CN104855984A - 过敏性鼻炎非全营养配方食品 - Google Patents
过敏性鼻炎非全营养配方食品 Download PDFInfo
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- CN104855984A CN104855984A CN201510192334.8A CN201510192334A CN104855984A CN 104855984 A CN104855984 A CN 104855984A CN 201510192334 A CN201510192334 A CN 201510192334A CN 104855984 A CN104855984 A CN 104855984A
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Abstract
本发明属于药食同源类配方与新资源食品技术领域，具体是提供了供过敏性鼻炎患者食用的非全营养配方食品、特定全营养配方食品或全营养配方食品；该配方根据《特殊医学用途配方食品通则》的要求，结合过敏性鼻炎患者的体质特征，根据传统中医精髓理论合理配伍多种“药食同源”之中药,采用多种经预水解SBE技术提取药食两用的中药提取物精华、生物酶解提取的短肽、益生元、氨基酸、碳水化合物、有保健功能的油脂、多种维生素及矿物质一起混合等工艺加工制成，不仅可作为单一营养来源满足过敏性鼻炎患者的营养需求，还起到了温肺固表、健脾补气、化湿通窍、祛散风寒、益气健脾，升清化湿、温阳补肾及增强免疫力的功效。
Description
技术领域
本发明属于药食同源类配方与新资源食品技术领域，具体是将 “药食同源之中药”的传统中医精髓理论和新资源食品有机结合起来，添加以短肽、益生元、氨基酸、碳水化合物、有保健功能的油脂、复合维生素、复合矿物质为辅料制成的过敏性鼻炎的全营养配方食品、特定全营养配方食品或非特定全营养配方食品。
背景技术
过敏性鼻炎即变应性鼻炎，是指特应性个体接触变应原后，主要由IgE介导的介质（主要是组胺）释放，并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病，其发生的必要条件有3个：特异性抗原即引起机体免疫反应的物质；特应性个体即所谓个体差异、过敏体质；特异性抗原与特应型个体二者相遇，变应性鼻炎是一个全球性健康问题，可导致许多疾病和劳动力丧失，变应性鼻炎是一种由基因与环境互相作用而诱发的多因素疾病，变应性鼻炎的危险因素可能存在于所有年龄段：1、遗传因素，变应性鼻炎患者具有特应性体质，通常显示出家族聚集性，已有研究发现某些基因与变应性鼻炎相关联；2、变应原暴露，变应原是诱导特异性IgE抗体并与之发生反应的抗原，它们多来源于动物、植物、昆虫、真菌或职业性物质，其成分是蛋白质或糖蛋白，极少数是多聚糖，变应原主要分为吸入性变应原和食物性变应原，吸入性变应原是变应性鼻炎的主要原因； “药食同源”是中华原创医学之中对人类最有价值的贡献之一；中医历来强调“药疗不如食疗”，食疗成为现代人追求返璞归真、健康饮食的最佳选择；让人们在享受美食的过程中祛除病痛，避免了打针、吃药，甚至手术之苦；
对于特殊营养食品，在美国、欧盟等发达国家都有相应的规定和开发应用；而我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中全营养食品明确规定：2.1.1全营养配方食品：可作为单一营养来源满足目标人群营养需求的特殊医学用途配方食品；2.1.2特定全营养配方食品：可作为单一营养来源满足目标人群在特定疾病或医学状况下营养需求的特殊医学用途配方食品；
目前市场上有利用以食源性短肽为主要原料，添加药食两用的香菇、陈皮、枸杞、山药、茯苓、黄精等的提取物、复合维生素和矿物质组成复合配方，还有利用益生菌为主要原料的产品，但还没有发现结合过敏性鼻炎的患者的体质特征，依据传统中医的精髓理论，因人而异，黄金配伍以多种药食两用的中药提取物精华、短肽为主要原料，以益生元、碳水化合物、氨基酸、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的全营养配方食品、特定全营养配方食品、非全营养配方食品或类似产品。
