CN104857051B - One kind is dispelled scar Silica hydrogel and preparation method - Google Patents
One kind is dispelled scar Silica hydrogel and preparation method Download PDFInfo
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- CN104857051B CN104857051B CN201510342241.9A CN201510342241A CN104857051B CN 104857051 B CN104857051 B CN 104857051B CN 201510342241 A CN201510342241 A CN 201510342241A CN 104857051 B CN104857051 B CN 104857051B
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Abstract
Dispelled scar Silica hydrogel and preparation method the invention discloses one kind, one kind scar Silica hydrogel of dispelling is made up of following raw materials by weight percentage：Asiaticosid 1 5%, laminarin 1 5%, Paeonol 1 5%, safflower seed oil 5 15%, dimethyl silicone polymer 15 20%, emulsifying agent 3 5%, water 41 60%, glycerine 5 15%.The scar Silica hydrogel of dispelling of the present invention, makes gel sensitization rate low, is provided for patient and safer effectively removes scar gel.Through long-time research and by screening, significant effect, cure rate is high, and scar preparation is removed with a kind of effectively external application that prior art is combined in combination with theory of traditional Chinese medical science " it is antipruritic that promoting blood circulation and removing blood stasis, software breaks product, myogenic ".The method preparation technology of the present invention is simple, saves cost.
Description
Technical field
The present invention relates to a kind of biomedicine field, relates generally to a kind of scar Silica hydrogel of dispelling of nonirritant treatment scar
And preparation method.
Technical background
Scar be the reasons such as physics, biochemistry cause human body skin soft tissue major injury and can not be completely voluntarily normal
Repair, turn by fibrous tissue replacement, leaving and influenceing function influences the local symptom of outward appearance again.In average every 5 people of China
Just there is one to be perplexed by scar, scar crowd is being currently a huge colony, and especially in the past few years various accidents largely increase
Add, and counted according to authoritative institution, China is high scar constitution country, and scar constitution crowd accounts for more than 85%, and scar crowd accounts for
More than 95%.
Scar annoyings the normal studying and living of most people, is even more serious especially when scar is in exposed position
The self-esteem and self-confidence of people is hit, present treatment means are substantially to be carried out by two ways：Operation repair and
Medicine softens.Both approaches cure that the cycle is long and cost over the course for the treatment of is high.
Asiaticosid is formed by the extraction of natural medicinal plant centella, has been used to treat various wounds, burn, hyperplasia
The clinical practice of scars, keloid, freckle, skin ulcer etc..Repaiied it has been investigated that asiaticosid can participate in tissue
It is multiple, activate epithelial cell；Improve fibroblastic ultra microstructure, promote the apoptosis of cell and with anti-inflammatory, antibacterial action.But
Meanwhile using asiaticosid when, some people can cause the allergic symptoms such as fash, local itch, stimulation, be brought to patient
Secondary injury.
He Guo, the increasing of sharp day et al. 2000《Chinese journals of practical medicine》Deliver《Asiaticoside adds external washout with traditional Chinese herbs agent treatment burn
Hyperplastic scar》In with asiaticoside combination lotion treat burn hyperplastic scar the effect of, wherein be used alone centella
There are 2 people the red small papule of fash occur in glycosides 30 people of frost, itching aggravates；Li Xueliang, Lv Hongde et al. in August, 2006 exist《Tianjin
Pharmacy》In deliver《The effect of asiaticosid piece and asiaticosid frost ointment preventing and treating burn hyperplastic scar, compares》Middle observation product
The treatment of glycosides piece and asiaticoside ointment preventing and treating burn hyperplastic scar is avenged, is had in the people of asiaticosid frost ointment 35 is used alone
There is slight fash adverse reaction in 1 people, and asiaticosid frost ointment is mixed with asiaticosid piece to have the slight intestines and stomach of 3 people and 2 people light
Spend fash adverse reaction.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided one kind can reduce fash reaction incidence, more pacify
Silica hydrogel that is complete, effectively removing scar.
Second object of the present invention is to provide a kind of manufacture craft and simply dispelled the preparation method of scar Silica hydrogel.
