CN104887819B - Niuhuang Shangqing Tablets and preparation method thereof - Google Patents
Niuhuang Shangqing Tablets and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses Niuhuang Shangqing Tablets and preparation method thereof, and in parts by mass, Niuhuang Shangqing Tablets include：2 parts of calculus bovis factitius；25 ~ 35 parts of peppermint；35 ~ 45 parts of chrysanthemum；12 ~ 18 parts of ching-chieh；12 ~ 18 parts of the root of Dahurain angelica；12 ~ 18 parts of Ligusticum wallichii；45 ~ 55 parts of cape jasmine；12 ~ 18 parts of the coptis；8 ~ 12 parts of golden cypress；45 ~ 55 parts of radix scutellariae；75 ~ 85 parts of rheum officinale；45 ~ 55 parts of the capsule of weeping forsythia；12 ~ 18 parts of the radix paeoniae rubrathe；45 ~ 55 parts of Radix Angelicae Sinensis；60 ~ 65 parts of glutinous rehmannia；12 ~ 18 parts of balloonflower root；8 ~ 12 parts of radix glycyrrhizae；75 ~ 85 parts of gypsum；8 ~ 12 parts of borneol；240 ~ 245 parts of starch；1 ~ 2 part of magnesium stearate；7 ~ 9 parts of film coating pre-mix dose.Niuhuang Shangqing Tablets prepared by the present invention, its effect is good, quick, and stable performance.
Description
Technical field
The present invention relates to drug field, more particularly to Niuhuang Shangqing Tablets and preparation method thereof.
Background technology
Niuhuang Shangqing Tablets, clearing heat-fire, dissipate wind analgesic.Dizziness of having a headache, hot eyes caused by being attacked on dominance of heat in the interior, wind fire
Tinnitus, abscess of throat, aphthae, swelling and aching of gum, dry feces.
Wherein, the effect of cow-bezoar is the main ingredient in prescription, and cow-bezoar has heat-clearing and fire-reducing removing toxic substances, and waking up the patient from unconsciousness by clearing away heart fire is calmed the nerves, is to control
Treat part of the body cavity above the diaphragm housing the heart and lungs hyperactivity of fire or the flourishing caused headache and dizziness of internal heat, the main ingredient of irritated insomnia.Existing Niuhuang Shangqing Tablets are due to each composition
The difference of content, cause its effect unobvious, and it is unstable.
Therefore, prior art has yet to be improved and developed.
The content of the invention
In view of above-mentioned the deficiencies in the prior art, it is an object of the invention to provide Niuhuang Shangqing Tablets and preparation method thereof, purport
Solving the problems, such as existing Niuhuang Shangqing Tablets effect unobvious and unstable.
Technical scheme is as follows：
Niuhuang Shangqing Tablets, wherein, in parts by mass, including：
2 parts of calculus bovis factitius；
25 ~ 35 parts of peppermint；
35 ~ 45 parts of chrysanthemum；
12 ~ 18 parts of ching-chieh；
12 ~ 18 parts of the root of Dahurain angelica；
12 ~ 18 parts of Ligusticum wallichii；
45 ~ 55 parts of cape jasmine；
12 ~ 18 parts of the coptis；
8 ~ 12 parts of golden cypress；
45 ~ 55 parts of radix scutellariae；
75 ~ 85 parts of rheum officinale；
45 ~ 55 parts of the capsule of weeping forsythia；
12 ~ 18 parts of the radix paeoniae rubrathe；
45 ~ 55 parts of Radix Angelicae Sinensis；
60 ~ 65 parts of glutinous rehmannia；
12 ~ 18 parts of balloonflower root；
8 ~ 12 parts of radix glycyrrhizae；
75 ~ 85 parts of gypsum；
8 ~ 12 parts of borneol；
240 ~ 245 parts of starch；
1 ~ 2 part of magnesium stearate；
7 ~ 9 parts of film coating pre-mix dose.
