CN104825933A - Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation Download PDFInfo
- Publication number
- CN104825933A CN104825933A CN201510277585.6A CN201510277585A CN104825933A CN 104825933 A CN104825933 A CN 104825933A CN 201510277585 A CN201510277585 A CN 201510277585A CN 104825933 A CN104825933 A CN 104825933A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- chinese medicine
- medicine preparation
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for treating paralysis and a method for manufacturing the traditional Chinese medicine preparation, and belongs to the field of traditional Chinese medicine. Various traditional Chinese medicinal materials are processed by the aid of the method to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the traditional Chinese medicinal materials mainly including achyranthes bidentata, hematite, oysters, herba artemisiae scopariae, radix asparagi, radix paeoniae rubra, cortex phellodendri, schisandra chinensis, dragon bones, eucommia ulmoides, poria cocos, atractylodes, ophiopogon japonicus, scrophularia ningpoensis, rehmannia glutinosa, angelica sinensis, fineleaf schizonepeta herbs, divaricate saposhnikovia roots, atractylodes lancea, malt and licorice. The traditional Chinese medicine preparation and the method have the advantages that obvious effects for treating the paralysis due to traumatic brain injury, tumor, inflammation, cerebral vascular diseases, transsexualism, intoxication, certain internal medicine diseases and the like can be realized by the traditional Chinese medicine preparation; the preparation is stable in efficacy and little in individual difference and can be conveniently carried and administered, the method for manufacturing the preparation is simple, convenient and feasible and is suitable for industrial mass production, and the traditional Chinese medicine preparation and the method are favorable for popularization.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine preparation for the treatment of paralysis and preparation method thereof.
Technical background
Paralysis is attenuating or the forfeiture of voluntary motor function, and be the common symptom of nervous system, paralysis is caused by upper and lower motor neuron, tractus pyramidalis and peripheral neuropathy.
The traditional Chinese medical science is thought, although paralytic's performance is almost above all hemiplegia, but symptom of having nothing in common with each other.Such as eye askew mouth, tongue Jian strong language, some physical pain, some was dementia, some physical relaxation, some members arrested.This disease is waited numerous and diverse, but dialectical not outer congenital defect and the day after tomorrow lose foster, should hold letter and drive numerous, grasp the essentials, first divide the cause of disease, then distinguish deficiency and excess, treat with card when facing card.Main differentiation of symptoms and signs for classification of syndrome is as follows:
1, deficiency of kidney-essence
Main symptom: quadriplegia, flaccidity weak need not, neck is soft not to be propped up, vertical, row difficulty, and chimney door closes late, mental retardation, lassitude, lusterless complexion, pale tongue, and in vain, thready pulse is micro-unable for tongue fur.
Analyze: assertive evidence by innate deficiency, caused by deficiency of kidney-essence.The kidney generating marrow and dominating bone, deficiency of kidney-essence, muscles and bones is not good for, therefore limbs flaccidity is weak, paralyse, vertical, row is difficult.Brains do not fill, thus mental retardation, lassitude.
Method for the treatment of: life essence-filling, marrow-benefitting, invigorating the kidney and strengthening the bones.
2, the hepatic and renal YIN deficiency
Main symptom: quadriplegia, spasm of muscles and vessels, amyotrophy, athetosis, foot is not just being carried out, dysphonia, time have tic, irritable, hectic fever night sweat, red tongue, few tongue, thready and rapid pulse.
Analyze: assertive evidence by hepatic and renal YIN deficiency, caused by liver-yang is partially high.Liver and kidney asthenia of essence and blood, cannot seek and note in muscles and bones, therefore see quadriplegia.Cloudy virtual loss Re Neisheng, priming liver-wind, therefore see spasm of muscles and vessels, athetosis, time have tic.
Method for the treatment of: the kidney invigorating nourishing the liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. YANG hyperactivity suppressing.
3, weakness of the spleen and stomach
Main symptom: quadriplegia, dull expression, mental retardation, the soft lip of mouth relaxes, masticatory atonia, and saliva goes out can't help, shallow complexion, and nausea is indigestion and loss of appetite, and body of the tongue is talked, and tongue is white, deep and weak pulse.
Analyze: assertive evidence is not enough by taste, caused by biochemical weary source.Weakness of the spleen and stomach, QI and bloodization is raw passive, and muscles and bones muscle loses supports, therefore sees quadriplegia.Insufficiency of vital energy and blood, brains do not fill, therefore see dull expression, mental retardation.The muscle of the main lip of spleen, insufficiency of the spleen then lip is soft thin, masticatory atonia.
Method for the treatment of: during spleen reinforcing is strong, benefiting QI and nourishing blood.
4, blood stagnant in cerebral venation syndrome
Main symptom: limbs flaccidity weak need not, or numb limbs and tense tendons, the hypophrenia, hair is withered, squamous and dry skin, extreme cold of the limbs, purplish tongue, thready and hesitant pulse.
Analyze: assertive evidence is delayed by the course of disease, caused by channels is not too logical.Obstinate disease, QI-blood circulation is smooth, and channels numbness hinders, therefore see that limbs flaccidity is weak need not.Blood vessels are not too logical, therefore see the disease such as numb limbs and tense tendons and extreme cold of the limbs.
Method for the treatment of: blood circulation promoting and blood stasis dispelling, brain-refreshing and channel obstruction-removing.
