CN104855835B - A kind of preparation and application of ultra micro microencapsulation wheat germ powder - Google Patents
A kind of preparation and application of ultra micro microencapsulation wheat germ powder Download PDFInfo
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- CN104855835B CN104855835B CN201510203876.0A CN201510203876A CN104855835B CN 104855835 B CN104855835 B CN 104855835B CN 201510203876 A CN201510203876 A CN 201510203876A CN 104855835 B CN104855835 B CN 104855835B
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of preparation and application of ultra micro microencapsulation wheat germ powder.Using wheat as raw material, three crushing means are crushed using coarse crushing, air-flow crushing and wet ball grinding so that wheat reaches the degree of ultramicro grinding.Addition using sucrose fatty ester and beta cyclodextrin is respectively the 4% and 1.4% of wheat germ powder quality, the technical parameter of the air-flow crushing used is crushing pressure 0.85MPa, the Mpa of feed pressure 0.45, charging rate 30mA, ratio of grinding media to material is 4g/g when wet ball grinding crushes, and wheat germ concentration of slurry is 25%, agitator power 41kw, radio sterilization is carried out in the condition that irradiation dose is 6 8kGy, so as to prepare ultra micro microencapsulation wheat germ powder.Ultra micro microencapsulation wheat germ powder makes the nutriment in wheat preferably be utilized, and active material not easy in inactivation, and in terms of reducing blood lipid, ultra micro microencapsulation wheat germ powder has a significant effect, and has extensive value.
Description
Technical field
The present invention relates to the technical field of wheat deep processing, and specifically, the present invention relates to a kind of ultra micro microencapsulation
Wheat germ powder prepares and the technical field of application.
Background technology
Wheat is that mankind's cultivated area is most wide, crops most ancient, yield is larger, and it is always and the mankind for a long time
Food life it is inseparable.The mankind as important cereal crops about 35% make a living according to wheat, and wheat is made all the time
For flour food is provided for the mankind.Wheat is the accessory substance of wheat flour production, and wheat accounts for the 2%-3% of wheat, wheat
Nutritive value with very abundant.Because its nutritive value height is described as the laudatory title of " the natural nutrition treasure-house of the mankind ", its egg
White matter, unrighted acid, mineral matter, various vitamin contents are high, various amino acid classes Compositional balances, so as to turn into the mankind
The Major Nutrient material of research.But because wheat is intolerant to storage, and cause the waste of wheat.
Certain scale is not yet formed to the Commercial cultivation of wheat both at home and abroad at present, the annual wheat flour that produces can all produce
Raw substantial amounts of wheat, about at 5.6 hundred million tons.Wheat is not easy to store so that this precious resources of wheat is not yet abundant
Utilization.As the mankind gradually increase the demand of nutrition, the Research Requirements of the storage to wheat become increasingly conspicuous, from
And make the utilization of wheat and be developed into a big focus of wheat deep processing research.
The application of the broken technology of Food Super-tiny Powder is a kind of new try of food-processing industry, for traditional handicraft, formula
Improve, the exploitation of new product will bring huge motive force.Proportion of China's food industry gross output value in industrial department is
Leap to the first position, reaches 500,000,000,000 yuan of scale, but product structure is unreasonable, and deep processed product instant food manufacturing industry only accounts for
16%.At present, the deep processing of food industry is promoted, improve added value of product has turned into the common recognition of society and enterprise.Therefore, ultra micro
Crushing technology will have broad application prospects as a kind of new and high technology in food processing.
Through retrieval, have at present be much used to preparing solid beverage on wheat stability and wheat, Yoghourt is ground
Study carefully, and the research of some material ultramicro grindings, but on superfine communication technique, microcapsules technology are protected for wheat
Hide, the research of ultra micro wheat germ powder capsule has no report.Contain the battalion such as abundant protein, vitamin, amino acid in wheat
Material is supported, nutritive value is high, but wheat is not easy to store, and the amount of activated material in wheat is easily destroyed, and is caused
The waste of resource.Therefore, the active material explored and studied in wheat farthest retains, can make the nutrition of wheat
Function is preferably realized, the industrialization continuous production of ultra micro microencapsulation wheat germ powder, and industrial operation simply prepares work
Skill process has great importance.
The content of the invention
For having no at present ultra micro microencapsulation wheat germ powder is prepared using superfine communication technique and microencapsulation technology
Present Research.It is contemplated that in the offer a kind of preparation and application of ultra micro microencapsulation wheat germ powder, it is therefore intended that make full use of
Wheat germ resource, the nutriment for causing wheat germ using superfine communication technique and microencapsulation technology are fully utilized, and prepare
Ultra micro microencapsulation wheat germ powder sense organ is good, stability is strong, realizes ultra micro microencapsulation wheat germ powder industrializes continuous production,
Industrial operation is simple.The present invention solves problem of complex utilization of the Xinjiang wheat germ resource in industry development, to lengthening manufacturing chain,
Finishing and the level of comprehensive utilization of wheat germ are lifted, is all had great importance in terms of the added value for improving wheat germ and processed goods
And value.