Described Niuhuang Shangqing Tablets, wherein, in parts by mass, including：
2 parts of calculus bovis factitius；
30 parts of peppermint；
40 parts of chrysanthemum；
16 parts of ching-chieh；
16 parts of the root of Dahurain angelica；
16 parts of Ligusticum wallichii；
50 parts of cape jasmine；
16 parts of the coptis；
10 parts of golden cypress；
50 parts of radix scutellariae；
80 parts of rheum officinale；
50 parts of the capsule of weeping forsythia；
16 parts of the radix paeoniae rubrathe；
50 parts of Radix Angelicae Sinensis；
64 parts of glutinous rehmannia；
16 parts of balloonflower root；
10 parts of radix glycyrrhizae；
80 parts of gypsum；
10 parts of borneol；
241 parts of starch；
1.25 parts of magnesium stearate；
7.95 parts of film coating pre-mix dose.
A kind of preparation method of Niuhuang Shangqing Tablets as described above, wherein, including step：
A, medicinal powder is made in rheum officinale and coptis co-grinding, crosses 100 mesh sieves, the medicinal powder of sieving is then subjected to sterilization treatment
Rheum officinale and the fine powder of the coptis are obtained, it is standby；
B, the capsule of weeping forsythia, ching-chieh and peppermint are added in the first Chinese medicine extracting tank, 6 times of medicinal material weight of injection drink water logging 1
After hour, distillating extracting oil is heated, when volatile oil no longer slips out, collects volatile oil, it is standby；It is small that the dregs of a decoction add water to cook 2
When, leaching decoction；Decoction is added into the first vacuum concentration pot and is concentrated under reduced pressure, be concentrated into relative density for 1.08~
1.10 medicinal extract, it is standby；
C, radix scutellariae, cape jasmine, balloonflower root, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae are added into the second Chinese medicine extracting tank, injection 6
The drinking water of times medicinal material weight soaks 1 hour, then decocts extraction 2 hours, and the dregs of a decoction add the drinking water of 4 times of medicinal material weight to decoct to carry
Take 2 hours, merge and decoct the decoction that extraction obtains twice；Decoction is added into the second vacuum concentration pot and is concentrated under reduced pressure,
The medicinal extract that relative density is 1.08~1.10 is concentrated into, it is standby；
D, golden cypress, Ligusticum wallichii and the root of Dahurain angelica are ground into medicinal powder, medicinal powder is added to 70% ethanol of 2 times of medicinal material weight, it is small to place 4
When make it be sufficiently humidified so as to expand, be then charged into percolate pot, 70% ethanol be slowly added to from the side of percolate pot, until solvent is high
Drug 10~20cm of face, dipping carry out diacolation after 24 hours：
Diacolation is carried out by solvent of 70% ethanol, diacolation speed is per kilogram medicinal material collection percolate 5ml per minute, diacolation
When remain that solvent is higher by 10~20cm of medicinal material face, diacolation to percolate stops diacolation when being about 6 times of weight of medicinal material, by diacolation
For liquid normal pressure recovery ethanol to without alcohol taste, the percolate reclaimed after ethanol is standby；
E, chrysanthemum is put into the 3rd Chinese medicine extracting tank, adds the drinking water of 6 times of medicinal material weight, be heated to 70 DEG C~80 DEG C,
Then stop heating, soak 2 hours, leaching decoction, the dregs of a decoction add the drinking water of 4 times of medicinal material weight, are heated to 70 DEG C~80 DEG C, so
Stop heating afterwards, soak 2 hours, leaching decoction, merge decoction twice, decoction is added into the 3rd vacuum concentration pot and subtracted
Pressure concentration, the medicinal extract that relative density is 1.08~1.10 is concentrated into, it is standby；
F, merge above medicinal extract and percolate is concentrated, when relative density is 1.25, receives cream and obtain thick paste；
G, by rheum officinale and the fine powder and starch of the coptis, add in granulator, spray into thick paste as adhesive, done in spray
It is dry, 80 DEG C of EAT, blanking when leaving air temp reaches 40 DEG C is sprayed onto, the particle obtained after drying is subjected to whole grain with pelletizing machine
Obtain drug particles；
H, drug particles, calculus bovis factitius, borneol and magnesium stearate are added in mixer, spray into volatile oil and mixed,
Rotating speed：14~16r/min, time：40 minutes, vexed 1 hour again after mixing；
I, carry out tabletting with rotary tablet machine and substrate is made；
J, substrate is put into seed-coating machine, the coating suspensions that will be configured to by film coating pre-mix dose, be sprayed on substrate
It is coated, produces.