Summary of the invention
The technical problem to be solved in the present invention is a kind of Chinese medicine preparation helpful to paralysis rehabilitation of invention and preparation method thereof.For solving this technical problem, the technical scheme of inventor is the feature in conjunction with modern pharmaceutical technique, invents brand-new Chinese prescription and an its preparation method, makes it under the prerequisite ensureing drug effect, is applicable to batch production.
A kind of Chinese medicine preparation for the treatment of paralysis of the present invention, be made up of the crude drug of following weight portion: Radix Achyranthis Bidentatae 12-28 part, Haematitum 11-27 part, Concha Ostreae 16-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Asparagi 11-25 part, Radix Paeoniae Rubra 10-24 part, Cortex Phellodendri 10-22 part, Fructus Schisandrae Chinensis 7-17 part, Os Draconis 15-29 part, Cortex Eucommiae 7-15 part, Poria 10-22 part, Rhizoma Atractylodis Macrocephalae 9-21 part, Radix Ophiopogonis 14-28 part, Radix Scrophulariae 11-23 part, Radix Rehmanniae Preparata 8-18 part, Radix Angelicae Sinensis 8-20 part, Herba Schizonepetae 7-16 part, Radix Saposhnikoviae 12-24 part, Rhizoma Atractylodis 12-24 part, Fructus Hordei Germinatus 10-22 part, Radix Glycyrrhizae 7-13 part.
In R&D process, inventor has found the proportioning raw materials that two curative effects are very outstanding, and weight portion is as follows respectively:
1, Radix Achyranthis Bidentatae 20 parts, Haematitum 19 parts, Concha Ostreae 23 parts, Herba Artemisiae Scopariae 14 parts, Radix Asparagi 18 parts, Radix Paeoniae Rubra 17 parts, Cortex Phellodendri 16 parts, Fructus Schisandrae Chinensis 12 parts, Os Draconis 22 parts, the Cortex Eucommiae 11 parts, 16 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 21 parts, Radix Scrophulariae 17 parts, 13 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 14 parts, Herba Schizonepetae 11 parts, Radix Saposhnikoviae 18 parts, Rhizoma Atractylodis 18 parts, 16 parts, Fructus Hordei Germinatus, 10 parts, Radix Glycyrrhizae.
2, Radix Achyranthis Bidentatae 22 parts, Haematitum 18 parts, Concha Ostreae 24 parts, Herba Artemisiae Scopariae 15 parts, Radix Asparagi 17 parts, Radix Paeoniae Rubra 18 parts, Cortex Phellodendri 15 parts, Fructus Schisandrae Chinensis 13 parts, Os Draconis 24 parts, the Cortex Eucommiae 12 parts, 18 parts, Poria, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Ophiopogonis 20 parts, Radix Scrophulariae 19 parts, 12 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 13 parts, Herba Schizonepetae 12 parts, Radix Saposhnikoviae 16 parts, Rhizoma Atractylodis 16 parts, 17 parts, Fructus Hordei Germinatus, 11 parts, Radix Glycyrrhizae.
The preparation method above-mentioned Chinese prescription being made finished product Chinese medicine preparation is following steps:
(1) each taste Chinese crude drugs such as Radix Achyranthis Bidentatae, Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Fructus Schisandrae Chinensis, Os Draconis, the Cortex Eucommiae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus, Radix Glycyrrhizae are taken respectively by Chinese prescription of the present invention;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 80-130 mesh sieve, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 80-130 mesh sieve, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 5-16 times weight, soak 4-24 hour, backflow decocts 1-7 hour, filters, then adds the distilled water of initial weight 3-12 times weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 55-80% of 3-12 times of weight, reflux, extract, 3 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (30-50 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 80-130 mesh sieve, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make clinical required Chinese medicine finished product preparation, as dosage forms such as pill (containing honeyed pill), powder, suspensoid, tincture, tablet, capsule (containing soft capsule), granule, syrup, plaster, patches.
The character feature of the raw materials used medical material of Chinese medicine preparation of the present invention:
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Bitter in the mouth, acid, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Haematitum: this product is oxide-based mineral corundum race bloodstone, main containing iron sesquioxide (Fe2O3).Bitter in the mouth, cold in nature; Return liver, heart channel; Suppressing the hyperactive liver and subsiding YANG, sending down the abnormal ascending QI, hemostasis.
Concha Ostreae: this product is the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Herba Artemisiae Scopariae: this product is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae.Bitter in the mouth, pungent, cold nature; Return spleen, stomach, liver, gallbladder meridian; Clearing away damp-heat, jaundice eliminating subcutaneous ulcer.
Radix Asparagi: this product is the dried root of liliaceous plant Radix Asparagi.Sweet in the mouth, hardship, cold in nature; Return lung, kidney channel; Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.
Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.
