CN104840770B - A kind of Chinese medicine for treating Anxiety depression - Google Patents
A kind of Chinese medicine for treating Anxiety depression Download PDFInfo
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- CN104840770B CN104840770B CN201510277580.3A CN201510277580A CN104840770B CN 104840770 B CN104840770 B CN 104840770B CN 201510277580 A CN201510277580 A CN 201510277580A CN 104840770 B CN104840770 B CN 104840770B
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Abstract
The present invention relates to the Chinese medicines for the treatment of Anxiety depression, it can effectively solve the problems, such as the medication of Anxiety depression, its solve technical solution be, by dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 30 60:20‑40:10‑20:10 30 are made, reasonable recipe of the present invention, abundant raw material, are pure plant, and green safe environmental protection can quickly and significantly alleviate the symptom of agitated depression, be the innovation treated on anxiety-depression disease drug.
Description
Technical field
The present invention relates to field of medicaments, especially a kind of Chinese medicine for treating Anxiety depression.
Background technology
Anxiety depression is also known as anxiety neurosis, is with generalized anxiety disorder (chronic) and panic attack (acute) shape
State is main clinical manifestation, while being often accompanied by the diseases such as dizzy, uncomfortable in chest, palpitaition, expiratory dyspnea, dry, perspiration and motility uneasiness
Disease.When morbidity, this anxiety-depression not caused by actual threat or its nervous terrified degree with reality very not
Match.Acute attack state often has dying sense, mad sense, and appearance is indescribable frightened, nervous and uneasy, there is a kind of phase
The feeling of risk of waiting for property feels that disaster comes, and worry be can do by myself out of hand, may be fainted suddenly or " going mad "；To current and next
Life lacks interest, and sometimes excited, disequilibrium is often gratuitously got angry.The disease duration is very long, such as without product
Very effective treatment, the even several years delay of several weeks, several months is refractory, and last Anxiety depression is in addition to being presented duration or ictal frightened
Probably outside state, while can be with a variety of somatizations, general fatigue, the decline of live and work ability, simple daily housework can not
Competent, such symptom depression and anxiety of making patients again in turn can also have the symptoms such as the disorders of digestion, insomnia.Anxiety
Depression endangers a bit common, and patient can exactly be allowed to experience pain, severe mental state the most.And this downbeat mood is
What no apparent external cause occurred, thus be difficult to resolve very much certainly allow have a depression patient mood be always in it is pessimistic and worldweary among.Another party
Face, depression is always adjoint with anxiety, and using climacteric depression as representative, this kind of depressive patients of suffering from not only feel depressed,
It there is also indescribable nervous, terrified not peaceful anxiety simultaneously.
With continuing to increase for social pressures, the incidence of depression is also increased, and how to be treated depression and is always
Medical field concern the most.Treatment for anxious depression symptom, mostly uses Western medicine.And Western medicine has serious poison more
Side effect, long-term use Western medicine is very big to the harm of body, the injury especially to liver kidney.It is burnt using natural plant material for treating at present
It is the hot spot studied from now on to consider depression of sex.Therefore, the improvement treated on anxiety-depression disease drug is asking for current urgent need to resolve
Topic.
Invention content
For the above situation, to solve the defect of the prior art, the purpose of the present invention is just to provide a kind of anxiety for the treatment of and presses down
The Chinese medicine of strongly fragrant disease can effectively solve the problems, such as the medication of Anxiety depression.