Beneficial effect：Niuhuang Shangqing Tablets provided by the invention and preparation method thereof, using calculus bovis factitius, peppermint, chrysanthemum, chaste tree
Mustard fringe, the root of Dahurain angelica, Ligusticum wallichii, cape jasmine, the coptis, golden cypress, radix scutellariae, rheum officinale, the capsule of weeping forsythia, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, balloonflower root, radix glycyrrhizae, gypsum, ice
Piece, starch, magnesium stearate, film coating pre-mix dose.Niuhuang Shangqing Tablets prepared by the present invention, its effect is good, quick, and property
Can be stable.
Brief description of the drawings
Fig. 1 is the process chart of the preparation method of Niuhuang Shangqing Tablets of the present invention.
Embodiment
The present invention provides Niuhuang Shangqing Tablets and preparation method thereof, to make the purpose of the present invention, technical scheme and effect more
Clear, clear and definite, the present invention is described in more detail below.It should be appreciated that specific embodiment described herein only to
The present invention is explained, is not intended to limit the present invention.
Niuhuang Shangqing Tablets provided by the present invention, in parts by mass, it includes：
2 parts of calculus bovis factitius；
25 ~ 35 parts of peppermint；
35 ~ 45 parts of chrysanthemum；
12 ~ 18 parts of ching-chieh；
12 ~ 18 parts of the root of Dahurain angelica；
12 ~ 18 parts of Ligusticum wallichii；
45 ~ 55 parts of cape jasmine；
12 ~ 18 parts of the coptis；
8 ~ 12 parts of golden cypress；
45 ~ 55 parts of radix scutellariae；
75 ~ 85 parts of rheum officinale；
45 ~ 55 parts of the capsule of weeping forsythia；
12 ~ 18 parts of the radix paeoniae rubrathe；
45 ~ 55 parts of Radix Angelicae Sinensis；
60 ~ 65 parts of glutinous rehmannia；
12 ~ 18 parts of balloonflower root；
8 ~ 12 parts of radix glycyrrhizae；
75 ~ 85 parts of gypsum；
8 ~ 12 parts of borneol；
240 ~ 245 parts of starch；
1 ~ 2 part of magnesium stearate；
7 ~ 9 parts of film coating pre-mix dose.
Described Niuhuang Shangqing Tablets, wherein, in parts by mass, including：
2 parts of calculus bovis factitius；
30 parts of peppermint；
40 parts of chrysanthemum；
16 parts of ching-chieh；
16 parts of the root of Dahurain angelica；
16 parts of Ligusticum wallichii；
50 parts of cape jasmine；
16 parts of the coptis；
10 parts of golden cypress；
50 parts of radix scutellariae；
80 parts of rheum officinale；
50 parts of the capsule of weeping forsythia；
16 parts of the radix paeoniae rubrathe；
50 parts of Radix Angelicae Sinensis；
64 parts of glutinous rehmannia；
16 parts of balloonflower root；
10 parts of radix glycyrrhizae；
80 parts of gypsum；
10 parts of borneol；
241 parts of starch；
1.25 parts of magnesium stearate；
7.95 parts of film coating pre-mix dose.