Technical scheme is summarized as follows：
One kind is dispelled scar Silica hydrogel, is made up by weight percentage of following raw materials：Asiaticosid 1-5%, laminarin 1-
5%th, Paeonol 1-5%, safflower seed oil 5-15%, dimethyl silicone polymer 15-20%, emulsifying agent 3-5%, water 41-60%, sweet
Oily 5-15%.
Preferably：Asiaticosid is 3%, laminarin 2.5%, Paeonol 3%, safflower seed oil 5%, poly- two
Methylsiloxane is 15%, emulsifying agent 3%, water 56.5%, glycerine 12%.
The viscosity of dimethyl silicone polymer is preferably 5-100mm2/s。
Emulsifying agent be preferably polyglyceryl -2- dimerization hydroxy stearic acid ester, polyglyceryl -3- dimerization hydroxy stearic acid ester,
One or more in cetearyl alcohol alcohol ether -6 and stearyl alcohol, PEG-7 rilanit specials.
A kind of preparation method for scar Silica hydrogel of dispelling, comprises the following steps：
1) raw material is weighed by weight percentage：Asiaticosid 1-5%, laminarin 1-5%, Paeonol 1-5%, kardiseed
Oily 5-15%, dimethyl silicone polymer 15-20%, emulsifying agent 3-5%, water 41-60%, glycerine 5-15%；
2) safflower seed oil, dimethyl silicone polymer and emulsifying agent are put into container, low whipping speed is 10-20 revs/min
70-90 DEG C is heated under conditions of clock, after being kept for 15-25 minutes, obtains oil phase；
3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 10-20 revs/min
75-90 DEG C is heated under conditions of clock, is kept for 15-25 minutes, obtains aqueous phase；
4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 500-800 seconds under vacuum；
5) 35-45 DEG C is cooled to, one kind is obtained and dispels scar Silica hydrogel.
Preferably asiaticosid be 3%, laminarin 2.5%, Paeonol 3%, safflower seed oil 5%, poly- two
Methylsiloxane is 15%, emulsifying agent 3%, water 56.5%, glycerine 12%.
The viscosity of dimethyl silicone polymer is preferably 5-100mm2/s。
Emulsifying agent be preferably polyglyceryl -2- dimerization hydroxy stearic acid ester, polyglyceryl -3- dimerization hydroxy stearic acid ester,
One or more in cetearyl alcohol alcohol ether -6 and stearyl alcohol, PEG-7 rilanit specials.
One kind of the present invention is dispelled scar Silica hydrogel, is improved and is formulated by long-term practice, made gel sensitization rate low, provided for patient
It is safer effective to remove scar gel.Through long-time research and by screening, significant effect, cure rate is high, simultaneously
With reference to theory of traditional Chinese medical science " it is antipruritic that promoting blood circulation and removing blood stasis, software breaks product, myogenic " scar system is removed with a kind of effectively external application that prior art is combined
Agent.The method preparation technology of the present invention is simple, saves cost.
Brief description of the drawings
Fig. 1 is photo before patient's Mr. Wang's inventive gel.
Fig. 2 is photo after patient's Mr. Wang's inventive gel.
Fig. 3 is that patient's week, so-and-so used photo before inventive gel.
Fig. 4 be patient's week so-and-so with photo after inventive gel.
Fig. 5 is photo before patient Lee's inventive gel.
Fig. 6 is photo after patient Lee's inventive gel.
Fig. 7 is photo before patient's Zheng's inventive gel.
Fig. 8 is photo after patient's Zheng's inventive gel.
Fig. 9 is that patient answers certain to use photo before inventive gel.
Figure 10 is that patient answers certain with photo after inventive gel.
Embodiment
Below by specific embodiment, the present invention is further illustrated.