The technical solution that the present invention solves is, by dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract, fourth
Perfume, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 30-60:20-40:
10-20:10-30 is made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：By drying and it is ground into coarse powder
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10-20:20-40:10-30:20-40:5-20 is blended in
Together, then plus the water boiling and extraction measured of 4-8 times of dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis dry weight 2-4 times, every time
20-40min is decocted, extracting solution is filtered, discards filter residue, merges extracting solution, the 1/5- of original volume is concentrated in vacuo at 60 DEG C
1/10, concentrate is obtained, it is finely ground with mortar by concentrate vacuum drying at dry powder, obtain dendrobium candidum, hawthorn, wilsonii, spina date seed
And coptis extract；
Cloves, dried orange peel, Radix Mussaendae and the Trinerve Agelaea extract be：By dry cloves, dried orange peel, Radix Mussaendae and
Trinerve Agelaea is cut into small pieces, according to weight ratio 10-20:20-30:20-40:20-30 is mixed, and is put into plant smashing extractor
In, the ethyl alcohol that the mass concentration measured with 3-8 times of cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea dry weight is 60%-95% is solvent,
18-25 DEG C is crushed extraction 2-3 times, and broken extraction time is 1-4min every time, raw material is first ground into homogenate shape, and can pass through 20
~60 mesh sieve, and then filter extracting solution, discard filter residue, merge extracting solution, the 1/4- of original volume is concentrated in vacuo at 60 DEG C
1/8, concentrate is obtained, it is finely ground with mortar by concentrate vacuum drying at dry powder, it obtains cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea and carries
Take object.
Reasonable recipe of the present invention, abundant raw material is pure plant, and green safe environmental protection can quickly and significantly be alleviated
The symptom of agitated depression is the innovation treated on anxiety-depression disease drug.
Specific implementation mode
The specific implementation mode of the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention is in the specific implementation, cloves, old by dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract
Skin, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 30:40:15:15 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：By drying and it is ground into coarse powder
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10:30:30:25:5 mix, and then add iron sheet
The stem of noble dendrobium, hawthorn, wilsonii, spina date seed and 8 times of the coptis dry weight water boiling and extraction measured 3 times, decoct 30min, by extracting solution every time
It filters, discards filter residue, merge extracting solution, be concentrated in vacuo to the 1/8 of original volume under the conditions of 60 DEG C, obtain concentrate, by concentrate
It is dried in vacuo into dry powder, it is finely ground with mortar, dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract are obtained, is computed and carries
The yield of object is taken to reach 25.6%~38.1%；
The cloves, dried orange peel, the preparation method of Radix Mussaendae and Trinerve Agelaea extract are as follows：By dry cloves, old
Skin, Radix Mussaendae and Trinerve Agelaea are cut into small pieces, according to weight ratio 15:25:30:30 mix, and are put into the broken extraction of plant
It is solvent with cloves, dried orange peel, the ethyl alcohol that the mass concentration of 5 times of amounts of Radix Mussaendae and Trinerve Agelaea dry weight is 75%, 18 DEG C broken in device
Broken extraction 3 times, broken extraction time is 2min every time, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, then will carried
It takes liquid to filter, discards filter residue, merge extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, by concentrate
It is dried in vacuo into dry powder, it is finely ground with mortar, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract are obtained, the receipts of extract are computed
Rate reaches 18.5%~26.7%.
Embodiment 2
The present invention is in the specific implementation, cloves, old by dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract
Skin, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 40:40:10:10 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：By drying and it is ground into coarse powder
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 15:25:25:25:10 mix, and then add iron
The skin stem of noble dendrobium, hawthorn, wilsonii, spina date seed and 6 times of the coptis dry weight water boiling and extraction measured 2 times, decoct 40min, will extract every time
Liquid filters, and discards filter residue, merges extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, and concentrate is true
Sky is dried to dry powder, finely ground with mortar, obtains dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract, is computed extraction
The yield of object reaches 21.4%~32.9%；
The cloves, dried orange peel, the preparation method of Radix Mussaendae and Trinerve Agelaea extract are as follows：By dry cloves, old
Skin, Radix Mussaendae and Trinerve Agelaea are cut into small pieces, according to weight ratio 20:30:20:30 mix, and are put into the broken extraction of plant
It is solvent with cloves, dried orange peel, the ethyl alcohol that the mass concentration of 6 times of amounts of Radix Mussaendae and Trinerve Agelaea dry weight is 80%, 21 DEG C broken in device
Broken extraction 2 times, broken extraction time is 3 minutes every time, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, then will
Extracting solution filters, and discards filter residue, merges extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, will be concentrated
Liquid vacuum drying is finely ground with mortar at dry powder, obtains cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, is computed extract
Yield reaches 15.4%~22.5%.