What the present invention was achieved through the following technical solutions：
The present invention crushes three crushing means using wheat as raw material, using coarse crushing, air-flow crushing and wet ball grinding, makes
Obtain the degree that wheat reaches ultramicro grinding.Using emulsifying agent sucrose fatty ester, stabilizer beta-schardinger dextrin by ultramicro grinding
Wheat carries out microencapsulation, and ultra micro microencapsulation wheat germ powder is sterilized using radio sterilization means, super so as to prepare
Pico- encapsulated wheat germ powder.Ultra micro microencapsulation wheat germ powder makes the nutriment in wheat preferably be utilized, active matter
Matter not easy in inactivation, and in terms of reducing blood lipid, ultra micro microencapsulation wheat germ powder have a significant effect.
The present invention specifically provides a kind of preparation of ultra micro microencapsulation wheat germ powder, and specific preparation method is as follows：
（1）The pretreatment of raw material：Select the wheat germ that clean, nothing is gone mouldy.
（2）Coarse crushing：By step（1）The wheat germ selected carries out coarse crushing, crosses 60 mesh sieves.
（3）Air-flow crushing：By step（2）Wheat germ after sieving carries out air-flow ultramicro grinding using air-flow crushing mode, adopts
The technical parameter of air-flow crushing is to crush pressure 0.85MPa, feed pressure 0.45 Mpa, charging rate 30mA, air-flow powder
Broken number is 2 times.
（4）Wet ball grinding crushes：By step（3）Wheat germ powder after the air-flow crushing of preparation carries out wet ball grinding crushing, wet
Ratio of grinding media to material is 4g/g during method ball mill grinding, and wheat germ concentration of slurry is 25%, agitator power 41kw.
（5）The microencapsulation of wheat germ：Weigh 7.5g steps（4）The ultra micro wheat germ powder of preparation, is dissolved in 50mL water, adds breast
Agent sucrose fatty ester, the addition of sucrose fatty ester is the 4% of wheat germ powder quality, while adds stabilizer beta-schardinger dextrin,
The addition of beta-schardinger dextrin is wheat germ powder quality 1.4%, and the heating water bath 60min under the conditions of 70 DEG C, makes its dissolving, is stirred,
It is well mixed.
（6）Homogeneous：By step（5）The mixed solution of the wheat germ, sucrose fatty ester and the beta-schardinger dextrin that prepare is in homogeneous
Pressure carries out homogeneous under conditions of being 50Mpa.
（7）Spray drying：EAT be 220 DEG C, leaving air temp be 95 DEG C under conditions of to step（6）After homogeneous
Material carries out spray drying treatment.
（8）Radio sterilization:By step（7）Wheat germ powder capsule after spray drying is packed with double-deck PE bags, packing inside bag
From Self-enclosing PE bags, outer packaging is sealed with PE bags thermoplastic, and per packed 50g, packaged wheat germ powder capsule is being irradiated
The condition that dosage is 6-8kGy carries out radio sterilization.
（9）Ultra micro microencapsulation wheat germ powder can be prepared by above-mentioned steps.
Different materials has different Crushing Behaviors, generally requires different breaking methods.Superfine communication technique is being eaten
Application in product processing has the significance of two aspects, first, improving the mouthfeel of food, and is advantageous to the suction of nutriment
Receive；Second, the raw material that can not be fully absorbed or utilize originally is re-used, prepares with deep processing into various functions food, develop
New food material, new food kind is added, improves resource utilization.The application of superfine communication technique not only includes grain
Feed manufacturing, biological products, Chinese herbal medicine are eaten, may also refer to the deep processing in the fields such as food, chemical industry, metallurgy.In food industry
In, it is significant by Raw material processings such as all kinds of animals and plants, microorganisms into Ultramicro-powder.It makes food have unique physics
Chemical property：Because the miniaturization of particle causes the increase of table and product and porosity, make food that there is good dispersiveness, absorption
Property, absorption affinity, affinity, dissolubility, chemism etc., thus the food of miniaturization have well admittedly fragrance, dispersiveness and
Dissolubility, it is particularly easy to digest and assimilate；The original bioactivity of material and nutritional ingredient are largely maintained, improves food
Mouthfeel.
The application is in order to solve how to prepare the " simple, practical to be adapted to industry of ultra micro microencapsulation wheat germ powder using wheat germ
Metaplasia production " preparation method, using coarse crushing technology to wheat germ carry out coarse crushing, and cross 60 mesh sieves, on the basis of coarse crushing
Air-flow crushing is carried out to wheat germ and wet ball grinding crushes, wherein the number of air-flow crushing is twice so that wheat germ powder reaches ultra micro
The degree of crushing, improve the utilization rate of nutriment in wheat germ powder；Sucrose fatty acid ester is emulsifying agent and beta-schardinger dextrin is steady
Determine agent and cause ultra micro wheat germ powder microencapsulation using the technology of homogeneous and spray drying；And killed by the feasible radiation of specific science
Bacterium technology carries out radio sterilization to ultra micro microencapsulation wheat germ powder, so as to obtain ultra micro microencapsulation wheat germ powder.These technologies are special
Sign turns into the typical production process for preparing the application and providing " ultra micro microencapsulation wheat germ powder ", this Shen with integrality and globality
Inventive concept please is in prior art basis, utilizes present superfine communication technique and feasible micro-encapsulation technology
It is combined theory, the creative specific viable process from most suitable superfine communication technique and microencapsulation, so as to make
Standby ultra micro microencapsulation wheat germ powder.
