CN104825857A - Traditional Chinese medicine preparation used for treating child suppurative tonsillitis, and preparation method thereof - Google Patents
Traditional Chinese medicine preparation used for treating child suppurative tonsillitis, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation used for treating child suppurative tonsillitis, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine preparation comprises following main raw materials, radix glehniae, honeysuckle flower, herba houttuyniae, agastache rugosus, fructus forsythiae, radix isatidis, blackberry lily, radix scrophulariae, platycodon grandiflorum, gypsum, dandelion, radix peucedani, rhizoma phragmitis, frankincense, chrysanthemum flower, and licorice. The traditional Chinese medicine preparation can be prepared from the raw materials above via the preparation method at a certain ratio. The traditional Chinese medicine preparation possesses excellent curative effects on child suppurative tonsillitis; and technical advantages are excellent compared with that of the prior art.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of children's's suppurative tonsillitis.
Background technology
The pathogen majority of suppurative tonsillitis is Hemolytic streptococcus, is secondly hemophilus influenza, streptococcus pneumoniae, staphylococcus etc.Onset is anxious, and pharyngalgia obviously, how with high heat, fear of cold, body temperature can reach more than 39 DEG C.Have a medical check-up and can find antiadoncus, hyperemia, there is yellow purulent secretion on surface.Sometimes with submandibular lymph nodes enlargement, tenderness, the absence of signs and pulmonary haves a medical check-up.
In the traditional Chinese medical science, suppurative tonsillitis is called as tonsillitis or throat moth.Mean pharyngeal tonsils (i.e. tonsil) one or both sides congestion and swelling pain, surface has yellow-white pus point as seen, and its shape is as the disease of Bombycis mori.See that " skin infection experience pandect " rolls up one.Primary disease is many to be stopped up by lung gastric heat, and fire-toxin is fumigated caused by the throat; Control suitable wind and heat dispersing, subduing swelling and detoxicating.In addition, stagnation of QI expectorant coagulates old expectorant liver-fire and ties mutually, also can cause primary disease after sense heresy, and controlling should clearing away heat and eliminating phlegm.The hepatic and renal YIN deficiency, the smoked throat that burns of hyperactivity of deficient fire also can cause primary disease, and controlling should nourishing YIN to lower pathogenic fire.
1, dialectical analysis
Primary disease is deficient with internal organs, and hyperactivity of deficient fire is Etiological pathology.Many because controlling in acute tonsillitis caused by pathogenic windheat or acute pharyngitis due to wind-heat and do not heal, with the passing of time touching, pathogenic heat damaging YIN and causing, or after epidemic febrile disease, waste heat is clear and send out.Internal organs are deficient is many with deficiency of lung-YIN, deficiency of the kidney yin.Deficiency of lung-YIN, then body fluid can not be gone up defeated to nourish throat, yin asthenia generating intrinsic heat, hyperactivity of deficient fire, and burning in pharyngeal tonsils is disease.Deficiency of the kidney yin, asthenic fire is followed through upper inflammation, and tying in pharyngeal tonsils is disease.Children's's internal organs are weak, and shape gas does not fill, and easily by exopathogen is felt, not only cloudy liquid is injured after being ill, and yang-energy is also often impaired, and resistance against diseases goes down, even if evil poison does not weigh, also not easy-clear and be stranded in pharyngeal tonsils, becomes primary disease then.Total Therapeutic Method is nourishing YIN and clearing away lung-heat, nourishing YIN to lower pathogenic fire.
2, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs
(1) damage of kidney-YIN type
Card is shown in: Yan Hou Gan inflammation is uncomfortable, and hypodynia, chokes unfavorable, xerostomia does not like polydipsia, flushing before and after pharyngeal tonsils and pharyngeal tonsils, on pharyngeal tonsils or have yellow-white pus point, during extruding pharyngeal tonsils or have yellow-white pus sample thing to overflow, whole body also has dizziness and blurred vision, Hiccough and deaf, soreness of the waist and knees, fidgets due to deficiency is had a sleepless night, the few tongue of red tongue, thready and rapid pulse etc.Method for the treatment of: nourishing YIN to lower pathogenic fire, clearing throat.
(2) lung yin deficiency
Card is shown in: pharyngeal Gan inflammation is uncomfortable, hypodynia, micro-ly to itch, dry cough without phlegm or expectorant few and sticky, choke unfavorable, pharyngeal tonsils be loose, flushing, connect and, pharyngeal tonsils have yellow-white pus point around.Generally obvious with afternoon symptom, and can with afternoon flushed cheeks, metal fatigue, feverish sensation in the palms and soles, talks weak, red tongue, few tongue, thready and rapid pulse.Method for the treatment of: nourishing YIN and clearing away lung-heat, promotes the production of body fluid and moisturizes.