发明目的
本发明的目的是在继承中医精髓理论治病方法上，开创性将多种改善过敏性鼻炎患者的肠道微生态的新资源食品与“药食同源之中药”复方的提取物有机结合起来, 添加以短肽、氨基酸、碳水化合物、有保健功能的油脂、多种维生素、多种矿物质为辅料，不仅能够补充免疫力低下的过敏性鼻炎患者所必需营养素，改善机体营养状况，还能并利用药食两用中草药中的功能因子调节机体功能，毒副作用小、安全有效，且人们容易接受的适合过敏性鼻炎患者食用的全营养配方食品、特定全营养配方食品或非特定全营养配方食品。
发明内容：
本研发团队根据《特殊医学用途配方食品通则》的要求，结合过敏性鼻炎患者的体质特征，综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果，依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用一种或几种药食两用的中药提取物精华及新资源食品、短肽为主要原料，以益生元、碳水化合物、氨基酸、多种维生素及矿物质辅料，不仅可作为单一营养来源满足过敏性鼻炎的患者的营养需求，还有温肺固表、健脾补气、化湿通窍、祛散风寒、益气健脾，升清化湿、温阳补肾及增强免疫力的功效的全营养配方食品、特定全营养配方食品或非特定全营养配方食品（组合成的复合配方）；
1、本发明配方的主要成分为：
中药提取物是根据过敏性鼻炎的患者的体质特征从中医理论中的肝、脾、肾三脏同调为主原则，利用药食两用中草药中的功能因子调节机体功能增强抵抗力,并选取以下几大类药物进行配伍；其中：冬虫夏草功效主要有调节免疫系统功能、抗肿瘤、抗疲劳、补肺益肾，止血化痰，秘精益气、美白祛黑等多种功效；铁皮石斛，益胃生津，滋阴清热；蛹虫草，能够调节全身功能、提高免疫能力、增强巨噬细胞的吞噬功能、促进抗体的形成，主要有保肺益肾养肝、止咳平喘祛痰、润肤防皱抗衰老、抗菌抗炎、镇静、扩张血管、降低血压、降低血糖、抗疲劳、耐缺氧等作用；乌梅，敛肺，涩肠，生津，安蛔；白芷，祛风，散湿，排脓，生肌止痛；薄荷，可缓解腹痛、胆囊问题如痉挛，还具有防腐杀菌、利尿、化痰、健胃和助消化等作用；鱼腥草，清热解毒、消肿疗疮、利尿除湿、清热止痢、健胃消食；金银花，具有清热解毒、抗炎、补虚疗风的作用；蒲公英，清热解毒，利尿散结；甘草，清热解毒、祛痰止咳、脘腹等；桔梗，宣肺，利咽，祛痰，排脓；菊花，疏风，清热，明目，解毒；大枣，具有补虚益气、养血安神、健脾和胃等作用；莲子，清心醒脾，补脾止泻，养心安神明目、补中养神，健脾补胃，止泻固精，益肾涩精止带；薏仁，利湿健脾；舒筋除痹；清热排脓；
本发明所述的药食两用中药提取物及新资源食品是指冬虫夏草（冬虫夏草菌丝体）、灵芝孢子粉（破壁）、灵芝、铁皮石斛、黄芪、党参、当归、白芍、白术、肉苁蓉，金英子、苍耳子、辛夷、防风、荆芥、诃子、柴胡、麻黄、细辛、羌活、川芎、黄芩、白鲜皮、丹皮、五爪龙、木贼、玄参、白蒺藜、太子参、五味子、石菖蒲、蝉蜕、鹅不食草、双黄连、虎杖，蛹虫草、乌梅，白芷、薄荷、鱼腥草、金银花、蒲公英、甘草、桔梗、菊花，百合、、大枣、莲子、薏仁、红糖、桂圆、牛蒡子、猴头菇、沙棘、木瓜、山楂、桃仁、芡实、生姜、线叶金雀花、显齿蛇葡萄叶、裸藻、显脉旋覆花（小黑药）、针叶樱桃果、耳叶牛皮消、青钱柳叶、雨生红球藻、金花茶、圆苞车前子壳、茶叶茶氨酸、 丹凤牡丹花、广东虫草子、蛋白核小球藻、茶藨子叶状层菌发酵菌丝体其中的一种、几种或全部,采用生物酶解或预水解SBE提取并微胶囊化，经喷雾干燥及冷冻干燥的提取物后的混合物；
2、短肽：即为低聚肽，是指利用生物酶工程技术从动物或植物蛋白中分离提取的一类小分子蛋白质，其平均分子量在1000Dalton以下，易溶于水，对酸、热稳定，可以不需经过消化而直接吸收，生物利用率高，在吸收和利用上优于游离的氨基酸和完整的蛋白质，可应用于蛋白质补充食品中，尤其对于消化吸收能力低下的人群，短肽是极佳的氮源，除营养功能外，短肽还具有一系列的生理活性功能：提高小肠的消化吸收功能, 增强机体免疫力,抗氧化, 辅助调节血糖，辅助调节血脂，辅助降血压，抗辐射, 促进矿物质吸收, 增强药食两用中草药中功能因子的作用效果；
