CN104857555A - Compound Japanese thistle herb stop-bleeding sponge for external use - Google Patents
Compound Japanese thistle herb stop-bleeding sponge for external use Download PDFInfo
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Abstract
The invention discloses a compound Japanese thistle herb stop-bleeding sponge for external use. The compound Japanese thistle herb stop-bleeding sponge for external use is prepared from the following main raw materials in parts by weight: 3 parts of Japanese thistle herb, 4 parts of folium isatidis, 3 parts of rhizoma coptidis, 4 parts of rhizoma corydalis, 0.5 part of procaine, and 10 parts of starch. The compound Japanese thistle herb stop-bleeding sponge for external use, disclosed by the invention, is simple in a preparation method, is low in building cost by using the selected principle, has obvious effects of stopping bleeding for external injuries, stopping nosebleed, and the like, and can well kill bacteria and stop bleeding.
Description
This case is divisional application, original applying number 2014104069364, original application day 2014.8.19, a kind of compound recipe Radix Cirsii Japonici external sthptic sponge of title and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of compound recipe Radix Cirsii Japonici external sthptic sponge and preparation method.
Background technology
Operation technique or wound, particularly hemorrhage, oozing of blood, be sometimes difficult to control, not only can increase blood loss but also can increase operating difficulty, even threat to life.Beijing Hospital's surgical specialist Cao Jin tongued bell is thought, any surgical procedures almost relates to hemorrhage with hemostasis bar none, and good hemostasis is the operation safety prerequisite of carrying out and guarantee.In operation, the choose reasonable of Hemostasis can control that wound surface is hemorrhage, oozing of blood, guarantee visual area is clear, improve procedure efficiency, shorten operating time, thus minimizing is lost blood and is transfused blood, be conducive to avoiding the generation with postoperative related complication in art, accelerate patient's post-operative recovery, and then alleviate misery and the medical expense of patient.Annual hemorrhagic disease number is more than 9,000,000 people, and be mainly distributed in surgical departments and part internal medicine section office, in multiple Hemostasis, hemorrhage is widely used.In recent decades, the haemostatic medicaments such as hemocoagulase, because it is not by the restriction of the aspect such as operative site, Surgical Operation, generally adopt in various operation.Along with the continuous renewal of hemostasis theory, new haemostatic medicament is also constantly released.
Wound, language goes out " Plain Questions distracting patient’s attention to change the flow of QI-blood opinion ".1. one of injury symptoms classification.Refer generally to pounce on the damage of skin caused by tumbling down, muscle, muscles and bones.2., for internal injury caused by excess of seven emotions, refer to that six climate exopathogens exopathogen hindered, as cold, typhoid fever, affection of dampness, Sunstroke etc.Wound comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc.The wounds such as bullet, Jin Ren, traumatic injury, injury by overexertion, can cause integumentary musculature swelling and pain due to blood stasis, hemorrhage, or injury of tendon and muscle fracture, dislocation.Heavy then damage internal organs, or Massive Bleeding, the serious change such as stupor, tic, YANG-depletion collapse can be caused.How burn and scald, caused by high temperature article, boiling water or deep fat or burn and scald etc.The lighter damages skin, red in injury, swollen, hot, bitterly, xerosis cutis or get blister, severe pain; Severe burn and scald then muscle injury, muscles and bones can make analgesis, and wound surface is as leather sample, or wax is white, sallow or carbonization; Serious burn and scald, then it is excessive to hinder face, and apart from outside local symptom, Chang Yin has an intense pain, fire-toxin inside fire attack, body fluid evaporation or ooze out, and can occur that dysphoria, heating, xerostomia are thirsty, oliguria etc., even dead.Cold injury, refers to that human body is damaged by the general caused by low temperature invasion and attack or locality.General cold injury, because of cold being a kind of YIN pathogen, easy impairment of YANG gas, YIN-cold crosses Sheng, and yang-energy is impaired, and lose in warm and promotion blood, then shiver with cold, body temperature declines gradually, pale complexion, bluish lip, and fingernail is livid purple, stolidity, spiritlessness and weakness, or lethargy, hypopnea, and slow pulse is thin.If do not given treatment to, easily lethally to die.Part frozen, mostly occurs in hands, foot, auricle, nose and face position.Fall ill from the beginning of, position of enduring cold is because of cold main spasm, and passages through which vital energy circulates contraction is