Summary of the invention
The technical problem to be solved in the present invention is a kind of new Chinese medicine preparation of exploitation, makes it have good therapeutic effect to children's's suppurative tonsillitis.Inventor takes following technical scheme and solves above-mentioned technical problem: inventor sum up traditional proved recipe and self for many years take up a job as a doctor on the basis of experience, meticulous compatibility medical material, the feature of modern pharmaceutical technology and preparation technique is taken into full account in the process of prescription, it is made to adapt to the needs of suitability for industrialized production, and through clinical repeated examinations, adjustment, finally, inventor has invented a brand-new Chinese prescription and has been made into the preparation technology of finished product Chinese medicine preparation, thus obtained Chinese medicine preparation is to dental ulcer of infant, suppurative tonsillitis, the diseases such as parotitis all have significant therapeutic effect.The raw medicinal material of the Chinese prescription of this Chinese medicine preparation is expressed as follows with weight portion:
Radix Glehniae 10-24 part, Flos Lonicerae 13-27 part, Herba Houttuyniae 8-22 part, Herba Pogostemonis 7-15 part, Fructus Forsythiae 7-17 part, Radix Isatidis 11-25 part, Rhizoma Belamcandae 6-10 part, Radix Scrophulariae 12-28 part, Radix Platycodonis 7-19 part, Gypsum Fibrosum 16-28 part, Herba Taraxaci 12-26 part, Radix Peucedani 11-23 part, Rhizoma Phragmitis 10-22 part, Olibanum 4-8 part, Flos Chrysanthemi 12-26 part, Radix Glycyrrhizae 7-14 part.
In R&D process, sum up 4 prescription proportionings with optimum therapeuticing effect and be respectively (with parts by weight):
1, Radix Glehniae 17 parts, Flos Lonicerae 20 parts, Herba Houttuyniae 15 parts, Herba Pogostemonis 11 parts, Fructus Forsythiae 12 parts, Radix Isatidis 18 parts, Rhizoma Belamcandae 8 parts, Radix Scrophulariae 20 parts, Radix Platycodonis 13 parts, Gypsum Fibrosum 22 parts, Herba Taraxaci 19 parts, Radix Peucedani 17 parts, Rhizoma Phragmitis 16 parts, Olibanum 6 parts, Flos Chrysanthemi 19 parts, 11 parts, Radix Glycyrrhizae.
2, Radix Glehniae 19 parts, Flos Lonicerae 22 parts, Herba Houttuyniae 14 parts, Herba Pogostemonis 11 parts, Fructus Forsythiae 14 parts, Radix Isatidis 16 parts, Rhizoma Belamcandae 8 parts, Radix Scrophulariae 22 parts, Radix Platycodonis 15 parts, Gypsum Fibrosum 21 parts, Herba Taraxaci 18 parts, Radix Peucedani 16 parts, Rhizoma Phragmitis 15 parts, Olibanum 6 parts, Flos Chrysanthemi 18 parts, 12 parts, Radix Glycyrrhizae.
3, Radix Glehniae 18 parts, Flos Lonicerae 21 parts, Herba Houttuyniae 16 parts, Herba Pogostemonis 12 parts, Fructus Forsythiae 13 parts, Radix Isatidis 19 parts, Rhizoma Belamcandae 7 parts, Radix Scrophulariae 21 parts, Radix Platycodonis 12 parts, Gypsum Fibrosum 24 parts, Herba Taraxaci 17 parts, Radix Peucedani 16 parts, Rhizoma Phragmitis 14 parts, Olibanum 7 parts, Flos Chrysanthemi 18 parts, 12 parts, Radix Glycyrrhizae.
4, Radix Glehniae 16 parts, Flos Lonicerae 18 parts, Herba Houttuyniae 16 parts, Herba Pogostemonis 13 parts, Fructus Forsythiae 14 parts, Radix Isatidis 19 parts, Rhizoma Belamcandae 9 parts, Radix Scrophulariae 24 parts, Radix Platycodonis 14 parts, Gypsum Fibrosum 23 parts, Herba Taraxaci 20 parts, Radix Peucedani 18 parts, Rhizoma Phragmitis 14 parts, Olibanum 5 parts, Flos Chrysanthemi 17 parts, 11 parts, Radix Glycyrrhizae.