本发明所述的短肽是指玉米低聚肽、小麦低聚肽、海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合；
3、益生元: 以促益生菌肠道定植、肠道收敛、降低肠道pH环境，也不被大多数的肠道腐败菌利用，但可以促进人体内有益细菌——乳杆菌、双歧 杆菌的生长繁殖，从而可以抑制腐败菌生长，有助于改善和维持肠道正常功能；长期食用可以延缓衰老、通便、提高免疫力、减轻肝脏负担、提高营养素的吸收率，特别是能够改善机体对钙、铁、锌等金属离子 的吸收；可选择性地促进有益菌（双歧、乳酸）的生长繁殖外，还可代谢为酸性产物如乳酸等有机酸，使结肠内pＨ值降低，抑制肠道有害细菌的生长；使小肠内水电解质滞留在肠腔，产生高渗效果，刺激肠蠕动引起缓泻，从而促进肠道内毒素及其他毒性物质的排出，乳果糖还可直接灭活肠道中内毒素、降低肠道pH值，已广范应用于增强过敏性鼻炎的抵抗力的治疗；
本是指低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖其中的一种、几种或全部混合。本发明所述的益生元为:山药、茯苓、薏仁、鸡内金、芡实、菊粉的提取物、棉子低聚糖、水苏糖、酵母、低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖其中的一种、几种或全部混合；
4、碳水化合物：碳水化合物是由碳、氢和氧三种元素组成，它是为人体提供热能的三种主要的营养素中最廉价的营养素，摄入充足时，在体内可迅速氧化及时提供能量，避免将宝贵的蛋白质用来提供能量，碳水化合物也是细胞膜的糖蛋白、神经组织的糖脂以及传递遗传信息的脱氧核糖核酸(DNA)的重要组成成分，而且碳水化合物中含有的糖原，当其在肝内储备充足时，肝细胞对某些有毒的化学物质和各种致病微生物产生的毒素有较强的解毒能力；
本发明所述的碳水化合物是指L-阿拉伯糖、果糖、蚌肉多糖、抗性糊精、壳寡糖、酵母β-葡聚糖、多聚果糖、海藻糖、半乳糖、乳糖、葡萄糖、麦芽糖、水溶性膳食纤维、淀粉、糖元其中的一种、几种或全部混合；
5.有保健功能的油酯是指对人身体有保健作用,并能增加终产品能量,使本发明的终产品每100 g所含有的能量应不低于295 kJ (70 kcal)；如鱼油是人体血管的清道夫，还能预防动脉硬化、中风和心脏病。鱼油是高血压、冠心病、脑中风、糖尿病、风湿性关节炎、癌症等疾病；亚麻籽油有减肥、降低胆固醇、改善肾功能等作用；牡丹籽油有降血脂和降血压,增强自身免疫,预防糖尿病,防治癌症的功效；翅果油有防止和治疗高血压，高血脂，血管硬化等病症的功效；
本发明所述的有保健功能的油脂是指亚麻籽油、牡丹籽油、翅果油、水飞蓟籽油、植物甾醇酯、御米油、茶叶籽油、鱼油、鱼油提取物、花生四烯酸油脂、蔗糖聚酯、DHA藻油、磷虾油、盐地碱蓬籽油、美藤果油、盐肤木果油、中链甘油三酯、黄明胶、光皮梾木果油、长柄扁桃油、中长链脂肪酸食用油、元宝枫籽油、表没食子儿茶素没食子酸酯、甘油二酯油、叶黄素酯其中的一种、几种或全部混合；
6.氨基酸:分为必需氨基酸与非必需氨基酸,是构成蛋白质的基本单位，赋予蛋白质特定的分子结构形态，使其具有生化活性；摄取适量的蛋氨酸有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用；亮氨酸能够修复肌肉，控制血糖，并给身体组织提供能量，必需氨基酸苯丙氨酸可以抑制癌瘤生长，又可以降低药物的毒副作用,赖氨酸可提高食物蛋白质的吸收和利用，达到均衡营养，促进生长发育；精氨酸有助于将血液中的氨转变为尿素而排泄出去；对于高氨血症，肝脏机能障碍等均有功效；组氨酸降低胃液酸度，缓和胃肠手术的疼痛，减轻妊娠期呕吐及胃部灼热感，抑制由植物神经紧张而引起的消化道溃烂，对过敏性疾病，如哮喘等也有功效；色氨酸可以预防糙皮病、抑郁症，改善睡眠和调节情绪；
本发明所述的氨基酸是指L-谷氨酰胺、γ-氨基丁酸、珠肽粉、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合；
7．维生素和矿物质：维生素和矿物质是人体必需的营养素，本发明中添加的维生素为维生素和矿物质是人体必需的营养素；