The purpose of the present invention is not easy to store around wheat, the active material easy in inactivation in wheat, the resource of wheat
The complex art problem such as do not developed sufficiently, obtain the specific preparation technology mistake of ultra micro microencapsulation wheat germ powder
Journey, using being selected wheat raw material, remove the pretreatments such as wheat germ powder of going mouldy, coarse crushing, air-flow crushing, wet ball grinding powder
It is broken to wait superfine communication technique, and the technology such as the microencapsulation of combination wheat germ, homogeneous, spray drying, radio sterilization is super so as to prepare
Pico- encapsulated wheat germ powder, ensure that making full use of for wheat germ resource.
It can reach following beneficial effect by implementing the specific content of the invention of the present invention：
（1）The improvement of ultra micro microencapsulation wheat germ powder quality：Ultra micro microencapsulation wheat germ powder prepared by the present invention not only solves
Wheat germ of having determined is storing the limitation with application aspect, also provides reference value to widen wheat germ application；The micro- glue of ultra micro
Encapsulated wheat germ powder improves the mouthfeel of wheat, and the nutriment be advantageous in wheat is digested so that wheat
The raw material that can not be fully absorbed or utilize originally in embryo is re-used, and is prepared with deep processing into wheat microcapsules, is developed
Wheat this food material, improve the resource utilization of wheat.
（2）The physical characteristic of ultra micro microencapsulation wheat germ powder is good：Ultra micro microencapsulation wheat germ powder prepared by the present invention is good
Dispersiveness, adsorptivity, absorption affinity, affinity and dissolubility.
（3）Ultra micro microencapsulation wheat germ powder has the function that reducing blood lipid：The ultra micro microencapsulation wheat prepared using the present invention
Embryo powder carries out Experiment of Zoology, animal groups and the hyperlipidemia model group phase of ultra micro microencapsulation wheat germ powder prepared by the gavage present invention
Than the TC index contents of experimental animal reduce 32.6%；LDL-C indexs reduce 30.8%, and difference has conspicuousness；
By statistical analysis compared with Normal group, the body weight of rat significantly reduces, and the organ coefficient of liver dramatically increases, high fat mould
Type group hepatic tissue section fat vacuole showed increased, show high fat modeling success, ultra micro microencapsulation wheat germ powder and hyperlipidemia model
Compare, fat vacuole substantially reduces.Ultra micro microencapsulation wheat germ powder has the function that reducing blood lipid.
（4）The application prospect of ultra micro microencapsulation wheat germ powder is good：Ultra micro microencapsulation wheat germ powder prepared by the present invention meets
The idea of development of natural green and the food industry of sustainable development, resource can be both made full use of, is reduced environmental pollution, for opening
Send out new, be natural, green nutraceutical additive, improving the comprehensive benefit of mulberries processing enterprise, before there is wide application
Scape.
Brief description of the drawings
Fig. 1 is shown as the preparation technology flow chart of ultra micro microencapsulation wheat germ powder.
Fig. 2 is shown as wheat germ powder grain graininess with ratio of grinding media to material, the response surface figure of wheat germ concentration of slurry.
Fig. 3 is shown as the response surface figure that wheat germ powder grain graininess changes with ratio of grinding media to material, agitator power.
Fig. 4 is shown as wheat germ concentration of slurry and the response surface figure of agitator power change.
Fig. 5 is shown as influence figure of the emulsifying agent to the stability of wheat germ slurries.
Fig. 6 is shown as influence figure of the stabilizer to the stability of wheat germ slurries.
Fig. 7 is shown as influence figure of the sucrose fatty ester addition to the stability of wheat germ slurries.
Fig. 8 is shown as influence figure of the beta-schardinger dextrin addition to the stability of wheat germ slurries.
Embodiment
Below, the present invention is illustrated for embodiment, still, the present invention is not limited to following embodiments.In addition, following
In explanation, unless otherwise instructed, % all refers to m/m mass percents.
Equipment and material have in the present invention:
Raw material：Wheat germ Xinjiang Aug. 1st flour mill
Reagent：Maltodextrin, Shandong Qing Yuan Food Co., Ltd.；β-cyclodextrin, the limited duty of Huaxing of Mengzhou City biochemical industry
Ren companies；Tween-80, Chinese Medicine（Group）Shanghai chemical reagent company；Potassium polyphosphate, the limited public affairs of sweetening treatment in Hangzhou
Department；Monoglyceride, the factory of Shanghai reagent two；Sucrose fatty ester, Hangzhou Jin Helai food additives Co., Ltd；Sodium alginate, Hangzhoupro
Zhou Zhongxiang Chemical Co., Ltd.s；Other reagents are that analysis is pure.