Embodiment 1
One kind is dispelled scar Silica hydrogel, is made of by weight percentage by following raw materials：Asiaticosid 5%, laminarin 1%,
Paeonol 1%, safflower seed oil 15%, dimethyl silicone polymer 15%, polyglyceryl -2- dimerization hydroxy stearic acid ester 5%, water
53%th, glycerine 5%.The viscosity of the dimethyl silicone polymer is 5mm2/s。
Embodiment 2
One kind is dispelled scar Silica hydrogel, is made of by weight percentage by following raw materials：Asiaticosid 4%, laminarin 5%,
It is Paeonol 5%, safflower seed oil 5%, dimethyl silicone polymer 20%, cetearyl alcohol alcohol ether -6 and stearyl alcohol 5%, water 41%, sweet
Oil 15%.The viscosity of the dimethyl silicone polymer is 20mm2/s。
Embodiment 3
One kind is dispelled scar Silica hydrogel, is made of by weight percentage by following raw materials：Asiaticosid 1%, laminarin 3%,
Paeonol 2%, safflower seed oil 5%, dimethyl silicone polymer 20%, polyglyceryl -3- dimerization hydroxy stearic acid ester 3%, water
60%th, glycerine 6%.The viscosity of the dimethyl silicone polymer is 50mm2/s。
Embodiment 4
One kind is dispelled scar Silica hydrogel, is made of by weight percentage by following raw materials：Asiaticosid 3%, laminarin
2.5%, Paeonol 3%, safflower seed oil 5%, dimethyl silicone polymer 15%, PEG-7 rilanit specials 1.5%, polyglyceryl-
3- dimerization hydroxy stearic acid ester 1.5%, water 56.5%, glycerine 12%.The viscosity of the dimethyl silicone polymer is 100mm2/s。
Embodiment 5
A kind of preparation method for scar Silica hydrogel of dispelling, comprises the following steps：
1) various raw materials are taken out according to the percentage by weight of raw material described in embodiment 1；
2) safflower seed oil, dimethyl silicone polymer and emulsifier polyglycerol base -2- dimerization hydroxy stearic acid esters are put into oil
In heat phase tank, low whipping speed is heated to 70 DEG C under conditions of being 10 revs/min, is kept for 25 minutes, obtains oil phase；
3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 10 revs/min
Under conditions of be heated to 75 DEG C, kept for 25 minutes, obtain aqueous phase；
4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 500 seconds under vacuum；
5) room temperature is cooled to, one kind is obtained and dispels scar Silica hydrogel.
Embodiment 6
A kind of preparation method for scar Silica hydrogel of dispelling, comprises the following steps：
1) various raw materials are taken out according to the percentage by weight of raw material described in embodiment 2；
2) safflower seed oil, dimethyl silicone polymer and emulsifying agent cetearyl alcohol alcohol ether -6 and stearyl alcohol are put into oil phase heating
In tank, low whipping speed is heated to 90 DEG C under conditions of being 20 revs/min, is kept for 15 minutes, obtains oil phase；
3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 20 revs/min
Under conditions of be heated to 90 DEG C, kept for 15 minutes, obtain aqueous phase；
4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 800 seconds under vacuum；
5) room temperature is cooled to, one kind is obtained and dispels scar Silica hydrogel.
Embodiment 7
A kind of preparation method for scar Silica hydrogel of dispelling, comprises the following steps：
1) various raw materials are taken out according to the percentage by weight of raw material described in embodiment 3；
2) safflower seed oil, dimethyl silicone polymer and emulsifier polyglycerol base -3- dimerization hydroxy stearic acid esters are put into oil
In heat phase tank, low whipping speed is heated to 75 DEG C under conditions of being 20 revs/min, is kept for 22 minutes, obtains oil phase；
3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 20 revs/min
Under conditions of be heated to 75 DEG C, kept for 22 minutes, obtain aqueous phase；
4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 600 seconds under vacuum；
5) room temperature is cooled to, one kind is obtained and dispels scar Silica hydrogel.
Embodiment 8
A kind of preparation method for scar Silica hydrogel of dispelling, comprises the following steps：
1) various raw materials are taken out according to the percentage by weight of raw material described in embodiment 4；
2) by safflower seed oil, dimethyl silicone polymer and emulsifying agent PEG-7 rilanit specials and polyglyceryl -3- dimerization hydroxyls
Base stearate is put into oil phase heating tank, and low whipping speed is heated to 80 DEG C under conditions of being 15 revs/min, is kept for 20 points
Clock, obtain oil phase；
3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 15 revs/min
Under conditions of be heated to 80 DEG C, kept for 20 minutes, obtain aqueous phase；
4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 700 seconds under vacuum；
5) room temperature is cooled to, one kind is obtained and dispels scar Silica hydrogel.