Embodiment 1
Calculus bovis factitius 2kg；
The kg of peppermint 30；
The kg of chrysanthemum 40；
The kg of ching-chieh 16；
The kg of the root of Dahurain angelica 16；
The kg of Ligusticum wallichii 16；
The kg of cape jasmine 50；
The kg of the coptis 16；
The kg of golden cypress 10；
The kg of radix scutellariae 50；
The kg of rheum officinale 80；
The kg of the capsule of weeping forsythia 50；
The kg of the radix paeoniae rubrathe 16；
The kg of Radix Angelicae Sinensis 50；
The kg of glutinous rehmannia 64；
The kg of balloonflower root 16；
The kg of radix glycyrrhizae 10；
The kg of gypsum 80；
The kg of borneol 10；
The kg of starch 241；
The kg of magnesium stearate 1.25；
The kg of film coating pre-mix dose 7.95.
Embodiment 2
Calculus bovis factitius 2kg；
The kg of peppermint 25；
The kg of chrysanthemum 45；
The kg of ching-chieh 12；
The kg of the root of Dahurain angelica 12；
The kg of Ligusticum wallichii 18；
The kg of cape jasmine 45；
The kg of the coptis 18；
Golden cypress 8kg；
The kg of radix scutellariae 45；
The kg of rheum officinale 85；
The kg of the capsule of weeping forsythia 45；
The kg of the radix paeoniae rubrathe 12；
The kg of Radix Angelicae Sinensis 55；
The kg of glutinous rehmannia 60；
The kg of balloonflower root 12；
The kg of radix glycyrrhizae 8；
The kg of gypsum 85；
The kg of borneol 8；
The kg of starch 245；
The kg of magnesium stearate 1；
The kg of film coating pre-mix dose 7.
Embodiment 3
Calculus bovis factitius 2kg；
The kg of peppermint 35；
The kg of chrysanthemum 35；
The kg of ching-chieh 18；
The kg of the root of Dahurain angelica 18；
The kg of Ligusticum wallichii 12；
The kg of cape jasmine 55；
The kg of the coptis 12；
The kg of golden cypress 12；
The kg of radix scutellariae 55；
The kg of rheum officinale 75；
The kg of the capsule of weeping forsythia 55；
The kg of the radix paeoniae rubrathe 18；
The kg of Radix Angelicae Sinensis 45；
The kg of glutinous rehmannia 65；
The kg of balloonflower root 18；
The kg of radix glycyrrhizae 12；
The kg of gypsum 75；
The kg of borneol 12；
The kg of starch 240；
The kg of magnesium stearate 2；
The kg of film coating pre-mix dose 9.
The present invention also provides a kind of preparation method of Niuhuang Shangqing Tablets as described above, as shown in figure 1, using embodiment 1
Formula, method includes step：
A, medicinal powder is made in rheum officinale and coptis co-grinding, crosses 100 mesh sieves, the medicinal powder of sieving is then subjected to sterilization treatment
Rheum officinale and the fine powder of the coptis are obtained, it is standby；
Specifically the medicinal powder after sieving is added in sterilization tray, 20~25mm of medicinal powder thickness on sterilization tray.Sterilize bar
Part is 121 DEG C and sterilized 30 minutes, blanking, crushes, and crosses 100 mesh sieves again and obtains rheum officinale and the fine powder of the coptis.
B, the capsule of weeping forsythia, ching-chieh and peppermint are added in the first Chinese medicine extracting tank, injects 6 times of medicinal material weight（That is the capsule of weeping forsythia, schizonepeta
6 times of fringe and peppermint gross weight）Drink water logging 1 hour after, heat distillating extracting oil, when volatile oil no longer slips out, receive
Collect volatile oil, it is standby；The dregs of a decoction add water to cook 2 hours（Timing after the boiling）, leaching decoction；Decoction is added to first true
It is concentrated under reduced pressure in empty concentration tank, temperature control is concentrated into relative density as 1.08~1.10 below 80 DEG C（70℃）'s
Medicinal extract, it is standby；
The steam pressure of first Chinese medicine extracting tank is：0.2MPa before boiling, 0.1MPa after boiling.