Equipment：752 type ultraviolet specrophotometers, constant temperature oven, constant temperature water bath incubator, light microscope, electric light analysis
Balance, thermostat water bath, superclean bench, high-pressure sterilizing pot；Radiation source,60Co gamma ray projectors, Wuxi City Jiang Yuan hospitals；DZF-
6020 type vacuum drying chamber Shanghai, one permanent Science and Technology Ltd.；GJB high pressure homogeneous pumps, Yixing Machinery Plant of Light Industry；DZ sprayings are made
Grain drying machine, Wuxi sunlight spray drying device factory；MP200A electronic balances, upper balance factory of Nereid section；TDL-40B types centrifuge
Machine, Anting Scientific Instrument Factory, Shanghai；Soxhlet extractor, Guangzhou Shi Ji tech equipments Co., Ltd；723D grating spectrophotometers
The laboratory apparatus such as Shanghai electro-optical technology research institute.
All reagents, instrument, the raw and auxiliary material selected in the present invention are all well known in the art selection, but do not limit this hair
Bright implementation, other some reagents well known in the art and equipment are applied both to the implementation of implementation below of the present invention.
Embodiment one：The preparation of ultra micro microencapsulation wheat germ powder
Referring to accompanying drawing 1, the specific preparation method of ultra micro microencapsulation wheat germ powder is as follows.
（1）The pretreatment of raw material：Select the wheat germ that clean, nothing is gone mouldy.
（2）Coarse crushing：By step（1）The wheat germ selected carries out coarse crushing, crosses 60 mesh sieves.
（3）Air-flow crushing：By step（2）Wheat germ after sieving carries out air-flow ultramicro grinding using air-flow crushing mode, adopts
The technical parameter of air-flow crushing is to crush pressure 0.85MPa, feed pressure 0.45 MPa, charging rate 30mA, air-flow powder
Broken number is 2 times.
（4）Wet ball grinding crushes：By step（3）Wheat germ powder after the air-flow crushing of preparation carries out wet ball grinding crushing, wet
Ratio of grinding media to material is 4g/g during method ball mill grinding, and wheat germ concentration of slurry is 25%, agitator power 41kw.
（5）The microencapsulation of wheat germ：Weigh 7.5g steps（4）The ultra micro wheat germ powder of preparation, is dissolved in 50mL water, adds breast
Agent sucrose fatty ester, the addition of sucrose fatty ester is the 4% of wheat germ powder quality, while adds stabilizer beta-schardinger dextrin,
The addition of beta-schardinger dextrin is wheat germ powder quality 1.4%, and the heating water bath 60min under the conditions of 70 DEG C, makes its dissolving, is stirred,
It is well mixed.
（6）Homogeneous：By step（5）The mixed solution of the wheat germ, sucrose fatty ester and the beta-schardinger dextrin that prepare is in homogeneous
Pressure carries out homogeneous under conditions of being 50Mpa.
（7）Spray drying：EAT be 220 DEG C, leaving air temp be 95 DEG C under conditions of to step（6）After homogeneous
Material carries out spray drying treatment.
（8）Radio sterilization:By step（7）Wheat germ powder capsule after spray drying is packed with double-deck PE bags, packing inside bag
From Self-enclosing PE bags, outer packaging is sealed with PE bags thermoplastic, and per packed 50g, packaged wheat germ powder capsule is being irradiated
The condition that dosage is 6-8kGy carries out radio sterilization.
（9）Ultra micro microencapsulation wheat germ powder can be prepared by above-mentioned steps.
The application is in order to solve how to prepare the " simple, practical to be adapted to industry of ultra micro microencapsulation wheat germ powder using wheat germ
Metaplasia production " preparation method, using coarse crushing technology to wheat germ carry out coarse crushing, and cross 60 mesh sieves, on the basis of coarse crushing
Air-flow crushing is carried out to wheat germ and wet ball grinding crushes, wherein the number of air-flow crushing is twice so that wheat germ powder reaches ultra micro
The degree of crushing, improve the utilization rate of nutriment in wheat germ powder；Sucrose fatty acid ester is emulsifying agent and beta-schardinger dextrin is steady
Determine agent and cause ultra micro wheat germ powder microencapsulation using the technology of homogeneous and spray drying；And killed by the feasible radiation of specific science
Bacterium technology carries out radio sterilization to ultra micro microencapsulation wheat germ powder, so as to obtain ultra micro microencapsulation wheat germ powder.These technologies are special
Sign turns into the typical production process for preparing the application and providing " ultra micro microencapsulation wheat germ powder ", this Shen with integrality and globality
Inventive concept please is in prior art basis, utilizes present superfine communication technique and feasible micro-encapsulation technology
It is combined theory, the creative specific viable process from most suitable superfine communication technique and microencapsulation, so as to make
Standby ultra micro microencapsulation wheat germ powder.
Protein, unrighted acid, mineral matter, various vitamin contents are high in wheat, and various in wheat
Amino acid classes Compositional balance, wheat are a kind of important nutriments.But wheat is intolerant to storage, therefore result in small
A large amount of wastes of wheat germ.Wheat ultra micro microencapsulation can be extended to the storage time of wheat, while the ultra micro of wheat
Superfine communication technique is applied in microencapsulation technology.On the one hand superfine communication technique can improve the mouthfeel of wheat, favorably
Nutriment in wheat is digested, and on the other hand to fully absorb originally in wheat or sharp
Raw material is re-used, and prepares and deep processing is into wheat microcapsules, is developed wheat this food material, is improved
The resource utilization of wheat.Ultra micro microencapsulation wheat germ powder meets the development of the food industry of natural green and sustainable development
Theory, resource can be both made full use of, is reduced environmental pollution, for developing new, natural, green nutraceutical additive, carried
The comprehensive benefit of high flour mill, has broad application prospects.
