soak 2 hours, leaching medicinal liquid, merges twice medicinal liquid, is added to by medicinal liquid in the 3rd vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

F, merge above extractum and percolate concentrates, when relative density is 1.25, receive cream and obtain thick paste;

G, by the fine powder of Radix Et Rhizoma Rhei and Rhizoma Coptidis and starch, add in granulator, spray into thick paste as binding agent, spray limit, limit is dry, inlet temperature 80 DEG C, is sprayed onto blanking when leaving air temp reaches 40 DEG C, the granule pelletizing machine obtained is carried out granulate obtain drug particles after drying;

H, drug particles, artificial Calculus Bovis, Borneolum Syntheticum and magnesium stearate are added in mixer, spray into volatile oil and mix, rotating speed: 14 ~ 16r/min, the time: 40 minutes, after mixing vexed 1 hour again;

I, carry out tabletting with rotary tablet machine and obtain substrate;

J, substrate is dropped in seed-coating machine, by the coating suspensions be mixed with by film coating pre-mix dose, be sprayed on substrate and carry out coating, to obtain final product.

Beneficial effect: Niuhuang Shangqing Tablets provided by the invention and preparation method thereof, adopts artificial Calculus Bovis, Herba Menthae, Flos Chrysanthemi, Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum, Borneolum Syntheticum, starch, magnesium stearate, film coating pre-mix dose.Niuhuang Shangqing Tablets prepared by the present invention, its effect is good, instant effect, and stable performance.

Accompanying drawing explanation

Fig. 1 is the process chart of the preparation method of Niuhuang Shangqing Tablets of the present invention.

Detailed description of the invention

The invention provides Niuhuang Shangqing Tablets and preparation method thereof, for making object of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.

Niuhuang Shangqing Tablets provided by the present invention, by mass parts, it comprises:

Artificial Calculus Bovis 2 parts;

Herba Menthae 25 ~ 35 parts;

Flos Chrysanthemi 35 ~ 45 parts;

Herba Schizonepetae 12 ~ 18 parts;

The Radix Angelicae Dahuricae 12 ~ 18 parts;

Rhizoma Chuanxiong 12 ~ 18 parts;

Fructus Gardeniae 45 ~ 55 parts;

Rhizoma Coptidis 12 ~ 18 parts;

Cortex Phellodendri 8 ~ 12 parts;

Radix Scutellariae 45 ~ 55 parts;

Radix Et Rhizoma Rhei 75 ~ 85 parts;

Fructus Forsythiae 45 ~ 55 parts;

Radix Paeoniae Rubra 12 ~ 18 parts;

Radix Angelicae Sinensis 45 ~ 55 parts;

Radix Rehmanniae 60 ~ 65 parts;

Radix Platycodonis 12 ~ 18 parts;

8 ~ 12 parts, Radix Glycyrrhizae;

75 ~ 85 parts, Gypsum Fibrosum;

Borneolum Syntheticum 8 ~ 12 parts;

Starch 240 ~ 245 parts;

Magnesium stearate 1 ~ 2 part;

Film coating pre-mix dose 7 ~ 9 parts.

Described Niuhuang Shangqing Tablets, wherein, by mass parts, comprising:

Artificial Calculus Bovis 2 parts;

Herba Menthae 30 parts;

Flos Chrysanthemi 40 parts;

Herba Schizonepetae 16 parts;

The Radix Angelicae Dahuricae 16 parts;

Rhizoma Chuanxiong 16 parts;

Fructus Gardeniae 50 parts;

Rhizoma Coptidis 16 parts;

Cortex Phellodendri 10 parts;

Radix Scutellariae 50 parts;

Radix Et Rhizoma Rhei 80 parts;

Fructus Forsythiae 50 parts;

Radix Paeoniae Rubra 16 parts;

Radix Angelicae Sinensis 50 parts;

Radix Rehmanniae 64 parts;

Radix Platycodonis 16 parts;

10 parts, Radix Glycyrrhizae;

80 parts, Gypsum Fibrosum;

Borneolum Syntheticum 10 parts;

Starch 241 parts;

Magnesium stearate 1.25 parts;

Film coating pre-mix dose 7.95 parts.

