CN104873588B - A kind of Chinese medicine for treating qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci - Google Patents
A kind of Chinese medicine for treating qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci Download PDFInfo
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Abstract
A kind of Chinese medicine for treating qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci, belongs to technical field of traditional Chinese medicines.The purpose of the present invention is using theory of traditional Chinese medical science, with dredging collateral promoting blood circulation and removing blood stasis and for expelling wind and cold pathogens, promoting qi circulation and relieving pain treats the Chinese medicine of qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci for principle.The raw material composition of active ingredient is made in the present invention：Rhizoma cibotii, teasel root, the root of Chinese clematis, corydalis tuber, Radix Angelicae Pubescentis, Fructus Liquidambaris, Cortex Eucommiae, Rhizoma Chuanxiong, lycopodium calvatum, ramulus mori, lopseed, bark of ash, pawpaw, Ramulus Taxilli, the root of bidentate achyranthes, wilsonii, Radix Paeoniae Alba, Chinese cassia tree, Radix Glycyrrhizae.The present invention is prepared simply, and cheap, curative effect is good, has no toxic side effect, and recurrence rate is low, society and good economical benefit.The present invention is primarily used for the Chinese medicine for the treatment of qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines.
Background technology
Lumber ertebral disc is made of the fibrous ring of upper and lower cartilage plate, the nucleus pulposus at center and periphery.Fiber is torn due to wound
It splits or is torn, Nucleus pulposus due to reversed torsion stress, form lumbar disc herniation.Cause pain in waist and lower extremities, pain is in radiation
Shape.It is a lot of in buttocks, to lower limb on rear side of radiate, along thigh on rear side of be radiated to shank, foot.Whenever run into cough, sneeze or
Firmly nerve root can be made more nervous during defecation, and pain aggravates；The property of melosalgia shows as distending pain, burning pain, shouting pain；Also
There can be numbness.If cauda equina nerve involvement can cause perineum numb, shouting pain, fecal and urinary functions imbalance, sex dysfunction and it is double under
The clinical symptoms such as acroparalysis.
The content of the invention
The purpose of the present invention is using theory of traditional Chinese medical science, with dredging collateral promoting blood circulation and removing blood stasis and for expelling wind and cold pathogens, promoting qi circulation and relieving pain is principle
Treat the Chinese medicine of qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci.
The important part composition of raw material of active ingredient is made in the present invention：
Rhizoma cibotii 15-25, teasel root 15-20, root of Chinese clematis 15-25, corydalis tuber 15-20, Radix Angelicae Pubescentis 10-20, Fructus Liquidambaris 10-20, Cortex Eucommiae
10-20, Rhizoma Chuanxiong 10-15, lycopodium calvatum 10-20, ramulus mori 10-20, lopseed 10-20, bark of ash 10-15, pawpaw 10-15, Ramulus Taxilli
10-20, root of bidentate achyranthes 10-20, wilsonii 10-20, Radix Paeoniae Alba 10-15, Chinese cassia tree 5-15, Radix Glycyrrhizae 5-15.
The parts by weight of raw materials composition of active ingredient is made in the present invention：
Rhizoma cibotii 25, teasel root 20, the root of Chinese clematis 25, corydalis tuber 20, Radix Angelicae Pubescentis 20, Fructus Liquidambaris 20, Cortex Eucommiae 20, Rhizoma Chuanxiong 15, lycopodium calvatum 20,
Ramulus mori 20, lopseed 20, bark of ash 15, pawpaw 15, Ramulus Taxilli 20, the root of bidentate achyranthes 20, wilsonii 20, Radix Paeoniae Alba 15, Chinese cassia tree 15, Radix Glycyrrhizae 10.
The present invention is prepared simply, and cheap, curative effect is good, has no toxic side effect, and recurrence rate is low, society and good economical benefit.
The present invention is primarily used for the Chinese medicine for the treatment of qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci.For be not suitable for operation and
The not serious patient of the state of an illness, the present inventor is through clinical for many years using Chinese medicine with dredging collateral promoting blood circulation and removing blood stasis and expelling wind and cold pathogens promoting qi circulation and relieving pain
Therapy treats this disease, obtains the effect of fine.
Specific embodiment
The important part composition of raw material of active ingredient is made in the present invention：
Rhizoma cibotii 15-25, teasel root 15-20, root of Chinese clematis 15-25, corydalis tuber 15-20, Radix Angelicae Pubescentis 10-20, Fructus Liquidambaris 10-20, Cortex Eucommiae
10-20, Rhizoma Chuanxiong 10-15, lycopodium calvatum 10-20, ramulus mori 10-20, lopseed 10-20, bark of ash 10-15, pawpaw 10-15, Ramulus Taxilli
10-20, root of bidentate achyranthes 10-20, wilsonii 10-20, Radix Paeoniae Alba 10-15, Chinese cassia tree 5-15, Radix Glycyrrhizae 5-15.
