CN104873561A - Maca preparation and preparation method thereof - Google Patents
Maca preparation and preparation method thereof Download PDFInfo
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- CN104873561A CN104873561A CN201510186506.0A CN201510186506A CN104873561A CN 104873561 A CN104873561 A CN 104873561A CN 201510186506 A CN201510186506 A CN 201510186506A CN 104873561 A CN104873561 A CN 104873561A
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- lycopene
- meyenii walp
- lepidinm meyenii
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Abstract
The invention discloses a Maca-lycopene compound preparation and a preparation method thereof. The Maca-lycopene compound preparation comprises the following main materials in parts by weight: 0.002-10 parts of Maca and 0.002-10 parts of lycopene. according to the Maca-lycopene compound preparation, Maca and lycopene are compounded and combined, and the Maca-lycopene compound preparation's curative effects on andropathy and male function are improved owing to the synergistic effect of Maca and lycopene; the Maca-lycopene compound preparation has a certain treatment effect on senile vascular dementia; meanwhile, lycopene is embedded by a one-step embedding method and then is mixed with Maca to prepare the preparation, so that the stability of Maca and lycopene is improved, and the utilization rate of lycopene is increased; pelletization is performed in one step, so that the number of steps is reduced; and embedded lycopene is dispersed more uniformly.
Description
Technical field
The invention belongs to medicine, field of health care products, be specifically related to a kind of Lepidinm meyenii Walp preparation improving sexual function and preparation method thereof.
Background technology
Lepidinm meyenii Walp is the plateau plant of Cruciferae, originates in the plateau plant in more than 4000 meters, South America Peru Andes.Significant effect is had to balanced human's hormone secretion containing exclusive macamide and Lepidinm meyenii Walp alkene.The firm immune system of Lepidinm meyenii Walp, improves sub-health state, antioxidation, blood fat reducing, prevents arteriosclerosis, and anti-cancer antitumor, enhances metabolism, hepatoprotective, and blood nourishing and calcium replenishing strengthens the motor capacity of muscle, improvement function, improves fertility.Resisting fatigue, improves sperm quality, regains one's strength of body, improve impotence and premature ejaculation, improving water flood, anti-climacteric, active fertility, the effects such as hypermnesis.(Xiao Wei, Peng Yong etc. " new development of Peru's special product medicinal plants Maca research " World Science technology-TCM Modernization, 2007, vol.9, No.3,102-104) and Lepidinm meyenii Walp be that men and women is suitable for, also have good regulating action to the climacteric syndrome of women.Lepidinm meyenii Walp is the original function exciting each organ, the various hormones making it naturally secrete needed by human body to want, and impels body from normal diet, draw the nutrient substance of synthesis required for health.
But because Lepidinm meyenii Walp is plant drying material, once excess moisture will mouldy long bacterium, hypohydration makes its preparation stiff, affects its digesting and assimilating in gastrointestinal tract, so strictly should control moisture in the application.Strict temperature control is wanted, easily being destroyed higher than the nutritional labeling in Lepidinm meyenii Walp when 60 DEG C in the process of drying.
Lycopene is a kind of very strong antioxidant, there is the ability of extremely strong scavenging free radicals, remarkable result is had to preventing and treating carcinoma of prostate, pulmonary carcinoma, breast carcinoma, uterus carcinoma etc., containing powerful antioxidation biology active material, growth and the regeneration of cell can be impelled, beauty treatment Eradicates wrinkle, maintains skin health, the effects such as slow down aging.Lycopene promotes glandular secretion hormone in vivo, thus makes the energy that human body keeps vigorous; Remove the free radical in these Organ and tissues, protect them to escape injury, enhancing human body immunity power.India scholar points out, lycopene can make the increase of Infertil man sperm quantity, vigor strengthens, thus cures sterile problem.Lycopene can help prevention and improve the diseases of urinary system such as prostatic hyperplasia, prostatitis, and contributes to improving mankind spermatozoon quality, reduces infertility risk.A research from Harvard University finds that carotenoid and carcinoma of prostate have certain relation.In the research of carotenoid, lycopene is only had to have clear and definite protective effect.The lycopene (every day more than 6.5 milligrams) that male takes maximal dose every day in the diet with take compared with those at least, the danger that carcinoma of prostate can be made to occur reduces 21%.