本发明中添加的维生素为维生素A、维生素D、维生素E、维生素K、维生素K1、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、维生素Be、维生素Bu、烟酸、叶酸、泛酸、胆碱、生物素其中的 一种、几种或全部混合；
本发明中添加的矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬、钼其中的一种、几种或全部混合，本发明所述的矿物质添加为该矿物质的有机或无机化合物；
本发明中维生素矿物质的添加量参照《特殊医学用途配方食品通则》执行，现以1000g成品为例，添加量为维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g；
8.采用上述集成创新工艺将各种配料混合均匀制成粉状的固体饮料、颗粒剂，并分装成10g/包,用约150ml开水溶解后，直接饮用或经鼻饲摄入；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥,少添加辅料等,分装成10-65ml/瓶，每日早、中、晚饭后0.5小时各饮1瓶，所有操作均在符合《特殊医学用途配方食品良好生产规范》要求的洁净干燥环境内进行；
本非全营养配方食品的特性及其对机体的作用主要表现在以下几个方面：
1.本发明是根据《特殊医学用途配方食品通则》的要求，结合过敏性鼻炎的患者的体质特征，综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果研制的，因人而异，黄金配伍；
2.本发明依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用多种药食两用的中药提取物精华、短肽为主要原料，以益生元、碳水化合物、氨基酸、有保健功能的油脂、多种维生素及矿物质为辅料，各种配料的有机组合，将各种功能进行融合，并通过有效成分之间的协同作用，增强作用效果；
3. 具有高效吸收性，利用本发明配方，各种组分采用适宜的比例搭配制备的食品，经一定量水溶解后呈等渗状态，能快速通过胃到达小肠，吸收快速、完全，可以迅速补充过敏性鼻炎患者所需营养；
4．本发明配方中采用各种药食两用中草药的提取物，含有多种功能活性成分，不仅提高了功能因子的浓度，减少各种杂质的摄入，有助于减轻肝肾负担，具有增强人体抵抗力的作用，还有温肺固表、健脾补气、化湿通窍、祛散风寒、益气健脾，升清化湿、温阳补肾及增强免疫力的功效；
5. 本发明配方食品以多种来源的食源性生物活性短肽为氮源，因为短肽不需消化即可吸收，更有利于机体的利用，可以有效改善过敏性鼻炎患者负氮平衡，而且食源性短肽能够改善肠粘膜上皮细胞的结构和功能，提高肠粘膜的吸收能力；
6.本发明配方中所含的益生元，通过促进肠内益生菌的生长繁殖，抑制腐败菌的生长，同时在肠粘膜表面形成一道保护屏障，可以抵御肠道腐败菌对肠粘膜的损伤，减少肠内有害物质的吸收，还可以促进肠道蠕动，加速肠内残留物质的排出，可以防止便秘，而且通过促进肠道益生菌的生长繁殖也可以增强机体免疫力，短肽、碳水化合物与活性多糖等生物活性物质具有协同作用；
7、本发明配方中所含的碳水化合物是为人体提供热能的三种主要的营养素，在体内可迅速氧化及时提供能量，避免将宝贵的蛋白质用来提供能量，碳水化合物也是细胞膜的糖蛋白、神经组织的糖脂以及传递遗传信息的脱氧核糖核酸(DNA)的重要组成成分，而且碳水化合物中含有的糖原，当其在肝内储备充足时，肝细胞对某些有毒的化学物质和各种致病微生物产生的毒素有较强的解毒能力；
8、本发明配方中所含的有保健功能的油酯不仅对人身体有保健作用,并为人体提供正常生活所需的能量,使本发明的终产品每100g所含有的能量应不低于295 kJ (70 kcal) ；
9、本发明配方中所含的氨基酸，是构成蛋白质的基本单位，赋予蛋白质特定的分子结构形态，使其具有生化活性，有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用，能够修复肌肉，控制血糖，并给身体组织提供能量，还可提高食物蛋白质的吸收和利用，达到均衡营养，促进生长发育；