The parts by weight of raw materials composition of active ingredient is made in the present invention：
Rhizoma cibotii 25, teasel root 20, the root of Chinese clematis 25, corydalis tuber 20, Radix Angelicae Pubescentis 20, Fructus Liquidambaris 20, Cortex Eucommiae 20, Rhizoma Chuanxiong 15, lycopodium calvatum 20,
Ramulus mori 20, lopseed 20, bark of ash 15, pawpaw 15, Ramulus Taxilli 20, the root of bidentate achyranthes 20, wilsonii 20, Radix Paeoniae Alba 15, Chinese cassia tree 15, Radix Glycyrrhizae 10.
Its preparation method is：
By above 19 taste Chinese medicine, add in 8 times of amount water and impregnate 30 minutes, decoct 2 times, every time 0.5 it is small when, filtration is merging
Filtrate, is concentrated into about 100ml, adds in sodium benzoate 2g, makes its dissolving, then refrigerate 12 it is small when, filtration, filtrate adds distilled water to be adjusted to
1000ml is stirred evenly, and is dispensed to obtain the final product.
Character：
This product is brown liquid, has the dispersible precipitation after shaking in a small amount, gas micro-perfume, bitter and puckery flavor.
Differentiate：
This product 20ml is taken, adds formic acid 80ml, stirs evenly, stands 30 minutes, filtration, filtrate is evaporated, and residue adds water 10ml, is allowed to
Dissolving with chloroform recovery 3 times, each 20ml, discards chloroform solution, and again with water saturation, n-butanol extracts 3 times, each 20ml water layer,
Merge n-butanol liquid, with n-butanol saturation water washing 2 times, each 25ml, after emulsification, in 4000 revs/min of centrifugations, point take n-butanol
Liquid is evaporated, and residue adds methanol 1ml to make dissolving, as test sample solution.Another extracting liquorice control medicinal material 1g, filtration, filtrate are evaporated.Mirror
Other result meets every regulation related under mixture item.（One annex 1J of Chinese Pharmacopoeia version in 2000；）
Example 1：
Rhizoma cibotii 15, teasel root 15, the root of Chinese clematis 15, corydalis tuber 15, Radix Angelicae Pubescentis 10, Fructus Liquidambaris 10, Cortex Eucommiae 10, Rhizoma Chuanxiong 10, lycopodium calvatum 10,
Ramulus mori 10, lopseed 10, bark of ash 10, pawpaw 10, Ramulus Taxilli 10, the root of bidentate achyranthes 10, wilsonii 10, Radix Paeoniae Alba 10, Chinese cassia tree 5, Radix Glycyrrhizae 5.
By taste medicine in above 19 kinds, add in 8 times of component water and impregnate 30 minutes, decoct 2 times, every time 0.5 it is small when, filtration,
Merging filtrate is concentrated into about 1000ml, adds in sodium benzoate 2g, makes its dissolving, and when refrigeration 2 is small, filtration, filtrate adds distilled water
It modulates 1000ml, stirs evenly and dispense to obtain the final product.
Example 2：
Rhizoma cibotii 20, teasel root 18, the root of Chinese clematis 20, corydalis tuber 18, Radix Angelicae Pubescentis 18, Fructus Liquidambaris 18, Cortex Eucommiae 18, Rhizoma Chuanxiong 12, lycopodium calvatum 18,
Ramulus mori 12, lopseed 18, bark of ash 12, pawpaw 12, Ramulus Taxilli 12, the root of bidentate achyranthes 15, wilsonii 15, Radix Paeoniae Alba 15, Chinese cassia tree 12, Radix Glycyrrhizae 10.
Preparation method is the same as embodiment 1.
Embodiment 3：
Rhizoma cibotii 25, teasel root 20, the root of Chinese clematis 25, corydalis tuber 20, Radix Angelicae Pubescentis 20, Fructus Liquidambaris 20, Cortex Eucommiae 20, Rhizoma Chuanxiong 15, lycopodium calvatum 20,
Ramulus mori 20, lopseed 20, bark of ash 15, pawpaw 15, Ramulus Taxilli 20, the root of bidentate achyranthes 20, wilsonii 20, Radix Paeoniae Alba 20, Chinese cassia tree 15, Radix Glycyrrhizae 15.
