CN104840251A - Laser thermal therapy probe based on photothermal effect of optical fiber material - Google Patents
Laser thermal therapy probe based on photothermal effect of optical fiber material Download PDFInfo
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- CN104840251A CN104840251A CN201510226946.4A CN201510226946A CN104840251A CN 104840251 A CN104840251 A CN 104840251A CN 201510226946 A CN201510226946 A CN 201510226946A CN 104840251 A CN104840251 A CN 104840251A
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Abstract
The invention relates to a laser thermal therapy probe based on a photothermal effect of an optical fiber material. The laser thermal therapy probe comprises a light transmission optical fiber, a protective sleeve, an optical fiber temperature sensor and a photothermal probe. The front end or the back end of the photothermal probe is connected with the optical fiber temperature sensor; the optical fiber temperature sensor on the back end is connected with the light transmission optical fiber; the protective sleeve wraps outside the light transmission optical fiber, the optical fiber temperature sensor and the photothermal probe. In a therapy process, the thermal therapy probe is put into a tissue requiring a treatment, the imported laser is converted into a thermal energy by the photothermal probe, and the thermal energy is conducted and radiated all around by centering on the probe, accordingly forming a certain temperature field distribution in the tissue. A complete distributed measurement of temperature distribution field temperature information around the tissue is achieved by the optical fiber temperature sensor. Being simple in structure, low in cost, small in size, and easy to manufacture, the laser thermal therapy probe based on the photothermal effect of the optical fiber material can measure the temperature distribution in real time, thereby providing a safe and highly practical probe structure as well as a small-size point heat source device with precise temperature control to the laser-induced interstitial thermal therapy.
Description
Technical field
The present invention relates to a kind of laserthermia based on fiber optic materials photo-thermal effect probe.
Background technology
Laserthermia a kind of directs light into inside of human body by optical fiber, condenses, downright bad novel tumor treatment technology after local biologic tissue is heated, and it reaches the object of tumor in situ removing by less invasion.Compared with traditional surgical resection, it is short that the method has operating time, and operation wound face is little, seldom occurs bleeding profusely, and the misery caused patient is little, and post-operative recovery is effective, and have the feature of certain anti-inflammation and sterilization effect.There is certain prospect in disease treatment, particularly in the Therapy study of tumor, be used to treatment at present and permitted eurypalynous tumor, the tumor at the positions such as such as liver, brain, mammary gland, retina.
In laserthermia, need, by light-conductive optic fibre, laser is imported tissue, general light-conductive optic fibre end face laterally cuts flat structure, this structure make light leave end face after still along the axial travels straight of optical fiber, its scattering angle is very little, only have the tissue of positive forward direction can illuminated extinction over the course for the treatment of, the circumferential tumor cell and organizing being positioned at bright dipping end be still survived.Solution conventional is at present that the leaded light end of light-conductive optic fibre is carried out physical grinding or chemical attack.The concordance ensureing severity of grind, time, angle is needed in physical grinding process; Often physical grinding effect is not fine, on this basis will in conjunction with chemical attack.Chemical corrosion process need utilize the corrosive liquids such as Fluohydric acid. to strengthen the roughness of face machined flat further.This class methods operating process is complicated, and needs independent leaded light probe during treatment, adds the quantity for the treatment of probe and increases the difficulty of operation.
In laserthermia treatment, the detection of temperature is the key of laserthermia safe treatment.Tissue temperature maintains the too low effect not reaching treatment, and the too high too fast tissue meeting carbonization of temperature or vaporization, injury is organized normally.And laser dosage is also the core affecting whole therapeutic process, directly determine scope and the safety of area for treatment, as in brain operation, need the tumor for the treatment of when closely key is organized, must strictly control to hurt vicinity and monitor and organize and sensitive structure.Way common at present utilizes nuclear magnetic resonance, NMR (MRI) imaging, computed tomography (CT) real time temperature measurement, but MIR imaging, CT imaging measurement time are long, measurement image and actual damage process have delay phenomenon, and equipment more complicated, and cost price is high.Also useful thermocouple is measured in addition, and the probe because of thermocouple is that metal obtains, and has absorption to laser, certain background noise can be produced, make measuring tempeature higher than actual temperature, simultaneously electromagnetism can produce certain interference to it, jointly can not use with the technology such as MRI imaging.Also have a kind of use ultrasonic measurement, it must measure sound characteristics and the temperature characterisitic of various tissue in advance.Because the characterisitic parameter between each individuality is different in reality, so measuring process is more complicated, consuming time longer, degree of accuracy is not high.