Fructus Schisandrae Chinensis: this product is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.Sour in the mouth, sweet, warm in nature; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Os Draconis: for ancient times mammal as if the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex etc.Sweet-puckery flavor, property is put down; GUIXIN, liver, kidney, large intestine channel; Tranquillizing the mind by relieving convulsion, suppressing the hyperactive liver and subsiding YANG, astringent or styptic treatment for spontaneous sweating, convergence.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae.Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Radix Ophiopogonis: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf).Sweet in the mouth, micro-hardship, cold nature; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel; Removing heat from blood YIN nourishing, eliminating fire and detoxication.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae.Sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fills out marrow.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae.Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata.Acrid in the mouth, sweet, warm in nature; Return bladder, liver, spleen channel; Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Fructus Hordei Germinatus: this product is that the mature fruit of grass Fructus Hordei Vulgaris obtains through drying of germinateing.Sweet in the mouth, property is put down; Return spleen, stomach warp; Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of Chinese prescription of the present invention separates:
This Chinese prescription is with Radix Achyranthis Bidentatae, Concha Ostreae, Os Draconis, Haematitum, Radix Asparagi, Radix Ophiopogonis for monarch drug, eliminating blood stasis and inducing menstruation, hard masses softening and resolving, suppressing the hyperactive liver and subsiding YANG, nourishing YIN to relieve dryness; With Radix Saposhnikoviae, Radix Paeoniae Rubra, Cortex Phellodendri, Rhizoma Atractylodis, Radix Scrophulariae, Poria for ministerial drug, the wet relieving convulsion of victory, eliminating stasis to stop pain, pathogenic fire purging are except steaming, expelling wind and cold, removing heat from blood YIN nourishing, eliminating dampness and diuresis; With Herba Artemisiae Scopariae, Radix Angelicae Sinensis, the Cortex Eucommiae, Radix Rehmanniae Preparata for adjuvant drug, clear wet heat of dispelling, enrich blood invigorate blood circulation, the kidney invigorating bone strengthening, nourishing YIN and supplementing blood; With Fructus Schisandrae Chinensis, Fructus Hordei Germinatus, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae for making medicine, supplementing QI for promoting the production of body fluid, promote qi circulation digestion promoting, dampness diuretic, induce sweat loose wind; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, the all medicines of monarch are coordinated, complement each other, jointly reach eliminating blood stasis and inducing menstruation, hard masses softening and resolving, suppressing the hyperactive liver and subsiding YANG, nourishing YIN to relieve dryness, victory wet relieving convulsion, eliminating stasis to stop pain, pathogenic fire purging except steaming, expelling wind and cold, enrich blood invigorate blood circulation, the kidney invigorating bone strengthening, nourishing YIN and supplementing blood, for the paralysis that treatment is caused by craniocerebral trauma, tumor, inflammation, cerebrovascular, degeneration, poisoning and some disease of internal medicine etc., Be very effective.
Compared with prior art, Chinese medicine preparation of the present invention has following technical advantage in treatment paralysis:
1, therapeutic effect is good, and rehabilitation rate is high, and conditioning combines with treatment, without any side effects;
2, preparation efficacy stability, individual variation little, be convenient for carrying and take, alleviate the misery of patient treatment;
3, formulation preparation method is simple and easy to do, is applicable to industrialized mass production, is beneficial to universal.
Detailed description of the invention
In order to check the operability of Chinese prescription of the present invention and preparation method, and provide test drug for follow-up pharmacological toxicology, clinical trial, inventor has carried out the actual production of different prescription proportioning to its Chinese prescription invented, these proportionings are raw material ratio representative within the scope of prescription, they are the minima of often kind of medical material scope, maximum and arbitrary value, also have two preferably proportionings out.Producing the technological parameter adopted is determined optimal operation parameter in R&D process.These embodiments are respectively:
Embodiment 1
(1) by Chinese prescription of the present invention take respectively Radix Achyranthis Bidentatae 12kg, Haematitum 11kg, Concha Ostreae 16kg, Herba Artemisiae Scopariae 8kg, Radix Asparagi 11kg, Radix Paeoniae Rubra 10kg, Cortex Phellodendri 10kg, Fructus Schisandrae Chinensis 7kg, Os Draconis 15kg, Cortex Eucommiae 7kg, Poria 10kg, Rhizoma Atractylodis Macrocephalae 9kg, Radix Ophiopogonis 14kg, Radix Scrophulariae 11kg, Radix Rehmanniae Preparata 8kg, Radix Angelicae Sinensis 8kg, Herba Schizonepetae 7kg, Radix Saposhnikoviae 12kg, Rhizoma Atractylodis 12kg, Fructus Hordei Germinatus 10kg, Radix Glycyrrhizae 7kg;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 100 mesh sieves, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the distilled water of initial weight 8 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 70% of 8 times of weight, reflux, extract, 3 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (40 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make capsule, specification 0.92g crude drug/capsules.
Embodiment 2
(1) by Chinese prescription of the present invention take respectively Radix Achyranthis Bidentatae 28kg, Haematitum 27kg, Concha Ostreae 30kg, Herba Artemisiae Scopariae 20kg, Radix Asparagi 25kg, Radix Paeoniae Rubra 24kg, Cortex Phellodendri 22kg, Fructus Schisandrae Chinensis 17kg, Os Draconis 29kg, Cortex Eucommiae 15kg, Poria 22kg, Rhizoma Atractylodis Macrocephalae 21kg, Radix Ophiopogonis 28kg, Radix Scrophulariae 23kg, Radix Rehmanniae Preparata 18kg, Radix Angelicae Sinensis 20kg, Herba Schizonepetae 16kg, Radix Saposhnikoviae 24kg, Rhizoma Atractylodis 24kg, Fructus Hordei Germinatus 22kg, Radix Glycyrrhizae 13kg;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 100 mesh sieves, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the distilled water of initial weight 8 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 70% of 8 times of weight, reflux, extract, 3 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (40 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make capsule, specification 0.92g crude drug/capsules.
