CN1048497A - The preparation technology of high efficiency liquor for strengthening immunologic function - Google Patents
The preparation technology of high efficiency liquor for strengthening immunologic function Download PDFInfo
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- CN1048497A CN1048497A CN 89104479 CN89104479A CN1048497A CN 1048497 A CN1048497 A CN 1048497A CN 89104479 CN89104479 CN 89104479 CN 89104479 A CN89104479 A CN 89104479A CN 1048497 A CN1048497 A CN 1048497A
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Abstract
The invention discloses a kind of high efficiency liquor for strengthening immunologic function and production technology thereof.These goods utilize the Rosa fragrant plant of natural fresh to be raw material, adopt scientific methods, easy technology, and reasonably formula development forms.It contains multiple flavone compound and multiple bioactive substance, several amino acids, mineral, vitamin B
6, vitamin e acetate, beta-carotene, polysaccharide and multivitamin, can increase hemoglobin, albumin, total protein, total complement, transaminase lowering reduces the positive titre of Australia antigen.The various chronic diseases that immunologic function degression is caused have tangible medical care effect.Physiologically active is stable, is convenient to preserve.
Description
The present invention relates to a kind of preparation method of high efficiency liquor for strengthening immunologic function, this product is that the root, stem, leaf, flower, the fruit that utilize natural fresh Rosa fragrant plant are raw material, mixes according to a certain percentage, adopts scientific methods to process.Enhancing liquid with this kind explained hereafter has kept original active ingredients and biological activity in the bright Rosa fragrant plant cell basically.
At present, aspect the processing of Rosa fragrant plant, the method that is adopted mainly is: chemical treatment, soak, pickle, distill, fermentation, high temperature steaming, method such as dry.Aspect the utilizing of Rosa fragrant plant, mainly be to utilize the essence of extraction from spend to make cosmetics, utilize the aromatic substance in the volatile oil to make wine, utilize a small amount of petal to intersperse cake, make fruit juice with fruit, utilize air dried flower to make Chinese crude drug.These products are flower or the fruit that utilizes the Rosa fragrant plant singlely, utilization rate is extremely low, causes very big waste, as: extract essence, calculate with oil yield peak 5/10000ths, have 99.9% material will discard after distillation, existing process technology is because high temperature steaming or distillation, and chemical treatment, make the Rosa fragrant plant reduce biological activity, destroyed effective ingredient, can not fully excavate the effect of high efficiency liquor for strengthening immunologic function.The present invention has overcome foregoing shortcoming.
Prior art has: the preparation technology of " Liquor Rosae Rugosae Distillata " (the new medical college in Jiangsu is write the 1224th page of " Chinese medicine voluminous dictionary " first volume), " preparation technology of pollen and honey wine " (" brewing science and technology " 1987.4), " processing of Flos Rosae Rugosae " (Ding Yongnan compiles " how planting Flos Rosae Rugosae " the 15th, 94 pages), the preparation technology of " SHENGMAI YIN " oral liquid (Pharmacopoeia of People's Republic of China 1985 version one one 42 pages), and foreign data " Flos Rosae Rugosae fermentation method " (Russian Patent 1154320A1985), " production of Flos Rosae Rugosae fruit juice " (Yugoslavia: Hrana i Ishrana 25(5/6) 123～125 1984), " utilization (Hungary lelmez IP 1978; 32(10), 376～80(Hung)) of polygalacturonase in Flos Rosae Rugosae fruit juice in the body-more than see Appendix.（1-7）。
The preparation technology of the high efficiency liquor for strengthening immunologic function that purpose of the present invention, the mixture that is to provide a kind of root that utilizes fresh Rosa fragrant plant, stem, leaf, flower, fruit are processed into for raw material.