Embodiment 3
The present invention is in the specific implementation, cloves, old by dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract
Skin, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 40:35:10:15 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：By drying and it is ground into coarse powder
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10:30:10:30:10 mix, and then add iron
The skin stem of noble dendrobium, hawthorn, wilsonii, spina date seed and 5 times of the coptis dry weight water boiling and extraction measured 4 times, decoct 20min, will extract every time
Liquid filters, and discards filter residue, merges extracting solution, the 1/5 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, and concentrate is true
Sky is dried to dry powder, finely ground with mortar, obtains dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract, is computed extraction
The yield of object reaches 20.4%~31.8%；
Cloves, dried orange peel, Radix Mussaendae and the Trinerve Agelaea extract be：By dry cloves, dried orange peel, Radix Mussaendae and
Trinerve Agelaea is cut into small pieces, according to weight ratio 15:30:25:30 mix, and are put into plant smashing extractor, with cloves, old
Skin, the ethyl alcohol that the mass concentration of 8 times of amounts of Radix Mussaendae and Trinerve Agelaea dry weight is 90% are solvent, and 25 DEG C are crushed extraction 2 times, every time
Broken extraction time is 2min, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, then filters extracting solution, discard
Filter residue merges extracting solution, the 1/8 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, by concentrate vacuum drying at dry
Powder, it is finely ground with mortar, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract are obtained, the yield for being computed extract reaches 19.7%
~26.1%.
In prescription of the present invention,
Dendrobium candidum is also known as iron bracketplant, ribbed hedyotis herb, it gains the name because epidermis is in iron green.Dendrobium candidum is in Traditional Chinese Medicine
A wonderful work, by common people be considered as Chinese celestial grass most, have promote the production of body fluid nourishing the stomach, nourishing Yin and clearing heat, moistening lung kidney-nourishing, the strong waist of improving eyesight work(
Effect.Dendrobium candidum is praised highly by ancient Chinese medicine doctor, expert in health preserving, is considered as the good medicine that yin-nourishing is empty, gets rid of illness.Modern medicine and pharmacology research shows that：
The main active ingredient of dendrobium candidum is dendrobium polysaccharide, dendrobine, trace element and amino acid etc., it can significantly improve human body
Immune function has enriching yin, removing toxic substances, anticancer, anti arteriosclerosis, expansion blood vessel, blood pressure lowering, antifatigue, radioresistance, anti-aging etc.
Effect is improving immunity, anti-oxidant, anti-aging and clearing profit by the relevant healthcare food of raw material of dendrobium candidum in recent years
Larynx etc. all has the effect of certain；Also there is certain auxiliary therapeutic action to cancer, especially cancer patient is being put, changed
The symptoms such as the thirsty, dry throat occurred after treatment and retch, have fine curative effect.
Hawthorn is the fruit of rose family hawthorn hawthorn, and fruit is raw-eaten or makees preserved fruit fruitcake, can be used as medicine after drying, be
The distinctive dual-purpose of drug and fruit seeds of China have the effects that reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, while being also that invigorating the spleen is opened
The good medicine of stomach, relieving dyspepsia, phlegm reduction of blood circulation promoting, to chest diaphragm spleen, the diseases such as full, hernia, blood stasis, amenorrhoea have fine curative effect.In hawthorn
Flavonoids has the effects that antifatigue, the internal growth of cancer cells of inhibition, proliferation and infiltration metastasis.