Embodiment 9
To the inhibitory action of rabbit ear hyperplastic scar.
Choose 80 cleaning grade New Zealand large ear rabbits, male and female half and half, body weight 2.5-3kg, Changsha day duty biotechnology
Co., Ltd.White rabbit adaptability is fed 48 hours.Anaesthetized using Su Mian Xin 0.2ml/kg intramuscular injection, rabbit ear veutro surface skin 75%
Alcohol disinfecting, operate under stringent asepsis requirements, cut off epidermis, corium and perichondrium with skin biopsy apparatus and scalpel, retain soft
Bone.The 6 diameter 5cm standard surface of a wound is prepared per ear.Postoperative wound exposes, and treats its self-heal, rabbit ear is Hypertrophic after about 21 days
Scar is formed, and 80 white rabbits are randomly divided into 8 groups.
From the 21st day, giving partial smearing medicine at each group rabbit ear hyperplastic scar respectively 2 times a day, the 49th day will be white
Rabbit is put to death, and cuts hyperplastic scar tissue specimen.
1 group of positive control：Commercially available Silica hydrogel (fragrant plant gram silica gel ointment, state's food medicine prison tool enter word 2012 the 2640403rd)；
2 groups of positive control：Commercially available accumulated snow cream ointment (Chinese medicines quasi-word Z31020564)；
3 groups of positive control：Manufactured gel after removing laminarin, Paeonol in embodiment 8；
5 groups of embodiment；6 groups of embodiment；7 groups of embodiment；8 groups of embodiment；Blank control group.
Scar thickness measurement：At the 21st, 28,35,42,49 day, the thickness of scar after being administered with vernier caliper measurement.
The scar thickness measurement (mm) of table 1
| Group | 21st day | 28th day | 35th day | 42nd day | 49th day |
| 1 group of positive control | 1.08 | 1.37 | 1.86* | 2.03* | 2.25** |
| 2 groups of positive control | 1.07 | 1.38 | 1.71* | 1.78** | 2.04** |
| 3 groups of positive control | 1.07 | 1.41 | 1.81* | 2.10* | 2.17** |
| 5 groups of embodiment | 1.06 | 1.32 | 1.47** | 1.59** | 1.87** |
| 6 groups of embodiment | 1.07 | 1.32 | 1.50* | 1.60** | 1.89** |
| 7 groups of embodiment | 1.08 | 1.30 | 1.49* | 1.61** | 1.90** |
| 8 groups of embodiment | 1.05 | 1.31 | 1.49* | 1.59** | 1.85** |
| Blank control | 1.08 | 1.57 | 2.51 | 2.98 | 3.27 |
*P<0.05,**P<0.01 compared with blank control.
As can be seen from Table 1 embodiment 5,6,7,8 groups with positive control 1,2,3 groups with that can subtract rabbit ear hyperplasia thickness
It is slow (with blank control ratio), but embodiment 5,6,7,8 groups become apparent from than positive control effect.
Hydroxyproline determination：Take the 49th Lepus ear scar tissue about 30mg to be put into 50ml conical flasks, add 6M hydrochloric acid
10ml, it is placed at 105 DEG C of electric drying oven with forced convection and hydrolyzes 16 hours, adjusts pH to 6.8-6.9, add successively by hydroxyproline kit
Enter reagent solution, mix, 60 DEG C of water-baths 15 minutes, after cooling, 3500 revs/min centrifuge 10 minutes, take supernatant at 550nm, 1cm
Optical path, survey absorbance.Hydroxyproline content is calculated according to formula in kit.