Embodiment 3
(1) by Chinese prescription of the present invention take respectively Radix Achyranthis Bidentatae 13kg, Haematitum 26kg, Concha Ostreae 17kg, Herba Artemisiae Scopariae 10kg, Radix Asparagi 22kg, Radix Paeoniae Rubra 11kg, Cortex Phellodendri 21kg, Fructus Schisandrae Chinensis 8kg, Os Draconis 28kg, Cortex Eucommiae 8kg, Poria 21kg, Rhizoma Atractylodis Macrocephalae 10kg, Radix Ophiopogonis 27kg, Radix Scrophulariae 12kg, Radix Rehmanniae Preparata 17kg, Radix Angelicae Sinensis 9kg, Herba Schizonepetae 15kg, Radix Saposhnikoviae 13kg, Rhizoma Atractylodis 23kg, Fructus Hordei Germinatus 11kg, Radix Glycyrrhizae 12kg;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 100 mesh sieves, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the distilled water of initial weight 8 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 70% of 8 times of weight, reflux, extract, 3 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (40 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make capsule, specification 0.92g crude drug/capsules.
Embodiment 4
(1) by Chinese prescription of the present invention take respectively Radix Achyranthis Bidentatae 20kg, Haematitum 19kg, Concha Ostreae 23kg, Herba Artemisiae Scopariae 14kg, Radix Asparagi 18kg, Radix Paeoniae Rubra 17kg, Cortex Phellodendri 16kg, Fructus Schisandrae Chinensis 12kg, Os Draconis 22kg, Cortex Eucommiae 11kg, Poria 16kg, Rhizoma Atractylodis Macrocephalae 15kg, Radix Ophiopogonis 21kg, Radix Scrophulariae 17kg, Radix Rehmanniae Preparata 13kg, Radix Angelicae Sinensis 14kg, Herba Schizonepetae 11kg, Radix Saposhnikoviae 18kg, Rhizoma Atractylodis 18kg, Fructus Hordei Germinatus 16kg, Radix Glycyrrhizae 10kg;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 100 mesh sieves, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the distilled water of initial weight 8 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 70% of 8 times of weight, reflux, extract, 3 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (40 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make capsule, specification 0.92g crude drug/capsules.
Embodiment 5
(1) by Chinese prescription of the present invention take respectively Radix Achyranthis Bidentatae 22kg, Haematitum 18kg, Concha Ostreae 24kg, Herba Artemisiae Scopariae 15kg, Radix Asparagi 17kg, Radix Paeoniae Rubra 18kg, Cortex Phellodendri 15kg, Fructus Schisandrae Chinensis 13kg, Os Draconis 24kg, Cortex Eucommiae 12kg, Poria 18kg, Rhizoma Atractylodis Macrocephalae 14kg, Radix Ophiopogonis 20kg, Radix Scrophulariae 19kg, Radix Rehmanniae Preparata 12kg, Radix Angelicae Sinensis 13kg, Herba Schizonepetae 12kg, Radix Saposhnikoviae 16kg, Rhizoma Atractylodis 16kg, Fructus Hordei Germinatus 17kg, Radix Glycyrrhizae 11kg;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 100 mesh sieves, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the distilled water of initial weight 8 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 70% of 8 times of weight, reflux, extract, 3 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and low temperature (40 DEG C) vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make capsule, specification 0.92g crude drug/capsules.
the toxicity test of Chinese medicine preparation of the present invention
In order to check the safety of the clinical application of Chinese medicine preparation of the present invention, for clinical trial below provides Data support, the capsule that inventor utilizes embodiment 1-5 to produce has carried out animal toxicity experiment:
1, acute toxicity testing
(1) capsule that test drug: embodiment of the present invention 1-5 produces, abolishes capsule shells, and adding distil water is modulated into the magma of required concentration, for subsequent use;
(2) experimental animal: regular grade Kunming mouse, body weight 21g ± 2g, male and female half and half, female mice is all without pregnant; Thered is provided by laboratory animal research center, Beijing.
(3) test method and result:
This product is because recording median lethal dose(LD 50) (LD by the restriction of liquor strength, gastric infusion volume
50), with gastric infusion 3 times (4 hours, interval) in maximum liquor strength (0.62g/ml) and the maximum administration volume of animal (0.4ml/10g body weight) a day, in one day, maximum dosage is 74.4g/kg.For 323.5 times of adult's clinical medicine dose (0.23g/kg/d).Continuous Observation 14 days, under this dosage, animal does not all occur that overt toxicity reacts.After administration, all animals body weight increases gradually, in 14 days animal none is dead, have no any toxic reaction, also do not find toxicity target organ, in illustrate that embodiment of the present invention 1-5 produces 5, capsule is without acute toxicity.
2, long term toxicity test
(1) capsule that test drug: embodiment of the present invention 1-5 produces, abolishes capsule shells, and adding distil water is modulated into the magma of required concentration, for subsequent use;
(2) experimental animal: regular grade SD rat, body weight 221g ± 8g, male and female half and half, female rats is all without pregnant; Thered is provided by laboratory animal research center, Beijing.
