CN104840498B - A kind of compound amino acid capsule and preparation method thereof - Google Patents
A kind of compound amino acid capsule and preparation method thereof Download PDFInfo
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- CN104840498B CN104840498B CN201510181785.1A CN201510181785A CN104840498B CN 104840498 B CN104840498 B CN 104840498B CN 201510181785 A CN201510181785 A CN 201510181785A CN 104840498 B CN104840498 B CN 104840498B
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Abstract
The present invention relates to a kind of compound amino acid capsules and preparation method thereof, belong to health food preparing technical field;The compound amino acid capsule is formed by four to be grouped as:(1)Group, 1 ~ 10 part of ginseng extract, 1 ~ 10 part of Notogineng Extract;(2)Group, 20 ~ 30 parts of tryptophan;(3)Group, 10 ~ 30 parts of leucine, 10 ~ 20 parts of phenylalanine, 20 ~ 50 parts of threonine, 20 ~ 40 parts of valine;(4)Group, 10 ~ 30 parts of R-gene, 10 ~ 20 parts of histidine monohydrochloride, 20 ~ 50 parts of isoleucine, 10 ~ 30 parts of lysine hydrochloride, 40 ~ 80 parts of methionine;Preparation method is that four groups of materials will be separately added into sugar-coat cylinder, with high-pressure spray gun be interrupted spray into adhesive, material is constantly rolled in pot and be interrupted add in material piller is made;Piller obtained is uniformly mixed after selecting ball, drying, coating, polishing, is packed into capsule to obtain the final product;The characteristics of active ingredient height of the compound amino acid capsule, functional, performance are stable, convenient oral.
Description
Technical field
The present invention relates to a kind of compound capsules and preparation method thereof, and in particular to a kind of active constituent height, functional, property
Compound amino acid capsule that can stablize and preparation method thereof, belongs to functional food preparing technical field.
Background technology
Protein is the material base of human life activity, and numerous functions such as immune function, cellular damage of human body are repaiied
Multiple function and growth and development function all have close relationship with the metabolism of protein, and amino acid is the base of synthetic tissue albumen
Our unit and for synthesizing many small-molecule substances(Such as nitric oxide, polyamines, glutathione, creatine, carnitine, thyroid gland
Hormone, 5- hydroxytryptamines, melanin and heme)Important matrix, have numerous important physiologic meanings.Based on life
Long or nitrogen balance standard, traditional upper amino acid can be divided into essential amino acid and nonessential amino acid in nutrition.In human body
In 20 kinds of amino acid needed for protein synthesis, leucine, phenylalanine, threonine, tryptophan, valine, relies isoleucine
What 8 kinds of amino acid of propylhomoserin and methionine cannot be synthesized for human body itself, it is necessary to be absorbed from food, because of referred to herein as necessary amino
Acid.It cannot meet self-demand since human body synthesizes histidine and arginic amount, need to absorb a part from food, so
Histidine and arginine are also classified as necessary amino acid by people at present.
Amino acid have different physiological roles, if lysine is the constituent of liver and courage, can promote brain development and
Fat metabolism adjusts pineal body, mammary gland, corpus luteum and ovary, prevents cell from returning;Tryptophan can be converted into human brain
A kind of important transmitter substance-- 5-hydroxytryptamine, and 5-hydroxytryptamine has the work for neutralizing adrenaline and norepinephrine
With, and the duration of sleep can be improved;Contain hydroxyl in the structure of threonine, there is water holding ability to human skin, with widow
Sugar chain combines, and plays an important role to protection cell membrane, can promote phosphatide synthesis and fatty acid oxidation in vivo;Isoleucine can be controlled
Neurological disorder, anorexia and anaemia are treated, it is also extremely important in Protein metabolism.If amino acid starvation, albumen
Matter metabolic disorder eventually results in various diseases, when such as lacking methionine, anorexia, growth can be caused to slow down or do not increase
Phenomena such as weight, kidney enlargement and liver iron are accumulated, finally results in hepatonecrosis or fibrosis, so the supply of nitrogen matter is very heavy
It will.