anxious, and coagulation of QI-blood is smooth, and impact is endured cold the warm and nutrition of local, and cause local skin pale, cold fiber crops, the then swelling that continues is livid purple, itches bitterly scorching hot, or occurs the blister etc. that differs in size, normal easy infection after diabrosis.Insect-animal injury, comprises poisonous snake, the beast of prey, mad dog bites, or scorpion, bee sting wound etc.Swelling and ache, appear in light then local damage, hemorrhage etc.; Heavy then damage internal organs, or Massive Bleeding and dead.Then there is systemic toxicity profiles symptom in venom, as given treatment to not in time, often causes being poisoned to death.Mad dog is bitten, from the beginning of rarely seen local pain, hemorrhage, after wound healing, through one period of incubation period, then can occur agitation, greatly alarmed, gnathospasma, tic, hydrophobia, the probably disease such as wind.Wound, inevitable in people's daily life, traumatic hemorrhage can cause very large impact to the health of people, when treatment wound, stops blooding, wraps up, fixes, carrying is four basic fundamentals that wound is given first aid to.When implementing the rescue of on-the-spot wound, Field Force will in line with the spirit of humanitarianism of healing the wounded and rescue the dying, and is notifying that nearby while hospital, want calm, promptly carry out field first aid work, its principle is: first rob and rescue afterwards, light after first heavy, slow after first anxious, far away after first near; First stop blooding and wrap up afterwards, more fixing rear carrying.Stop blooding as the first step for the treatment of wound, most important, therefore, trauma hemostasis medicine used and sponge just become most important.
Hemorrhage by shrinking small artery and blood capillary, or strengthens platelet function, or accelerates, strengthens Blood Coagulation Process, or suppresses clot dissolution process and produce anastalsis.In recent ten years, universal in clinical practice with the biochemical class hemorrhage that the hemostasis enzyme extracted from snake venom is main component, and become the mainstream medicine of clinical treatment hemorrhage or bleeding state.Current domestic clinical conventional hemorrhage about has kind more than 20, according to the different links acting on clotting mechanism, is divided into four large classes.
1, clot-promoting factor active drug: be by affecting some thrombin, promotes or recovers coagulation process and stop blooding.Represent medicine and have hemocoagulase, Desmopressin, vitamin K1, vitamin K3, methylnaphthohydroquinone, Diaceturate Ethylenediamine etc.2, reduce capillary permeability medicine: the resistance of blood capillary to damage can be strengthened, reduce the permeability of blood capillary, promote that impaired hair and blood pipe end shrinks and stops blooding.Represent medicine and have carbazochrome, carbazochrome sodium sulfonate.3, antifibrinolytics: by suppressing the activity factor of plasminogen, plasminogen can not be activated, thus suppress fibrinous dissolving.Represent medicine and have aminocaproic acid, aminomethylbenzoic acid, tranexamic acid, aprotinin etc.Wherein 6-aminocaproic acid is because the action intensity weak sustain time is short, side effect is more, now few use.This kind of medicine is better to general chronic oozing of blood effect, hemorrhage and wound hemorrhage effect is poor to cancer.Common untoward reaction has headache, dizziness, Nausea and vomiting, diarrhoea.Used time is careful and selects patient, must clearly have fibrinolytic function hyperfunction, otherwise hemorrhage can be transformed into fatal thrombotic disease.Elderly patients are careful especially.Should forbid having thrombotic tendency and embolic blood vessel medical history person.4, other hemostatic for external uses: Absorbable rod Wound hemostatic sealant, gelfoam, absorbable stanching satin, berbamine, YUNNAN BAIYAO, No. 8, styptic powder, hemostasis and anti-inflammation subsides etc.Above-mentioned haemostatic medicament defect be Clinical practice costly, cause patient burden heavier.
Authorization Notice No. CN 102225135 B(Authorization Notice No. CN 102225135 B) Chinese patent literature disclose a kind of Chinese medicine hemostasis powder for external use, it is characterized in that making with following weight parts Chinese medicine: Cortex Jujubae 1-20, Sanguis Draxonis 1-6, Radix Angelicae Sinensis (parched)--1-20, Radix Notoginseng--1-5, Crinis Carbonisatus 1-13, Herba Cirsii--1-15, Lignum Sappan--1-13 Flos Carthami--1-12.Authorization Notice No. CN 101537094 B(application number 200910022258.0) Chinese patent literature disclose a kind of Chinese medicine hemostasis powder for external use for anus postoperation hemostatic, it is characterized in that making with following weight parts Chinese medicine: Radix Notoginseng 1.5-3, Ophicalcitum 3-9, Olibanum 3-9, Myrrha 3-9, Sanguis Draxonis 1-1.5, Flos Carthami 3-10, Halloysitum Rubrum 10-18, Lignum Sappan 3-9.