Wilsonii (Eleutherococcus senticosus) alias sting bent stick, slender acanthopanax ginseng, machaka, root and
Root-like stock can be used as medicine.Root skin is containing a variety of carbohydrates, amino acid, aliphatic acid, vitamin, volatile oil, tannin, brown eleostearic acid, linseed oil
Acid, sterol, coumarin, flavones, suberone, nonaro-maticity unsaturated organic acid and lot of trace minerals etc..Root skin, which has, dispels
Rheumatism, strengthening the bones and muscles, filling liver kidney, adjustment internal organs qi and blood function improve blood circulation, boost metabolism.There is adjusting machine simultaneously
Body is disorderly, is allowed to tend to normal function.There is good antifatigue effect, and can significantly improve hypoxia-bearing capability.For wind
Arthritis with fixed pain caused by dampness pain, soreness of waist and knee joint, neurasthenia, the diseases such as insomnia and dreamful sleep and poor memory, vegetative nerve functional disturbance.
Spina date seed, alias jujube kernel, jujube nucleus, mountain jujube benevolence.Pulp, nucleocapsid are gone by Rhamnaceae arbor wild jujube ripening fruits, received
Collect seed, dries.It is born in endroit, roadside, mainly originates in Henan, Hebei, Shaanxi, Liaoning, Shanxi, Shandong, Yunnan
Etc. ground.It harvests when the fruit matures in the fall, removes pulp and stone, seed, raw use or micro- stir-fry is taken to use.Mainly containing jujuboside, white
Pine gum acid, betulin etc..With nourishing the liver, calming heart is calmed the nerves, and restlessness of asrhenia type and insomnia is controlled in the effect of arrest sweating, palpitation of palpitating with fear, polydipsia, abnormal sweating.
The coptis is Ranunculaceae herbaceos perennial, and alias, Jiang Lian, RHIZOMA COPTIDIS from Sichuan of China, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, prepared RHIZOMA COPTIDIS with vino, beverage connect, salt is fried
The coptis, coptis charcoal, ginger juice fry river company etc..Main component in the coptis is alkaloid, based on jamaicin (berberine), also has Huang
Even alkali, jateorrhizine, epiberberine, worenine etc..The coptis has heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating.For damp and hot ruffian
It is full, vomit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, the diseases such as dysphoria and insomnia.
Cloves is Myrtaceae Genus Syringa machaka or dungarunga.Because cylindrical fireworks are elongated such as nail and fragrant therefore named.Also known as cloves,
Syring vulgaris.With bud and its fruit medicine.Bud claims flos caryophylli or male cloves, fruit to claim Fructus Caryophylli or female cloves.Mainly contain and waves
Hair oil ingredient separately has the ingredients such as syringone, triterpenic acid based on eugenol, has antibacterial, middle benefit gas, appetizing, warm kidney, drop inverse
Effect.Control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addictions, hernia, ringworm.
Radix Mussaendae (Mussaenda hainanensis Merr.) is that Rubiaceae (Rubiaceae) Mussaenda is climbed
Help shrub.Radix Mussaendae is used as medicine with rattan in root, and whole year can adopt, using fresh herb or clean dry, chopping it is spare.Property is sweet, light, cool.Function
It cures mainly：Clearing away summerheat, removing pattogenic heat from the blood and toxic material from the body.For being poisoned, flu, bronchitis, tonsillitis, sphagitis, nephritic dropsy, enteritis,
Uterine hemorrhage, venomous snake bite.Containing saponins, phenols, amino acid, organic acid, carbohydrate, higher aliphatic and ring in Radix Mussaendae stem
Alkene ether terpene glycoside etc..With heatstroke, cold, fever is controlled, cough, bronchitis, sphagitis, nephritic dropsy, the work of relieving superficies by cooling
With.
Trinerve Agelaea (Agelaea trinervis (Llanos) Merr.) is Connaraceae Trinerve Agelaea platymiscium, belongs to liana
Or climbing shrub, stem thickness is hairless, and spray part is by olive drab(O.D) down.Leaf has 3 leaflets, keratin, elliptical or oval shape, circular cone flower
Sequence, axillary cluster, spends fragrance；Sepal ovum shape lanceolar, petal white, long round shape fall lanceolar, and fruit slightly deflection, obovate has
Beak, pericarp tool wrinkle or knob, seed black oblong, base portion are surrounded by yellow aril.It is born in sparse woods.It is distributed in
The states such as Hainan, Malaysia, the India of China.
