CN104867529B - A kind of medical-isotope production method and device based on laser wakefield accelerator - Google Patents

A kind of medical-isotope production method and device based on laser wakefield accelerator Download PDF

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Publication number
CN104867529B
CN104867529B CN201510239684.5A CN201510239684A CN104867529B CN 104867529 B CN104867529 B CN 104867529B CN 201510239684 A CN201510239684 A CN 201510239684A CN 104867529 B CN104867529 B CN 104867529B
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laser
target
medical
isotope
bremsstrahlung
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CN104867529A (en
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罗文�
艾念
宋英明
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XIAOGAN CENTRAL HOSPITAL
University of South China
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XIAOGAN CENTRAL HOSPITAL
University of South China
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/02—Neutron sources

Abstract

The present invention provides a kind of medical-isotope production method and device based on laser wakefield accelerator, INTENSE RELATIVISTIC ELECTRON BEAM is produced using ultra-short intense laser and Plasma Interaction, Gao Liuqiang bremsstrahlung gamma light is produced using the electron beam irradiation high Z target, bremsstrahlung gamma light bombards target interested, induce (γ, xn+yp) photonuclear reaction or (γ, γ ') light provocative reaction, produce target isotope, including gamma rays, electronics, positive electron, α emitters.The method of the present invention can produce the higher radio isotope of activity, and expense is more economical；The present invention device there is compactedness and portable, can be placed near larger medical mechanism, can preferably application and service in the medical application such as radiodiagnosis and targeted therapy.