In a word, Chinese medicine does not also achieve fine effect in development external sthptic sponge, needs to be improved further.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is that providing a kind of prepares compound recipe Radix Cirsii Japonici external sthptic sponge simple, easy to use, has effect of quick-acting haemostatic powder, bactericidal antiphlogistic, to the treatments for bleeding Be very effective that wound causes.
Another object of the present invention is to provide the preparation method of above-mentioned wound gelfoam.
Technical scheme of the present invention is:
A kind of compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from: Radix Cirsii Japonici 3-7 part, Folium Isatidis 4-8 part, Rhizoma Coptidis 3-7 part, Rhizoma Corydalis 4-9 part, procaine 0.5-1.5 part, starch 10-20 part.
A kind of compound recipe Radix Cirsii Japonici external sthptic sponge, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 4-6 part, Folium Isatidis 5-7 part, Rhizoma Coptidis 4-6 part, Rhizoma Corydalis 5-8 part, procaine 0.8-1.3 part, starch 13-18 part.
A kind of compound recipe Radix Cirsii Japonici external sthptic sponge, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 5 parts, Folium Isatidis 6 parts, Rhizoma Coptidis 5 parts, Rhizoma Corydalis 7 parts, procaine 1 part, starch 15 parts.
4, according to the preparation method of the arbitrary described compound recipe Radix Cirsii Japonici external sthptic sponge of claim 1-3, preferred scheme is: step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 70-80 DEG C of hot-water soak to room temperature, terrine are placed on tile, big fire decocts 1-3 hour, turns low baking temperature and simmers slowly 10-30 minute (preferably 20 minutes), cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-2 to-6 DEG C of freezing 24-40 hour;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter step (4) cut immerses in ethanol and soaks 3 times, immerses 0.5-1.5 hour in the ethanol of 60-80% for the first time, and second time immerses 1-3 hour in the ethanol of 70-90%, takes out stand-by in the ethanol of third time immersion 90-100% after 18-24 hour;
(6) ethanol in removing step (5) gained fritter, dry under 40-60 DEG C (preferably 50 DEG C), obturage with paper wrapper, in 100-140 DEG C of dry heat sterilization, be sealed in plastic bag, obtain final product.
Foregoing preparation method, preferred scheme is, the consumption of step (1) hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 1-5 doubly (preferred, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 2-4 doubly, be more preferably, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 3 times).
Foregoing preparation method, preferred scheme is: step (1) adds 73-78 DEG C of hot-water soak to room temperature (preferred, to add 75 DEG C of hot-water soaks to room temperature).
Foregoing preparation method, preferred scheme is: step (3) is put in water-bath and heated, and is heated to 50-70 DEG C and (preferably, puts in water-bath and heat, be heated to 55-65 DEG C; Be more preferably, put in water-bath and heat, be heated to 60 DEG C).
Foregoing preparation method, preferred scheme is: step (3) was-3 to-5 DEG C of freezing 30-34 hours (preferred, freezing 32 hours at-4 DEG C).
Foregoing preparation method, preferred scheme is: step (5) first time immerses 0.8-1.3 hour in the ethanol of 65-75%, second time immerses 1.5-2.5 hour in the ethanol of 75-85%, third time immerses in the ethanol of 93-98% and takes out after 20-22 hour that stand-by (preferred first time to immerse in the ethanol of 70% 1 hour, second time immerse 80% ethanol in 2 hours, third time immerse 95% ethanol in take out after 21 hours stand-by).
Foregoing preparation method, preferred scheme is: step (6) is in 110-130 DEG C of dry heat sterilization (being preferable over 120 DEG C of dry heat sterilizations).
Using method: after traumatic hemorrhage, epistaxis, gets one block of compound recipe Radix Cirsii Japonici external sthptic sponge directly by being pressed in bleeding part.
The pharmacological effect of each crude drug is respectively:
Radix Cirsii Japonici: nature and flavor: sweet, bitter, cold.Gui Jing: GUIXIN, Liver Channel.Effect: cooling blood for hemostasis, removing blood stasis to reduce swelling.Cure mainly: for epistaxis.Spit blood.Hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Folium Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Effect: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Cure mainly: seek for pathogenic warmth people.Unconsciousness due to high fever, sends out speckle dermexanthesis, yellow cellulitis, hematodiarrhoea, mumps, sore throat, erysipelas.Carbuncle.
Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Rhizoma Corydalis: nature and flavor: pungent, bitter, temperature.Gui Jing: return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.Cure mainly: for the breast side of body, epigastric pain.Amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Procaine is local anesthetic.Clinical its hydrochlorate conventional, also known as " novocain ".White crystals or crystalline powder, soluble in water.Toxicity ratio cocaine is low.Add micro-epinephrine in injection, can action time be extended.For infiltration anesthesia, lumbar anesthesia, " block therapy " etc.Except over administration causes central nervous system and cardiovascular system reaction, accidental anaphylaxis, should make skin anaphylactic test before medication.Its metabolite aminobenzoic acid (PABA) can weaken the antibacterial efficacy of sulfonamides.
Starch: starch is the high polymer of glucose, in catering trade also known as starch, general formula is (C6H10O5) n, and being hydrolyzed the disaccharide stage is maltose, and chemical formula is C12H22O11, and obtain monosaccharide (glucose) after complete hydrolysis, chemical formula is C6H12O6.Starch has amylose and amylopectin two class.The former is branchiess helical structure; The latter joins end to end with 24 ~ 30 glucose residues form with α-Isosorbide-5-Nitrae-glycosidic bond, is α-1,6-glycosidic bond at side chain place.Amylose meets iodine in blue, and it is aubergine that amylopectin meets iodine.This is not that starch and iodine there occurs chemical reaction (reaction), and produce and interact (interaction), but starch spiral central cavity be able to hold iodine molecule, by Van der Waals force, both form a kind of black-and-blue misfit thing.Test and prove, independent iodine molecule can not make starch become blue, and that in fact make starch become indigo plant is Iodine molecule ion (I3).Starch is the nutrient stored in plant, and be stored in seed and tuber, the content of starch in all kinds of plant is all higher.
Compound recipe Radix Cirsii Japonici external sthptic sponge preparation method of the present invention is simple, and selected principle is cheap, and very remarkable to wound haemostatic effect, can good bactericidal haemostatic.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Cirsii Japonici 3-7 part, Folium Isatidis 4 parts, Rhizoma Coptidis 3 parts, Rhizoma Corydalis 4 parts, procaine 0.5 part, starch 10 parts.
The preparation method of above-mentioned compound recipe Radix Cirsii Japonici external sthptic sponge, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 70 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 1 times, terrine is placed on tile, big fire decocts 1 hour, turns low baking temperature and simmers 10 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 24 hours at-2 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 60% 0.5 hour, and second time to immerse in the ethanol of 70% 1 hour, third time immerse take out after 18 hours in the ethanol of 90% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 40 DEG C, obturage with paper wrapper, in 100 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
embodiment 2compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Radix Cirsii Japonici 7 parts, Folium Isatidis 8 parts, Rhizoma Coptidis 7 parts, Rhizoma Corydalis 9 parts, procaine 1.5 parts, starch 20 parts.
The preparation method of above-mentioned compound recipe Radix Cirsii Japonici external sthptic sponge, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 80 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 5 times, terrine is placed on tile, big fire decocts 3 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 40 hours at-6 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 80% 1.5 hours, and second time to immerse in the ethanol of 90% 3 hours, third time immerse take out after 24 hours in the ethanol of 100% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 60 DEG C, obturage with paper wrapper, in 140 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
model case one: Zhu XX, female, 27 years old.Patient is before 1 hour, go on a visit to the seaside together with colleague, accidentally by the little shell incised wound right crus of diaphragm thumb on seashore, in water, do not have pain at once, after disembarkation, sensation right crus of diaphragm thumb pain, also has many blood to bleed, limitation of activity, oneself stops blooding with the alcohol wipe carried with, subsides adhesive bandage, and effect is all not obvious, and kind colleague allows it use the compound recipe Radix Cirsii Japonici external sthptic sponge oneself carried with.
Using the embodiment of the present invention 2 gained compound recipe Radix Cirsii Japonici external sthptic sponge, by gelfoam directly by being pressed in export department position, pressing after 1 minute, hemorrhage obvious minimizing; Press 3 minutes, wound hemostasis, bleeds and stops completely.
embodiment 3compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Radix Cirsii Japonici 4 parts, Folium Isatidis 5 parts, Rhizoma Coptidis 4 parts, Rhizoma Corydalis 5 parts, procaine 0.8 part, starch 13 parts.