Ginseng and Radix Notoginseng have the applicating history of two thousand years as precious Chinese medicine in tcm clinical practice.After several generation
The chemistry and pharmacological research of discipline, a large amount of science data prove that ginseng and Radix Notoginseng have extensive bioactivity indisputablely
And medical application.Ginseng can adjust central nervous system, improve excitement and the process of inhibition of brain, be allowed to tend to balance;It can carry
The high mental ability with manual labor improves working efficiency, and plays the role of antifatigue;Promote profit of the brain to energy matter
With improving enhances learning and memory ability in ability of learning and memory ginseng, and with improvement cardiac function and enhancing immunity of organism
The special efficacy of function.The expansible blood vessel of Radix Notoginseng reduces blood pressure, and improves microcirculation, increases blood flow, and prevention and treatment heart and brain tissues lack
Blood, bidirectional modulation nervous centralis improve mental, enhancing learning and memory ability;Promote protein, ribonucleic acid, deoxyribose
Nucleic acid synthesizes, and keeps fit and healthy;Equally also there is enhancing body's immunity, it is antitumor, it slows down aging, inhibits the work(of artery sclerosis
Effect.
CN103989692A discloses a kind of compound amino acid ginsenoside capsule preparation method thereof, by compound amino acid and people
Ginseng saponin(e raw material is sufficiently mixed uniformly, capsule is packed into after 100 DEG C of dry sterilizations, finished product is made, and convenient to take, effect is good, but each
Kind raw material mixes to be easy to cause to be chemically reacted, and high temperature drying can reduce amino acid, ginseng in storage period
With the physiological activity of Radix Notoginseng.
Invention content
The object of the present invention is to provide a kind of compound amino acid capsule, active constituent height, functional, performance are stablized.
It is a further object to provide a kind of preparation methods of compound amino acid capsule.
To realize the purpose of foregoing invention, the technical solution that the present invention takes is as follows:
A kind of compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:1 ~ 5 part of ginseng extract, 1 ~ 5 part of Notogineng Extract;
(2)Group:20 ~ 30 parts of tryptophan;
(3)Group:10 ~ 30 parts of leucine, 10 ~ 20 parts of phenylalanine, 20 ~ 50 parts of threonine, 20 ~ 40 parts of valine;
(4)Group:10 ~ 30 parts of R-gene, 10 ~ 20 parts of histidine monohydrochloride, 20 ~ 50 parts of isoleucine, lysine hydrochloride
10 ~ 30 parts, 40 ~ 80 parts of methionine.
The ginseng extract is refluxing extraction 2 ~ 3 times in the ethanol solution of 8 times of amounts 60 ~ 80% by Ginseng Root Powder,
1 ~ 1.5h every time, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 20 ~ 30U/g cellulase and
The pectase of 40 ~ 60U/g adjusts and 1 ~ 2h is digested in pH4 ~ 5, with 50 ~ 60 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
A kind of preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, by material in pot not
It is disconnected roll and be interrupted add in material piller be made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating, and with insect wax polishing;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Step(1)The adhesive is 3% gelatin solution.
Step(4)The different colours are:(1)Group is brown;(2)Group is orange;(3)Group is yellow;(4)Group is white
Color.
Step(4)The Chinese wax weight is the 0.01% of ball weight.
The beneficial effects of the invention are as follows:
(1)By ginseng, Radix Notoginseng and amino acid is ingenious combines, which has extensive pharmacological activity, has a variety of
Physiological function has prominent effect in terms of strengthen immunity and fatigue-relieving;And proportioning is scientific and reasonable, in giving full play to
The synergistic effect of medicine ingredient and amino acid makes amino acid is balanced in human body to absorb, improves bioavailability.
(2)By modified technique, by the way of pill is grouped, raw material is respectively prepared four kinds according to different physicochemical properties
Piller, and ensure that and will not chemically react and degrade in storage period between each ingredient, improve various work in product
The stability of property ingredient.
(3)Tryptophan chance light is easy to change, and stability is poor, and piller is made merely, can improve the stability of product, and every
Group component carries out color differentiation with different colours, and identification easy to produce is easy to mass production.
Specific embodiment
The present invention is described in further details below by example, these examples are only used for illustrating the present invention, and unlimited
The scope of the present invention processed.
Embodiment 1
Compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:1 part of ginseng extract, 5 parts of Notogineng Extract;
(2)Group:20 parts of tryptophan;
(3)Group:10 parts of leucine, 10 parts of phenylalanine, 20 parts of threonine, 20 parts of valine;
(4)Group:30 parts of R-gene, 20 parts of histidine monohydrochloride, 50 parts of isoleucine, 30 parts of lysine hydrochloride, egg ammonia
80 parts of acid.