Lycopene can eliminate the harmful chemicals thing making male sterility.5 urology department expert random chooses of the department of the Chinese Academy of Sciences of biochemical section of The University of Portsmouth of Britain mean age, the able-bodied man of about 42 years old, requires that they drink one bowl of tomato soup every day in two weeks, collects their semen sample therebetween.Found that, can eliminate and make the lycopene levels of the harmful chemicals thing free radical of male sterility significantly increase in seminal fluid, increasing degree is situated between 7% to 12%.
As factor impacts such as biological active substances light, heat, oxygen, pH, very easily there is oxidation Sum decomposition in lycopene, thus the physiological active functions lost human body and nutritive value, even cause the serious consequences such as body canceration.(Feng Xiaomei, Han Yuqian, Sui Xiao, Guan Huashi " research of lycopene stability " Qingdao Marine University's journal, 2003, vol.33, No.6,875-880)
We find that Lepidinm meyenii Walp lycopene formulations has certain therapeutical effect to vascular senile dementia under study for action.
Summary of the invention
The technical issues that need to address of the present invention are to provide a kind of Lepidinm meyenii Walp lycopene compound preparation and preparation method thereof improving sexual function, motility of sperm, and said preparation more common Lepidinm meyenii Walp preparation better effects if is effective faster.
For solving the problem, the technical solution used in the present invention is:
A kind of Lepidinm meyenii Walp preparation, it comprises the major ingredient of following weight portion: Lepidinm meyenii Walp 0.002 ~ 10 part, lycopene 0.002 ~ 10 part.
Further, also comprise the adjuvant of following weight portion: binding agent 0 ~ 1 part, lubricant 0 ~ 1 part, embedded material 0.006 ~ 20 part.
Preferably, described binding agent is any one or the two or more compositions in polyvidone, starch.
Preferably, described lubricant is magnesium stearate.
Preferably, described embedded material is any one or the two or more combination in arabic gum, pectin, xanthan gum, guar gum, angle fresh kidney beans, sodium alginate, carrageenan, dextrin, oligosaccharide, modified starch, gelatin, casein, soybean protein, lactalbumin, CMC, ethyl cellulose, methylcellulose, insect wax, paraffin or Cera Flava.
The present invention is by Lepidinm meyenii Walp and lycopene compounded combination, and improve the curative effect of preparation, the invention provides a kind of Lepidinm meyenii Walp preparation and preparation method thereof, its step is as follows:
1) Lepidinm meyenii Walp raw material is carried out 80 orders to sieve pretreatment;
2) get a certain amount of modified starch and make solution as in embedded material and whole lycopene homogenizers;
3) by step 2) gained solution adopt spray drying method in the spray drying tower feed liquid is carried out drying, first by air after filtration with heating after, hot-air enters hothouse in the shape of a spiral equably; Feed liquid is through the high speed centrifugal atomization device at tower body top, and rotating spraying becomes imperceptible vaporific liquid pearl, flows Contact drying for finished product with hot-air; Finished product exports by bottom drying tower He in cyclone separator continuously, and waste gas is emptying by air-introduced machine; One step makes embed microcapsule, in preparation process, controls inlet temperature scope 120 ~ 300 DEG C, leaving air temp scope 60 ~ 120 DEG C;
4) will embed body with through the suction three-dimensionally to mix homogeneously under fluidized drying pelletizer negative pressure state of step 1) gained Lepidinm meyenii Walp raw material, again the povidone solution in high pressure liquid pump and mixed material are carried out a step drying and granulating, control inlet temperature at 80 ~ 85 DEG C, temperature of charge is no more than 50 DEG C, leaving air temp is at 60 ~ 70 DEG C, and material moisture controls between 4% ~ 6% the most at last;
5) granule that step 4) is made is mixed homogeneously at three-dimensional mixer with magnesium stearate, incorporation time 30 minutes;
6) material mixed is made tablet or capsule or granule.