Lucidum spore powder is ganoderma lucidum in growth and maturity phase, the extremely small oval reproduction ejected from glossy ganoderma lamella
Cell is living body biological.Lucidum spore powder has the effects that raising immunity of organisms, three height of reduction, liver protection, lipid-loweringing disinfect, are right
Neurasthenia effect is the most notable, can improve sleep, improve a poor appetite, and so that headache, alliteration symptom is mitigated or is disappeared, memory is gradual
Enhancing, refreshing tired, weak phenomenon disappear.Lucidum spore powder improves the blood circulation of human body heart and brain and the effect of peripheral blood circulation is aobvious
It writes, the symptom of the disease such as coronary heart disease, hyperlipemia disease, arrhythmia cordis, angina pectoris can be made to be eased, dizziness, chest can be made
The symptoms such as bored, shortness of breath, memory loss are clearly better.
The efficient combination of said medicine is supported mutually, and is prepared through science, and effective for treating Anxiety depression, stabilization can
It leans on, good effect, the present invention obtains satisfied technique effect through repeated tests, and related test situation is as follows：
Rat force swimming test, forced swimming test, the experiment of light and shade case and Elevated plus-maze experiment are after verification is administered
It is no that there is the conventional animal experiment for being relieved Anxiety depression.Cleaning grade male Kunming strain mice, 18~22g of weight.Experiment
20~24 degree of environment temperature, humidity 50%~60%.Mouse freely ingests and drinks water, and is adapted to 5 days before testing, and is opened after check is qualified
Begin formally to test.Mouse is randomly divided into 5 groups, respectively model group, positive group, the high, medium and low dosage group (2g/ of drug of the present invention
Kg, 1.0g/kg, 0.5g/kg), every group 10.Positive group Fluoxetine hydrochloride dosage is 0.01g/kg, medicine group physiological saline
It is made into suspension, the dosage physiological saline such as model group is injected during administration.One time a day, daily gastric infusion is primary, continuous to fill
Stomach is administered 14 days, is tested after last dose 2h.Data are handled using statistical method.
(1) rat force swimming test
Rat force swimming test mainly makes its head hang downwards by fixed mouse tail, and mouse is in probably in this context
The flurried and state escaped, and can not escaped of struggling of risking one's life, gives mouse to provide a compressing environment that can not avoid, a period of time
Afterwards, mouse of the record under the environment generates the dead time of desperate motionless state procedure, the treatment after being administered with observation
Effect.Mouse tail end is sticked on the holder on outstanding boot top, it, which is become the state that hangs upside down, carries out tail-suspention test.Projecting mouse
Head distance bottom 10cm, once hangs 2 mouse, and centre is separated with partition board in order to avoid colliding.Mouse is after projecting due to fear
Struggle activity can be carried out, it is motionless discontinuity occur in disappointed state after fatigue of struggling.Hang mouse 10 minutes, statistics
Tail is hanged in 5 minutes afterwards and hangs upside down the mouse accumulative dead time.
1 rat force swimming test of table
*P<0.05,**P<0.0
(2) mouse forced swimming is forced
Forced swim test mainly by the way that experiment mice to be placed in the water of a limitation, risk one's life earn in this context by mouse
Bundle makes an attempt at escaping and can not escape, and provides one without avoidable compressing environment, after the experiment of a period of time, mouse shows
Go out the motionless state of typical behavioral despair state, record mouse generates dead time when desperate motionless state, with observation
Therapeutic effect after medication.Mouse is put into long 50cm, antidepressant effect examination is done in the plastics swimming trunk of wide 40cm, high 40cm
Test, from mouse into the water after timing 10 minutes, mouse only has small limb motion without struggling, showing in 5 minutes after record
The accumulative dead time of rest and floating state.