Description

A kind of medical-isotope production method and device based on laser wakefield accelerator
Technical field
The present invention relates to applied nuclear technologies field, and in particular to a kind of medical-isotope production based on laser wakefield accelerator Generation method and device.
Background technology
As a branch of medical science, nuclear medicine using non-natural isotope (including radio isotope and stability it is same Position element) and nuclear radiation carry out biomedical research and disease treatment.On the one hand, the radiation that radio isotope is produced can be used for The diagnostic message of some certain organs of organism is provided, current this kind of diagnostic program turns into routine business；On the other hand, may be used Radionuclide is selectively introduced into pathological tissues, using its transmitting α, β irridiation injury active growth cancer cell or Other pathological tissues, to reach the purpose for the treatment of.
10,000 hospitals are had more than in world wide and have carried out nuclear medicine procedure of the number in terms of necessarily altogether every year, wherein 90% program is used for nuclear medicine diagnostic.Isotope for radiodiagnosis mainly has99Mo/99mTc,18F,11C,68Ga,123, 124I,131I,64Cu etc., and mainly having for radiotherapy131I,177Lu,186 , 188Re,90Y,153Sm,213Bi,212At,225Ra/225Ac,67Cu,111In,103Pd,195mPt etc..These isotope producing methods are relatively simple, generally accelerated by charged particle Device (including linear accelerator or cyclotron) or nuclear reactor are produced.99mTc is said apparatus production for radiodiagnosis The most frequently used radio isotope, it is annual to utilize99mThe diagnostic program up to 40,000,000 to 4,005,000,000 that Tc carries out, accounts for the world The 80% of upper all nuclear medicine procedures.In 26% developed country of world population is accounted for, the frequency of annual radiodiagnosis is 1.9%, and the frequency of radiotherapy is about 1/10th of radiodiagnosis.At the U.S. (3.1 hundred million population), use more than every year 2000 ten thousand nuclear medicine procedures, European (500,000,000 population) is 1,000 ten thousand times, and Australian (0.2 hundred million population) is 560,000 times.
In radiodiagnosis, the use annual growth of radiopharmaceutical is more than 10%.However, due to existing medical same position The production capacity of plain generation device reaches the upper limit already, along with the market demand increased fast, the confession of medical radioisotope Situation should not be asked increasingly serious.With99Mo/99mExemplified by the process units of Tc isotopes, there are 5 block response heaps in the world at present (in Son induces highly enriched235U about 95%) is produced99Mo market supplies.However, wherein three block response heaps are faced with because of the operation time limit Stop production.Canadian Chalk River NRU reactors be (production about 40%99Mo market supplies) brought into operation in nineteen fifty-seven, its In run successively again after shutdown for several times, it is contemplated that in final plant closure in 2016；French Saclay OSIRIS (70 megawatts) reactor Announced and closed in the end of the year 2015 by French Government；Belgian BR2 reactors predicted operation is appointed to 2016, and not What technical reason not shutdown before the year two thousand twenty.
What is particularly worth mentioning is that, due to 200899Mo supplies crisis, and most case control is because that can not use99mTc carries out SPECT and is postponed or canceled.Separately there are hundreds thousand of patients to be forced to select more higher-priced PET, or use imaging effect Really goodish radio isotope.As can be seen here, the ever-increasing market demand and nearest supply discontinuity and plan In reactor shut-down, this will force countries in the world scientific research personnel to seek more effective ways to ensure99Mo and its decay Product99mTc stable supply.
The content of the invention
It is and traditional it is an object of the invention to provide a kind of medical-isotope production method based on laser wakefield accelerator Isotope production method is compared, and can produce the higher radio isotope of activity, and expense is more economical.
In addition, another object of the present invention is to provide a kind of medical-isotope generation device based on laser wakefield accelerator, There is compactedness and portable, can be placed near larger medical mechanism, preferably application and service can be examined in radiation The medical applications such as disconnected and targeted therapy.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of medical-isotope production method based on laser wakefield accelerator, using ultra-short intense laser and plasma Interaction produces INTENSE RELATIVISTIC ELECTRON BEAM, and Gao Liuqiang bremsstrahlung is produced using the electron beam irradiation high Z target Gamma light, bremsstrahlung gamma light bombards target interested, induces (γ, xn+yp) photonuclear reaction or (γ, γ ') light swashs Hair reaction, produces target isotope, including gamma rays, electronics, positive electron, α emitters.
According to above scheme, a kind of medical-isotope generation device based on laser wakefield accelerator, including for producing Laser compression chamber, the laser of ultra-intense ultra-short laser pulse assemble and diagnostic system, high pressure jetting gas generating unit, electron beam are examined Disconnected system, bremsstrahlung target (high Z target), target (medical-isotope generation target), gamma light and neutron detection Device, lead screen device.
According to above scheme, laser aggregation and diagnostic system include time reversal, speculum or spectroscope, from turning parabolic Face mirror, autocorrelation function analyzer, interferometer, resolution optical switch and imaging spectrometer.
According to above scheme, the time-dependent spectra system includes integration rectifier transformer, fluorescent screen and CCD.
According to above scheme, the bremsstrahlung target includes lead target, tungsten target, gold target.
According to above scheme, the gamma light and neutron detector include helium 3 neutron detector, GM counting tubes and ionization Room.
The beneficial effects of the invention are as follows：
1) method of the invention can produce the same position of the higher radioactivity of activity compared with traditional isotope production method Element, and expense is more economical；
2) method of the invention can be produced47Sc、44Ti、64Cu、103Pd、117mSn、165Er、169Er、195mPt、 99Mo/99mTc、225Ra/225A variety of isotopes such as Ac, for medical diagnosis and targeted therapy；
3) device of the invention has the advantages that compactedness (floor space is small) and portable, can be placed in larger medical machine Near structure, can preferably application and service in the medical application such as radiodiagnosis and targeted therapy.
Brief description of the drawings
Fig. 1 is the device operation principle schematic diagram of the present invention.
In figure：10th, laser compression chamber；21st, time reversal；22nd, speculum or spectroscope；23rd, from turning paraboloidal mirror；24th, certainly Correlator；25th, interferometer；26th, resolution optical is switched；27th, imaging spectrometer；30th, high pressure jetting gas generating unit；41st, product Divide rectifier transformer；42nd, fluorescent screen；43rd, CCD charge coupled cells；50th, bremsstrahlung target；60th, target；71st, helium 3 Neutron detector；72nd, GM counting tubes；73rd, ionisation chamber；80th, lead screen device.
Embodiment
Technical scheme is illustrated with embodiment below in conjunction with the accompanying drawings.
The present invention provides a kind of medical-isotope production method based on laser wakefield accelerator and uses ultra-short intense laser INTENSE RELATIVISTIC ELECTRON BEAM is produced with Plasma Interaction, Gao Liuqiang is produced using the electron beam irradiation high Z target Bremsstrahlung gamma light, bremsstrahlung gamma light bombards target interested, induce (γ, xn+yp) photonuclear reaction or (γ, γ ') light provocative reaction, produces target isotope, including gamma rays, electronics, positive electron, α emitters.
According to above scheme, a kind of medical-isotope generation device based on laser wakefield accelerator, including for producing Laser compression chamber 10, the laser of ultra-intense ultra-short laser pulse are assembled and diagnostic system, high pressure jetting gas generating unit 30, electronics Beam diagnostic system, bremsstrahlung target 50, target 60, gamma light and neutron detector, lead screen device 80.
Further, laser aggregation and diagnostic system include time reversal 21, speculum or spectroscope 22, from turning parabolic Face mirror 23, autocorrelation function analyzer 24, interferometer 25, resolution optical switch 26 and imaging spectrometer 27.
Further, the time-dependent spectra system includes integration rectifier transformer 41, fluorescent screen 42 and CCD Charged Couples Element 43.
Further, the bremsstrahlung target is gold target.
Further, the gamma light and neutron detector include helium 3 neutron detector 71, GM counting tubes 72 and ionisation chamber 73。
The inventive method and the operation principle of device are as follows：Launch superpower ultrashort sharp using the laser compression chamber 10 Light, assembles with the speculum or spectroscope 22 of diagnostic system, from paraboloidal mirror 23 is turned, the height incided by the laser Press insufflation gas generating means 30, by with Plasma Interaction, make gas molecule therein by laser-beam ionization, ionization Electronics by high field intensity gradient laser coda wave capture and by sync plus white to obtain ten to tens million electro-volts of electron beams, the electricity Beamlet irradiates high atomic number bremsstrahlung target through the integration rectifier transformer 41 in the time-dependent spectra system 50 produce Gao Liuqiang bremsstrahlung gamma light, and bremsstrahlung gamma light bombards the target 60 interested, induce (γ, Xn+yp) photonuclear reaction or (γ, γ ') light provocative reaction, obtain radio isotope interested, including gamma rays, electricity Son, positive electron, α emitters, applied to nuclear medicine applications such as radiodiagnosis and targeted therapies.
Laser aggregation and diagnostic system include the time reversal 21, speculum or spectroscope 22, from turning paraboloidal mirror 23rd, autocorrelation function analyzer 24, interferometer 25, resolution optical switch 26 and imaging spectrometer 27, mainly to the laser compression chamber 10 The ultra-short intense laser launched carries out detection and focused on and diagnosis；The time-dependent spectra system includes the integration rectifier transformer Device 41, fluorescent screen 42 and charge coupled cell CCD43, are mainly to surplus after the quantity of electric charge of the electron beam of generation and interaction Remaining electronics carries out fluorescent screen CCD imagings；The gamma light and neutron detector include the helium 3 neutron detector 71, GM and counted Pipe 72 and ionisation chamber 73, mainly to gamma light and the radiation detection of neutron；Institute's lead screen device 80 mainly shields electron beam, Prevent from damaging the person with surrounding environment.
Above example is only used to illustrative and not limiting technical scheme, although above-described embodiment enters to the present invention Detailed description is gone, the person skilled of this area should be understood：The present invention can be modified or replaced on an equal basis, but Not departing from any modification and local replacement of spirit and scope of the invention all should cover in scope of the presently claimed invention.