C, radix scutellariae, cape jasmine, balloonflower root, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae are added into the second Chinese medicine extracting tank, injection 6
Times medicinal material weight（That is 6 times of radix scutellariae, cape jasmine, balloonflower root, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae gross weight）Drinking water immersion 1
Hour, then decoct extraction 2 hours（Timing after the boiling）, the dregs of a decoction add 4 times of medicinal material weight（I.e. radix scutellariae, cape jasmine, balloonflower root,
4 times of the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae gross weight）Drink water boiling and extraction 2 hours（Timing after the boiling）, close
And the decoction that extraction obtains is decocted twice；Decoction is added into the second vacuum concentration pot and is concentrated under reduced pressure, temperature control exists
Less than 80 DEG C, relative density is concentrated into as 1.08~1.10（70℃）Medicinal extract, it is standby；
The steam pressure of second Chinese medicine extracting tank is：0.2MPa before boiling, 0.1MPa after boiling.
D, golden cypress, Ligusticum wallichii and the root of Dahurain angelica are ground into medicinal powder（Coarse powder）, medicinal powder is added into 2 times of medicinal material weight（Golden cypress, Ligusticum wallichii and
2 times of angelica dahurica powder gross weight）70% ethanol（Mass percent, similarly hereinafter）, placing 4 hours makes it be sufficiently humidified so as to expand, then
It is fitted into percolate pot, 70% ethanol is slowly added to from the side of percolate pot, until solvent is higher by 10~20cm of medicinal material face, dipping 24
Diacolation is carried out after hour：
Diacolation is carried out by solvent of 70% ethanol, diacolation speed is per kilogram medicinal material collection percolate 5ml per minute, diacolation
When remain that solvent is higher by 10~20cm of medicinal material face, diacolation to percolate is about 6 times of weight of medicinal material（Golden cypress, Ligusticum wallichii and the root of Dahurain angelica
6 times of powder gross weight）When stop diacolation, percolate normal pressure is reclaimed into ethanol to without alcohol taste, the percolate reclaimed after ethanol is standby；
E, chrysanthemum is put into the 3rd Chinese medicine extracting tank, adds 6 times of medicinal material weight（6 times of chrysanthemum weight）Drinking water, heating
To 70 DEG C~80 DEG C（Such as 75 DEG C）, then stop heating, soak 2 hours, leaching decoction, the dregs of a decoction add 4 times of medicinal material weight（Chrysanthemum weight
4 times of amount）Drinking water, be heated to 70 DEG C~80 DEG C（Such as 75 DEG C）, then stop heating, soak 2 hours, leaching decoction, merge
Decoction twice, decoction is added into the 3rd vacuum concentration pot and is concentrated under reduced pressure, temperature control is concentrated into phase below 80 DEG C
It is 1.08~1.10 to density（70℃）Medicinal extract, it is standby；
F, merge above medicinal extract and percolate is concentrated（It is concentrated in vacuo）, temperature control treats relatively close at 80 DEG C
Spend for 1.25 when, receive cream obtain thick paste；
G, by rheum officinale and the fine powder and starch of the coptis, add in granulator, spray into thick paste as adhesive, done in spray
Dry, 80 DEG C of EAT, it is in single-size to be sprayed onto no fine powder, blanking when leaving air temp reaches 40 DEG C, that will be obtained after drying
Grain carries out whole grain with pelletizing machine and obtains drug particles；Dried particle is installed into 18 eye mesh screen whole grains with pelletizing machine.