The preparation method of above-mentioned compound recipe Radix Cirsii Japonici external sthptic sponge, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 73 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 2 times, terrine is placed on tile, big fire decocts 1.5 hours, turns low baking temperature and simmers 15 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-3 freezing 30 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.8 hour, and second time to immerse in the ethanol of 75% 1.5 hours, third time immerse take out after 20 hours in the ethanol of 93% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 43 DEG C, obturage with paper wrapper, in 110 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
model case two: Lee XX, man, 13 years old, the student in certain middle school, from June, the always epistaxis of unknown cause, each is all wake up morning, within one week, sometimes can occur 2 times, remove examination in hospital, it is abnormal what does not find yet, but or epistaxis, neighbours see that its symptom tells its father and mother, say compound recipe Radix Cirsii Japonici external sthptic sponge effect of the present invention very good, go home to use to son so patient has just bought some.
Use the present embodiment 3 gained compound recipe Radix Cirsii Japonici external sthptic sponge, get gelfoam directly by being pressed on nostril, after 2 minutes, hemorrhage obvious minimizing, after 4 minutes, blood flow stops.
embodiment 4compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): Radix Cirsii Japonici 6 parts, Folium Isatidis 7 parts, Rhizoma Coptidis 6 parts, Rhizoma Corydalis 8 parts, procaine 1.3 parts, starch 18 parts.
The preparation method of above-mentioned compound recipe Radix Cirsii Japonici external sthptic sponge, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 78 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 4 times, terrine is placed on tile, big fire decocts 2.5 hours, turns low baking temperature and simmers 25 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 34 hours at-5 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 75% 1.3 hours, and second time to immerse in the ethanol of 85% 2.5 hours, third time immerse take out after 22 hours in the ethanol of 98% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 55 DEG C, obturage with paper wrapper, in 130 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
embodiment 5compound recipe Radix Cirsii Japonici external sthptic sponge, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Radix Cirsii Japonici 5 parts, Folium Isatidis 6 parts, Rhizoma Coptidis 5 parts, Rhizoma Corydalis 7 parts, procaine 1 part, starch 15 parts.
The preparation method of above-mentioned compound recipe Radix Cirsii Japonici external sthptic sponge, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 75 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 3 times, terrine is placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 20 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 32 hours at-4 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 70% 1 hour, and second time to immerse in the ethanol of 80% 2 hours, third time immerse take out after 21 hours in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 50 DEG C, obturage with paper wrapper, in 120 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
experimental example 1the clinical practice of embodiment 5 gained compound recipe Radix Cirsii Japonici external sthptic sponge: in November ,-2013 in August, 2010, hinders bleeding patients 4 hospital's screening 200 exceptions.And being divided into two groups at random, experimental group and matched group, experimental group uses the present embodiment 5 products obtained therefrom, and matched group uses other hemostasis medicine (the conventional hemostatic for external use thing such as styptic powder, adhesive bandage).Using method: get compound recipe Radix Cirsii Japonici external sthptic sponge and directly press on bleeding part.Curative effect situation criterion: recovery from illness: use 3 minutes, blood flow stops completely, and pain obviously alleviates; Effective: to use 3 minutes, blood flow reduces, and pain is alleviated to some extent; Invalid: use 3 minutes, symptom is unchanged.Result is as shown in table 1.
Table 1: embodiment 5 gained compound recipe Radix Cirsii Japonici external sthptic sponge compliance test result
Therapeutic effect: use 3 minutes and cure 71 examples (71%), effective 26 examples (26%), invalid 3 examples (3%), total effective rate 97%.Successful is better than matched group.
During using embodiment 5 gained compound recipe Radix Cirsii Japonici external sthptic sponge, patient's self-induction symptom is as shown in table 2:
Table 2
Use gained compound recipe Radix Cirsii Japonici external sthptic sponge of the present invention, within 3 minutes, no matter which kind of reason cause hemorrhage, can stop, and can sterilize to wound, antiinflammatory.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a compound recipe Radix Cirsii Japonici external sthptic sponge, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Cirsii Japonici 3 parts, Folium Isatidis 4 parts, Rhizoma Coptidis 3 parts, Rhizoma Corydalis 4 parts, procaine 0.5 part, starch 10 parts.