Embodiment 1

Artificial Calculus Bovis 2kg;

Herba Menthae 30 kg;

Flos Chrysanthemi 40 kg;

Herba Schizonepetae 16 kg;

The Radix Angelicae Dahuricae 16 kg;

Rhizoma Chuanxiong 16 kg;

Fructus Gardeniae 50 kg;

Rhizoma Coptidis 16 kg;

Cortex Phellodendri 10 kg;

Radix Scutellariae 50 kg;

Radix Et Rhizoma Rhei 80 kg;

Fructus Forsythiae 50 kg;

Radix Paeoniae Rubra 16 kg;

Radix Angelicae Sinensis 50 kg;

Radix Rehmanniae 64 kg;

Radix Platycodonis 16 kg;

Radix Glycyrrhizae 10 kg;

Gypsum Fibrosum 80 kg;

Borneolum Syntheticum 10 kg;

Starch 241 kg;

Magnesium stearate 1.25 kg;

Film coating pre-mix dose 7.95 kg.

Embodiment 2

Artificial Calculus Bovis 2kg;

Herba Menthae 25 kg;

Flos Chrysanthemi 45 kg;

Herba Schizonepetae 12 kg;

The Radix Angelicae Dahuricae 12 kg;

Rhizoma Chuanxiong 18 kg;

Fructus Gardeniae 45 kg;

Rhizoma Coptidis 18 kg;

Cortex Phellodendri 8kg;

Radix Scutellariae 45 kg;

Radix Et Rhizoma Rhei 85 kg;

Fructus Forsythiae 45 kg;

Radix Paeoniae Rubra 12 kg;

Radix Angelicae Sinensis 55 kg;

Radix Rehmanniae 60 kg;

Radix Platycodonis 12 kg;

Radix Glycyrrhizae 8 kg;

Gypsum Fibrosum 85 kg;

Borneolum Syntheticum 8 kg;

Starch 245 kg;

Magnesium stearate 1 kg;

Film coating pre-mix dose 7 kg.

Embodiment 3

Artificial Calculus Bovis 2kg;

Herba Menthae 35 kg;

Flos Chrysanthemi 35 kg;

Herba Schizonepetae 18 kg;

The Radix Angelicae Dahuricae 18 kg;

Rhizoma Chuanxiong 12 kg;

Fructus Gardeniae 55 kg;

Rhizoma Coptidis 12 kg;

Cortex Phellodendri 12 kg;

Radix Scutellariae 55 kg;

Radix Et Rhizoma Rhei 75 kg;

Fructus Forsythiae 55 kg;

Radix Paeoniae Rubra 18 kg;

Radix Angelicae Sinensis 45 kg;

Radix Rehmanniae 65 kg;

Radix Platycodonis 18 kg;

Radix Glycyrrhizae 12 kg;

Gypsum Fibrosum 75 kg;

Borneolum Syntheticum 12 kg;

Starch 240 kg;

Magnesium stearate 2 kg;

Film coating pre-mix dose 9 kg.

The present invention also provides a kind of preparation method of Niuhuang Shangqing Tablets as above, and as shown in Figure 1, adopt the formula of embodiment 1, method comprises step:

A, Radix Et Rhizoma Rhei and Rhizoma Coptidis co-grinding are obtained medicated powder, cross 100 mesh sieves, then the medicated powder sieved is carried out the fine powder that sterilization treatment obtains Radix Et Rhizoma Rhei and Rhizoma Coptidis, for subsequent use;

Specifically the medicated powder after sieving is joined in sterilization tray, the medicated powder thickness 20 ~ 25mm on sterilization tray.Sterilising conditions is 121 DEG C of sterilizings 30 minutes, blanking, pulverizes, and again crosses the fine powder that 100 mesh sieves obtain Radix Et Rhizoma Rhei and Rhizoma Coptidis.

B, Fructus Forsythiae, Herba Schizonepetae and Herba Menthae are added in the first Chinese medicine extracting tank, that injects 6 times of medical material weight (i.e. Fructus Forsythiae, Herba Schizonepetae and Herba Menthae gross weight 6 times) drank water logging after 1 hour, and heating distillating extracting oil, when volatile oil no longer slips out, collect volatile oil, for subsequent use; Medicinal residues decoct with water 2 hours (from boiling after timing), leaching medicinal liquid; Be added to by medicinal liquid in the first vacuum concentration pot and carry out concentrating under reduced pressure, temperature controls below 80 DEG C, and being concentrated into relative density is 1.08 ~ 1.10(70 DEG C) extractum, for subsequent use;

The steam pressure of the first Chinese medicine extracting tank is: 0.2MPa before boiling, 0.1MPa after boiling.