The beneficial effect adopting technique scheme to produce is: Lepidinm meyenii Walp and lycopene are carried out compounded combination by the present invention, utilize the synergism of Lepidinm meyenii Walp and lycopene, improve the curative effect of Lepidinm meyenii Walp lycopene formulations in andropathy and function of male, Lepidinm meyenii Walp lycopene formulations has certain therapeutical effect to vascular senile dementia, adopt a step embedding method to be embedded by lycopene simultaneously, preparation is carried out after mixing with Lepidinm meyenii Walp again, improve the stability of Lepidinm meyenii Walp and lycopene, improve the utilization rate of lycopene, granulate and adopt one-step palletizing, step is less, and make lycopene embed body dispersion evenly.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail; should be understood that; below be only preferred embodiments more of the present invention; protection scope of the present invention is not limited in this; every not creative improvement done under spiritual principles of the present invention, all within protection scope of the present invention.Unless stated otherwise, in the present invention, all numbers are parts by weight, and percentage ratio is all weight percentage, and useful water is purified water.
Embodiment 1 ~ 6
Following table is the component data of eye care example of formulations 1 ~ 6 of the present invention:
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
| Pueraria root powder | 10 | 0.002 | 0.2 | 4 | 2.1 | 6 |
| Lycopene | 0.002 | 10 | 7 | 1.5 | 3 | 0.53 |
| Binding agent | 0.05 | 0 | 0.01 | 0.2 | 0.105 | 0.3 |
| Lubricant | 0.1 | 0 | 0.02 | 0.4 | 0.021 | 0.06 |
| Embedded material | 0.002 | 20 | 14 | 3 | 6 | 1.06 |
Lycopene in the present invention is easily subject to the factor impacts such as light, heat, oxygen, pH; very easily there is oxidation Sum decomposition; in order to ensure that lycopene is not destroyed in this preparation process, protect it intact, inventor have employed following different preparation method pilot production preparation and verifies.
Preparation method A
1) each raw material is crossed 60-100 mesh sieve, pueraria root powder and lycopene mixing;
2) the wet granulation of conventional formulation method is adopted;
3) dry, granulate;
4) lubricant mixing is added;
5) material mixed is made granule.
Preparation method B
1) each raw material is crossed 60-100 mesh sieve, adopt embedded material to embed lycopene, and pueraria root powder mix homogeneously;
2) wet granulation is adopted;
3) dry, granulate; (granulate process can make lycopene embed body destruction)
4) lubricant mixing is added;
5) material mixed is made granule.
Preparation method C
1) Lepidinm meyenii Walp raw material is carried out 80 orders to sieve pretreatment;
2) get a certain amount of modified starch and make solution as in embedded material and whole lycopene homogenizers;
3) by step 2) gained solution adopt spray drying method in the spray drying tower feed liquid is carried out drying, first by air after filtration with heating after, hot-air enters hothouse in the shape of a spiral equably; Feed liquid is through the high speed centrifugal atomization device at tower body top, and rotating spraying becomes imperceptible vaporific liquid pearl, flows Contact drying for finished product with hot-air; Finished product exports by bottom drying tower He in cyclone separator continuously, and waste gas is emptying by air-introduced machine; One step makes embed microcapsule, in preparation process, controls inlet temperature scope 120 ~ 300 DEG C, leaving air temp scope 60 ~ 120 DEG C.
4) will embed body with through the suction three-dimensionally to mix homogeneously under fluidized drying pelletizer negative pressure state of step 1) gained Lepidinm meyenii Walp raw material; again the povidone solution in high pressure liquid pump and mixed material are carried out a step drying and granulating; control inlet temperature at 80 ~ 85 DEG C; temperature of charge is no more than 50 DEG C; leaving air temp is at 60 ~ 70 DEG C, and material moisture controls between 4% ~ 6% the most at last.
5) granule that step 4) is made is mixed homogeneously at three-dimensional mixer with magnesium stearate, incorporation time 30 minutes;
6) material mixed is made granule.
For embodiment 1, adopt preparation method A, preparation method B, preparation method C respectively, be prepared into Lepidinm meyenii Walp lycopene formulations a.
