CN104867529A - Medical isotope generation method and device based on laser wake-field accelerator - Google Patents

Medical isotope generation method and device based on laser wake-field accelerator Download PDF

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Publication number
CN104867529A
CN104867529A CN201510239684.5A CN201510239684A CN104867529A CN 104867529 A CN104867529 A CN 104867529A CN 201510239684 A CN201510239684 A CN 201510239684A CN 104867529 A CN104867529 A CN 104867529A
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laser
target
medical
gamma
isotope
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CN104867529B (en
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罗文�
艾念
宋英明
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XIAOGAN CENTRAL HOSPITAL
Nanhua University
University of South China
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XIAOGAN CENTRAL HOSPITAL
University of South China
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/02—Neutron sources

Abstract

The invention provides a medical isotope generation method and device based on a laser wake-field accelerator. Interaction between super-strong and super-short lasers and plasma is utilized to generate a strong flow relativity electron beam. The electron beam is utilized to irradiate a high atomic number target to generate high-flow-strength bremsstrahlung gamma light. The bremsstrahlung gamma light bombards an interested object target to induce a ([gamma], xn+yp) photonuclear reaction or a ([gamma], [gamma]') optical excitation reaction, and object isotopes including gamma rays, electrons, positive electrons and [alpha] particle emitters are generated. By adopting the method provided by the invention, radio isotopes higher in activity are generated, and the cost is relatively low; in addition, the device provided by the invention is compact and convenient to carry, and the device is capable of being placed near a large-sized medical mechanism to be better applied to and serve radiation diagnosis, targeting treatment and other medical applications.