C, by Radix Scutellariae, Fructus Gardeniae, Radix Platycodonis, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Gypsum Fibrosum and Radix Glycyrrhizae add the second Chinese medicine extracting tank, inject 6 times of medical material weight (i.e. Radix Scutellariaes, Fructus Gardeniae, Radix Platycodonis, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Gypsum Fibrosum and Radix Glycyrrhizae gross weight 6 times) drinking water soak 1 hour, then extraction 2 hours (timing from after boiling) is decocted, medicinal residues add 4 times of medical material weight (i.e. Radix Scutellariaes, Fructus Gardeniae, Radix Platycodonis, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Gypsum Fibrosum and Radix Glycyrrhizae gross weight 4 times) drink water boiling and extraction 2 hours (from boiling after timing), merge twice decoction and extract the medicinal liquid obtained, be added to by medicinal liquid in the second vacuum concentration pot and carry out concentrating under reduced pressure, temperature controls below 80 DEG C, and being concentrated into relative density is 1.08 ~ 1.10(70 DEG C) extractum, for subsequent use,

The steam pressure of the second Chinese medicine extracting tank is: 0.2MPa before boiling, 0.1MPa after boiling.

D, Cortex Phellodendri, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ground into medicated powder (coarse powder), medicated powder is added 70% ethanol (mass percent of 2 times of medical material weight (Cortex Phellodendri, Rhizoma Chuanxiong and Radix Angelicae Dahuricae powder gross weight 2 times), lower same), place and within 4 hours, make its abundant moistening expansion, then load in percolate pot, slowly add 70% ethanol from the side of percolate pot, until solvent exceeds medical material face 10 ~ 20cm, flood and carry out percolation after 24 hours:

With 70% ethanol for solvent carries out percolation, percolation speed is per kilogram medical material collection percolate per minute 5ml, remain during percolation that solvent exceeds medical material face 10 ~ 20cm, percolation is stopped when percolation to percolate is medical material about 6 times of weight (Cortex Phellodendri, Rhizoma Chuanxiong and Radix Angelicae Dahuricae powder gross weight 6 times), percolate normal pressure is reclaimed ethanol extremely without alcohol taste, the percolate reclaimed after ethanol is for subsequent use;

E, Flos Chrysanthemi is put into the 3rd Chinese medicine extracting tank, add the drinking water of 6 times of medical material weight (Flos Chrysanthemi weight 6 times), be heated to 70 DEG C ~ 80 DEG C (as 75 DEG C), then heating is stopped, soak 2 hours, leaching medicinal liquid, medicinal residues add the drinking water of 4 times of medical material weight (Flos Chrysanthemi weight 4 times), be heated to 70 DEG C ~ 80 DEG C (as 75 DEG C), then heating is stopped, soak 2 hours, leaching medicinal liquid, merge twice medicinal liquid, medicinal liquid is added in the 3rd vacuum concentration pot and carries out concentrating under reduced pressure, temperature controls below 80 DEG C, being concentrated into relative density is 1.08 ~ 1.10(70 DEG C) extractum, for subsequent use,

F, merge above extractum and percolate carries out concentrating (vacuum concentration), temperature controls at 80 DEG C, when relative density is 1.25, receives cream and obtains thick paste;

G, by the fine powder of Radix Et Rhizoma Rhei and Rhizoma Coptidis and starch, add in granulator, spray into thick paste as binding agent, spray limit, limit is dry, inlet temperature 80 DEG C, and being sprayed onto without fine powder is single-size, blanking when leaving air temp reaches 40 DEG C, carries out granulate by the granule pelletizing machine obtained after drying and obtains drug particles; Dried granule pelletizing machine is installed 18 eye mesh screen granulate.