Under pH2.0(simulates gastric acid condition) environment under, the light absorption value of lycopene in the preparation of determination experiment example and comparative example, measurement result is in table 1.
The absorbance of lycopene in preparation when table 1:pH2.0, light absorption value A274nm
As can be seen from above-mentioned test data, preparation method C is more suitable for the preparation of invention formulation, and that is, preparation method C is best preparation method of the present invention.
the effect experimental of technical solution of the present invention
In order to verify the different-effect with common Lepidinm meyenii Walp preparation after Lepidinm meyenii Walp of the present invention and lycopene compounded combination, inventor is prepared into Lepidinm meyenii Walp lycopene formulations according to the component proportion of embodiment 1 ~ 6 respectively with preparation method C.Called after experimental example 1 ~ 6 respectively, 7 groups are divided into 200 male of 20 ~ 40 years old, take experimental example 1 ~ 6 and common single Lepidinm meyenii Walp preparation respectively, the experimental subject of experimental example 1 ~ 6 is daily contained to the preparation of Lepidinm meyenii Walp+lycopene 4g, take 30 days, take common single Lepidinm meyenii Walp preparation person daily containing the preparation of Lepidinm meyenii Walp 4g, take 30 days, carry out Lepidinm meyenii Walp lycopene compound preparation of the present invention to the clinical research improving sperm liveness.It is below data table 2.
Table 2: clinical test results
| Experimental example | Experimental example 1(1 group) | Experimental example 2(2 group) | Experimental example 3(3 group) | Experimental example 4(4 group) | Experimental example 5(5 group) | Experimental example 6(6 group) | Common single Lepidinm meyenii Walp (7 groups) |
| Average active sperm quantity (unit: hundred million) before experiment | 0.866 | 0.865 | 0.87 | 0.871 | 0.867 | 0.867 | 0.868 |
| Average active sperm quantity (unit: hundred million) after test | 2.39 | 2.36 | 2.23 | 2.51 | 2.45 | 2.50 | 1.83 |
By the analysis to above 7 groups of experimental results, find that taking Lepidinm meyenii Walp lycopene compound preparation person sperm enlivens quantity and significantly promote, and apparently higher than taking common single Lepidinm meyenii Walp preparation person.Therefore Lepidinm meyenii Walp lycopene compound preparation curative effect is much larger than common single Lepidinm meyenii Walp preparation.
Inventor adopts experimental example 1 ~ 6, find when 200 male's clinical researches of 20 ~ 40 years old, take experimental example 1 ~ 6 preparation person in lipids contents, menopause syndrome also improves significantly, for this reason, inventor has carried out the clinical research of taking Lepidinm meyenii Walp lycopene formulations half a year to 100 more than 60 years old old men.Experimental result show its except blood fat reducing, improve except menopause syndrome, also have certain curative effect to senile dementia, experiment middle-aged and elderly people cognitive competence increase.As can be seen here, invention formulation also can become the novel composing prescription preparation for the treatment of vascular senile dementia.
Claims (6)
1. a Lepidinm meyenii Walp lycopene compound preparation, is characterized in that: it comprises the major ingredient of following weight portion: Lepidinm meyenii Walp 0.002 ~ 10 part, lycopene 0.002 ~ 10 part.
2. a kind of Lepidinm meyenii Walp lycopene compound preparation according to claim 1, characterized by further comprising the adjuvant of following weight portion: binding agent 0 ~ 1 part, lubricant 0 ~ 1 part, embedded material 0.006 ~ 20 part.
3. a kind of Lepidinm meyenii Walp lycopene compound preparation according to claim 2, is characterized in that described binding agent is any one or two or more compositionss in polyvidone, starch.
4. a kind of Lepidinm meyenii Walp lycopene compound preparation according to claim 2, is characterized in that described lubricant is magnesium stearate.
5. a kind of Lepidinm meyenii Walp lycopene compound preparation according to claim 2, is characterized in that described embedded material is any one or two or more combinations in arabic gum, pectin, xanthan gum, guar gum, angle fresh kidney beans, sodium alginate, carrageenan, dextrin, oligosaccharide, modified starch, gelatin, casein, soybean protein, lactalbumin, CMC, ethyl cellulose, methylcellulose, insect wax, paraffin or Cera Flava.