H, drug particles, calculus bovis factitius, borneol and magnesium stearate are added into mixer（Such as two-dimensional mixing machine）In, penetrating is waved
Hair oil is mixed, rotating speed：14~16r/min, time：40 minutes, vexed 1 hour again after mixing；
I, carry out tabletting with rotary tablet machine and substrate is made；
Specifically available rotary tablet machine carries out tabletting, punch die：Scrobicula, piece footpath：9mm, piece weight=criticize and mix（H steps）Afterwards
Grain gross weight ÷ batches, tablet weight variation ± 7%.Disintegration time limited：≤ 40 minutes.In production process once piece was checked every 15 minutes
The method of double differences is different, when piece recurrence deviates, should adjust charging quantity in time.The substrate pressed loads after weighing in the container of cleaning, hangs up
Label, intermediate station is sent, please test.
J, substrate is put into seed-coating machine, the coating suspensions that will be configured to by film coating pre-mix dose, be sprayed on substrate
It is coated, produces.
The preparation of coating suspensions：
The dosage of purified water=coating pre-mixing agent weight（1- solid contents）/ solid content, solid content are：16%；
Compound method：Load weighted purified water is poured into pulper, start agitator, liquid is stirred completely, liquid
Face forms vortex and spatter liquid is not advisable.The film coating pre-mix dose measured is thrown makes powder quilt rapidly on vortex liquid level
Vortex is stirred into, feeding intake should complete in 10 minutes.After feeding intake, agitator is slowed down, stirs 45 minutes, produces.
Coating：Substrate is put into seed-coating machine, opens blower fan, regulation coating pan makes rotating speed reach 2-3r/min, by substrate
Excess surface dust blows off and label temperature is reached 38~45 DEG C.Then air pressure is first opened, then drives spray gun, adjusts the mist on spray gun
Change air pressure button, atomization is reached maximum, mix up covering of the fan, further according to needing to adjust discharge rate.The coating suspensions prepared are sprayed on base
In piece, coating pan rotating speed 2-3r/min is kept, observes label, after film forming, coating pan rotating speed is improved to 5-7r/min, until bag
Clothing suspension has sprayed.Coating first closes spray gun after terminating, then closes air pressure, stops coating pan, blanking, dry in the air piece.
Blister package, outer packing, inspection and storage are finally carried out successively, you can.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can
To be improved or converted according to the above description, all these modifications and variations should all belong to the guarantor of appended claims of the present invention
Protect scope.
Claims (2)
1. Niuhuang Shangqing Tablets, it is characterised in that in parts by mass, including：
2 parts of calculus bovis factitius；
30 parts of peppermint；
40 parts of chrysanthemum；
16 parts of ching-chieh；
16 parts of the root of Dahurain angelica；
16 parts of Ligusticum wallichii；
50 parts of cape jasmine；
16 parts of the coptis；
10 parts of golden cypress；
50 parts of radix scutellariae；
80 parts of rheum officinale；
50 parts of the capsule of weeping forsythia；
16 parts of the radix paeoniae rubrathe；
50 parts of Radix Angelicae Sinensis；
64 parts of glutinous rehmannia；
16 parts of balloonflower root；
10 parts of radix glycyrrhizae；
80 parts of gypsum；
10 parts of borneol；
241 parts of starch；
1.25 parts of magnesium stearate；
7.95 parts of film coating pre-mix dose；
The Niuhuang Shangqing Tablets are prepared as follows：A, medicinal powder is made in rheum officinale and coptis co-grinding, crosses 100 mesh sieves, so
The medicinal powder of sieving is subjected to sterilization treatment afterwards and obtains rheum officinale and the fine powder of the coptis, it is standby；
B, the capsule of weeping forsythia, ching-chieh and peppermint are added in the first Chinese medicine extracting tank, 6 times of medicinal material weight of injection drink water logging 1 hour