Preparation method is the same as embodiment 1
The suggested use and dosage of the present invention：
It is oral, a 100ml, two times a day, temperatureization aftermeals.
Adverse reaction：Few patients occasionally have times of defecation to increase, but disappear after being discontinued.
Taboo and points for attention：1st, clothes are avoided to this Chinese medicine allergy sufferers；It is used with caution when the 2nd, catching a cold；3rd, women physiological period avoids clothes, and 4
Avoid Aqua Folium Camelliae sinensis and congee with mung beans.
Monarch drug in a prescription of the present invention is rhizoma cibotii, and teasel root, the root of Chinese clematis has promoting blood circulation and removing blood stasis, filling liver kidney, strong waist and knee, and has cold-dispelling, logical
Channels and collaterals, the work(of no pain by smooth breath.
Ministerial drug is Radix Angelicae Pubescentis, Fructus Liquidambaris, Cortex Eucommiae, lycopodium calvatum, corydalis tuber, Chinese cassia tree, and pawpaw etc. has warming and activating meridian, eliminating cold to stop pain
And the work(of qualcomm meridian.Adjutant is Ramulus Taxilli, and the root of bidentate achyranthes, wilsonii, Radix Paeoniae Alba is with cold-dispelling filling liver kidney, and making medicine, reconciliation is all for Radix Glycyrrhizae
Medicine.Its medicine disease is consistent, and treats both principal and secondary aspect of disease, brings out the best in each other.In conclusion among the present invention medical instrument have it is promoting blood circulation and removing blood stasis, dredging collateral and with dredge
The effect of wind, dissipating cold, promoting qi circulation and relieving pain.
Clinical data：
1st, 115 protrasion of the lumbar intervertebral disci [LIDP] patients of this group meet《New Chinese medicine treats the protrasion of the lumbar intervertebral disci
Guideline of clinical investigations》In Western medicine diagnostic criteria.It is outpatient service and the patient being hospitalized, it is randomly divided into two groups, is seen
Examine group 58, gender：Man 31, female 27 are 37 ~ 74 years old age, average（47.5±14.5）Year, the course of disease：It is most 5 days short, it is most long by 7
It is year half, average（21.5±8.6）My god, control group 57, gender：Man 32, female 25 are age 35-71 Sui, average（45.5±
14.1）Year, the course of disease：It is most 3 days short, it is most 9 years long,（Average 23.5 ± 5.5）My god.The moneys such as the gender of two groups of patients, age and the course of disease
Material compares, and there was no significant difference（P>0.05）It is comparable.
2nd, therapy：
Observation group is treated using traditional Chinese medicine for oral administration, prescription：Rhizoma cibotii 20, teasel root 15, the root of Chinese clematis, corydalis tuber 20, Radix Angelicae Pubescentis 15, Fructus Liquidambaris
15, Cortex Eucommiae 15, Rhizoma Chuanxiong 15, lycopodium calvatum 15, ramulus mori 15, lopseed 15, bark of ash 10, pawpaw 10, Ramulus Taxilli 15, the root of bidentate achyranthes 15, thorn five
Add 15, Radix Paeoniae Alba 15, Chinese cassia tree 10, Radix Glycyrrhizae 10.
One day 1 dose, decocting to 300ml warmly takes after meal at twice, and 4 weeks are as a treatment course.
Control group is taken radicular pain and is put down, Chinese medicines quasi-word：[20060182], provided by grand pharmaceutcal corporation, Ltd of Linjiang City.With
Method, two times a day, one time 6, one after each meal, surrounding is as a treatment course.
3rd, observation of curative effect：
3.1 criterion of therapeutical effect：
With reference to Ministry of Health of the People's Republic of China《New Chinese medicine guideline of clinical investigations》It drafts.
Clinical recovery：Lumbocrural pain disappears substantially, Negative straight-leg raising test, recovers normal work；It is effective；Lumbocrural pain
Partial disappearance.Without apparent tender point, Negative straight-leg raising test is basic to recover, normal work；Effectively；There is slight lumbocrural pain,
Straight-leg raising test probable positive, partly resumes work；It is invalid；Lumbocrural pain is without improvement, the straight-leg raising test positive, it is impossible to win
Appoint work.
3.2 statistical procedures：
Using SPSS11.0 softwares, curative effect compares between group and recurrence rate compares, using X2Examine, measurement data with mean+
Standard（X±S）It represents.