Description

A kind of medical-isotope production method based on laser wakefield accelerator and device
Technical field
The present invention relates to applied nuclear technologies field, be specifically related to a kind of medical-isotope production method based on laser wakefield accelerator and device.
Background technology
As a branch of medical science, nuclear medicine utilizes non-natural isotope (comprising radioactive isotope and stable isotope) and nuclear radiation to carry out biomedical research and disease treatment.On the one hand, the radiation that radioactive isotope produces can be used for the diagnostic message of certain certain organs providing biosome, and current this kind of diagnostic routine becomes routine business; On the other hand, radioactive nuclide can be introduced pathological tissues selectively, the cancer cell of α, β irridiation injury active growth utilizing it to launch or other pathological tissues, to reach the object for the treatment of.
Have in world wide and altogether carried out number every year in nuclear medicine procedure necessarily more than 10,000 hospitals, wherein the program of 90% is used for nuclear medicine diagnostic.Isotope for radiodiagnosis mainly contains 99mo/ 99mtc, 18f, 11c, 68ga, 123,124i, 131i, 64cu etc., and mainly contain for radiocurable 131i, 177lu, 186 , 188re, 90y, 153sm, 213bi, 212at, 225ra/ 225ac, 67cu, 111in, 103pd, 195mpt etc.These isotope producing methods are more single, usually produced by charged particle accelerator (comprising linear accelerator or cyclotron) or nuclear reactor. 99mtc is the most frequently used radioactive isotope for radiodiagnosis that said apparatus is produced, and utilizes every year 99mthe diagnostic routine that Tc carries out reaches 4,000 ten thousand to four thousand five hundred ten thousand, accounts for 80% of all nuclear medicine procedure in the world.In the developed country of world population accounting for 26%, the frequency of annual radiodiagnosis is 1.9%, and radiocurable frequency is about 1/10th of radiodiagnosis.At the U.S. (3.1 hundred million population), use more than 2,000 ten thousand nuclear medicine procedure every year, Europe (500,000,000 population) is 1,000 ten thousand times, and Australia's (0.2 hundred million population) is 560,000 times.
In radiodiagnosis, radiopharmaceutic use annual growth is more than 10%.But because the productive capacity of existing medical-isotope generation device reaches the upper limit already, add the market demand and increased fast, supply falls short of demand that situation is increasingly serious for medical radioisotope.With 99mo/ 99mthe isotopic process units of Tc is example, has 5 block response heaps (to bring out highly enriched with neutron at present in the world 235u) about 95% is produced 99mo market supply.But wherein three block response heaps are faced with stopping production because running the time limit.The NRU reactor of Canada Chalk River (produces about 40% 99mo market supply) bring into operation in nineteen fifty-seven, wherein run successively again after shutdown for several times, estimate in 2016 years final plant closures; OSIRIS (70 megawatt) reactor of France Saclay announced the end of the year 2015 by French Government closes; Belgian BR2 reactor predicted operation to 2016 year, and without any technical reason not shutdown before the year two thousand twenty.
What is particularly worth mentioning is that, due to 2008 years 99mo supplies crisis, and most case control is because using 99mtc carries out SPECT and is postponed or canceled.Separately there is hundreds thousand of patient to be forced to select more higher-priced PET, or use the goodish radioactive isotope of imaging effect.As can be seen here, the ever-increasing market demand and nearest supply failure and calculated reactor shut-down, this will force countries in the world scientific research personnel to seek more effective way to guarantee 99mo and decay product thereof 99mthe stable supply of Tc.
Summary of the invention
The object of this invention is to provide a kind of medical-isotope production method based on laser wakefield accelerator, compared with traditional isotope production method, the radioactive isotope that activity is higher can be produced, and expense less expensive.
In addition, another object of the present invention is to provide a kind of medical-isotope generation device based on laser wakefield accelerator, there is compactedness and the advantage such as portable, can be placed near larger medical mechanism, can better application and service in the medical application such as radiodiagnosis and targeted therapy.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of medical-isotope production method based on laser wakefield accelerator, ultra-short intense laser and Plasma Interaction is adopted to produce INTENSE RELATIVISTIC ELECTRON BEAM, this electron beam irradiation high Z target is utilized to produce the bremsstrahlung gamma light of Gao Liuqiang, bremsstrahlung gamma light bombards interested target, bring out (γ, xn+yp) photonuclear reaction or (γ, γ ') optical excitation reaction, produce target isotope, comprise gamma rays, electronics, positron, α emitter.
According to above scheme, based on a medical-isotope generation device for laser wakefield accelerator, comprise and assembling and diagnostic system, high pressure jetting gas generating unit, time-dependent spectra system, bremsstrahlung target (high Z target), target (medical-isotope generation target), gamma light and neutron detector, lead shield device for generation of the laser compression chamber of ultra-intense ultra-short laser pulse, laser.
According to above scheme, described laser is assembled and diagnostic system comprises time reversal, catoptron or spectroscope, from turning paraboloidal mirror, autocorrelation function analyzer, interferometer, resolution optical switch and imaging spectrometer.