10、本发明配方食品含多种维生素和矿物质，可迅速补充过敏性鼻炎患者所需的微量营养素，短肽通过与钙、铁、锌等的螯合后，更增加了矿物质元素的吸收率；
11、本发明配方中不含脂肪和胆固醇，能够在补充蛋白质、微量营养素的同时，不会增加脂肪、胆固醇的摄入，避免了肉、蛋等髙蛋白食物的不利影响。
具体实施方式
下面通过以下实施案例对本发明作进一步说明，它将有助于理解本发明；
实施案例一
实现本发明目的过敏性鼻炎非全营养配方食品是以结合过敏性鼻炎患者的体质特征，依据传统中医的精髓理论，因人而异，黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、益生元为主要原料，以一种、几种或全部的短肽、碳水化合物、氨基酸、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的全营养配方,或制成特定全营养配方食品和非全营养配方食品；
按下列原料及其用量进行配方,药食两用的提取物及新资源食品: 冬虫夏草（冬虫夏草菌丝体）11g、灵芝孢子粉（破壁）11g、灵芝10g、铁皮石斛10g、黄芪10g、党参9g、当归8g、白芍8g、白术8g、肉苁蓉8g、金英子7g、苍耳子7g、辛夷7g、防风6g、荆芥6g、诃子6g、柴胡6g、麻黄6g、细辛6g、羌活6g、川芎6g、黄芩6g、白鲜皮6g、丹皮6g、五爪龙6g、木贼5g、玄参5g、白蒺藜5g、太子参5g、五味子5g、石菖蒲4g、蝉蜕4g、鹅不食草4g、双黄连4g、虎杖4g、蛹虫草4g、线叶金雀花4g、显齿蛇葡萄叶4g、裸藻4g、显脉旋覆花（小黑药）4g、针叶樱桃果4g、耳叶牛皮消4g、青钱柳叶4g、雨生红球藻4g、金花茶4g、圆苞车前子壳4g、乌梅4g、白芷4g、薄荷4g、鱼腥草4g、金银花3g、蒲公英3g、甘草3g、桔梗3g、菊花3g、百合2g、大枣2g、莲子2g、薏仁2g、红糖2g、桂圆2g、牛蒡子1g、猴头菇1g、沙棘1g、木瓜1g、山楂1g、桃仁1g、芡实1g、生姜1g、茶叶茶氨酸1g、 丹凤牡丹花1g、广东虫草子1g,蛋白核小球藻1g、茶藨子叶状层菌发酵菌丝体1g 、雪莲培养物10g、短肽100g、益生元100g、多种氨基酸100g、碳水化合物100g、有保健功能的油脂100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g；
制作时先将以是灵芝、铁皮石斛、黄芪、党参、当归、白芍、白术、肉苁蓉，金英子、苍耳子、辛夷、防风、荆芥、诃子、柴胡、麻黄、细辛、羌活、川芎、黄芩、白鲜皮、丹皮、五爪龙，木贼，玄参、白蒺藜、太子参，五味子、石菖蒲、蝉蜕、鹅不食草、双黄连、虎杖、线叶金雀花、显齿蛇葡萄叶、裸藻、显脉旋覆花（小黑药）、针叶樱桃果、耳叶牛皮消、青钱柳叶、雨生红球藻、金花茶、圆苞车前子壳、乌梅，白芷、薄荷、鱼腥草、金银花、蒲公英、甘草、桔梗、菊花、百合、大枣、莲子、薏仁、红糖、桂圆、牛蒡子、猴头菇、沙棘、木瓜、山楂、桃仁、芡实、生姜、茶叶茶氨酸、 丹凤牡丹花、广东虫草子、浸泡后加入β-环状糊精，用预水解SBE技术提取后,经喷雾干燥而制备的粉状提取物，再添加生物酶解提取的冬虫夏草（冬虫夏草菌丝体）、灵芝孢子粉（破壁）、蛋白核小球藻、茶藨子叶状层菌发酵菌丝体 雪莲培养物、蛹虫草、短肽、益生元、氨基酸、碳水化合物、多种维生素及矿物质一起粉碎混合后进行120摄氏度高温灭菌1小时，然后混合均匀制成粉状的固体饮料、颗粒剂，并分装成10g/包,用约150ml开水溶解后，直接饮用或经鼻饲摄入；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥,少添加辅料等,分装成10-65ml/瓶，每日早、中、晚饭后0.5小时各饮1瓶，所有操作均在符合《特殊医学用途配方食品良好生产规范》要求的洁净干燥环境内进行。
实施案例二