Table 2 forces mouse forced swimming
*P<0.05,**P<0.01
Find out from table 1~2, compared with model group, the qutstanding tail test of the administration group mouse of positive group and various dose is motionless
Time and swimming test dead time significantly reduce, and have significant difference.Show that drug of the present invention has significantly to control
Treat the effect of agitated depression.
(3) mouse elevated plus-maze is tested
Elevated plus-maze experiment is to probe into characteristic and the frightened shape to uphanging unlimited arm to strange environment using mouse
The anxiety state of mouse is investigated at contradiction behavior.Using plus maze component, by mouse from center lattice when experiment starts
It is put into labyrinth towards closure arm, records the activity condition in 5 minutes.Open arms are observed into indegree and residence time, closure arm
Into indegree and residence time.It calculates mouse open arms number and accounts for total degree respectively in the open arms residence time and (into open arms and close
The sum of arm number) and total time (open arms and close the sum of arm residence time) percentage, as evaluation anxiety index.Into
The anxiety of open arms number and residence time and mouse is negatively correlated, and fewer into open arms number, the residence time is shorter,
Illustrate that the anxiety of mouse is more serious.
3 mouse elevated plus-maze of table is tested
*P<0.05,**P<0.01
(4) mouse light and shade case is tested
Open chest above one is made in wooden case, inside is divided into camera-lucida and camera bellows, and camera-lucida accounts for the 3/5 of chest, camera bellows
2/5 is accounted for, intermediate to be separated with a partition board, a square opening is opened in the bottom of partition board.Painted white in camera-lucida is illuminated by an incandescent lamp bulb,
A cold red light bulb is set in painted black in camera bellows, top.Draw the grid of upper length of side 9cm in chest bottom.Animal is placed in
Camera bellows red light no power, camera-lucida incandescent lighting cause animal anxiety.Mouse is put into camera-lucida center, facing away from partition board, observation is small
Mouse is shuttled in 10 minutes in light and shade case number, and shuttle number is more, illustrates that the anxiety of mouse is more serious.
4 mouse light and shade case of table, which shuttles, to be tested
*P<0.05,**P<0.01
Find out from table 3~4, is compared with model group, the plus maze experiment and the examination of light and shade case of positive group and administration group mouse
It tests after showing administration and shows apparent angst resistance effect, and there is significant difference, especially high dose group, show this hair
Bright drug therapy agitated depression has a significant effect.The present invention through testing repeatedly, obtain it is same or similar as tie
Fruit, for prevent it is unnecessary it is tired state, be no longer described in detail one by one.
Compared with prior art, the present invention haing the following advantages：
1, using broken extraction, which is that will break for cloves, dried orange peel, Radix Mussaendae, Trinerve Agelaea in the present invention
Broken be combined into one with extraction process is completed at the same time.Cardinal principle is that the medicinal material that will be extracted is set with certain density hydrous ethanol and carried
It takes in device, medicinal material is broken into homogenate shape using high-speed rotating special tool, while effect ingredient in medicinal material tissue is fast
Speed is transferred into solvent, by the way that extracting solution is obtained by filtration.The extracting method is fast with speed, extraction is complete, primary to extract only
Need a few minutes that can complete；Room temperature extraction is not heated, and the thermo-labile component damage in medicinal material is protected；Save time, molten
Agent and extraction efficiency height.It can be by most of functional component in cloves, dried orange peel, Radix Mussaendae, Trinerve Agelaea using this method extraction
Extraction is complete, improves the recovery rate of functional component.
2, reasonable recipe of the present invention, be pure plant, green safe environmental protection, animal experiment proves, can be quickly and apparent
Alleviation agitated depression symptom.The effect of product, the high, quality of component content was good, and therapeutic efficiency is notable, and convenient for taking
Band, it is convenient to take, production cost is low, is produced on a large scale.