3.3 treatment results：
Two groups of patient clinical curative effects are relatively shown in Table 1
1 two groups of patient clinical curative effects of table compare：
| Group | Clinical recovery | It is effective | Effectively | It is invalid | Total effective rate（%） | |
| Observation group | 58 | 21 | 14 | 17 | 6● | （89.7） |
| Control group | 57 | 15 | 7 | 22 | 13● | （77.2） |
Note：Observation group and control group Clinical efficacy comparison ● [P>0.05]
Follow-up recurrence rate is relatively shown in Table 2 after two groups of patient's half a year
Recurrence rate compares after 2 two groups of patient's half a year of table：
| Group | Follow-up proportional numbers | Recurrence rate number | Recurrence effect（%） |
| Observation group | 35 | 6★ | （17.1） |
| Control group | 22 | 9★ | （40.9） |
Note：Observation group ★ [P compared with control group follow-up recurrence rate>0.01]
4th, discuss
The common person between twenty and fifty of the protrasion of the lumbar intervertebral disci, 20-40 Sui patient account for 80%, male to female ratio 8:1, there are about 1/3rd
Patient has trauma history, is physical labourer there are about patients more than half.One side lower limb are numb like ant row, the shallow sense in innervation area
Feel, the pain sensation, thermhypesthesia.Sick time can often find that the limbs of pain attenuate powerless, i.e. muscular atrophy compared with elder.
Most patients have wound, suffer from cold or be overworked after induce waist, buttocks is ached dull pain, pain is delayed after rest
Solution, recurrent exerbation feel one side lower limb gradually and ache after several weeks or several months.Some patient's sudden onset, waist buttocks acutely ache
Bitterly, it is difficult to endure, this some patients has specific trauma history mostly.
Patient has the radiated pain of one side lower limb more（Sciatica）.It is fallen ill after waist stern pain, also has few
Part occur simultaneously with waist-leg or lower limb radiated pain formerly and pain in the back rear.Melosalgia is mostly unilateral side, is opened by waist, buttocks
Begin, be radiated to thigh shank and foot gradually downward, painful area and property are because of nerve, compression position, the compression degree of being pressurized
It is different and different.The intraspinal pressures such as cough, sneezing increase suddenly, can induce that the pain increased, need to reflect with lower limb vascular disease
Not.
Waist disc is made of the fibrous ring of upper and lower cartilage plate, the nucleus pulposus at center and periphery, and protrusion of lumber intervertebral disc mostly occurs in
Between waist 4 ~ 5 and waist 5- sacrums 1, because it is the centrostigma of whole body stress, bears a heavy burden and mobility maximum fibrous ring is due to reversed torsion
Stress and tear, Nucleus pulposus, formed protrusion of lumber intervertebral disc.Locally because of the histamine of rupture tissue release after protrusion of lumber intervertebral disc
And causing chemical inflammation, nucleus pulposus protrusion causes wound caused by autoimmune inflammation and spinal nerve, cauda equina compression
Property inflammation, triple interaction shows corresponding symptom, sign, so as to form the protrasion of the lumbar intervertebral disci, causes pain in waist and lower extremities.
In the course of time, this nerve root sticks together and fibrosis with rupture protrusion, makes the persistent sensation of the nerve to occur and fortune
Dynamic dysfunction, feeling of pain is radial, a lot of in buttocks, is radiated to lower limb rear side, shank, foot are radiated to along thigh rear side
Portion, as the sensation of electro photoluminescence sample.Cough, sneeze, firmly defecation when nerve root can be made more nervous and pain aggravates, it is walking, curved
Waist stretches knee, rises and sit back and wait that the action of drawing nerve root can also make that the pain increased, and the property of melosalgia shows as distending pain, burning pain,
Shouting pain, numbness, with numb originally common, if cauda equina compression can cause perineum numbness, pain, shouting pain, fecal and urinary functions, property work(
There is stool, urine incontinence and double lower limb paralysis in energy obstacle and lower limb radicular pain, severe patient.Course of disease elder, lower limb performance
For Rediating Pain position stolidity.Also someone has Charcot's syndrome symptom, i.e., when patient walks, extends at any time, cause waist
Bitterly, limb pain is numb aggravates, and pain symptom disappears behind squatting position or bed, severe patient's extremity numbness, muscular atrophy, but also has
Some patientss are showed only as pain in the back, without skelagia or only leg disease, without pain in the back.Risk factor has fatigue, suffers from cold, wound, special
It is not stoop labor.The treatment protrasion of the lumbar intervertebral disci is without No operation and non-operative treatment at present, though the traditional Chinese medical science is without protrusion of lumber intervertebral disc
This name of disease of disease, but the traditional Chinese medical science is recognized the protrasion of the lumbar intervertebral disci very early.Such as《Plain Questions pierces pain in the back》It is middle to say " weighing apparatus two arteries and veins of network
Make us pain in the back, can not internal organs face upward, fourth of the twelve Earthly Branches side probably flutter, waist is hindered in the weight lifting obtained " but cloud " three arteries and veins make us pain in the back in meat, it is not possible to cough, cough side muscle
Contracting is anxious ".《Medicine innermost thoughts and feelings》Also say " pain in the back arrested anxious, traction leg foot ".This illustrates motherland's medicine to this sick understanding very early.