Embodiment two：The determination of wet ball grinding disintegrating process parameter in ultra micro microencapsulation wheat germ powder craft
Ball mill grinding technology be exactly in ball mill using the extruding force between abrasive media and shearing force come comminuting matter,
In order to solve to be related to many mathematical modelings on the research of ball mill grinding mechanism：Grindability model, comminution ratio model, grinding
Capability model, particle-size distribution model, ratio of grinding media to material model etc..Ball mill grinding method is divided into 2 kinds of dry pulverization process and wet pulverizing, due to powder
Broken object is wheat germ, its protein in crushing process, and the material such as fat can be dispersed to extracellular from intracellular, influence ball-milling medium
Service behaviour, wet ball grinding use water as decentralized medium, the effective classical agglomeration traits solved in crushing process, have compared with
Good crushing effect.
Under agitating ball mill rigid condition, the slurry volume of agitating ball mill is 3.6L, main engine power 2.5KW, is stirred
Cylinder internal diameter Φ 250mm.The principal element for influenceing ball mill ultramicro grinding effect has ratio of grinding media to material, agitator speed, wheat germ slurries dense
Degree.Therefore the present invention carries out Dan Yin using ratio of grinding media to material, agitator power, these three factors of wheat germ concentration of slurry as experimental factor
Element experiment, fixed ball-milling medium is Φ 10mm zirconia balls；On the basis of single factor experiment, by response surface analysis optimization most
Good technological parameter, with the grain graininess d after crushing（50）As ultramicro grinding evaluation effect.
（1）Ratio of grinding media to material, agitator speed, the single factor experiment of wheat germ concentration of slurry these three factors：
Ratio of grinding media to material single factor experiment factor index：3g/g、4g/g、5g/g、6g/g、7 g/g.
Agitator power single factor experiment factor index：30kw、35kw、40kw、45kw、50kw.
Wheat germ concentration of slurry single factor experiment factor index：15%、25%、35%、45%.
（2）Response surface experiments：
In order to determine the optimum process condition of ball mill soybean dietary fiber wheat germ, optimize ultra micro using Responds Surface Methodology
Disintegrating process parameter, on the basis of single factor test trial test, response surface analysis is carried out using SAS software systems, devises one
The functional relation that the horizontal regression equation of three factor five comes between data fitting and index, selects ratio of grinding media to material（X1）, wheat germ slurries
Concentration (X2) and agitator speed (X3) factor is used as, with the grain graininess d after crushing（50）As response to ball mill wet method
Ultramicro grinding technique optimizes.The processing of data and the generation of three-dimension curved surface are carried out using SAS analysis softwares, is therefrom disclosed
Each influence factor and grain graininess d（50）Between inherent law, and find out the optimal region of each factor, experimental design is shown in Table
1, with the grain graininess d after crushing（50）As response.
Table 1：The factor level table of response surface analysis
（3）Result of the test
Table 2:Ratio of grinding media to material, wheat germ concentration of slurry and agitator power are to grain graininess d(50)The response surface analysis of influence tests knot
Fruit
| Number | X1 | X2 | X3 | Y |
| 1 | 3 | 35 | 30 | 33.74 |
| 2 | 5.68 | 25 | 40 | 27.90 |
| 3 | 5 | 35 | 30 | 31.49 |
| 4 | 5 | 15 | 30 | 32.35 |
| 5 | 4 | 25 | 56.82 | 29.43 |
| 6 | 4 | 25 | 23.18 | 32.88 |
| 7 | 4 | 25 | 40 | 18.56 |
| 8 | 4 | 25 | 40 | 18.56 |
| 9 | 4 | 8.18 | 40 | 30.56 |
| 10 | 4 | 41.82 | 40 | 28.51 |
| 11 | 5 | 15 | 50 | 29.53 |
| 12 | 4 | 41.82 | 40 | 28.51 |
| 13 | 4 | 25 | 40 | 18.57 |
| 14 | 3 | 35 | 50 | 32.46 |
| 15 | 4 | 25 | 40 | 18.56 |
| 16 | 4 | 25 | 40 | 18.57 |
| 17 | 3 | 15 | 30 | 31.36 |
| 18 | 3 | 15 | 50 | 34.04 |
| 19 | 5 | 35 | 50 | 24.71 |
Using regression equation Y=a0+a1X1+a2X2+a3X3+a11X12+a22X22+a33X32+a12X1X2+a13X1 X3+ a23X2 X3,
Regression analysis is carried out to the data in table, result of the test is analyzed and predicted, and to pulverized particles d50Model carries out overall
And each analysis of variance is examined, while significance test, regression coefficient and variance point are carried out to regression model and model coefficient
Analysis.