According to above scheme, described time-dependent spectra system comprises integration rectifier transformer, video screen and CCD.
According to above scheme, described bremsstrahlung target comprises plumbous target, tungsten target, gold target.
According to above scheme, described gamma light and neutron detector comprise helium 3 neutron detector, GM counter tube and ionization chamber.
The invention has the beneficial effects as follows:
1) method of the present invention is compared with traditional isotope production method, can produce the radioactive isotope that activity is higher, and expense less expensive;
2) method of the present invention can produce 47sc, 44ti, 64cu, 103pd, 117msn, 165er, 169er, 195mpt, 99mo/ 99mtc, 225ra/ 225the multiple isotope such as Ac, for medical diagnosis and targeted therapy;
3) device of the present invention has compactedness (floor area is little) and the advantage such as portable, can be placed near larger medical mechanism, can better application and service in the medical application such as radiodiagnosis and targeted therapy.
Accompanying drawing explanation
Fig. 1 is device principle of work schematic diagram of the present invention.
In figure: 10, laser compression chamber; 21, time reversal; 22, catoptron or spectroscope; 23, from turning paraboloidal mirror; 24, autocorrelation function analyzer; 25, interferometer; 26, resolution optical switch; 27, imaging spectrometer; 30, high pressure jetting gas generating unit; 41, integration rectifier transformer; 42, video screen; 43, CCD charge coupled cell; 50, bremsstrahlung target; 60, target; 71, helium 3 neutron detector; 72, GM counter tube; 73, ionization chamber; 80, lead shield device.
Embodiment
Below in conjunction with accompanying drawing and embodiment, technical scheme of the present invention is described.
The invention provides a kind of medical-isotope production method based on laser wakefield accelerator adopts ultra-short intense laser and Plasma Interaction to produce INTENSE RELATIVISTIC ELECTRON BEAM, this electron beam irradiation high Z target is utilized to produce the bremsstrahlung gamma light of Gao Liuqiang, bremsstrahlung gamma light bombards interested target, bring out (γ, xn+yp) photonuclear reaction or (γ, γ ') optical excitation reaction, produce target isotope, comprise gamma rays, electronics, positron, α emitter.
According to above scheme, based on a medical-isotope generation device for laser wakefield accelerator, comprise for generation of the laser compression chamber 10 of ultra-intense ultra-short laser pulse, laser assembles and diagnostic system, high pressure jetting gas generating unit 30, time-dependent spectra system, bremsstrahlung target 50, target 60, gamma light and neutron detector, lead shield device 80.
Further, described laser gathering and diagnostic system comprise time reversal 21, catoptron or spectroscope 22, from turning paraboloidal mirror 23, autocorrelation function analyzer 24, interferometer 25, resolution optical switch 26 and imaging spectrometer 27.
Further, described time-dependent spectra system comprises integration rectifier transformer 41, video screen 42 and CCD charge coupled cell 43.
Further, described bremsstrahlung target is gold target.
Further, described gamma light and neutron detector comprise helium 3 neutron detector 71, GM counter tube 72 and ionization chamber 73.
The principle of work of the inventive method and device is as follows: utilize described laser compression chamber 10 to launch ultra-short intense laser, assemble and the catoptron of diagnostic system or spectroscope 22 through described laser, from turning paraboloidal mirror 23, the described high pressure jetting gas generating unit 30 incided, by with Plasma Interaction, make gas molecule wherein by laser-beam ionization, the electronics of ionization is caught by the laser coda wave of high field intensity gradient and by sync plus white to obtain ten to tens MeV electron beams, the described integration rectifier transformer 41 of this electron beam in described time-dependent spectra system, irradiation high atomic number bremsstrahlung target 50 produces the bremsstrahlung gamma light of Gao Liuqiang, the interested described target 60 of bremsstrahlung gamma light bombardment, bring out (γ, xn+yp) photonuclear reaction or (γ, γ ') optical excitation reaction, obtain interested radioactive isotope, comprise gamma rays, electronics, positron, α emitter, be applied to the nuclear medicine application such as radiodiagnosis and targeted therapy.
Described laser assembles and diagnostic system comprises described time reversal 21, catoptron or spectroscope 22, from turning paraboloidal mirror 23, autocorrelation function analyzer 24, interferometer 25, resolution optical switch 26 and imaging spectrometer 27, the ultra-short intense laser mainly launched described laser compression chamber 10 carries out detection and focuses on and diagnosis; Described time-dependent spectra system comprises described integration rectifier transformer 41, video screen 42 and charge coupled cell CCD43, mainly carries out video screen CCD imaging to the quantity of electric charge of the electron beam produced and the excess electron after interacting; Described gamma light and neutron detector comprise described helium 3 neutron detector 71, GM counter tube 72 and ionization chamber 73, mainly to the radiation detection of gamma light and neutron; Institute's lead shield device 80 mainly screening electron bundle, prevents from damaging the person and surrounding environment.
Above embodiment is the unrestricted technical scheme of the present invention in order to explanation only, although above-described embodiment is to invention has been detailed description, the person skilled of this area is to be understood that: can modify to the present invention or replace on an equal basis, but any amendment not departing from spirit and scope of the invention all should be encompassed in right of the present invention with local replacement.