2. the preparation method of compound recipe Radix Cirsii Japonici external sthptic sponge according to claim 1, it is characterized in that, step is as follows:
(1) Radix Cirsii Japonici, Folium Isatidis, Rhizoma Coptidis and Rhizoma Corydalis are together placed in terrine, when adding 70-80 DEG C of hot-water soak to room temperature, terrine are placed on tile, big fire decocts 1-3 hour, turns low baking temperature and simmers slowly 10-30 minute (preferably 20 minutes), cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-2 to-6 DEG C of freezing 24-40 hour;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter step (4) cut immerses in ethanol and soaks 3 times, immerses 0.5-1.5 hour in the ethanol of 60-80% for the first time, and second time immerses 1-3 hour in the ethanol of 70-90%, takes out stand-by in the ethanol of third time immersion 90-100% after 18-24 hour;
(6) ethanol in removing step (5) gained fritter, dry under 40-60 DEG C (preferably 50 DEG C), obturage with paper wrapper, in 100-140 DEG C of dry heat sterilization, be sealed in plastic bag, obtain final product.
3. preparation method according to claim 2, it is characterized in that, the consumption of step (1) hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 1-5 doubly (preferred, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 2-4 doubly, be more preferably, the consumption of hot water be Radix Cirsii Japonici, Folium Isatidis, Radix Scutellariae and Cacumen Platycladi preparata gross weight 3 times).
4. preparation method according to claim 2, is characterized in that, step (1) adds 73-78 DEG C of hot-water soak to room temperature (preferred, to add 75 DEG C of hot-water soaks to room temperature).
5. preparation method according to claim 2, is characterized in that, step (3) is put in water-bath and heated, and is heated to 50-70 DEG C and (preferably, puts in water-bath and heat, be heated to 55-65 DEG C; Be more preferably, put in water-bath and heat, be heated to 60 DEG C).
6. preparation method according to claim 2, is characterized in that, step (3) was-3 to-5 DEG C of freezing 30-34 hours (preferred, freezing 32 hours at-4 DEG C).
7. preparation method according to claim 2, it is characterized in that, step (5) first time immerses 0.8-1.3 hour in the ethanol of 65-75%, second time immerses 1.5-2.5 hour in the ethanol of 75-85%, third time immerses in the ethanol of 93-98% and takes out after 20-22 hour that stand-by (preferred first time to immerse in the ethanol of 70% 1 hour, second time immerse 80% ethanol in 2 hours, third time immerse 95% ethanol in take out after 21 hours stand-by).
8. preparation method according to claim 2, is characterized in that, step (6) is in 110-130 DEG C of dry heat sterilization (being preferable over 120 DEG C of dry heat sterilizations).
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| CN201510290072.9A Pending CN104857555A (en) | 2014-08-19 | 2014-08-19 | Compound Japanese thistle herb stop-bleeding sponge for external use |
| CN201410406936.4A Active CN104189949B (en) | 2014-08-19 | 2014-08-19 | A kind of compound recipe Radix Cirsii Japonici external sthptic sponge and preparation method |
| CN201510290088.XA Pending CN104841003A (en) | 2014-08-19 | 2014-08-19 | Compounded radix cirsii jeponici external-application sponge for arresting bleeding and preparation process thereof |
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| CN1539508A (en) * | 2003-10-27 | 2004-10-27 | 武汉锐力科技有限公司 | Ground substance, dressing for renovating wound surface and preparing technique |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
| CN102133340A (en) * | 2011-03-16 | 2011-07-27 | 四川同人泰药业有限公司 | Chinese herbal wound and burn patch for external use and preparation method thereof |
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| JPS62240621A (en) * | 1986-04-11 | 1987-10-21 | Hokuriku Seiyaku Co Ltd | Styptic |
| CN100453070C (en) * | 2003-12-13 | 2009-01-21 | 昆明紫健生物技术有限公司 | Aseptic dry powder spray agent and production method in use for stopping the blood and diminishing inflammation in wound |
| CN101623350A (en) * | 2009-07-09 | 2010-01-13 | 刘宁 | Rapid hemostasis powder |
| CN101647894B (en) * | 2009-08-20 | 2011-02-16 | 荣伟 | Haemostasia medicine of Chinese herbs |
| CN103845418B (en) * | 2014-03-25 | 2015-08-05 | 崔新明 | A kind of Chinese medicine composition for the treatment of retinal hemorrhage and uses thereof |
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| CN1539508A (en) * | 2003-10-27 | 2004-10-27 | 武汉锐力科技有限公司 | Ground substance, dressing for renovating wound surface and preparing technique |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
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