The difference of the present invention and prior art is: 1. no any chemical substance in this prepared flow process, and alcohol-free dipping, sugar-free salts down, does not have the fermentation operation.2. plucking the back directly pulverizes; through micronize; to extracting water-soluble substances; in this process, saved pickle, flood, intermediate link such as fermentation, distillation, keep its biological activity so to greatest extent; reduced waste; simultaneously, owing to utilized most positions of Rosa fragrant plant, this has relatively increased the quantity of raw material.3. this preparation technology is placed on the high temperature distillation operation full-range last, that is: the distillating method of a small amount of volatile material of handle extraction is placed on and extracts after the water-soluble substances, surplus slag behind the extracting solution that separation is obtained distills, to extract volatile material, this just changes the disposable use of extracting essential oil in the prior art.Can carry out repeatedly micronize to mixed water slurry among this preparation technology, multiple extraction stock solution (being water-soluble substances).The Main Ingredients and Appearance that the immunologic function that adopts this preparation technology to produce strengthens liquid all compositions, also contains multiple flavone compound and bioactive substance and multivitamin and aminoacid in containing pollen liquid.According to animal experiment and the evidence of part hospital clinical: 1. this product has the effect of enhancing non-specific immunity function, show that mainly the chronic disease that causes because of immunologic function degression, aging, hepatopathy, Australia antigen, anemia, climacteric syndrome etc. are had unique medical care effect.2. nutritional anemia, nephritis etc. is had therapeuticing and health effect, show that mainly content of hemoglobin obviously increases, albumin, total protein concentration obviously raise.3. the effect of prevention anti-radiation protection erythrocyte is arranged, and this has protective effect to patients undergoing chemotherapy.4. transaminase lowering reduces the positive titre of Australia antigen.To documents and materials and the patent retrieval over nearly 20 years both at home and abroad, up to the present, do not find to have (see and look into new proof) that utilizes the Rosa fragrant plant to make the health care nutritional solution as yet both at home and abroad through search consultation portion of Chinese science and technology information institute.
This preparation technology:
1, with fresh of the Rosa fragrant plant of plucking, stem, leaf, flower, fruit (holder), calyx, is 1.5～2.5: 0.5～1.5, mixes by the weight of flower and the weight ratio of other organ (root, stem, leaf, calyx, fruit, holder).
2, this mixture is cleaned, sterilized, put in the pulverizer, add water purification (former water is through activated carbon treatment) the controlling the water circulation slurry of 1～3 times of weight, put the water slurry of making into high pressure homogenizer and carry out micronize, granularity 0.15～1 μ.
3, adopt rotating separation device, micronized water slurry is extracted stock solution (water-soluble substances).In order fully to extract active ingredient in the plant, can repeat 2～3 times from pulverizing → micronize → extraction.
4, will extract surplus slag after the stock solution (water-soluble substances), compile, add the water purification of 3～5 times of weight again, carry out 100 ℃ of high temperature distillations, extractive distillation liquid.
5, will distill the stock solution of preceding extraction and the distillate after the distillation and mix, be mixed into nutritional solution.
6, with after the nutritional solution filtration that is mixed into, cooled off 48 hours, get supernatant, then supernatant is gone into bottle or go into jar (bottled or canned), then fill nitrogen after the vacuum, encapsulation, the finished product of microwave sterilization sterilization promptly becoming at last.Disinfecting time 30～90 seconds, 50～100 ℃ of temperature can keep a year and a half under the room temperature.This preparation technology flow process is provided by accompanying drawing.
Production instance:
1, pluck Rosa fragrant plant petal 700 grams early morning, calyx, holder (fruit), root, stem, leaf be totally 300 grams, amounts to 1000 grams.
2, flower, calyx, holder (fruit), root, stem, the leaf with above-mentioned harvesting mixes, and pulverizer is put in clean sterilization, and adds the water purification (former water is through activated carbon treatment) of 1～3 times of weight, makes the water slurry mixture.
3, the water slurry mixture of making is put into 40～60MPa(MPa) the high pressure homogenizer micronize, granularity 0.15～1 μ.
4, micronized water slurry mixture is rotated separation and Extraction stock solution,,, can repeats 1～3 time and carry out from pulverizing → micronize → extraction stock solution for effective component extracting more fully.
5, the surplus slag that will extract after the stock solution compiles, and adds purifying waste water of 3～5 times of weight and carries out high temperature (100 ℃) distillation, extractive distillation liquid.
6, blending nutritional solution.Extracting solution and distillate are mixed, be mixed into nutritional solution.
7, with after the nutritional solution filtration that is mixed into, cooled off 48 hours, get supernatant then and go into bottle or tinning (bottled or canned), carry out vacuum nitrogen again, encapsulation with the microwave sterilization sterilization, is promptly made high efficiency liquor for strengthening immunologic function.This product physiologically active is stable, preserves at normal temperatures more than a year and a half, can take separately, also can be mixed with in new nutrition oral administration or other with other nutrient oral liquor or Chinese crude drug to become the health care medicine.