2 are shown in Table, optimal ultramicro grinding process conditions can be drawn with reference to the response surface figure provided referring to accompanying drawing 2,3 and 4
For：Ratio of grinding media to material 4.32g/g, wheat germ concentration of slurry 26.23%, agitator power 41.46kw.But according to actual conditions, it is impossible to completely
Meet the optimum data designed by software, in the light of actual conditions test, data be set to ratio of grinding media to material 4g/g, wheat germ concentration of slurry 26%,
Agitator power 41kw, experiment particle size results are 18.3um.
Embodiment three：The selection of emulsifying agent and stabilizer and its determination of content
（1）The selection of emulsifying agent：After wheat germ ultramicro grinding, 4 parts of 7.5g ultra micro wheat germ powders are weighed respectively, are dissolved in 50mL water
In, it is then respectively adding monoglyceride, Tween-80, potassium polyphosphate and sucrose fatty ester and accounts for wheat as emulsifying agent, its addition
The 4% of embryo Ultramicro-powder quality, heating water bath 60min under the conditions of 70 DEG C, the stability of wheat germ slurries is determined, as a result sees accompanying drawing 5.
As can be seen that Tween-80, monoglyceride and potassium polyphosphate are to the less stable of wheat germ slurries, sugarcane from accompanying drawing 5
Sugar fatty acid ester is good to the stability of wheat germ slurries, and the coefficient of stability reaches 0.81, so selection sucrose fatty ester is as suitable
Emulsifying agent.
（2）The selection of stabilizer：After wheat germ ultramicro grinding, 4 parts of 7.5g ultra micro wheat germ powders are weighed, is dissolved in 50mL water, adds
Enter 4% sucrose fatty ester, be then respectively adding stabilizer maltodextrin, beta-schardinger dextrin and sodium alginate, its addition is wheat
Embryo silty amount 1.4%, and after heating water bath 60min under the conditions of 70 DEG C determine wheat germ slurries stability, as a result see accompanying drawing 6.
As can be seen that beta-schardinger dextrin can significantly improve the stability of wheat germ slurries, it is thus determined that properly from accompanying drawing 6
Stabilizer be beta-schardinger dextrin.
（3）The determination of sucrose fatty ester addition：5 parts of 7.5g ultra micro wheat germ powders are weighed, are dissolved in 50mL water, add sugarcane
Sugar fatty acid ester, its addition account for 2%, 4%, 6%, 8%, the 10% of wheat germ slurry weight, stirred respectively, and under the conditions of 70 DEG C
The stability of wheat germ slurries is determined after heating water bath 60min, as a result sees accompanying drawing 7.
As can be seen that when the addition of sucrose fatty ester is 4% from accompanying drawing 7, its coefficient of stability reaches 0.92, with
The further increase of addition, the stability change of wheat germ slurries is little, considers the suitable of selected sucrose fatty ester and adds
Dosage is 4%.
（4）The determination of beta-schardinger dextrin addition：5 parts of 7.5g ultra micro wheat germ powders are weighed, is dissolved in 50mL water, adds 4% sugarcane
Sugar fatty acid ester, beta-schardinger dextrin being added, its addition accounts for 1%, 1.2%, 1.4%, the 1.6% of wheat germ quality, stirred respectively, and
The stability of wheat germ slurries is determined after heating water bath 60min under the conditions of 70 DEG C, as a result sees accompanying drawing 8.
From accompanying drawing 8 as can be seen that with the increase of beta-schardinger dextrin addition, the stability increase of wheat germ slurries, when adding
When dosage reaches 1.4%, the coefficient of stability reaches 0.63, further increase, and stability change is little, it is thus determined that suitable β-ring
Dextrin addition is 1.4%.
Example IV：The determination of radio sterilization condition
（1）Experimentation：Ultra micro microencapsulation wheat germ powder, is packed from double-deck PE bags, and packing inside bag selects Self-enclosing PE
Bag, outer packaging are sealed with PE bags thermoplastic, per packed 50g.Packaged wheat germ powder is placed in irradiation field, in radiation dose rate
For 2kGy, 4kGy, 6kGy, 8kGy, 10kGy, preserved at ambient temperature after irradiation, in the bacterium colony of the 5th day sampling detection sample
Sum, coliform, moisture, ash content and observation wheat germ powder organoleptic quality.
（2）Experimental result
Wheat germ powder bactericidal effect：In order to draw suitable radio sterilization dosage, experiment sets 5 groups of dose of radiations, respectively
For 2kGy, 4kGy, 6kGy, 8kGy, 10kGy.Gamma-ray irradiation wheat germ powder has good bactericidal effect, through 6kGy dose deliveries
Afterwards, the inactivation ratio of the total plate count of the miscellaneous bacteria in wheat germ powder and thermoduric bacteria gemma respectively reaches 97.7% and 91.8%, and with spoke
Penetrate the increase of dosage, bacteria containing amount declines in synchronous, therefore using gamma-rays wheat germ powder is carried out radiation sterilizing be technically can
Capable, it is determined that suitable dose of radiation 6-8kGy.