上述过敏性鼻炎非全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蛹虫草12g、线叶金雀花12g、显齿蛇葡萄叶12g、裸藻12g、青钱柳叶12g、雨生红球藻11g、金花茶11g、圆苞车前子壳11g、乌梅11g、白芷11g、薄荷11g、鱼腥草11g、金银花10g、蒲公英10g、甘草10g、桔梗9g、菊花9g、百合8g、、大枣7g、莲子6g、薏仁6g、红糖5g、桂圆5g、牛蒡子4g、显脉旋覆花（小黑药）4g、针叶樱桃果4g、耳叶牛皮消4g、猴头菇3g、沙棘2g、木瓜2g、山楂2g、桃仁1g、芡实1g、生姜1g、茶叶茶氨酸1g、 丹凤牡丹花1g、广东虫草子1g、雪莲培养物10g、蛋白核小球藻1g、茶藨子叶状层菌发酵菌丝体1g 、益生元350g、短肽150g、多种氨基酸100g、碳水化合物100g、有保健功能的油酯100g、水溶性膳食纤维50g、维生素和矿物质25g。
实施案例三
上述过敏性鼻炎非全营养配方食品，还包括以重量计的下列组分:几种药食两用的中药提取物精华及新资源食品500g、益生元450g、短肽200g、有保健功能的油脂150g、氨基酸150g、多种维生素25g、多种矿物质25g；每100g所含有的能量应不低于295kJ(70kcal)。
实施案例四
上述过敏性鼻炎非全营养配方食品，还包括以重量计的下列组分：药食两用中药提取物精华及新资源食品500g、益生元450g，碳水化合物300g、短肽250g、氨基酸150g、多种维生素25g、多种矿物质25g；每100g所含有的能量应不低于295kJ(70kcal)。
实施案例五
上述过敏性鼻炎非全营养配方食品，还包括以重量计的下列组分：药食两用中药提取物精华及新资源食品500g、益生元480g，短肽250g、碳水化合物250g、有保健功能的油脂150g、多种维生素25g、多种矿物质25g；每100g所含有的能量应不低于295kJ(70kcal)。
Claims (10)
1.过敏性鼻炎非全营养配方食品，其特征是结合过敏性鼻炎患者的体质特征，依据传统中医的精髓理论，因人而异，黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、益生元为主要原料，以一种、几种或全部的短肽、碳水化合物、氨基酸、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的全营养配方,或制成特定全营养配方食品和非全营养配方食品；
按下列原料及其用量进行配方，药食两用的提取物及新资源食品: 冬虫夏草（冬虫夏草菌丝体）11g、灵芝孢子粉（破壁）11g、灵芝10g、铁皮石斛10g、黄芪10g、党参9g、当归8g、白芍8g、白术8g、肉苁蓉8g、金英子7g、苍耳子7g、辛夷7g、防风6g、荆芥6g、诃子6g、柴胡6g、麻黄6g、细辛6g、羌活6g、川芎6g、黄芩6g、白鲜皮6g、丹皮6g、五爪龙6g、木贼5g、玄参5g、白蒺藜5g、太子参5g、五味子5g、石菖蒲4g、蝉蜕4g、鹅不食草4g、双黄连4g、虎杖4g、蛹虫草4g、线叶金雀花4g、显齿蛇葡萄叶4g、裸藻4g、显脉旋覆花（小黑药）4g、针叶樱桃果4g、耳叶牛皮消4g、青钱柳叶4g、雨生红球藻4g、金花茶4g、圆苞车前子壳4g、乌梅4g、白芷4g、薄荷4g、鱼腥草4g、金银花3g、蒲公英3g、甘草3g、桔梗3g、菊花3g、百合2g、大枣2g、莲子2g、薏仁2g、红糖2g、桂圆2g、牛蒡子1g、猴头菇1g、沙棘1g、木瓜1g、山楂1g、桃仁1g、芡实1g、生姜1g、茶叶茶氨酸1g、 丹凤牡丹花1g、广东虫草子1g,蛋白核小球藻1g、茶藨子叶状层菌发酵菌丝体1g 、雪莲培养物10g、短肽100g、益生元100g、多种氨基酸100g、碳水化合物100g、有保健功能的油脂100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g；
制作时先将以是灵芝、铁皮石斛、黄芪、党参、当归、白芍、白术、肉苁蓉，金英子、苍耳子、辛夷、防风、荆芥、诃子、柴胡、麻黄、细辛、羌活、川芎、黄芩、白鲜皮、丹皮、五爪龙，木贼，玄参、白蒺藜、太子参，五味子、石菖蒲、蝉蜕、鹅不食草、双黄连、虎杖、线叶金雀花、显齿蛇葡萄叶、裸藻、显脉旋覆花（小黑药）、针叶樱桃果、耳叶牛皮消、青钱柳叶、雨生红球藻、金花茶、圆苞车前子壳、乌梅，白芷、薄荷、鱼腥草、金银花、蒲公英、甘草、桔梗、菊花、百合、大枣、莲子、薏仁、红糖、桂圆、牛蒡子、猴头菇、沙棘、木瓜、山楂、桃仁、芡实、生姜、茶叶茶氨酸、 