The medical health effect example: through the zoopery and the explanation of part clinical observation material of the toxicity of research units such as medical courses in general institute, pharmacology, pathology, the effect of taking this product is: 1. content of hemoglobin obviously increases.2. albumin, total protein concentration obviously raise, and these two all reach statistical significant level P＜0.05, P＜0.01.Increase content of hemoglobin and can treat nutritional anemia, increase albumin, total protein, to lack proteic chronic disease as: diseases such as liver cirrhosis, nephritis all have therapeuticing and health effect.For example: certain patient's suffering from liver cirrhosis for many years, 1987 seriously ill during per 15 days once hemorrhage, be in hospital immediately, emergent with the globulin injection, more than 100 yuan on every pin, after playing 10 pins, total protein only increases by 0.20, and changes reinforcing agent oral liquid that clothes the present invention produces after one month, and sb.'s illness took a favorable turn, take continuously, now be tending towards normal.Measurement result is as follows:
| Time: 1987.11.5～1987,12.14 | 1988.7.11～1988.9.12 | |
| Various albumen recruitments | Total protein increases: 1.4 | Increase: 1.0 |
| Albumin increases: 0.5 | Increase: 0.19 | |
| Globulin increases: 0.9 | Increase: 0.85 | |
| Australia antigen descends: 1:32/1:0 | ||
53. pre-radioprotective is arranged, the effect of protection erythrocyte.Mouse experiment: after accepting cobalt 60 irradiations, make medulla hematopoietic system be subjected to severe inhibition, cause aplastic anemia, the mice heavy dose of obeying behind this product is all higher than single irradiation control group with hemoglobin, the blood cell specific volume of low dose of two groups of mices, reach significance level P＜0.01, near normal.4. transaminase lowering.Rat was taken medicine 90 days, administration group GPT, GOT＜200 μ/l(20/20), matched group GPT, GOT＞200 μ/l(5/20).5. reduction Australia antigen.On August 30th, 1987, data provided: Australia antigen turns out cloudy 11,/20 55%, and Australia antigen descends 16,/20 80%.6. transaminase, Australia antigen descend 3/3(1989 May 29 simultaneously).7. raise immunity.After rat was taken medicine 90 days, through pathology section examination, all there were obvious performance in the humoral immunization of human body, two systems of cellular immunization: the immunocyte hypertrophy of rat lymph node, spleen, thymus, and engulf active.The every chronic disease that causes because of immunologic function degression of this explanation, aging, hepatopathy, Australia antigen, liver cirrhosis, anemia, climacteric syndrome etc. have unique medical care effect.
Claims (1)
1, a kind of is the technology of the high efficiency liquor for strengthening immunologic function that forms of feedstock production by the Rosa fragrant plant, it is characterized in that: the root of the bright Rosa fragrant plant that 1. will pluck, stem, leaf, holder (fruit) are 1.5～2.5 by the weight ratio of the weight of flower and other organ (root, stem, leaf, holder, fruit): 0.5～1.5 mixes.2. this mixture is cleaned sterilization and put in the pulverizer, the water purification (former water is through activated carbon treatment) that adds 1～3 times of weight is again made water slurry.3. put the water slurry of making into high pressure homogenizer and carry out micronize, its granularity diameter is 0.15～1 μ.4. adopt rotating separation device that micronized water slurry is extracted stock solution (water-soluble substances).The surplus slag that 5. will extract after the stock solution compiles, and adds 3～5 times purify waste water again and carries out 100 ℃ high temperature distillation, extractive distillation liquid.6. stock solution of extracting in the time of will not passing through distillation and the distillate through distillation extraction mix, and are mixed into nutritional solution.7. after the nutritional solution filtration with furnishing, cooled off 48 hours, get supernatant, then supernatant is gone into bottle or go into jar, vacuum nitrogen encapsulates again, uses microwave sterilization, promptly becomes high efficiency liquor for strengthening immunologic function.Disinfecting time is 30～90 seconds, and sterilisation temp is 50～100 ℃.Can preserve more than a year and a half at normal temperatures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104479 CN1048497A (en) | 1989-07-04 | 1989-07-04 | The preparation technology of high efficiency liquor for strengthening immunologic function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104479 CN1048497A (en) | 1989-07-04 | 1989-07-04 | The preparation technology of high efficiency liquor for strengthening immunologic function |
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| Publication Number | Publication Date |
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| CN1048497A true CN1048497A (en) | 1991-01-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 89104479 Pending CN1048497A (en) | 1989-07-04 | 1989-07-04 | The preparation technology of high efficiency liquor for strengthening immunologic function |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054499C (en) * | 1996-04-09 | 2000-07-19 | 昆明市康可凯食品有限责任公司 | Drink of red flower juice and production method thereof |
| GB2348794A (en) * | 1999-03-23 | 2000-10-18 | Daniel Vigdorovich | A dietetic confectionery composition |
-
1989
- 1989-07-04 CN CN 89104479 patent/CN1048497A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054499C (en) * | 1996-04-09 | 2000-07-19 | 昆明市康可凯食品有限责任公司 | Drink of red flower juice and production method thereof |
| GB2348794A (en) * | 1999-03-23 | 2000-10-18 | Daniel Vigdorovich | A dietetic confectionery composition |
| GB2348794B (en) * | 1999-03-23 | 2002-07-17 | Daniel I Vigdorovich | Confectionery for nourishment of obese |
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