Influence of the radio sterilization to total plate count and heat resistant spores bacterium：Total plate count and the testing result of heat resistant spores bacterium warp
Linear fit, the logarithm value of its survival rate（y）With irradiation dose x（KGy）Between to correspond with y=- 0.4105x+4.59 (related
Coefficients R2=0.9964) and y=- 0.304x+3.495 (coefficient Rs2=0.9215), exist between survival rate and irradiation dose aobvious
The correlation of work.The D of total plate count and thermoduric bacteria gemma in wheat germ powder10Value is respectively 4.31kGy and 5.87kGy, from D10Difference
It is different it can be seen that gemma to gamma-ray tolerance apparently higher than miscellaneous bacteria.
Irradiate the influence to wheat germ powder moisture and ash content：From table 3 it is observed that wheat germ powder moisture and content of ashes are in spoke
According to front and rear without occurring obvious change, moisture is in 10.79%-11.32%, and content of ashes is between 6.12%-6.21%.
Table 3：Irradiate the influence to wheat germ powder moisture and ash content
Irradiate the influence to wheat germ powder organoleptic quality：Wheat germ powder aesthetic quality evaluation is irradiated mainly from wheat germ powder color and luster, gas
Taste and acceptable aspect are carried out.Wheat germ powder evaluation result after radiation treatment 1 month is shown in Table.Show that non-irradiated wheat germ powder is in
Faint yellow, color and luster, smell do not influence after the processing of 2-8kGy dosage, are shown in Table 4.
Table 4：Irradiate the influence to wheat germ powder organoleptic quality
Dose of radiation is considered to the total plate count of sample, coliform, moisture, ash content and wheat germ powder organoleptic quality
Influence, determine the suitable dose of radiation 6-8kGy of ultra micro microencapsulation wheat germ powder.
Embodiment five：The Experiment of Zoology of ultra micro microencapsulation wheat germ powder
Experimentation is as follows：
1st, experimental design
（1）Rat is grouped and test arrangement：
SPF level SD male rats enter to be weighed after 7 d of basal feed feeding observation in SPF environment, random point
Into six groups：Blank control group, hyperlipidemia model group, fat-reducing medicament group, wheat group, ultra micro microencapsulation wheat germ group, every group 10
Only, be divided into Normal group gives conventional daily ration, hyperlipidemia model group gives high fat daily ration, fat-reducing medicament group give high fat daily ration+
Simvastatin, wheat group give high fat daily ration+wheat aqueous solution, ultra micro microencapsulation wheat germ group gives high fat daily ration+super
The pico- encapsulated wheat germ aqueous solution.Rat freely drinks ultra-pure water, weighs once, and records gavage amount and health within every 3 days
Situation.Rat Fast 16 hours after 28 days experimental periods, using orbital vein 1.5 mL of blood sampling, serum is separated, determines rat
Blood glucose（GLU）, serum total cholesterol（TC）, triglyceride（TG）, HDL-C（HDL-CH）, low-density lipoprotein
White cholesterol（LDL-CH）Content.
（2）Data processing
Total data is represented with average ± standard deviation (Mean ± SD), using SPASS17.0 statistics software logarithms
According to being handled, compare between two groups and examined using T, data more than two compare to be handled using the one-factor analysis of variance.
2nd, result of the test
（1）Each stage changes of weight of rat
There was no significant difference for each group rat body weight before experiment.Normal group has significant difference with other groups during experiment
(p<0.01), hyperlipidemia model group is not notable with other group of difference in addition to having significant difference with the body weight of Normal group group,
Show that test rat is influenceed by high fat modeling, daily ingestion amount is reduced, the g body weight of normal rat daily ingestion amount 15/200, high fat
The g body weight of modeling rat 10/200, Normal group body weight increase is slow, is shown in Table 5.
Table 5：Each stage body weight of SD rat tests
Note：With the one-factor analysis of variance is carried out between column data, * represents the P compared with control group<0.05；* represents P<
0.01.
（2）The foundation of high blood lipid model
Each group four items of blood lipid tests index serum total cholesterol before experiment（TC）, triglyceride（TG）, HDL courage consolidates
Alcohol（HDL-C）And LDL-C（LDL-C）Content no significant difference (p<0.05).The whole last hyperlipidemia model group of experiment
TC, LDL-C content are significantly higher than blank control group (p<0.01), show that high fat modeling replicates successfully, as a result see the table below 6,7.
Table 6：Indices during on-test（mmol/L）
| Group | TC | TG | HDL-C | LDL-C |
| Normal group | 1.99±0.19 | 0.96±0.33 | 0.72±0.13 | 0.41±0.04 |
| Fat-reducing medicament group | 2.00±0.18 | 0.83±0.20 | 0.65±0.05 | 0.45±0.06 |
| Hyperlipidemia model group | 1.97±0.29 | 0.93±0.46 | 0.64±0.06 | 0.44±0.11 |
Table 7：Indices during off-test（mmol/L）
| Group | TC | TG | HDL-C | LDL-C |
| Normal group | 1.64±0.23 | 0.49±0.14 | 0.42±0.06 | 0.41±0.81 |
| Fat-reducing medicament group | 9.59±6.37** | 0.38±0.13 | 0.48±0.09 | 2.87±2.03** |
| Hyperlipidemia model group | 18.04±4.20** | 0.64±0.20 | 0.62±0.70 | 5.09±1.8** |
Note：During on-test, with the one-factor analysis of variance is carried out between column data, * is represented compared with Normal group, P<
0.05 ；* represents P<0.01；（3）Liver histological changes
Pass through Normal group, high blood lipid model group, wheat group and ultra micro microencapsulation wheat germ powder group animal's liver group
Knit form and compare display, the hyperlipidemia model group hepatic tissue section fat vacuole showed increased compared with Normal group, display height
Fat modeling success, wheat group and ultra micro microencapsulation wheat germ powder group are compared with hyperlipidemia model group hepatic tissue section, fat vacuole
Reduce.