Afterwards, distillating extracting oil is heated, when volatile oil no longer slips out, collects volatile oil, it is standby；The dregs of a decoction add water to cook 2 hours, filter
Taking liquid；Decoction is added into the first vacuum concentration pot and is concentrated under reduced pressure, it is 1.08~1.10 to be concentrated into relative density
Medicinal extract, it is standby；
C, radix scutellariae, cape jasmine, balloonflower root, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae are added into the second Chinese medicine extracting tank, injects 6 times of medicines
The drinking water of material weight soaks 1 hour, then decocts extraction 2 hours, and what the dregs of a decoction added 4 times of medicinal material weight drinks water boiling and extraction 2
Hour, merge and decoct the decoction that extraction obtains twice；Decoction is added into the second vacuum concentration pot and is concentrated under reduced pressure, is concentrated
It is standby to the medicinal extract that relative density is 1.08~1.10；
D, golden cypress, Ligusticum wallichii and the root of Dahurain angelica are ground into medicinal powder, medicinal powder is added to 70% ethanol of 2 times of medicinal material weight, placing 4 hours makes
It is sufficiently humidified so as to expand, and is then charged into percolate pot, and 70% ethanol is slowly added to from the side of percolate pot, until the high drug of solvent
10~20cm of face, dipping carry out diacolation after 24 hours：
Diacolation is carried out by solvent of 70% ethanol, diacolation speed is per kilogram medicinal material collection percolate 5ml per minute, is begun during diacolation
Solvent is kept to be higher by 10~20cm of medicinal material face eventually, diacolation to percolate stops diacolation when being about 6 times of weight of medicinal material, and percolate is normal
Push back and receive ethanol to without alcohol taste, the percolate reclaimed after ethanol is standby；
E, chrysanthemum is put into the 3rd Chinese medicine extracting tank, adds the drinking water of 6 times of medicinal material weight, be heated to 70 DEG C~80 DEG C, then
Stop heating, soak 2 hours, leaching decoction, the dregs of a decoction add the drinking water of 4 times of medicinal material weight, are heated to 70 DEG C~80 DEG C, Ran Houting
Only heat, soak 2 hours, leaching decoction, merge decoction twice, decoction is added into the 3rd vacuum concentration pot depressurize it is dense
Contracting, the medicinal extract that relative density is 1.08~1.10 is concentrated into, it is standby；
F, merge above medicinal extract and percolate is concentrated, when relative density is 1.25, receives cream and obtain thick paste；
G, by rheum officinale and the fine powder and starch of the coptis, add in granulator, spray into thick paste as adhesive, dry, enter in spray
80 DEG C of air temperature, blanking when leaving air temp reaches 40 DEG C is sprayed onto, the particle obtained after drying is carried out into whole grain with pelletizing machine obtains
Drug particles；
H, drug particles, calculus bovis factitius, borneol and magnesium stearate are added in mixer, sprays into volatile oil and mixed, rotating speed：
14~16r/min, time：40 minutes, vexed 1 hour again after mixing；
I, carry out tabletting with rotary tablet machine and substrate is made；
J, substrate is put into seed-coating machine, the coating suspensions that will be configured to by film coating pre-mix dose, is sprayed on substrate and carries out
Coating, is produced；
The preparation of coating suspensions：
The dosage of purified water=coating pre-mixing agent weight ×（1- solid contents）/ solid content, solid content are：16%；
Compound method：Load weighted purified water is poured into pulper, start agitator, liquid is stirred completely, liquid level shape
Into vortex and spatter liquid is not advisable；The film coating pre-mix dose measured is thrown makes powder be whipped into rapidly on vortex liquid level
Vortex, feed intake and completed in 10 minutes；After feeding intake, agitator is slowed down, stirs 45 minutes, produces coating suspensions.
