CN104860942A - 一种含双酰胺基和硝基苯基结构的FXa抑制剂及其用途 - Google Patents
一种含双酰胺基和硝基苯基结构的FXa抑制剂及其用途 Download PDFInfo
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- CN104860942A CN104860942A CN201510209847.5A CN201510209847A CN104860942A CN 104860942 A CN104860942 A CN 104860942A CN 201510209847 A CN201510209847 A CN 201510209847A CN 104860942 A CN104860942 A CN 104860942A
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- compound
- fxa inhibitor
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- nitrobenzophenone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | IC50(nM) |
Edoxaban | 4.0 |
参比化合物D-1 | 7.8 |
化合物I-1 | 1.6 |
Claims (3)
Priority Applications (1)
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CN201510209847.5A CN104860942B (zh) | 2015-02-14 | 2015-04-27 | 一种含双酰胺基和硝基苯基结构的FXa抑制剂及其用途 |
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CN201510083415 | 2015-02-14 | ||
CN2015100834154 | 2015-02-14 | ||
CN201510209847.5A CN104860942B (zh) | 2015-02-14 | 2015-04-27 | 一种含双酰胺基和硝基苯基结构的FXa抑制剂及其用途 |
Publications (2)
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CN104860942A true CN104860942A (zh) | 2015-08-26 |
CN104860942B CN104860942B (zh) | 2016-08-24 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008065503A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | (r) -5-methyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylic acid 1- [ ( 4 -chlorophenyl) amide 5-{ [2-fluoro-4- (2-oxo-2h-pyridin-1-yl) -phenyl]amide) as a factor xa inhibitor |
CN101309919A (zh) * | 2005-11-16 | 2008-11-19 | 弗·哈夫曼-拉罗切有限公司 | 作为凝血因子xa抑制剂的新的吡咯烷衍生物 |
CN102464658A (zh) * | 2010-11-03 | 2012-05-23 | 天津药物研究院 | 噁唑烷酮衍生物及其制备方法和用途 |
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2015
- 2015-04-27 CN CN201510209847.5A patent/CN104860942B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101309919A (zh) * | 2005-11-16 | 2008-11-19 | 弗·哈夫曼-拉罗切有限公司 | 作为凝血因子xa抑制剂的新的吡咯烷衍生物 |
WO2008065503A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | (r) -5-methyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylic acid 1- [ ( 4 -chlorophenyl) amide 5-{ [2-fluoro-4- (2-oxo-2h-pyridin-1-yl) -phenyl]amide) as a factor xa inhibitor |
CN102464658A (zh) * | 2010-11-03 | 2012-05-23 | 天津药物研究院 | 噁唑烷酮衍生物及其制备方法和用途 |
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Publication number | Publication date |
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CN104860942B (zh) | 2016-08-24 |
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C14 | Grant of patent or utility model | ||
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: FXa inhibitor containing bisamide radical and nitrobenzophenone structure and application thereof Effective date of registration: 20170816 Granted publication date: 20160824 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160824 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201201 Address after: No.1 wulidun, Quanjiao economic Park, Chuzhou, Anhui Province Patentee after: Anhui Jinghuan medical supplies Co., Ltd Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY Co.,Ltd. |
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