H, drug particles, artificial Calculus Bovis, Borneolum Syntheticum and magnesium stearate to be added in mixer (as two-dimensional mixing machine), spray into volatile oil and mix, rotating speed: 14 ~ 16r/min, the time: 40 minutes, after mixing vexed 1 hour again;

I, carry out tabletting with rotary tablet machine and obtain substrate;

Concrete available rotary tablet machine carries out tabletting, punch die: scrobicula, sheet footpath: 9mm, and sheet weighs=batch mixed (H step) granule gross weight ÷ batch afterwards, tablet weight variation ± 7%.Disintegration :≤40 minutes.Checked a tablet weight variation every 15 minutes in production process, when sheet retransmits raw departing from, charging quantity should be regulated in time.The substrate pressed loads after weighing in clean container, hangs up label, send intermediate station, please test.

J, substrate is dropped in seed-coating machine, by the coating suspensions be mixed with by film coating pre-mix dose, be sprayed on substrate and carry out coating, to obtain final product.

The preparation of coating suspensions:

Consumption=coating pre-mixing agent weight (1-the solid content)/solid content of purified water, solid content is: 16%;

Compound method: by load weighted purified water, pours in pulper, starts agitator, liquid is stirred completely, and liquid level forms vortex and the liquid that do not splash is advisable.Thrown by the film coating pre-mix dose measured makes powder be whipped into vortex rapidly on vortex liquid level, feeds intake and should complete in 10 minutes.After feeding intake, slow down agitator, stir 45 minutes, to obtain final product.

Coating: dropped into by substrate in seed-coating machine, open blower fan, regulates coating pan to make rotating speed reach 2-3r/min, is blown off by unnecessary for substrate surface dust and make label temperature reach 38 ~ 45 DEG C.Then first open air pressure, then drive spray gun, regulate the atomization gas press button on spray gun, make atomization reach maximum, mix up covering of the fan, then adjust discharge rate as required.The coating suspensions prepared is sprayed in substrate, keeps coating pan rotating speed 2-3r/min, observe label, after film forming, make coating pan rotating speed be increased to 5-7r/min, until coating suspensions has sprayed.Coating terminates first to close spray gun afterwards, then closes air pressure, and stop coating pan, blanking, dry in the air sheet.

Finally carry out blister package, outer package, inspection and warehouse-in successively.

Should be understood that, application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.

Claims (3)

1. Niuhuang Shangqing Tablets, is characterized in that, by mass parts, comprising:

Artificial Calculus Bovis 2 parts;

Herba Menthae 25 ~ 35 parts;

Flos Chrysanthemi 35 ~ 45 parts;

Herba Schizonepetae 12 ~ 18 parts;

The Radix Angelicae Dahuricae 12 ~ 18 parts;

Rhizoma Chuanxiong 12 ~ 18 parts;

Fructus Gardeniae 45 ~ 55 parts;

Rhizoma Coptidis 12 ~ 18 parts;

Cortex Phellodendri 8 ~ 12 parts;

Radix Scutellariae 45 ~ 55 parts;

Radix Et Rhizoma Rhei 75 ~ 85 parts;

Fructus Forsythiae 45 ~ 55 parts;

Radix Paeoniae Rubra 12 ~ 18 parts;

Radix Angelicae Sinensis 45 ~ 55 parts;

Radix Rehmanniae 60 ~ 65 parts;

Radix Platycodonis 12 ~ 18 parts;

8 ~ 12 parts, Radix Glycyrrhizae;

75 ~ 85 parts, Gypsum Fibrosum;

Borneolum Syntheticum 8 ~ 12 parts;

Starch 240 ~ 245 parts;

Magnesium stearate 1 ~ 2 part;

Film coating pre-mix dose 7 ~ 9 parts.

2. Niuhuang Shangqing Tablets according to claim 1, is characterized in that, by mass parts, comprising:

Artificial Calculus Bovis 2 parts;

Herba Menthae 30 parts;

Flos Chrysanthemi 40 parts;

Herba Schizonepetae 16 parts;

The Radix Angelicae Dahuricae 16 parts;

Rhizoma Chuanxiong 16 parts;

Fructus Gardeniae 50 parts;

Rhizoma Coptidis 16 parts;

Cortex Phellodendri 10 parts;

Radix Scutellariae 50 parts;

Radix Et Rhizoma Rhei 80 parts;

Fructus Forsythiae 50 parts;

Radix Paeoniae Rubra 16 parts;

Radix Angelicae Sinensis 50 parts;

Radix Rehmanniae 64 parts;

Radix Platycodonis 16 parts;

10 parts, Radix Glycyrrhizae;

80 parts, Gypsum Fibrosum;

Borneolum Syntheticum 10 parts;

Starch 241 parts;

Magnesium stearate 1.25 parts;

Film coating pre-mix dose 7.95 parts.