Realize laserthermia safe, effective, injure little, need to record the complete distributed information of tissue temperature in real time on the basis of reducing probe quantity, control Laser output metering.Current research is state-of-the-art is the Monteris medical science company of the U.S. in 2014, by leaded light device and being integrated in of thermocouple, makes a probe, uses demodulation software to measure the temperature of tissue in real time, and utilizes MRI imaging to come simultaneous observation and monitor treatment.Do not possess electromagnetism interference due to thermocouple production background noise, so this probe temperature is measured in real time or based on MRI, and the size of this probe is comparatively large, and cost of manufacture is high.
Summary of the invention
The present invention is directed in laserthermia that number of popping one's head in is many, size be large, some distributed measurement temperature, the uppity problem of Laser output dosage, a kind of laserthermia based on fiber optic materials photo-thermal effect probe is proposed, its structure is simple, make easily, cost is low, precision is high, practical, realize passing light sensing integrated.This probe can realize, to the complete distributed temperature high-acruracy survey of area for treatment, reaching the effect of safe treatment.
For achieving the above object, the present invention adopts following technical proposals:
A kind of probe of the laserthermia based on fiber optic materials photo-thermal effect, comprises Optic transmission fiber, protective sleeve, fibre optic temperature sensor and photo-thermal probe; The front end of described photo-thermal probe or rear end connecting fiber temperature sensor, the fibre optic temperature sensor of rear end connects described Optic transmission fiber, and described protective sleeve is coated on the outside of Optic transmission fiber, fibre optic temperature sensor and photo-thermal probe.Be placed on by hyperthermia applicator during treatment in the tissue that need treat, the laser conversion that Optic transmission fiber imports by photo-thermal probe is heat energy, and to surrounding conduction and radiation centered by this probe, forms certain thermo parameters method in the tissue; Fibre optic temperature sensor realizes the complete distributed measurement of the Temperature Distribution field temperature information around treated tissue.
The present invention, compared with existing hyperthermia applicator, has following apparent outstanding substantive distinguishing features and remarkable advantage:
1. photo-thermal probe can form certain Temperature Distribution field, easily can realize the thermotherapy of tissue, avoid the processing technology of thermotherapy complexity; 2. with utilize light-conductive optic fibre to import to treat laser to carry out treatment respectively with sensor to compare with temperature measurement technology, the present invention only need use a probe can realize passing simultaneously can and sensing; 3. fibre optic temperature sensor is not by the impact of input laser, and the interference of anti-electromagnetism, can be applicable to more occasions; 4. obtain optical signal by demodulation and realize the complete distributed satellite systems of treated tissue, avoid multipoint temperature measuring loaded down with trivial details and tissue is had to the problem of injury, ensure the safety of treated tissue surrounding tissue or sensitive part, reduce the risk of operation; 5. this probe makes simple and easy, and cost is low, and precision is high.
When laserthermia, fibre optic temperature sensor realizes in real time distributed satellite systems completely on the one hand, and energy feedback regulation laser output power, probe is made to keep the temperature of setting, luminous energy can be converted to heat energy by photo-thermal probe on the other hand, form the hot source point of hyperthermia applicator, avoid the temperature distributing disproportionation that the directivity because of laser causes.
Accompanying drawing explanation
Fig. 1 is the laserthermia probe schematic diagram based on fiber optic materials photo-thermal effect.
Detailed description of the invention
Details are as follows by reference to the accompanying drawings for the preferred embodiments of the present invention:
As shown in Figure 1, a kind of probe of the laserthermia based on fiber optic materials photo-thermal effect, comprises Optic transmission fiber 1, protective sleeve 2, fibre optic temperature sensor 3 and photo-thermal probe 4; The front end of described photo-thermal probe 4 or rear end connecting fiber temperature sensor 3, the fibre optic temperature sensor 3 of rear end connects described Optic transmission fiber 1, and described protective sleeve 2 is coated on the outside of Optic transmission fiber 1, fibre optic temperature sensor 3 and photo-thermal probe 4.Laser imports in photo-thermal probe 4 by Optic transmission fiber 1, and light energy conversion is heat energy by photo-thermal probe 4, conduction towards periphery and the certain Temperature Distribution field of radiation formation; The temperature information in fibre optic temperature sensor 3 Real-Time Monitoring temperature field.