Claims (4)

1. a kind of medical-isotope generation device based on laser wakefield accelerator, it is characterised in that including superpower for producing The laser compression chamber of ultrashort laser pulse（10）, laser aggregation and diagnostic system, high pressure jetting gas generating unit（30）, electronics Beam diagnostic system, bremsstrahlung target（50）, target (60), gamma light and neutron detector and lead screen device（80）, The laser compression chamber（10）, laser aggregation and diagnostic system and high pressure jetting gas generating unit（30）Between pass through laser phase Connect, the high pressure jetting gas generating unit（30）, time-dependent spectra system and bremsstrahlung target（50）Between lead to Cross electron beam connection, the bremsstrahlung target（50）, between target (60) and gamma light and neutron detector pass through gal Agate light connects.
2. the medical-isotope generation device according to claim 1 based on laser wakefield accelerator, it is characterised in that institute Stating laser aggregation and diagnostic system includes the time reversal by laser interconnection（21）, speculum or spectroscope（22）, from turn Paraboloidal mirror（23）, autocorrelation function analyzer（24）, interferometer（25）, resolution optical switch（26）And imaging spectrometer（27）.
3. the medical-isotope generation device according to claim 1 based on laser wakefield accelerator, it is characterised in that institute Stating bremsstrahlung target includes lead target, tungsten target or gold target.
4. the medical-isotope generation device according to claim 1 based on laser wakefield accelerator, it is characterised in that institute Stating gamma light and neutron detector includes helium 3 neutron detector（71）, GM counting tubes（72）And ionisation chamber（73）, in the helium 3 Sub- detector（71）, GM counting tubes（72）And ionisation chamber（73）Between electrically connect.
CN201510239684.5A 2015-05-12 2015-05-12 A kind of medical-isotope production method and device based on laser wakefield accelerator Expired - Fee Related CN104867529B (en)

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BR112019027879A2 (en) * 2017-06-29 2020-08-18 The South African Nuclear Energy Corporation Soc Limited radioisotope production
CN107622807A (en) * 2017-09-20 2018-01-23 西安海达威科技有限责任公司 It is a kind of to produce radioisotopic device and method with phot-neutron source
JP2021532365A (en) * 2018-08-02 2021-11-25 エルイーエヌアール—シティーズ スイス エスエーアールエルLenr−Cities Suisse Sarl Methods and systems for producing radioisotopes for medical applications
CN110853792B (en) * 2019-11-11 2021-07-23 西安迈斯拓扑科技有限公司 Method and apparatus for producing medical isotopes based on high power electron accelerators
CN114302552B (en) * 2021-12-09 2023-02-07 清华大学 Composite conversion target

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