(3) test method and result:
Method: according to rat pharmacodynamics effective dose and the clinical plan daily dose of this product, this EXPERIMENTAL DESIGN three dosage groups, a matched group.3 dosage component Wei 41.4g/kg, 13.8g/kg and 4.6g/kg group, be respectively 180,60,20 times of adult's clinical medicine dose, matched group gives the normal saline of 20 times, often organize 40 rats, male and female half and half, oral administration gavage administration 3 times every day, administration volume 2ml/100g body weight, Per-Hop behavior 6 days, successive administration 26 weeks.The outward appearance behavior of duration of test to rat is observed, is detected the index such as body weight, food ration, and terminate to calculate organ coefficient respectively at administration 13 weekend, 26 ends and surrounding convalescent period, carry out hematology, blood biochemical analysis detects and histopathologic examination.
Result: duration of test, each administration treated animal behavioral activity and the performance without exception of outward appearance sign; The growth of each administration treated animal food ration, body weight has no significant effect, and compares without difference (P > 0.05) with matched group; Each administration group does not find the harmful effect relevant to drug toxicity to the index such as hematology and blood biochemical analysis, compares without difference (P > 0.05) with matched group; Each administration treated animal organs and tissues mode of appearance, position and internal organs tangent plane no abnormality seen, administration 13 weekend, 26 weekend spleen with thymus organ coefficient compared with matched group without significant difference (P > 0.05 or P > 0.01), other organ coefficient has no significant effect (comparing P > 0.05 with matched group); The pathological change relevant to medicine is not found in this product 41.4g/kg treated animal internal organs.
3, conclusion: by acute toxicity testing and long term toxicity test, result shows that Chinese medicine preparation of the present invention did not both have acute toxicity, does not also have long term toxicity, also without retardance toxic reaction, the capsule clinical drug safety that embodiment of the present invention 1-5 produces is described.
the pharmacodynamic study of Chinese medicine preparation of the present invention
In order to check the clinical drug effect of Chinese medicine preparation of the present invention, inventor has carried out pharmacodynamic study with the capsule that the embodiment of the present invention 5 is produced:
1 Chinese medicine preparation of the present invention is tested mice soft bus wire
1.1 experiment material
1.1.1 laboratory animal:
KM mice 80, body weight 20 ± 2g, Mus 45-50 days in age, male and female half and half, by the Academy of Medical Sciences, Beijing, institute of lab animals provides, and at room temperature 22-24 DEG C, raises, freely drink water and ingest under light and shade cycle 12h/12h condition.
1.1.2 medicine and reagent:
Investigational agent: the capsule that the embodiment of the present invention 5 is produced, specification 0.92g crude drug/capsules;
Contrast medicine: nimodipine tablet, Jiangsu Ju Rong pharmacy Group Co., Ltd; Noradrenaline bitartrate injection, Shanghai Hefeng Pharmaceutical Co., Ltd..
1.1.3 key instrument and reagent is tested:
XTW-CTV microcirculation color television microscope, Tyke, Beijing Instrument Ltd. produces.
1.2 experimental technique
Get mice 100, be divided into 5 groups, be i.e. blank group, nimodipine matched group (positive controls), the high, medium and low dosage group of Chinese medicine preparation of the present invention; The dosage of high, medium and low group is respectively clinical people's consumption 40,20,10 times (18.4g/kg, 9.2 g/kg, 4.6g/kg), often organizes 20 respectively.Successive administration is after 7 days, after the anesthesia of lumbar injection 1% pentobarbital sodium, ventral decubitus head is fixed, and calvarium center skin T-shape cuts, with the outer 3mm of sagittal suture, under coronal suture centered by 3mm, raise skull with knife blade, expose pia mater encephali, form the cranium window that a diameter is about 5mm, add normal saline 20ul, start test after post surgery stabilization 30min, whole process of the test keeps animal heat 37 DEG C.Diameter is selected to be 30-50um arteriole blood vessel under laboratory animal being placed in microcirculation microscope, stablize 30min, survey pipe diameter size, drip the NA10ul of 0.1% again, the change of arteriole blood vessels caliber size when dripping 3min, 9min after NA with XTW-CTV microcirculation color television microscope by means of JS micrometer ocular Continuous Observation.Microcirculatory color, every intertexture site, visual field number after the NA observing normal pia mater encephali simultaneously and drip 0.1%.The results are shown in Table 1, table 2.
Table 1 on the impact in mice pial arteriole blood vessels caliber (every visual field) (
, n=20)
Note: compare with blank group, * P < 0.05, * * P < 0.01.
Table 2 on the impact of mice pia mater encephali blood capillary intertexture site number (every visual field) (
, n=20)
Note: compare with blank group, * P < 0.05, * * P < 0.01.
1.3 conclusion
From table 1, table 2, relative to blank group, Yan Junke improves the rat's pial local microcirculation obstacle caused by norepinephrine to each group of drug test in various degree, and make arteriole vasodilation, blood flow speeds, and every visual field intertexture net number increases; Compared with positive controls, the effect low dose group of Chinese medicine preparation of the present invention is slightly excellent, and high, middle dosage group is then obviously better than contrasting medicine.
The test of 2 Chinese medicine preparation of the present invention anti-A β hippocampal injection dementia rats model
2.1 experiment material
2.1.1 laboratory animal
SPF level SD rat, at the 3-4 monthly age, male and female dual-purpose half and half, body weight 210 ± 10g, buys from Guangdong Medical Lab Animal Center.Rat, all at room temperature 22-24 DEG C, is raised under light and shade cycle 12h/12h condition, freely drinks water and ingest.