丹凤牡丹花、广东虫草子、浸泡后加入β-环状糊精，用预水解SBE技术提取后,经喷雾干燥而制备的粉状提取物，再添加生物酶解提取的冬虫夏草（冬虫夏草菌丝体）、灵芝孢子粉（破壁）、蛋白核小球藻、茶藨子叶状层菌发酵菌丝体 雪莲培养物、蛹虫草、短肽、益生元、氨基酸、碳水化合物、多种维生素及矿物质一起粉碎混合后进行120摄氏度高温灭菌1小时，然后混合均匀制成粉状的固体饮料、颗粒剂，并分装成10g/包,用约150ml开水溶解后，直接饮用或经鼻饲摄入；也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用，若做成饮料则省去经喷雾干燥,少添加辅料等,分装成10-65ml/瓶，每日早、中、晚饭后0.5小时各饮1瓶，所有操作均在符合《特殊医学用途配方食品良好生产规范》要求的洁净干燥环境内进行。
2.根据权利要求1所述的过敏性鼻炎非全营养配方食品,还包括依据传统中医的精髓理论，因人而异，黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、益生元为主要原料，以一种、几种的短肽、有保健功能的油脂、氨基酸、多种维生素、多种矿物质为辅料制成的非全营养配方食品,或制成特定全营养配方食品和全营养配方食品。
3.根据权利要求1所述的过敏性鼻炎非全营养配方食品,还包括依据传统中医的精髓理论，因人而异，黄金配伍以一种、几种的药食两用中药提取物精华及新资源食品、益生元为主要原料，碳水化合物、短肽、氨基酸、多种维生素、多种矿物质为辅料制成的非全营养配方食品,或制成全营养配方食品和全营养配方食品。
4.根据权利要求1所述的过敏性鼻炎非全营养配方食品,还包括依据传统中医的精髓理论，因人而异，黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、益生元为主要原料，短肽、碳水化合物、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的非全营养配方食品,或制成特定全营养配方食品和全营养配方食品。
5.根据权利要求1所述的过敏性鼻炎非全营养配方食品，其特征是所述的药食两用中草药提取物及新资源食品为: 灵芝、铁皮石斛、黄芪、党参、当归、白芍、白术、肉苁蓉，金英子、苍耳子、辛夷、防风、荆芥、诃子、柴胡、麻黄、细辛、羌活、川芎、黄芩、白鲜皮、丹皮、五爪龙，木贼，玄参、白蒺藜、太子参，五味子、石菖蒲、蝉蜕、鹅不食草、双黄连、虎杖、线叶金雀花、显齿蛇葡萄叶、裸藻、显脉旋覆花（小黑药）、针叶樱桃果、耳叶牛皮消、青钱柳叶、雨生红球藻、金花茶、圆苞车前子壳、乌梅，白芷、薄荷、鱼腥草、金银花、蒲公英、甘草、桔梗、菊花、百合、大枣、莲子、薏仁、红糖、桂圆、牛蒡子、猴头菇、沙棘、木瓜、山楂、桃仁、芡实、生姜、茶叶茶氨酸、 丹凤牡丹花、广东虫草子，冬虫夏草（冬虫夏草菌丝体）、灵芝孢子粉（破壁）、蛋白核小球藻、茶藨子叶状层菌发酵菌丝体 雪莲培养物、蛹虫草其中的一种、几种或全部混合。
6.根据权利要求1所述的过敏性鼻炎非全营养配方食品，其特征是所述的短肽为:海洋胶原肽、玉米低聚肽、小麦低聚肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合。
7.根据权利要求1所述的过敏性鼻炎非全营养配方食品，其特征是所述的益生元为:山药、茯苓、薏仁、鸡内金、芡实、菊粉的提取混合物,棉子低聚糖、海藻糖、水苏糖、酵母、低聚异麦芽糖、低聚果糖、大豆低聚糖、低聚木糖其中的一种、几种或全部混合。
8.根据权利要求1所述的过敏性鼻炎非全营养配方食品，其特征是所述的氨基酸为:L-谷氨酰胺、γ-氨基丁酸、珠肽粉、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合。
9.根据权利要求1所述的过敏性鼻炎的非全营养配方食品，其特征是所述的碳水化合物为本发明所述的碳水化合物是指L-阿拉伯糖、果糖、蚌肉多糖、抗性糊精、壳寡糖、酵母β-葡聚糖、多聚果糖、半乳糖、乳糖、葡萄糖、麦芽糖、水溶性膳食纤维、淀粉、糖元其中的一种、几种或全部混合。