The ginseng extract is refluxing extraction 2 times in the ethanol solution of 8 times of amounts 80% by Ginseng Root Powder, every time
1.5h, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 30U/g cellulase and
The pectase of 40U/g adjusts and 2h is digested in pH4, with 50 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
The preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, adhesive is 3% gelatin
Solution, material is constantly rolled in pot and be interrupted add in material piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating,(1)Group is brown,(2)
It is orange to organize,(3)Group is yellow,(4)Group is white;And with insect wax polishing, Chinese wax add weight is the 0.01% of ball weight;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Embodiment 2
Compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:5 parts of ginseng extract, 1 part of Notogineng Extract;
(2)Group:30 parts of tryptophan;
(3)Group:30 parts of leucine, 20 parts of phenylalanine, 50 parts of threonine, 40 parts of valine;
(4)Group:10 parts of R-gene, 10 parts of histidine monohydrochloride, 20 parts of isoleucine, 10 parts of lysine hydrochloride, egg ammonia
40 parts of acid.
The ginseng extract is refluxing extraction 3 times in the ethanol solution of 8 times of amounts 60% by Ginseng Root Powder, every time
1.5h, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 20U/g cellulase and
The pectase of 60U/g adjusts and 1h is digested in pH5, with 60 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
The preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, adhesive is 3% gelatin
Solution, material is constantly rolled in pot and be interrupted add in material piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating,(1)Group is brown,(2)
It is orange to organize,(3)Group is yellow,(4)Group is white;And with insect wax polishing, Chinese wax add weight is the 0.01% of ball weight;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Embodiment 3
Compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:3 parts of ginseng extract, 3 parts of Notogineng Extract;
(2)Group:25 parts of tryptophan;
(3)Group:20 parts of leucine, 15 parts of phenylalanine, 30 parts of threonine, 30 parts of valine;
(4)Group:20 parts of R-gene, 15 parts of histidine monohydrochloride, 30 parts of isoleucine, 20 parts of lysine hydrochloride, egg ammonia
60 parts of acid.
The ginseng extract is refluxing extraction 3 times in the ethanol solution of 8 times of amounts 70% by Ginseng Root Powder, every time
1h, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 25U/g cellulase and
The pectase of 50U/g adjusts and 1.5h is digested in pH4.5, with 55 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
The preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, adhesive is 3% gelatin
Solution, material is constantly rolled in pot and be interrupted add in material piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating,(1)Group is brown,(2)
It is orange to organize,(3)Group is yellow,(4)Group is white;And with insect wax polishing, Chinese wax add weight is the 0.01% of ball weight;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Embodiment 4
Compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:2 parts of ginseng extract, 4 parts of Notogineng Extract;
(2)Group:24 parts of tryptophan;
(3)Group:18 parts of leucine, 12 parts of phenylalanine, 25 parts of threonine, 35 parts of valine;
(4)Group:25 parts of R-gene, 18 parts of histidine monohydrochloride, 40 parts of isoleucine, 15 parts of lysine hydrochloride, egg ammonia
70 parts of acid.
The ginseng extract is refluxing extraction 2 times in the ethanol solution of 8 times of amounts 65% by Ginseng Root Powder, every time
1.5h, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 25U/g cellulase and
The pectase of 60U/g adjusts and 1h is digested in pH4, with 55 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
The preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, adhesive is 3% gelatin
Solution, material is constantly rolled in pot and be interrupted add in material piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating,(1)Group is brown,(2)
It is orange to organize,(3)Group is yellow,(4)Group is white;And with insect wax polishing, Chinese wax add weight is the 0.01% of ball weight;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Embodiment 5
Compound amino acid capsule is made of four groups of components of following parts by weight:
(1)Group:2 parts of ginseng extract, 3 parts of Notogineng Extract;
(2)Group:20 parts of tryptophan;
(3)Group:20 parts of leucine, 20 parts of phenylalanine, 26 parts of threonine, 33 parts of valine;
(4)Group:22 parts of R-gene, 15 parts of histidine monohydrochloride, 40 parts of isoleucine, 24 parts of lysine hydrochloride, egg ammonia
60 parts of acid.
The ginseng extract is refluxing extraction 3 times in the ethanol solution of 8 times of amounts 75% by Ginseng Root Powder, every time
1h, filtration drying to obtain the final product.