Hydroxyproline content in the scar tissue of table 2
| Group | Hydroxyproline content |
| 1 group of positive control | 5.54±0.31**△△ |
| 2 groups of positive control | 5.67±0.30**△△ |
| 3 groups of positive control | 5.41±0.30**△△ |
| 5 groups of embodiment | 4.31±0.20** |
| 6 groups of embodiment | 4.32±0.25** |
| 7 groups of embodiment | 4.30±0.21** |
| 8 groups of embodiment | 4.29±0.29** |
| Blank control | 9.18±0.19 |
*P<0.05,**P<0.01 compared with blank control
△P<0.05,△△P<0.01 5,6,7,8 groups of embodiment and positive controls ratio
Hydroxyproline is one of collagen characteristic component, the process that scar is formed be mainly collagen with into fiber finer
Born of the same parents' hyperproliferative, i.e. hydroxyproline content are higher, and scar is more serious.Table 2 shows that embodiment 5,6,7,8 groups of hydroxyproline contents are bright
It is aobvious compared with positive control 1,2,3 groups it is few, and there is statistical significance.
Embodiment 10
Clinical test：
The selection of case：269 patients, the wherein people of male 110, the people of women 159 are chosen altogether, and the age is 7-66 year, adult
214, children 55；Case is the scar that acne infection, burn, scald, wound or Post operation wound healing are formed.
Case is divided into following groups：
Positive controls：Manufactured gel after removing laminarin, Paeonol in embodiment 8；
5 groups of embodiment；6 groups of embodiment；7 groups of embodiment；8 groups of embodiment；
Medicine it is daily it is early, middle and late is applied to three times on scar, with finger on scar massage and drug until fully absorbing；
40 days are a course for the treatment of, such as more can not be continuing with more courses for the treatment of.
Skin lesion color score：Crimson or scarlet companion's telangiectasis meter 3 divides；Light red, disappear 2 points of meter after pressing；It is red,
Some grey dark counts 1 divide；Normal skin tone meter 0 divides.
The height point of skin lesion protuberance：Height counts 4 points in more than 4mm；4mm >=height ＞ 2mm count 3 points；2mm >=height ＞
1mm counts 2 points；Highly≤1mm counts 1 point；Flat or 0 point of depression meter.
Skin lesion hardness scores：Normal 0 point of meter, soft (skin is flexible under minimum resistance) count 1 point；Submissive
2 points of (under stress can amoebula) meter；Hard (not flexible, to be moved into bulk, have resistance to pressure) 3 points of meter；Bending
(tissue such as rope form, scar stretch when can shrink back) meter 4 points；(the permanent cripetura of scar causes maimed with distorting) meter 5 of contracture
Point.
Itch scores：Violent or continuation itch is simultaneously divided with scratch meter 3；Often have but less acutely, meter 2 can be endured
Point；Sometimes itch and count 1 point；Without 0 point of meter of itching.
Touch a tender spot and score：There is very strong " hyperalgia ", tenderness meter 3 divides when touching；There is pain when medium hyperalgia, pressing
Keenly feel but can endure and count 2 points；Pain unobvious meter 1 divides when having pain, pressing sometimes；Painless 0 point of meter.
Above-mentioned each index scoring is added as scar order of severity overall score, 1-5 points of overall score is slight, and 6-11 points are
Moderate, 12-18 point are severe.
Recruitment evaluation standard：Overall score * before therapeutic index=(overall score after overall score-treatment before treatment)/treatment
100%.Assess by be almost recovered, effective, effective, invalid four standards.
It is basic to cure：Therapeutic index >=90%；It is effective：Therapeutic index 70%-89%；Effectively：Therapeutic index 30%-
69%；It is invalid：Therapeutic index ＜ 30%.It is efficient by cure substantially+it is effective+effectively in terms of.
Table 3
As a result count：
In 53 patients of positive controls, the lighter patient of symptom smears 1 course for the treatment of of this product, and the state of an illness is clearly better,
Some patientss smear 3-4-3 course for the treatment of of this product, and sb.'s illness took a favorable turn, and the patient that is in a bad way individually smears 4-5 course for the treatment of state of an illness of this product
Take a turn for the better；Efficient wherein dark raised scar is 90.35%, and the efficient raised scar of light color is 87.01%.