6. a kind of Lepidinm meyenii Walp lycopene compound preparation preparation method according to claim 1, under its step:
1) Lepidinm meyenii Walp raw material is carried out 80 orders to sieve pretreatment;
2) get a certain amount of modified starch and make solution as in embedded material and whole lycopene homogenizers;
3) by step 2) gained solution adopt spray drying method in the spray drying tower feed liquid is carried out drying, first by air after filtration with heating after, hot-air enters hothouse in the shape of a spiral equably; Feed liquid is through the high speed centrifugal atomization device at tower body top, and rotating spraying becomes imperceptible vaporific liquid pearl, flows Contact drying for finished product with hot-air; Finished product exports by bottom drying tower He in cyclone separator continuously, and waste gas is emptying by air-introduced machine; One step makes embed microcapsule, in preparation process, controls inlet temperature scope 120 ~ 300 DEG C, leaving air temp scope 60 ~ 120 DEG C;
4) will embed body with through the suction three-dimensionally to mix homogeneously under fluidized drying pelletizer negative pressure state of step 1) gained Lepidinm meyenii Walp raw material, again the povidone solution in high pressure liquid pump and mixed material are carried out a step drying and granulating, control inlet temperature at 80 ~ 85 DEG C, temperature of charge is no more than 50 DEG C, leaving air temp is at 60 ~ 70 DEG C, and material moisture controls between 4% ~ 6% the most at last;
5) granule that step 4) is made is mixed homogeneously at three-dimensional mixer with magnesium stearate, incorporation time 30 minutes;
6) material mixed is made tablet or capsule or granule.
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Cited By (7)
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| CN105495590A (en) * | 2015-12-18 | 2016-04-20 | 华北制药秦皇岛有限公司 | Perilla frutescens kernel chewable tablet and preparation method thereof |
| CN106579111A (en) * | 2016-11-29 | 2017-04-26 | 广州汇圣森丰农业科技发展有限公司 | Black tomato chewable tablet with anti-oxidation effect |
| CN106578899A (en) * | 2016-12-30 | 2017-04-26 | 贝克尔（天津）药业有限公司 | Instant cereal powder for improving male sperm motility |
| CN106722996A (en) * | 2016-12-29 | 2017-05-31 | 闫文文 | A kind of nutrient health-care powder with anti-fatigue effect and preparation method thereof |
| CN107158060A (en) * | 2017-05-05 | 2017-09-15 | 上海宣泰生物科技有限公司 | Treat the compound slow release preparation of male sterility |
| CN107668755A (en) * | 2017-09-25 | 2018-02-09 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of anti-oxidant microencapsulation material |
| CN113317495A (en) * | 2021-06-03 | 2021-08-31 | 宁夏医科大学总医院 | Instant cereal powder for improving male sperm motility and processing method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105495590A (en) * | 2015-12-18 | 2016-04-20 | 华北制药秦皇岛有限公司 | Perilla frutescens kernel chewable tablet and preparation method thereof |
| CN106579111A (en) * | 2016-11-29 | 2017-04-26 | 广州汇圣森丰农业科技发展有限公司 | Black tomato chewable tablet with anti-oxidation effect |
| CN106722996A (en) * | 2016-12-29 | 2017-05-31 | 闫文文 | A kind of nutrient health-care powder with anti-fatigue effect and preparation method thereof |
| CN106578899A (en) * | 2016-12-30 | 2017-04-26 | 贝克尔（天津）药业有限公司 | Instant cereal powder for improving male sperm motility |
| CN107158060A (en) * | 2017-05-05 | 2017-09-15 | 上海宣泰生物科技有限公司 | Treat the compound slow release preparation of male sterility |
| CN107668755A (en) * | 2017-09-25 | 2018-02-09 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of anti-oxidant microencapsulation material |
| CN113317495A (en) * | 2021-06-03 | 2021-08-31 | 宁夏医科大学总医院 | Instant cereal powder for improving male sperm motility and processing method |
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| CN104873561B (en) | 2018-08-24 |
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