The Notogineng Extract, be by Notoginseng Root be placed in 8 times amount water in, add in 30U/g cellulase and
The pectase of 45U/g adjusts and 2h is digested in pH4, with 58 DEG C of water-baths, and ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
The preparation method of compound amino acid capsule, includes the following steps:
(1)Four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive, adhesive is 3% gelatin
Solution, material is constantly rolled in pot and be interrupted add in material piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating,(1)Group is brown,(2)
It is orange to organize,(3)Group is yellow,(4)Group is white;And with insect wax polishing, Chinese wax add weight is the 0.01% of ball weight;
(5)By the good each group piller of polishing after mixing, it is packed into capsule.
Claims (4)
1. a kind of compound amino acid capsule, it is characterised in that:It is made of four groups of components of following parts by weight:
(1)Group:1 ~ 5 part of ginseng extract, 1 ~ 5 part of Notogineng Extract;
(2)Group:20 ~ 30 parts of tryptophan;
(3)Group:10 ~ 30 parts of leucine, 10 ~ 20 parts of phenylalanine, 20 ~ 50 parts of threonine, 20 ~ 40 parts of valine;
(4)Group:10 ~ 30 parts of R-gene, 10 ~ 20 parts of histidine monohydrochloride, 20 ~ 50 parts of isoleucine, lysine hydrochloride 10 ~ 30
Part, 40 ~ 80 parts of methionine;
Preparation methods steps are as follows:
(1)Four groups of materials are weighed, then four groups of materials are separately added into sugar-coat cylinder, is interrupted with high-pressure spray gun and sprays into adhesive,
Material in pot is constantly rolled and is interrupted addition material, piller is made;
(2)Piller is made and selects ball with vibrating screening machine;
(3)Piller after sorting is dried, ball is received in moisture control≤4%;
(4)The Opadry that dried piller is put to sugar-coat cylinder different colours does material spray coating, and with insect wax polishing;
(5)By the good each group piller of polishing after mixing, it is packed into capsule;
By Ginseng Root Powder in the ethanol solution of 8 times of amounts 60 ~ 80% refluxing extraction 2 ~ 3 times, every time 1 ~ 1.5h, filtration drying to obtain the final product;
Notoginseng Root is placed in the water of 8 times of amounts, adds in the cellulase of 20 ~ 30U/g and the pectase of 40 ~ 60U/g, adjusted
1 ~ 2h is digested in pH4 ~ 5, with 50 ~ 60 DEG C of water-baths, ultrasound 1h after enzymolysis, filtration drying to obtain the final product.
2. a kind of method for being used to prepare compound amino acid capsule according to claim 1, it is characterised in that:Step(1)
The adhesive is 3% gelatin solution.
3. a kind of method for being used to prepare compound amino acid capsule according to claim 1, it is characterised in that:Step(4)
The different colours are:(1)Group is brown;(2)Group is orange;(3)Group is yellow;(4)Group is white.
4. a kind of method for being used to prepare compound amino acid capsule according to claim 1, it is characterised in that:Step(4)
The Chinese wax weight is the 0.01% of ball weight.
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CN107441134A (en) * | 2017-08-11 | 2017-12-08 | 南京圣诺生物科技实业有限公司 | It is a kind of to contain 1,6 diphosphofructoses, the health products and preparation method thereof of pseudo-ginseng |
CN113016967A (en) * | 2021-04-15 | 2021-06-25 | 深圳仙草生物科技股份有限公司 | Specific immunity-inducing composition and specific immunity-inducing beverage |
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CN1685970A (en) * | 2005-04-06 | 2005-10-26 | 云南白药集团股份有限公司 | Health protection food for antifatigue and raising oxygen deficiency tolerance |
CN1919204A (en) * | 2005-06-23 | 2007-02-28 | 维京仲华(上海)生物医药科技有限公司 | Method for enhancing nutrient absorption with astragalosides |
CN103989720A (en) * | 2014-06-09 | 2014-08-20 | 吉林农业大学 | Preparation method of compound amino acid suncured ginseng capsule |
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2015
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1685970A (en) * | 2005-04-06 | 2005-10-26 | 云南白药集团股份有限公司 | Health protection food for antifatigue and raising oxygen deficiency tolerance |
CN1919204A (en) * | 2005-06-23 | 2007-02-28 | 维京仲华(上海)生物医药科技有限公司 | Method for enhancing nutrient absorption with astragalosides |
CN103989720A (en) * | 2014-06-09 | 2014-08-20 | 吉林农业大学 | Preparation method of compound amino acid suncured ginseng capsule |
Non-Patent Citations (1)
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