In 54 patients of embodiment 5 group, the lighter patient of symptom smears 1 course for the treatment of of this product, and the state of an illness is clearly better, portion
Dividing patient to smear 2-3 course for the treatment of of this product, sb.'s illness took a favorable turn, and it is good that the patient that is in a bad way individually smears 3-4 course for the treatment of state of an illness of this product
Turn；Efficient wherein dark raised scar is 93.62%, and the efficient raised scar of light color is 95.26%.
In 55 patients of embodiment 6 group, the lighter patient of symptom smears 1 course for the treatment of of this product, and the state of an illness is clearly better, portion
Dividing patient to smear 2-3 course for the treatment of of this product, sb.'s illness took a favorable turn, and it is good that the patient that is in a bad way individually smears 3-4 course for the treatment of state of an illness of this product
Turn；Efficient wherein dark raised scar is 92.69%, and the efficient raised scar of light color is 96.39%.
In 53 patients of embodiment 7 group, the lighter patient of symptom smears 1-3 course for the treatment of of this product, and the state of an illness is clearly better,
Some patientss smear 2-3 course for the treatment of of this product, and sb.'s illness took a favorable turn, and it is good that the patient that is in a bad way individually smears 3-4 course for the treatment of state of an illness of this product
Turn；Efficient wherein dark raised scar is 95.34%, and the efficient raised scar of light color is 97.10%.
In 54 patients of embodiment 8 group, the lighter patient of symptom smears 1-3 course for the treatment of of this product, and the state of an illness is clearly better,
Some patientss smear 2-3 course for the treatment of of this product, and sb.'s illness took a favorable turn, and it is good that the patient that is in a bad way individually smears 3-4 course for the treatment of state of an illness of this product
Turn；Efficient wherein dark raised scar is 97.26%, and the efficient raised scar of light color is 95.34%.
Effect of the present invention is illustrated with the product model case of embodiment in clinical test 8.
Model case 1
Mr. Wang, 33 years old age, man, people from Zhengzhou, because the new wound type scar that scratch is formed is shown in Fig. 1.Scar position in face,
The product prepared using the embodiment of the present invention 6, substantially disappeared using only half of course for the treatment of, scar, after being continuing with half of course for the treatment of again,
Red scar is substantially to disappear on the face, and also ruddy exquisiteness is shown in Fig. 2 to newborn skin.
Model case 2
Week so-and-so, at 50 years old age, because of constitution reason, there is keloid at ear, and fester, itch bitterly, wound can not be cured
Close (see Fig. 3), and hinder at ear, itch unbearably, when wearing the clothes gently rubs all that pain is endlessly.It is refrigerant comfortable when beginning to use,
Alleviated using gel prepared by embodiment 7 less than a course for the treatment of itch and pain symptom, keloid substantially becomes after two courses for the treatment of
Small, keloid projection has almost become flat (see Fig. 4) after four courses for the treatment of.
Model case 3
Lee, 7 years old age, man, people from Liuzhou, instep injury are performed an operation and leave common hyperplastic scar (see Fig. 5).Lee
The gel prepared with 2 course for the treatment of embodiments 8 finds that scar is substantially thin out, and after 2 courses for the treatment of, it is found that original scar is several can not
See (see Fig. 6).
Model case 4
Zheng, at 39 years old age, female, people from Chengdu, because burn leaves contracture type scar (see Fig. 7), scar position is in oxter, use
Find that scar is substantially thin out after gel 2 courses for the treatment of prepared by embodiment 5, scar loses substantially after 5 courses for the treatment of, and skin becomes more
Glossy (see Fig. 8).
Model case 5
It answer certain, 21 years old age, man, Pekinese, whelk.A lot of useless fellows, pore are have also appeared when long whelk
Start to become thick, one course for the treatment of of gel for having used embodiment 8 to prepare, acne print color on the face substantially shoals, and pore also diminishes
, then after having used a course for the treatment of, the colour of skin is obviously improved, and acne print almost disappears, and skin becomes bright and clean, bright.
Claims (8)
- The scar Silica hydrogel 1. one kind is dispelled, it is characterized in that being made up by weight percentage of following raw materials：Asiaticosid 1-5%, kelp are more Sugared 1-5%, Paeonol 1-5%, safflower seed oil 5-15%, dimethyl silicone polymer 15-20%, emulsifying agent 3-5%, water 41- 60%th, glycerine 5-15%.