The protrasion of the lumbar intervertebral disci belongs to traditional Chinese medical science pain in the back, rheumatism scope, mostly because waist suffers from cold, chill, fatigue, wound cause waist-leg
Portion's channels and collaterals are obstructed, and stagnation of QI-blood operation is not smooth, obstructed side pain.Monarch drug in a prescription of the present invention is treated as rhizoma cibotii, teasel root, the root of Chinese clematis has and lives
Blood stagnation resolvation, filling liver kidney, strong waist and knee, and have cold-dispelling, and degrading the channel, the work(of no pain by smooth breath.Ministerial drug is Radix Angelicae Pubescentis, Fructus Liquidambaris, and Cortex Eucommiae is stretched
Muscle grass, corydalis tuber, Chinese cassia tree, pawpaw etc. have the work(of warming and activating meridian, eliminating cold to stop pain and qualcomm meridian.Adjutant is Ramulus Taxilli, and the root of bidentate achyranthes pierces
Slender acanthopanax, Radix Paeoniae Alba have cold-dispelling filling liver kidney, make medicine for Radix Glycyrrhizae, coordinating the drug actions of a prescription.Its medicine disease is consistent, and treats both principal and secondary aspect of disease, brings out the best in each other.
In conclusion medical instrument has the effect of promoting blood circulation and removing blood stasis, dredging collateral and with expelling wind and cold pathogens, promoting qi circulation and relieving pain among the present invention.With promoting blood circulation and removing blood stasis,
Dispelling wind and eliminating dampness, it is warming channel and expelling cold, based on promoting qi circulation and relieving pain, supplemented by kidney tonifying.Modern research shows that drug for invigorating blood circulation and eliminating stasis can improve microcirculation, make
Extravasated blood is gone, and new blood life improves local organization blood circulation state, promotes local organization metabolism, extravasated blood and inflammatory is promoted to ooze
Go out the absorption of object, accelerate the reparation of tissue adhesion object and scar, effectively eliminate and largely harmful algogenic substance is generated due to ischemic, add
The nutrition supply of strong Waist disc.
Claims (2)
1. a kind of Chinese medicine for treating qi depression to blood stasis and the cold solidifying resistance network type protrasion of the lumbar intervertebral disci, it is characterised in that：Wherein it is formed with
Imitate the parts by weight of raw materials composition of ingredient：
Rhizoma cibotii 15-25, teasel root 15-20, root of Chinese clematis 15-25, corydalis tuber 15-20, Radix Angelicae Pubescentis 10-20, Fructus Liquidambaris 10-20, Cortex Eucommiae 10-
20, Rhizoma Chuanxiong 10-15, lycopodium calvatum 10-20, ramulus mori 10-20, lopseed 10-20, bark of ash 10-15, pawpaw 10-15, Ramulus Taxilli 10-
20, root of bidentate achyranthes 10-20, wilsonii 10-20, Radix Paeoniae Alba 10-15, Chinese cassia tree 5-15, Radix Glycyrrhizae 5-15.
2. the Chinese medicine for the treatment of qi depression to blood stasis according to claim 1 and cold solidifying resistance network type lumbar disc herniation, feature exist
In：The parts by weight of raw materials composition of active ingredient is wherein made：
Rhizoma cibotii 25, teasel root 20, the root of Chinese clematis 25, corydalis tuber 20, Radix Angelicae Pubescentis 20, Fructus Liquidambaris 20, Cortex Eucommiae 20, Rhizoma Chuanxiong 15, lycopodium calvatum 20, ramulus mori
20, lopseed 20, bark of ash 15, pawpaw 15, Ramulus Taxilli 20, the root of bidentate achyranthes 20, wilsonii 20, Radix Paeoniae Alba 15, Chinese cassia tree 15, Radix Glycyrrhizae 10.
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| 三棱针放血加拔罐中药内服治疗腰椎间盘突出症58例;杨孟林;《陕西中医》;20071231(第5期);第595-596页，尤其是第596页左栏第1段 * |
| 中药内服外敷治疗老年腰椎间盘突出症45例;方铄英;《医药世界》;20071231(第9期);第119页，尤其是左栏第20-23行、右栏第11-13、16-23行 * |
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