3. a preparation method for Niuhuang Shangqing Tablets as claimed in claim 1, is characterized in that, comprises step:

A, Radix Et Rhizoma Rhei and Rhizoma Coptidis co-grinding are obtained medicated powder, cross 100 mesh sieves, then the medicated powder sieved is carried out the fine powder that sterilization treatment obtains Radix Et Rhizoma Rhei and Rhizoma Coptidis, for subsequent use;

B, add in the first Chinese medicine extracting tank by Fructus Forsythiae, Herba Schizonepetae and Herba Menthae, that injects 6 times of medical material weight drank water logging after 1 hour, heating distillating extracting oil, when volatile oil no longer slips out, collected volatile oil, for subsequent use; Medicinal residues decoct with water 2 hours, leaching medicinal liquid; Medicinal liquid is added in the first vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

C, Radix Scutellariae, Fructus Gardeniae, Radix Platycodonis, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Rehmanniae, Gypsum Fibrosum and Radix Glycyrrhizae are added the second Chinese medicine extracting tank, the drinking water injecting 6 times of medical material weight soaks 1 hour, then extraction 2 hours is decocted, what medicinal residues added 4 times of medical material weight drinks water boiling and extraction 2 hours, merges twice decoction and extracts the medicinal liquid obtained; Medicinal liquid is added in the second vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

D, Cortex Phellodendri, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ground into medicated powder, medicated powder is added 70% ethanol of 2 times of medical material weight, place and within 4 hours, make its abundant moistening expansion, then load in percolate pot, 70% ethanol is slowly added from the side of percolate pot, until solvent exceeds medical material face 10 ~ 20cm, flood and carry out percolation after 24 hours:

With 70% ethanol for solvent carries out percolation, percolation speed is per kilogram medical material collection percolate per minute 5ml, remain during percolation that solvent exceeds medical material face 10 ~ 20cm, percolation is stopped when percolation to percolate is medical material about 6 times of weight, percolate normal pressure is reclaimed ethanol extremely without alcohol taste, the percolate reclaimed after ethanol is for subsequent use;

E, Flos Chrysanthemi is put into the 3rd Chinese medicine extracting tank, add the drinking water of 6 times of medical material weight, be heated to 70 DEG C ~ 80 DEG C, then stop heating, soak 2 hours, leaching medicinal liquid, medicinal residues add the drinking water of 4 times of medical material weight, are heated to 70 DEG C ~ 80 DEG C, then stop heating, soak 2 hours, leaching medicinal liquid, merges twice medicinal liquid, is added to by medicinal liquid in the 3rd vacuum concentration pot and carries out concentrating under reduced pressure, be concentrated into the extractum that relative density is 1.08 ~ 1.10, for subsequent use;

F, merge above extractum and percolate concentrates, when relative density is 1.25, receive cream and obtain thick paste;

G, by the fine powder of Radix Et Rhizoma Rhei and Rhizoma Coptidis and starch, add in granulator, spray into thick paste as binding agent, spray limit, limit is dry, inlet temperature 80 DEG C, is sprayed onto blanking when leaving air temp reaches 40 DEG C, the granule pelletizing machine obtained is carried out granulate obtain drug particles after drying;

H, drug particles, artificial Calculus Bovis, Borneolum Syntheticum and magnesium stearate are added in mixer, spray into volatile oil and mix, rotating speed: 14 ~ 16r/min, the time: 40 minutes, after mixing vexed 1 hour again;

I, carry out tabletting with rotary tablet machine and obtain substrate;

J, substrate is dropped in seed-coating machine, by the coating suspensions be mixed with by film coating pre-mix dose, be sprayed on substrate and carry out coating, to obtain final product.