2.1.2 experimental drug
Experimental drug: the capsule that the embodiment of the present invention 5 is produced, specification 0.92g crude drug/capsules;
Contrast medicine: donepezil hydrochloride (aricept), defends material (China) pharmaceutical Co. Ltd and produces;
Reagent: amyloid fragment (A β 25-35, SIGMA company).
2.2 methods and result
2.2.1 prepared by A β burin-in process and model
(final concentration is 2 μ g μ l A β 25-35 to be dissolved in normal saline
-1), it is aging for subsequent use that 37 DEG C of calorstats hatch 72h.List of references prepares model.Rat 0.3% pentobarbital sodium is anaesthetized (30mgkg
-1, ip) after, preserved skin, rat is fixed on brain solid positioner, after povidone iodine and 75% ethanol routine disinfection scalp, cut one with aseptic operation cutter at rat scalp median line place and be about 1.5cm stringer otch, expose bregma, blunt separation subcutaneous tissue and periosteum, then according to rat brain stereotaxic atlas, first 3.0mm after rat bregma, 2.0mm place, right side bores by aseptic dental burr and opens skull, Hippocampus back on the right side of rat is entered from skull tapping with 5 μ l microsyringes, depth of needle 3.3mm, slowly at the uniform velocity inject 5 μ l condensed state A β 25-35, injection speed is 1ulmin
-1, 5min injection is complete, and let the acupuncture needle remain at a certain point 2min slowly removes pin, same method, at left hippocampus dorsal injection 5 μ l condensed state A β 25-35, causes dementia like rat model.Postoperative sewing-up cut, sterilization, sham operated rats injects isometric normal saline, postoperatively freely raises one week.
2.2.2 grouping and administration
100 animal patterns of survival are divided into 5 groups at random according to body weight, i.e. the positive group (1.4mgkg in Shen in model control group, peace
-1) and the high, medium and low dosage group of Chinese medicine preparation of the present invention; The dosage of high, medium and low group is respectively clinical people's consumption 40,20,10 times (18.4g/kg, 9.2 g/kg, 4.6g/kg), often organizes 20 respectively.Separately get with batch 20 normal rats, same operational approach, 5 μ l normal saline are respectively injected as blank group in Hippocampus back, both sides.Except blank group and model control group rat ig give except isopyknic normal saline, all the other respectively organize the corresponding medicine of rat ig, and administration volume is 10mlkg
-1body weight, qd, continuous ig administration 90d.
1.2.3 the test learning and memory in rats ability constant-bearing navigation of Morris water maze and space exploration list of references carry out, and record escape latency in 2min and the first-phase limit time of staying, platform time of staying and through platform number of times respectively, the results are shown in Table 3 and table 4.
Table 3 pharmaceutical composition of the present invention on the impact of A β injection model escape latency (
, n=20)
Note: compare with blank group, * P < 0.05, * * P < 0.01.
Table 4 pharmaceutical composition of the present invention on the impact of A β injection model space exploration (
, n=20)
Note: compare with blank group, * P < 0.05, * * P < 0.01.
2.3 conclusion
From table 3 and table 4: model group compares with blank group, escape latency and third quadrant time equal significant prolongation, first-phase all significantly shortens with effective district in limited time the time of staying, has significant statistical significance (P < 0.01); Administration group compares with model group, pharmaceutical composition of the present invention high, medium and low dosage group escape latency train the 3rd day and the 5th day comparatively model control group significantly shorten, the third quadrant time comparatively model control group significantly shorten, first-phase in limited time between and then significant prolongation of effective time of staying, have significant statistical significance (P < 0.05).Point out pharmaceutical composition of the present invention to have the effect of the function improving rat model learning and memory, and compared with positive controls, the effect low dose group of Chinese medicine preparation of the present invention is slightly excellent, high, middle dosage group is then obviously better than contrasting medicine.
3 pharmacodynamic experiment conclusions
To sum up several description of test, Chinese medicine preparation of the present invention not only can improve the rat's pial local microcirculation obstacle caused by norepinephrine effectively, and make arteriole vasodilation, blood flow speeds, and every visual field intertexture net number increases; Effectively can also improve the function of rat model learning and memory.Therefore, Chinese medicine preparation of the present invention has good repairing and treating effect to nerve injury, thus can play a great role to the rehabilitation of paralysis.
the clinical trial of Chinese medicine preparation of the present invention
In order to verify the clinical effectiveness of Chinese medicine preparation of the present invention further, inventor has carried out clinical trial with the capsule that embodiment 5 is produced:
Inventor collects 172 paralysed patients and take part in clinical trial, this 172 patient age 24-68 year, man 93 example, female 79 example; The course of disease 3 months-10 years.Capsule manufactured by the oral embodiment of the present invention 5 of all patients, specification 0.92g crude drug/capsules; Every day 3 times, each 54 weeks is a course for the treatment of, treats 5 courses for the treatment of continuously.
Treatment evaluation criterion: cure: the symptom of paralysis disappears completely, is made a definite diagnosis fully recover by doctor; Effective: the symptom of paralysis is clearly better or significantly alleviates; Effective: some symptom of paralysis alleviates or makes moderate progress; Invalid: the symptom of paralysis does not change even more serious.
After treatment all terminates, by therapeutic outcome statistical analysis be: cure 11 examples, account for 6.4%; Effective 106 examples, account for 61.6%; Effective 42 examples, account for 24.4%; Invalid 13 examples, account for 7.6%.