10.根据权利要求1所述的过敏性鼻炎非全营养配方食品，其特征是所述的有保健功能的油脂为:指亚麻籽油、牡丹籽油、翅果油、水飞蓟籽油、植物甾醇酯、御米油、茶叶籽油、鱼油、鱼油提取物、花生四烯酸油脂、蔗糖聚酯、DHA藻油、磷虾油、盐地碱蓬籽油、美藤果油、盐肤木果油、中链甘油三酯、黄明胶、光皮梾木果油、长柄扁桃油、中长链脂肪酸食用油、元宝枫籽油、表没食子儿茶素没食子酸酯、甘油二酯油、叶黄素酯其中的一种、几种或全部混合。
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| CN107349345A (zh) * | 2017-07-18 | 2017-11-17 | 北京国医九和医药科技有限公司 | 一种调节过敏体质的中药及提取工艺 |
| CN107823268A (zh) * | 2017-12-12 | 2018-03-23 | 阜阳市平衡医疗保健器械有限公司 | 一种治疗鼻炎的消炎喷粉剂 |
| CN108713641A (zh) * | 2018-05-08 | 2018-10-30 | 广东海洋大学 | 一种壳聚糖季铵盐和中草药复合饲料添加剂及其制备方法和应用 |
| CN109512854A (zh) * | 2019-01-03 | 2019-03-26 | 中国人民解放军第四军医大学 | 用于预防和治疗过敏性鼻炎的益生菌组合物及基于其的鼻用制剂和制备方法 |
| CN110432482A (zh) * | 2019-07-05 | 2019-11-12 | 上海奥医高科技实业有限公司 | 一种小儿过敏性皮炎专用型临床营养配方及其制备方法 |
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| CN107349345A (zh) * | 2017-07-18 | 2017-11-17 | 北京国医九和医药科技有限公司 | 一种调节过敏体质的中药及提取工艺 |
| CN107823268A (zh) * | 2017-12-12 | 2018-03-23 | 阜阳市平衡医疗保健器械有限公司 | 一种治疗鼻炎的消炎喷粉剂 |
| CN108713641A (zh) * | 2018-05-08 | 2018-10-30 | 广东海洋大学 | 一种壳聚糖季铵盐和中草药复合饲料添加剂及其制备方法和应用 |
| CN109512854A (zh) * | 2019-01-03 | 2019-03-26 | 中国人民解放军第四军医大学 | 用于预防和治疗过敏性鼻炎的益生菌组合物及基于其的鼻用制剂和制备方法 |
| CN109512854B (zh) * | 2019-01-03 | 2021-09-10 | 中国人民解放军第四军医大学 | 用于预防和治疗过敏性鼻炎的益生菌组合物及基于其的鼻用制剂和制备方法 |
| CN110432482A (zh) * | 2019-07-05 | 2019-11-12 | 上海奥医高科技实业有限公司 | 一种小儿过敏性皮炎专用型临床营养配方及其制备方法 |
| CN111728223A (zh) * | 2020-07-07 | 2020-10-02 | 西安因子元素科技有限公司 | 一种发酵生产复合细胞因子元素的方法 |
| CN115429832A (zh) * | 2022-10-09 | 2022-12-06 | 北京知蜂堂健康科技股份有限公司 | 一种缓解变应性鼻炎的组合物及其制备方法和应用 |
| CN116267921A (zh) * | 2023-02-17 | 2023-06-23 | 江西劲农作物保护有限公司 | 除草剂安全剂的制备方法及其在缓解水稻药害中的应用 |
| CN116350746A (zh) * | 2023-05-16 | 2023-06-30 | 海口桥水联合科技有限责任公司 | 沙丁鱼肽组合物在治疗过敏性鼻炎的药物中的应用 |
| CN116350746B (zh) * | 2023-05-16 | 2024-03-22 | 海口桥水联合科技有限责任公司 | 沙丁鱼肽组合物在治疗过敏性鼻炎的药物中的应用 |
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