Claims (6)

1. the medical-isotope production method based on laser wakefield accelerator, it is characterized in that, ultra-short intense laser and Plasma Interaction is adopted to produce INTENSE RELATIVISTIC ELECTRON BEAM, this electron beam irradiation high Z target is utilized to produce the bremsstrahlung gamma light of Gao Liuqiang, bremsstrahlung gamma light bombards interested target, bring out (γ, xn+yp) photonuclear reaction or (γ, γ ') optical excitation reaction, produce target isotope, comprise gamma rays, electronics, positron, α emitter.
2. the medical-isotope generation device based on laser wakefield accelerator, it is characterized in that, comprise for generation of the laser compression chamber (10) of ultra-intense ultra-short laser pulse, laser assembles and diagnostic system, high pressure jetting gas generating unit (30), time-dependent spectra system, bremsstrahlung target (50), target (60), gamma light and neutron detector, lead shield device (80).
3. the medical-isotope generation device based on laser wakefield accelerator according to claim 2, it is characterized in that, described laser is assembled and diagnostic system comprises time reversal (21), catoptron or spectroscope (22), from turning paraboloidal mirror (23), autocorrelation function analyzer (24), interferometer (25), resolution optical switch (26) and imaging spectrometer (27).
4. the medical-isotope generation device based on laser wakefield accelerator according to claim 2, is characterized in that, comprises integration rectifier transformer (41), video screen (42) and CCD (43).
5. the medical-isotope generation device based on laser wakefield accelerator according to claim 2, it is characterized in that, described bremsstrahlung target comprises plumbous target, tungsten target, gold target.
6. the medical-isotope generation device based on laser wakefield accelerator according to claim 2, it is characterized in that, described gamma light and neutron detector comprise helium 3 neutron detector (71), GM counter tube (72) and ionization chamber (73).
CN201510239684.5A 2015-05-12 2015-05-12 A kind of medical-isotope production method and device based on laser wakefield accelerator Expired - Fee Related CN104867529B (en)

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CN105934065A (en) * 2016-05-18 2016-09-07 中国科学院高能物理研究所 Acceleration system for low-energy pulse charged particle beam
CN107622807A (en) * 2017-09-20 2018-01-23 西安海达威科技有限责任公司 It is a kind of to produce radioisotopic device and method with phot-neutron source
CN110853792A (en) * 2019-11-11 2020-02-28 西安迈斯拓扑科技有限公司 Method and apparatus for producing medical isotopes based on high power electron accelerators
CN111052262A (en) * 2017-06-29 2020-04-21 南非核能Soc有限公司 Preparation of radioisotopes
CN112567478A (en) * 2018-08-02 2021-03-26 Lenr西提斯瑞士有限责任公司 Method and system for generating radioisotopes for medical applications
CN114302552A (en) * 2021-12-09 2022-04-08 清华大学 Composite conversion target

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105934065A (en) * 2016-05-18 2016-09-07 中国科学院高能物理研究所 Acceleration system for low-energy pulse charged particle beam
CN111052262A (en) * 2017-06-29 2020-04-21 南非核能Soc有限公司 Preparation of radioisotopes
CN107622807A (en) * 2017-09-20 2018-01-23 西安海达威科技有限责任公司 It is a kind of to produce radioisotopic device and method with phot-neutron source
CN112567478A (en) * 2018-08-02 2021-03-26 Lenr西提斯瑞士有限责任公司 Method and system for generating radioisotopes for medical applications
CN110853792A (en) * 2019-11-11 2020-02-28 西安迈斯拓扑科技有限公司 Method and apparatus for producing medical isotopes based on high power electron accelerators
CN110853792B (en) * 2019-11-11 2021-07-23 西安迈斯拓扑科技有限公司 Method and apparatus for producing medical isotopes based on high power electron accelerators
CN114302552A (en) * 2021-12-09 2022-04-08 清华大学 Composite conversion target

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