Result of the test shows, and the cure rate of the capsule that the embodiment of the present invention 5 is produced adds obvious effective rate and reaches 67.4%, and total effective rate reaches 92.4%; Therefore, this result of the test proves further, and Chinese medicine preparation of the present invention has very significant curative effect and technical advantage in treatment paralysis, and the present invention achieves creationary technological innovation, and the rehabilitation for paralysed patient provides a new way.
Claims (5)
1. treat a Chinese medicine preparation for paralysis, it is characterized in that being made up of the crude drug of following weight portion: Radix Achyranthis Bidentatae 12-28 part, Haematitum 11-27 part, Concha Ostreae 16-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Asparagi 11-25 part, Radix Paeoniae Rubra 10-24 part, Cortex Phellodendri 10-22 part, Fructus Schisandrae Chinensis 7-17 part, Os Draconis 15-29 part, Cortex Eucommiae 7-15 part, Poria 10-22 part, Rhizoma Atractylodis Macrocephalae 9-21 part, Radix Ophiopogonis 14-28 part, Radix Scrophulariae 11-23 part, Radix Rehmanniae Preparata 8-18 part, Radix Angelicae Sinensis 8-20 part, Herba Schizonepetae 7-16 part, Radix Saposhnikoviae 12-24 part, Rhizoma Atractylodis 12-24 part, Fructus Hordei Germinatus 10-22 part, Radix Glycyrrhizae 7-13 part.
2. the Chinese medicine preparation for the treatment of paralysis as claimed in claim 1, is characterized in that being made up of the crude drug of following weight portion: Radix Achyranthis Bidentatae 20 parts, Haematitum 19 parts, Concha Ostreae 23 parts, Herba Artemisiae Scopariae 14 parts, Radix Asparagi 18 parts, Radix Paeoniae Rubra 17 parts, Cortex Phellodendri 16 parts, Fructus Schisandrae Chinensis 12 parts, Os Draconis 22 parts, the Cortex Eucommiae 11 parts, 16 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 21 parts, Radix Scrophulariae 17 parts, 13 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 14 parts, Herba Schizonepetae 11 parts, Radix Saposhnikoviae 18 parts, Rhizoma Atractylodis 18 parts, 16 parts, Fructus Hordei Germinatus, 10 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of paralysis as claimed in claim 1, is characterized in that being made up of the crude drug of following weight portion: Radix Achyranthis Bidentatae 22 parts, Haematitum 18 parts, Concha Ostreae 24 parts, Herba Artemisiae Scopariae 15 parts, Radix Asparagi 17 parts, Radix Paeoniae Rubra 18 parts, Cortex Phellodendri 15 parts, Fructus Schisandrae Chinensis 13 parts, Os Draconis 24 parts, the Cortex Eucommiae 12 parts, 18 parts, Poria, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Ophiopogonis 20 parts, Radix Scrophulariae 19 parts, 12 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 13 parts, Herba Schizonepetae 12 parts, Radix Saposhnikoviae 16 parts, Rhizoma Atractylodis 16 parts, 17 parts, Fructus Hordei Germinatus, 11 parts, Radix Glycyrrhizae.
4. prepare as arbitrary in claim 1-3 as described in the method for Chinese medicine preparation for the treatment of paralysis, it is characterized in that comprising following processing step:
(1) each taste Chinese crude drugs such as Radix Achyranthis Bidentatae, Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Fructus Schisandrae Chinensis, Os Draconis, the Cortex Eucommiae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus, Radix Glycyrrhizae are taken respectively by Chinese prescription of the present invention;
(2) Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae are pulverized respectively, parch is levigate, crosses 80-130 mesh sieve, obtains fine powder a, for subsequent use;
(3) Os Draconis, Radix Rehmanniae Preparata, Radix Scrophulariae are pulverized respectively, drying and grinding, cross 80-130 mesh sieve, obtain fine powder b, for subsequent use;
(4) Haematitum, Concha Ostreae, Herba Artemisiae Scopariae, Radix Asparagi, Radix Paeoniae Rubra, Cortex Phellodendri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Angelicae Sinensis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Atractylodis, Fructus Hordei Germinatus are pulverized and mixed respectively, add the distilled water of initial medical material 5-16 times weight, soak 4-24 hour, backflow decocts 1-7 hour, filters, then adds the distilled water of initial weight 3-12 times weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.21 is for subsequent use;
(5) filtering residue of step (4) is added the ethanol of the concentration 55-80% of 3-12 times of weight, reflux, extract, 3 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.21 is for subsequent use;
(6) merged by the concentrated solution of step (4) and (5) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.33-1.37, and at 30-50 DEG C, vacuum drying is to dry extract, pulverizes levigate, crosses 80-130 mesh sieve, obtains fine powder c, for subsequent use;
(7) by fine powder a, b, c mix homogeneously, be Effective Component of Chinese Medicine fine powder, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make clinical required Chinese medicine finished product preparation.