2. a kind of preparation method of Niuhuang Shangqing Tablets as claimed in claim 1, it is characterised in that including step：
A, medicinal powder is made in rheum officinale and coptis co-grinding, crosses 100 mesh sieves, the medicinal powder of sieving then is carried out into sterilization treatment obtains greatly
Yellow and the coptis fine powder, it is standby；
B, the capsule of weeping forsythia, ching-chieh and peppermint are added in the first Chinese medicine extracting tank, 6 times of medicinal material weight of injection drink water logging 1 hour
Afterwards, distillating extracting oil is heated, when volatile oil no longer slips out, collects volatile oil, it is standby；The dregs of a decoction add water to cook 2 hours, filter
Taking liquid；Decoction is added into the first vacuum concentration pot and is concentrated under reduced pressure, it is 1.08~1.10 to be concentrated into relative density
Medicinal extract, it is standby；
C, radix scutellariae, cape jasmine, balloonflower root, the radix paeoniae rubrathe, Radix Angelicae Sinensis, glutinous rehmannia, gypsum and radix glycyrrhizae are added into the second Chinese medicine extracting tank, injects 6 times of medicines
The drinking water of material weight soaks 1 hour, then decocts extraction 2 hours, and what the dregs of a decoction added 4 times of medicinal material weight drinks water boiling and extraction 2
Hour, merge and decoct the decoction that extraction obtains twice；Decoction is added into the second vacuum concentration pot and is concentrated under reduced pressure, is concentrated
It is standby to the medicinal extract that relative density is 1.08~1.10；
D, golden cypress, Ligusticum wallichii and the root of Dahurain angelica are ground into medicinal powder, medicinal powder is added to 70% ethanol of 2 times of medicinal material weight, placing 4 hours makes
It is sufficiently humidified so as to expand, and is then charged into percolate pot, and 70% ethanol is slowly added to from the side of percolate pot, until the high drug of solvent
10~20cm of face, dipping carry out diacolation after 24 hours：
Diacolation is carried out by solvent of 70% ethanol, diacolation speed is per kilogram medicinal material collection percolate 5ml per minute, is begun during diacolation
Solvent is kept to be higher by 10~20cm of medicinal material face eventually, diacolation to percolate stops diacolation when being about 6 times of weight of medicinal material, and percolate is normal
Push back and receive ethanol to without alcohol taste, the percolate reclaimed after ethanol is standby；
E, chrysanthemum is put into the 3rd Chinese medicine extracting tank, adds the drinking water of 6 times of medicinal material weight, be heated to 70 DEG C~80 DEG C, then
Stop heating, soak 2 hours, leaching decoction, the dregs of a decoction add the drinking water of 4 times of medicinal material weight, are heated to 70 DEG C~80 DEG C, Ran Houting
Only heat, soak 2 hours, leaching decoction, merge decoction twice, decoction is added into the 3rd vacuum concentration pot depressurize it is dense
Contracting, the medicinal extract that relative density is 1.08~1.10 is concentrated into, it is standby；
F, merge above medicinal extract and percolate is concentrated, when relative density is 1.25, receives cream and obtain thick paste；
G, by rheum officinale and the fine powder and starch of the coptis, add in granulator, spray into thick paste as adhesive, dry, enter in spray
80 DEG C of air temperature, blanking when leaving air temp reaches 40 DEG C is sprayed onto, the particle obtained after drying is carried out into whole grain with pelletizing machine obtains
Drug particles；
H, drug particles, calculus bovis factitius, borneol and magnesium stearate are added in mixer, sprays into volatile oil and mixed, rotating speed：
14~16r/min, time：40 minutes, vexed 1 hour again after mixing；
I, carry out tabletting with rotary tablet machine and substrate is made；
J, substrate is put into seed-coating machine, the coating suspensions that will be configured to by film coating pre-mix dose, is sprayed on substrate and carries out
Coating, is produced；
The preparation of coating suspensions：
The dosage of purified water=coating pre-mixing agent weight ×（1- solid contents）/ solid content, solid content are：16%；
Compound method：Load weighted purified water is poured into pulper, start agitator, liquid is stirred completely, liquid level shape
Into vortex and spatter liquid is not advisable；The film coating pre-mix dose measured is thrown makes powder be whipped into rapidly on vortex liquid level
Vortex, feed intake and completed in 10 minutes；After feeding intake, agitator is slowed down, stirs 45 minutes, produces coating suspensions.
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