Claims (4)
1. a kind of Chinese medicine for treating Anxiety depression, which is characterized in that by dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis
Extract, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze-dried powder is according to weight ratio 30-
60: 20-40:10-20:10-30 is made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：It will dry and be ground into the iron sheet of coarse powder
The stem of noble dendrobium, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10-20:20-40:10-30:20-40:5-20 is blended in one
It rises, then plus the water boiling and extraction measured of 4-8 times of dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis dry weight 2-4 times, every time
20-40min is decocted, extracting solution is filtered, discards filter residue, merges extracting solution, the 1/5- of original volume is concentrated in vacuo at 60 DEG C
1/10, concentrate is obtained, it is finely ground with mortar by concentrate vacuum drying at dry powder, obtain dendrobium candidum, hawthorn, wilsonii, spina date seed
And coptis extract；
Cloves, dried orange peel, Radix Mussaendae and the Trinerve Agelaea extract be：By dry cloves, dried orange peel, Radix Mussaendae and chestnut beans
Rattan is cut into small pieces, according to weight ratio 10-20:20-30:20-40:20-30 is mixed, and is put into plant smashing extractor,
The ethyl alcohol that the mass concentration measured with 3-8 times of cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea dry weight is 60% -95% is solvent,
18-25 DEG C is crushed extraction 2-3 times, and broken extraction time is 1-4min every time, raw material is first ground into homogenate shape, and can pass through
20~60 mesh sieve, and then filter extracting solution, discard filter residue, merge extracting solution, original volume is concentrated in vacuo at 60 DEG C
, concentrate is obtained, it is finely ground with mortar by concentrate vacuum drying at dry powder, obtain cloves, dried orange peel, Radix Mussaendae and chestnut beans
Boisiana extract.
2. according to the Chinese medicine of the treatment Anxiety depression described in claim 1, which is characterized in that by dendrobium candidum, hawthorn, thorn
Slender acanthopanax, spina date seed and coptis extract, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze
Dry powder is according to weight ratio 30: 40 : 15:15 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：It will dry and be ground into the iron sheet of coarse powder
The stem of noble dendrobium, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10: 30 : 30 : 25 :5 mix, and then add
Dendrobium candidum, hawthorn, wilsonii, spina date seed and 8 times of the coptis dry weight water boiling and extraction measured 3 times, decoct 30min every time, will
Extracting solution filters, and discards filter residue, merges extracting solution, is concentrated in vacuo to the 1/8 of original volume under the conditions of 60 DEG C, obtains concentrate, will
Concentrate vacuum drying is finely ground with mortar at dry powder, obtains dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract；
The cloves, dried orange peel, the preparation method of Radix Mussaendae and Trinerve Agelaea extract are as follows：By dry cloves, dried orange peel, jade
Leaf golden flower and Trinerve Agelaea are cut into small pieces, according to weight ratio 15: 25 : 30 :30 mix, and are put into the broken extraction of plant
In device, ethyl alcohol that the mass concentrations with cloves, dried orange peel, Radix Mussaendae and 5 times of Trinerve Agelaea dry weight amount are 75% is solvent, 18 DEG C
Broken extraction 3 times, broken extraction time is 2min every time, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, then
Extracting solution is filtered, filter residue is discarded, merges extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, it will be dense
The vacuum drying of contracting liquid is finely ground with mortar at dry powder, obtains cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract.
3. according to the Chinese medicine of the treatment Anxiety depression described in claim 1, which is characterized in that by dendrobium candidum, hawthorn, thorn
Slender acanthopanax, spina date seed and coptis extract, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze
Dry powder is according to weight ratio 40: 40: 10 :10 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：It will dry and be ground into the iron sheet of coarse powder
The stem of noble dendrobium, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 15: 25 : 25 : 25 :10 mix, then
Add dendrobium candidum, hawthorn, wilsonii, spina date seed and 6 times of the coptis dry weight water boiling and extraction measured 2 times, decoct 40min every time,
Extracting solution is filtered, filter residue is discarded, merges extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, it will be dense
The vacuum drying of contracting liquid is finely ground with mortar at dry powder, obtains dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract；
The cloves, dried orange peel, the preparation method of Radix Mussaendae and Trinerve Agelaea extract are as follows：By dry cloves, dried orange peel, jade
Leaf golden flower and Trinerve Agelaea are cut into small pieces, according to weight ratio 20: 30 : 20 :30 mix, and are put into the broken extraction of plant
In device, ethyl alcohol that the mass concentrations with cloves, dried orange peel, Radix Mussaendae and 6 times of Trinerve Agelaea dry weight amount are 80% is solvent, 21 DEG C
Broken extraction 2 times, broken extraction time is 3 minutes every time, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, so
Extracting solution is filtered afterwards, discards filter residue, merges extracting solution, the 1/6 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, it will
Concentrate vacuum drying is finely ground with mortar at dry powder, obtains cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract.