5. the Chinese medicine preparation of the treatment paralysis as described in as arbitrary in claim 1-3, is characterized in that: the dosage form of described Chinese medicine preparation is: pill, powder, suspensoid, tincture, tablet, capsule, granule, syrup, plaster or patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510277585.6A CN104825933A (en) | 2015-05-27 | 2015-05-27 | Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510277585.6A CN104825933A (en) | 2015-05-27 | 2015-05-27 | Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104825933A true CN104825933A (en) | 2015-08-12 |
Family
ID=53804376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510277585.6A Withdrawn CN104825933A (en) | 2015-05-27 | 2015-05-27 | Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104825933A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259209A (en) * | 2008-04-10 | 2008-09-10 | 北京万寿通医药科技有限公司 | Chinese medicine preparation for treating asthenia |
| CN101869600A (en) * | 2010-07-05 | 2010-10-27 | 成都中医药大学 | Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof |
| CN102973678A (en) * | 2012-12-26 | 2013-03-20 | 房守和 | Chinese medicinal formulae for treating cerebral apoplexy and method of application thereof |
| CN103156876A (en) * | 2013-04-12 | 2013-06-19 | 成都中医药大学 | Medicine composition for treating central nervous system diseases and preparation method and application thereof |
| CN103181954A (en) * | 2013-04-12 | 2013-07-03 | 成都中医药大学 | Medicine composition used for treating neurodegenerative disease as well as preparation method and application thereof |
| CN104524167A (en) * | 2014-12-19 | 2015-04-22 | 崔合芳 | Traditional Chinese medicine preparation for treating liver cirrhosis and liver ascites and preparation method of traditional Chinese medicine preparation |
| CN104547486A (en) * | 2014-12-29 | 2015-04-29 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating anemia and qi-deficiency weakness and preparation process for traditional Chinese medicine preparation |
-
2015
- 2015-05-27 CN CN201510277585.6A patent/CN104825933A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259209A (en) * | 2008-04-10 | 2008-09-10 | 北京万寿通医药科技有限公司 | Chinese medicine preparation for treating asthenia |
| CN101869600A (en) * | 2010-07-05 | 2010-10-27 | 成都中医药大学 | Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof |
| CN102973678A (en) * | 2012-12-26 | 2013-03-20 | 房守和 | Chinese medicinal formulae for treating cerebral apoplexy and method of application thereof |
| CN103156876A (en) * | 2013-04-12 | 2013-06-19 | 成都中医药大学 | Medicine composition for treating central nervous system diseases and preparation method and application thereof |
| CN103181954A (en) * | 2013-04-12 | 2013-07-03 | 成都中医药大学 | Medicine composition used for treating neurodegenerative disease as well as preparation method and application thereof |
| CN104524167A (en) * | 2014-12-19 | 2015-04-22 | 崔合芳 | Traditional Chinese medicine preparation for treating liver cirrhosis and liver ascites and preparation method of traditional Chinese medicine preparation |
| CN104547486A (en) * | 2014-12-29 | 2015-04-29 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating anemia and qi-deficiency weakness and preparation process for traditional Chinese medicine preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104491801A (en) | Traditional Chinese medicine preparation for treating acute or chronic gastritis and preparation method thereof | |
| CN104225417A (en) | Traditional Chinese medicine composition with function of assisting improvement of memory and preparation method thereof | |
| CN104887747A (en) | Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method therefor | |
| CN104352793A (en) | Traditional Chinese medicine preparation for treating gastrointestinal bleeding and preparation method thereof | |
| CN112057501A (en) | Traditional Chinese medicine composition, traditional Chinese medicine ointment and external hot compress plaster for treating muscular atrophy and myasthenia | |
| CN105311492A (en) | Medicine for treating coronary atherosclerotic heart disease | |
| CN105343660A (en) | Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation | |
| CN104225507A (en) | Chinese medicine for treating limb paralysis and pain caused by cerebral hemorrhage | |
| CN101112498B (en) | Chinese traditional medicine having functions of promoting blood circulation, relaxing vein and strengthening muscles and bones and method for preparing the same | |
| CN103920058A (en) | Traditional Chinese medicine preparation for treating headache and preparation method thereof | |
| CN105343675A (en) | Traditional Chinese medicine preparation for treating adiposis and preparation method thereof | |
| CN105343808A (en) | Traditional Chinese medicine composition with weight reducing effect and preparation method of traditional Chinese medicine composition | |
| CN104800610A (en) | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof | |
| CN104548020A (en) | Application of medicine composition in preparing medicine curing senile dementia | |
| CN104825933A (en) | Traditional Chinese medicine preparation for treating paralysis and method for manufacturing traditional Chinese medicine preparation | |
| CN104645080A (en) | Traditional Chinese medicine preparation for treating dizziness and preparation method of traditional Chinese medicine preparation | |
| CN104740210B (en) | A kind of Chinese medicine and preparation method for the treatment of qi stagnation and blood stasis type craniocerebral trauma syndrome | |
| CN105267349A (en) | Traditional Chinese medicine preparation for treating prosopalgia | |
| CN1316989C (en) | Capsule with dried human placemta and red sage root and its preparing process | |
| CN105326948A (en) | Method for preparing traditional Chinese medicine preparation for treating prosopalgia | |
| CN104971236A (en) | Traditional Chinese medicine preparation for treating prosopalgia and preparation method thereof | |
| CN105709060A (en) | Application of traditional Chinese medicine preparation in preparing medicine for treating viral myocarditis | |
| CN104547865A (en) | Application of traditional Chinese medicine preparation in preparing medicine for treating senile dementia | |
| CN104491602A (en) | Traditional Chinese medicine for treating chronic heart failure, premature beat and arrhythmia and preparation method thereof | |
| CN105288212A (en) | Traditional Chinese medicine composition for treating yin deficiency fire excess type insomnia and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20150812 |