Claims (1)
1. the probe of the laserthermia based on fiber optic materials photo-thermal effect, is characterized in that, comprise Optic transmission fiber (1), protective sleeve (2), fibre optic temperature sensor (3) and photo-thermal probe (4); The front end of described photo-thermal probe (4) or rear end connecting fiber temperature sensor (3); the fibre optic temperature sensor (3) of rear end connects described Optic transmission fiber (1), and described protective sleeve (2) is coated on the outside of Optic transmission fiber (1), fibre optic temperature sensor (3) and photo-thermal probe (4).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510226946.4A CN104840251A (en) | 2015-05-07 | 2015-05-07 | Laser thermal therapy probe based on photothermal effect of optical fiber material |
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| CN201510226946.4A CN104840251A (en) | 2015-05-07 | 2015-05-07 | Laser thermal therapy probe based on photothermal effect of optical fiber material |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038038A (en) * | 2016-07-06 | 2016-10-26 | 马胜林 | Skin temperature monitoring system used for tumor thermotherapy |
| CN107412957A (en) * | 2017-07-12 | 2017-12-01 | 华东师范大学 | A kind of photo-thermal therapy probe based on photo-thermal nano material |
| CN108523991A (en) * | 2018-02-13 | 2018-09-14 | 南京亿高微波系统工程有限公司 | A kind of efficiently cooling multifunction microwave ablation needle |
| CN109116468A (en) * | 2018-11-26 | 2019-01-01 | 中聚科技股份有限公司 | A kind of optical fiber and preparation method thereof of the end for laser therapy with optothermal material |
| CN109259858A (en) * | 2018-08-29 | 2019-01-25 | 北京华夏光谷光电科技有限公司 | Laser therapy/thermometric coenosarc fiber device |
| CN109276818A (en) * | 2018-11-16 | 2019-01-29 | 中聚科技股份有限公司 | A kind of laser fiber shield |
| CN109452969A (en) * | 2018-12-07 | 2019-03-12 | 中聚科技股份有限公司 | A kind of laser surgey optical fiber of the flexible end with optothermal material |
| CN112675304A (en) * | 2021-01-13 | 2021-04-20 | 北京工业大学 | Endogenous photothermal therapy device system with micro-nano quantum dots and preparation method thereof |
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| CN2576191Y (en) * | 2002-11-04 | 2003-10-01 | 中国科学院福建物质结构研究所 | Microwave thermal-treatment radiator |
| CN1498600A (en) * | 2002-11-04 | 2004-05-26 | 中国科学院福建物质结构研究所 | Laseer heat treatment appliance for treating tumour |
| US20050203496A1 (en) * | 2004-03-12 | 2005-09-15 | Ritchie Paul G. | Medical apparatus and method useful for thermal treatment of a lumen |
| US7153299B1 (en) * | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2576191Y (en) * | 2002-11-04 | 2003-10-01 | 中国科学院福建物质结构研究所 | Microwave thermal-treatment radiator |
| CN1498600A (en) * | 2002-11-04 | 2004-05-26 | 中国科学院福建物质结构研究所 | Laseer heat treatment appliance for treating tumour |
| US7153299B1 (en) * | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
| US20050203496A1 (en) * | 2004-03-12 | 2005-09-15 | Ritchie Paul G. | Medical apparatus and method useful for thermal treatment of a lumen |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038038A (en) * | 2016-07-06 | 2016-10-26 | 马胜林 | Skin temperature monitoring system used for tumor thermotherapy |
| CN107412957A (en) * | 2017-07-12 | 2017-12-01 | 华东师范大学 | A kind of photo-thermal therapy probe based on photo-thermal nano material |
| CN107412957B (en) * | 2017-07-12 | 2019-09-10 | 华东师范大学 | A kind of photo-thermal therapy probe based on photo-thermal nano material |
| CN108523991A (en) * | 2018-02-13 | 2018-09-14 | 南京亿高微波系统工程有限公司 | A kind of efficiently cooling multifunction microwave ablation needle |
| CN109259858A (en) * | 2018-08-29 | 2019-01-25 | 北京华夏光谷光电科技有限公司 | Laser therapy/thermometric coenosarc fiber device |
| CN109276818A (en) * | 2018-11-16 | 2019-01-29 | 中聚科技股份有限公司 | A kind of laser fiber shield |
| CN109116468A (en) * | 2018-11-26 | 2019-01-01 | 中聚科技股份有限公司 | A kind of optical fiber and preparation method thereof of the end for laser therapy with optothermal material |
| CN109116468B (en) * | 2018-11-26 | 2019-02-22 | 中聚科技股份有限公司 | A kind of optical fiber and preparation method thereof of the end for laser therapy with optothermal material |
| CN109452969A (en) * | 2018-12-07 | 2019-03-12 | 中聚科技股份有限公司 | A kind of laser surgey optical fiber of the flexible end with optothermal material |
| CN109452969B (en) * | 2018-12-07 | 2019-09-06 | 中聚科技股份有限公司 | A kind of laser surgey optical fiber of the flexible end with optothermal material |
| CN112675304A (en) * | 2021-01-13 | 2021-04-20 | 北京工业大学 | Endogenous photothermal therapy device system with micro-nano quantum dots and preparation method thereof |
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