CN104862380B - 家族特异性遗传病关联等位基因单体型变异标签确认方法 - Google Patents
家族特异性遗传病关联等位基因单体型变异标签确认方法 Download PDFInfo
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- CN104862380B CN104862380B CN201410065331.3A CN201410065331A CN104862380B CN 104862380 B CN104862380 B CN 104862380B CN 201410065331 A CN201410065331 A CN 201410065331A CN 104862380 B CN104862380 B CN 104862380B
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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Abstract
Description
基因名 | 编号 | 长度 | 正向引物 | 反向引物 |
EXT1 | 1 | 1735 | gtgtaacattcagaaccgggt | cacaatgcacgggagagag |
1 | 1735 | ccctgggtgcgagatattca | tggagactctgcactttgga | |
1 | 1735 | gagggctccaggttctacac | aaggctgactcccaaagaca | |
EXT1 | 2 | 94 | ggtcaatatccccacattcgc | ttcggtcctcagccctattc |
EXT1 | 3 | 108 | gctgtcgctttcctcacatt | ctgctgatgtgttgaaggcc |
EXT1 | 4 | 120 | ctctttgcagctgacacttct | accattattcaagcccaagagc |
EXT1 | 5 | 133 | cactactctgactgccacca | tcagggtaaacaagggcaac |
EXT1 | 6 | 119 | tttccagcgcttcattaggc | ttctctgtcaacttcccgct |
EXT1 | 7 | 96 | gctttgggttggaggcatac | tctagggccaagacccaaag |
EXT1 | 8 | 90 | gcaggtgaggatgggagaat | ctcctcaggcatgggttctt |
EXT1 | 9 | 161 | tgcttgtttggcttgtgttct | agagacatgtccagattcctca |
EXT1 | 10 | 172 | cccctgtgaaacccatctttg | gaaccaccagtgagtgaagc |
EXT1 | 11 | 535 | cttgtttctctccttctccctag | ggaaaaggaatagcagctttgaa |
EXT2 | 1 | 304 | gtggtgtctcgtttgggttt | cttgtcccgacccagcag |
EXT2 | 2 | 125 | acctgttctcctagccaacc | catctagttcccggtcaccc |
EXT2 | 3 | 566 | atttctctccctggtgacca | cccatccttcccttcccttt |
EXT2 | 4 | 90 | gggcttggggatccttgata | gacagccccaaatatgcctc |
EXT2 | 5 | 117 | tgttcctctccacagtgtgt | tggctgggatgaatgtacct |
EXT2 | 6 | 196 | ccagctgcaattttccaatcac | cccatgtaagcaaactctcctg |
EXT2 | 7 | 140 | ttgcctctttgtgttcctgc | cgcagaaccactaatgtagagt |
EXT2 | 8 | 94 | gctttctgtgaagggctgtg | gctcctgtccctctgtatcc |
EXT2 | 9 | 132 | tttcccactctgtctcgctt | tcatgtggctagcactggaa |
EXT2 | 10 | 190 | acccgtgttaatctgtcctct | gatccagctgagagaggcac |
EXT2 | 11 | 167 | ggatttgatgagagccgtgg | aacccacactcttacgcaca |
EXT2 | 12 | 144 | gcactgaatggttgctgtct | tcagttttgtcaccttgccag |
EXT2 | 13 | 129 | tgctgccccttatttatcagc | acaaagcaagtgagtggcag |
EXT2 | 14 | 83 | gaggtgtgtgtgtgtgtgtg | gcacttttggttggaggctc |
EXT2 | 15 | 1282 | cctcctctccaaatcccaca | tggaactgaaaacaaagggagc |
15 | 1282 | tggaagactttgtggcatgc | tgggaccttcttacgcttga | |
15 | 1282 | taactccgtctttggcctga | cgccagggtagatttgttca |
Claims (5)
Priority Applications (2)
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CN201410065331.3A CN104862380B (zh) | 2014-02-25 | 2014-02-25 | 家族特异性遗传病关联等位基因单体型变异标签确认方法 |
PCT/CN2015/072589 WO2015127853A1 (zh) | 2014-02-25 | 2015-02-09 | 家族特异性遗传病关联等位基因单体型变异标签确认方法 |
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CN201410065331.3A CN104862380B (zh) | 2014-02-25 | 2014-02-25 | 家族特异性遗传病关联等位基因单体型变异标签确认方法 |
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CN104862380A CN104862380A (zh) | 2015-08-26 |
CN104862380B true CN104862380B (zh) | 2018-04-13 |
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WO (1) | WO2015127853A1 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105154543A (zh) * | 2015-09-07 | 2015-12-16 | 健路生物科技(苏州)有限公司 | 一种用于生物样本核酸检测的质控方法 |
CN105335625B (zh) * | 2015-11-04 | 2018-02-16 | 和卓生物科技(上海)有限公司 | 胚胎植入前的遗传学检测装置 |
CN105385755A (zh) * | 2015-11-05 | 2016-03-09 | 上海序康医疗科技有限公司 | 一种利用多重pcr技术进行snp-单体型分析的方法 |
US11238957B2 (en) * | 2018-04-05 | 2022-02-01 | Ancestry.Com Dna, Llc | Community assignments in identity by descent networks and genetic variant origination |
CN109086571B (zh) * | 2018-08-03 | 2019-08-23 | 国家卫生健康委科学技术研究所 | 一种单基因病遗传变异智能解读及报告的方法和系统 |
CN112639129A (zh) * | 2018-09-03 | 2021-04-09 | 深圳华大智造科技有限公司 | 确定新发突变在胚胎中的遗传状态的方法和装置 |
CN110444251B (zh) * | 2019-07-23 | 2023-09-22 | 中国石油大学(华东) | 基于分支定界的单体型格局生成方法 |
CN110349631B (zh) * | 2019-07-30 | 2021-10-29 | 苏州亿康医学检验有限公司 | 确定子代对象的单体型的分析方法和装置 |
WO2022027212A1 (zh) * | 2020-08-04 | 2022-02-10 | 广州金域医学检验中心有限公司 | 基于NGS-trio的单亲二倍体检测方法及应用 |
CN113689914B (zh) * | 2020-12-17 | 2024-02-20 | 武汉良培医学检验实验室有限公司 | 一种单基因遗传病扩展性携带者筛查方法及芯片 |
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CN102206701B (zh) * | 2010-09-19 | 2015-01-21 | 深圳华大基因科技有限公司 | 遗传性疾病相关基因的鉴定方法 |
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