（4）Blood glucose and blood lipids index change
Table 8：Blood glucose and four items of blood lipid tests index content when testing the 28th day
| Group | GLU | TC | TG | HDL-C | LDL-C |
| Hyperlipidemia model group | 2.25±0.81 | 18.04±4.20## | 0.64±0.20## | 0.62±0.70# | 5.09±1.85## |
| Fat-reducing medicament group | 2.61±1.58 | 9.59±6.37** | 0.38±0.13** | 0.48±0.09* | 2.87±2.03** |
| Ultra micro microencapsulation wheat germ powder group | 4.03±1.04*# | 10.96±4.09** | 0.28±0.06** | 0.55±0.13 | 3.04±1.23** |
| Wheat group | 2.89±1.14 | 12.15±3.53** | 0.30±0.11** | 0.58±0.17 | 3.52±1.01* |
Note：With the one-factor analysis of variance is carried out between column data, compared with hyperlipidemia model, * represents P<0.05, * * represents P<
0.01；Represent compared with lipid-lowering medicine group, # represents P<0.05, ## represents P<0.01
As seen from Table 8：Blood glucose (GLU) index between ultra micro microencapsulation wheat germ powder group and hyperlipidemia model group exists aobvious
Difference is write, and compared with fat-reducing medicament group, ultra micro microencapsulation wheat germ powder group significant difference, wheat group difference is notable.It is super
Significant difference be present in TC, TG and LDL-C index slightly between encapsulated wheat germ powder group and hyperlipidemia model group.To animal blood glucose
And lipid aspects, ultra micro microencapsulation wheat germ powder group are substantially better than wheat group.
Conclusion：Ultra micro microencapsulation wheat germ powder and wheat prepared by the present invention all has the effect of reducing blood fat, to liver
Dirty fat lesion has certain elimination effect, and show has the effect of certain to the functional rehabilitation of liver.But relative to small
For wheat germ, ultra micro microencapsulation wheat germ powder prepared by the present invention is substantially better than wheat group in terms of reducing blood lipid.
In summary, you can preferably realize the present invention, the above embodiments are only the side of being preferable to carry out to the present invention
Formula is described, and not the scope of the present invention is defined, and on the premise of design spirit of the present invention is not departed from, this area is general
The various modifications and improvement that logical technical staff makes to technical scheme, all should fall into present invention determine that protection domain
It is interior.
Claims (1)
1. a kind of preparation of ultra micro microencapsulation wheat germ powder, it is characterised in that specific preparation method is as follows：
(1) pretreatment of raw material：Select the wheat germ that clean, nothing is gone mouldy；
(2) coarse crushing：The wheat germ that step (1) is selected carries out coarse crushing, crosses 60 mesh sieves；
(3) air-flow crushing：Wheat germ after step (2) is sieved carries out air-flow ultramicro grinding using air-flow crushing mode, use
The technical parameter of air-flow crushing is to crush pressure 0.85MPa, feed pressure 0.45Mpa, charging rate 30mA, air-flow crushing number
For 2 times；
(4) wet ball grinding crushes：Wheat germ powder after air-flow crushing prepared by step (3) carries out wet ball grinding crushing, wet method ball
Ratio of grinding media to material is 4g/g when being milled broken, and wheat germ concentration of slurry is 25%, agitator power 41kw；
(5) microencapsulation of wheat germ：The ultra micro wheat germ powder of 7.5g steps (4) preparation is weighed, is dissolved in 50mL water, adds emulsifying agent
Sucrose fatty ester, the addition of sucrose fatty ester are the 4% of wheat germ powder quality, while add stabilizer beta-schardinger dextrin, β-
The addition of cyclodextrin is wheat germ powder quality 1.4%, and the heating water bath 60min under the conditions of 70 DEG C, makes its dissolving, is stirred, and is mixed
Close uniform；
(6) homogeneous：The mixed solution of wheat germ, sucrose fatty ester and beta-schardinger dextrin that step (5) is prepared is in homogenization pressure
To carry out homogeneous under conditions of 50Mpa；
(7) it is spray-dried：EAT be 220 DEG C, leaving air temp be 95 DEG C under conditions of to the material after step (6) homogeneous
Carry out spray drying treatment；
(8) radio sterilization:Wheat germ powder capsule after step (7) is spray-dried is packed with double-deck PE bags, and packing inside bag is selected
Self-enclosing PE bags, outer packaging are sealed with PE bags thermoplastic, per packed 50g, by packaged wheat germ powder capsule in irradiation dose
Radio sterilization is carried out for 6-8kGy condition；
(9) ultra micro microencapsulation wheat germ powder can be prepared by above-mentioned steps.
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