4. according to the Chinese medicine of the treatment Anxiety depression described in claim 1, which is characterized in that by dendrobium candidum, hawthorn, thorn
Slender acanthopanax, spina date seed and coptis extract, cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract, lucidum spore powder, royal jelly freeze
Dry powder is according to weight ratio 40: 35 : 10:15 are made；
Dendrobium candidum, hawthorn, wilsonii, spina date seed and the coptis extract be：It will dry and be ground into the iron sheet of coarse powder
The stem of noble dendrobium, hawthorn, wilsonii, spina date seed and the coptis are according to weight ratio 10: 30 : 10 : 30 :10 mix, then
Add dendrobium candidum, hawthorn, wilsonii, spina date seed and 5 times of the coptis dry weight water boiling and extraction measured 4 times, decoct 20min every time,
Extracting solution is filtered, filter residue is discarded, merges extracting solution, the 1/5 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, it will be dense
The vacuum drying of contracting liquid is finely ground with mortar at dry powder, obtains dendrobium candidum, hawthorn, wilsonii, spina date seed and coptis extract；
Cloves, dried orange peel, Radix Mussaendae and the Trinerve Agelaea extract be：By dry cloves, dried orange peel, Radix Mussaendae and chestnut beans
Rattan is cut into small pieces, according to weight ratio 15: 30 : 25:30 mix, and are put into plant smashing extractor, with cloves,
Dried orange peel, the ethyl alcohol that the mass concentration of 8 times of amounts of Radix Mussaendae and Trinerve Agelaea dry weight is 90% are solvent, and 25 DEG C are crushed extraction 2 times,
Broken extraction time is 2min every time, raw material is first ground into homogenate shape, and can be sieved by 20 mesh, then filters extracting solution,
Discard filter residue, merge extracting solution, the 1/8 of original volume is concentrated in vacuo at 60 DEG C, obtains concentrate, by concentrate vacuum drying at
Dry powder, it is finely ground with mortar, obtain cloves, dried orange peel, Radix Mussaendae and Trinerve Agelaea extract.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN101062161A (en) * | 2007-05-29 | 2007-10-31 | 沈信堂 | Traditional Chinese medicine for curing neurasthenia |
| CN101129978A (en) * | 2007-08-23 | 2008-02-27 | 张秀丽 | Orally taken traditional Chinese medicine composition for treating melancholia |
| CN103071080A (en) * | 2012-11-28 | 2013-05-01 | 甘肃省药物研究院 | Traditional Chinese medicine preparation for treating depressive disorder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN101062161A (en) * | 2007-05-29 | 2007-10-31 | 沈信堂 | Traditional Chinese medicine for curing neurasthenia |
| CN101129978A (en) * | 2007-08-23 | 2008-02-27 | 张秀丽 | Orally taken traditional Chinese medicine composition for treating melancholia |
| CN103071080A (en) * | 2012-11-28 | 2013-05-01 | 甘肃省药物研究院 | Traditional Chinese medicine preparation for treating depressive disorder |
Non-Patent Citations (2)
| Title |
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| 刘延泽等.中草药化学成分提取的新方法-植物组织破碎提取法（EMS）.《河南科学》.1993,第11卷(第4期),第265-268页. * |
| 徐春燕.中药复方治疗抑郁症的临床研究.《中国博士学位论文全文数据库 医药卫生科技辑》.2013,(第8期),第19-22页. * |
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