- The scar Silica hydrogel 2. one kind according to claim 1 is dispelled, it is characterized in that the asiaticosid is 3%, laminarin is 2.5%th, Paeonol 3%, safflower seed oil 5%, dimethyl silicone polymer 15%, emulsifying agent 3%, water 56.5%, Glycerine is 12%.
- The scar Silica hydrogel 3. one kind according to claim 1 or 2 is dispelled, it is characterized in that the viscosity of the dimethyl silicone polymer is 5‐100mm2/s。
- The scar Silica hydrogel 4. one kind according to claim 1 or 2 is dispelled, it is characterized in that the emulsifying agent is polyglyceryl -2- two Poly- hydroxy stearic acid ester, polyglyceryl -3- dimerization hydroxy stearic acid ester, cetearyl alcohol alcohol ether -6 and stearyl alcohol, PEG-7 hydrogenation castors One or more in sesame oil.
- A kind of 5. preparation method for scar Silica hydrogel of dispelling, it is characterized in that comprising the following steps：1) raw material is weighed by weight percentage：Asiaticosid 1-5%, laminarin 1-5%, Paeonol 1-5%, safflower seed oil 5- 15%th, dimethyl silicone polymer 15-20%, emulsifying agent 3-5%, water 41-60%, glycerine 5-15%；2) safflower seed oil, dimethyl silicone polymer and emulsifying agent are put into container, low whipping speed is 10-20 revs/min Under the conditions of be heated to 70-90 DEG C, after being kept for 15-25 minutes, obtain oil phase；3) asiaticosid, laminarin, Paeonol, water, glycerine are put into container, low whipping speed is 10-20 revs/min Under the conditions of be heated to 75-90 DEG C, kept for 15-25 minutes, obtain aqueous phase；4) by oil phase and aqueous phase in vacuum homogeneous emulsifying machine, homogeneous 500-800 seconds under vacuum；5) room temperature is cooled to, one kind is obtained and dispels scar Silica hydrogel.
- 6. according to the method for claim 5, it is characterized in that the asiaticosid is 3%, laminarin 2.5%, the root bark of tree peony Phenol is 3%, safflower seed oil 5%, dimethyl silicone polymer 15%, emulsifying agent 3%, water 56.5%, glycerine 12%.
- 7. the method according to claim 5 or 6, it is characterized in that the viscosity of the dimethyl silicone polymer is 5-100mm2/s。
- 8. the method according to claim 5 or 6, it is characterized in that the emulsifying agent is polyglyceryl -2- dimerization hydroxy stearates One in acid esters, polyglyceryl -3- dimerization hydroxy stearic acid ester, cetearyl alcohol alcohol ether -6 and stearyl alcohol, PEG-7 rilanit specials Kind is several.
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| CN107157986B (en) * | 2017-05-22 | 2020-02-18 | 天津嘉氏堂科技有限公司 | Silica gel capable of concealing and treating scar and preparation method thereof |
| CN107970140A (en) * | 2017-12-19 | 2018-05-01 | 广州汇川医药科技有限公司 | A kind of dispel scar composition and its application containing alligator oil |
| CN110711263A (en) * | 2019-12-03 | 2020-01-21 | 河南汇博医疗股份有限公司 | Functional dressing with functions of preventing, repairing and modifying scars and preparation method thereof |
| CN113384400A (en) * | 2021-06-25 | 2021-09-14 | 江苏弘生生物工程有限公司 | Preparation method of silica gel navel protection patch |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015509A (en) * | 2007-02-14 | 2007-08-15 | 郑州三创释药技术有限公司 | Cosmetic product for treating acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015509A (en) * | 2007-02-14 | 2007-08-15 | 郑州三创释药技术有限公司 | Cosmetic product for treating acne |
Non-Patent Citations (1)
| Title |
|---|
| 复方积雪草苷凝胶的制备与质量控制;夏林虹等;《中国心药杂志》;20101231;第19卷(第14期);第1266-1269页 * |
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