Preparation technology Chinese prescription of the present invention being made finished product Chinese medicine preparation is following steps:
(1) take Radix Glehniae, Flos Lonicerae, Herba Houttuyniae, Herba Pogostemonis, Fructus Forsythiae, Radix Isatidis, Rhizoma Belamcandae, Radix Scrophulariae, Radix Platycodonis, Gypsum Fibrosum, Herba Taraxaci, Radix Peucedani, Rhizoma Phragmitis, Olibanum, Flos Chrysanthemi, Radix Glycyrrhizae ingredients respectively by Chinese prescription, pulverize respectively, for subsequent use;
(2) all medical materials are added the purified water of initial medical material 6-13 times weight, soak 6-24 hour, backflow decocts 1-5 hour, filter, add the purified water of initial weight 3-9 times weight again, backflow decocts 1-4 hour, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.23-1.27 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 50-80% of 5-11 times of weight, reflux, extract, 2 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.23-1.27 is for subsequent use;
(4) merged by the concentrated solution of step (2) and (3) gained, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5) Chinese medical concrete of step (4) is added adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs, the dosage forms such as such as pill, tincture, capsule, tablet, granule, oral liquid, powder, syrup.
The source of the raw materials used medical material of Chinese medicine preparation of the present invention, meridian distribution of property and flavor and special efficacy:
Radix Glehniae: this product is the dry root of samphire glehnia littoralis.Sweet in the mouth, micro-hardship, cold nature; Attach to the lung and stomach meridians; Nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.
Flos Lonicerae: the flower that this product is caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis or band are just opened.Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, wind-heat dissipating.
Herba Houttuyniae: this product is the dry aerial parts of saururaceae plant houttuynia cordata.Acrid in the mouth, cold nature; Return lung meridian; Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Herba Pogostemonis: be the herb of labiate Herba Pogostemonis or Herba Pogostemonis.Acrid in the mouth, slightly warm in nature; Enter lung, spleen, stomach warp; Fast gas, and in, ward off dirty, damp eliminating.
Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae.Bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Radix Isatidis: this product is the dry root of cruciferae isatis.Bitter in the mouth, cold in nature; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
Rhizoma Belamcandae: this product is the dry rhizome of irides Rhizoma Belamcandae.Bitter in the mouth, cold in nature; Return lung meridian; Heat-clearing and toxic substances removing, expectorant, sore-throat relieving.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel; Removing heat from blood YIN nourishing, eliminating fire and detoxication.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis.Bitter in the mouth, pungent, property is put down; Return lung meridian; Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.
Gypsum Fibrosum: this product is Sulfates mineral anhydrite race Gypsum Fibrosum, main containing hydrous calcium sulfate (CaSO42H2O), after excavating, removing silt and assorted stone.Sweet in the mouth, pungent, property Great Cold; Attach to the lung and stomach meridians; Clearing away heat-fire, relieving restlessness is quenched the thirst.
Herba Taraxaci: this product is feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together.Bitter in the mouth, sweet, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Radix Peucedani: this product is the dry root of samphire Peucedanum praeruptorum DUNN or RADIX PEUCEDANI.Bitter in the mouth, pungent, cold nature; Return lung meridian; Loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.
Rhizoma Phragmitis: this product is the fresh of grass phragmites communis or dry rhizome.Sweet in the mouth, cold in nature; Attach to the lung and stomach meridians; Clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.
Olibanum: Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii etc., is used as medicine with the oleo-gum-resin that its trunk skin zone wound oozes out.Acrid in the mouth is bitter, warm in nature; Enter the heart, liver, spleen channel; Regulating qi and activating blood, analgesic therapy, chases after poison.
Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum.Sweet in the mouth, hardship, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of the Chinese prescription of Chinese medicine preparation of the present invention separates:
This prescription is with Flos Lonicerae, Radix Scrophulariae, Gypsum Fibrosum, Herba Taraxaci, Flos Chrysanthemi for monarch drug, heat-clearing and toxic substances removing, removing heat from blood YIN nourishing, clearing away heat-fire, dispersing swelling and dissipating binds; With Radix Glehniae, Herba Houttuyniae, Radix Isatidis, Radix Peucedani for ministerial drug, nourishing YIN and clearing away lung-heat, eliminating carbuncle evacuation of pus, removing heat from blood sore-throat relieving, lowering the adverse-rising QI to resolve phlegm; With Rhizoma Phragmitis, Fructus Forsythiae, Radix Platycodonis, Rhizoma Belamcandae for adjuvant drug, clearing away heat and promoting diuresis, dispersing swelling and dissipating binds, evacuation of pus of eliminating the phlegm, resolving toxin and disinhibiting the throat; With Herba Pogostemonis, Olibanum for making medicine, fast gas and in, analgesic therapy chases after poison; With all taste property of medicine of Radix Glycyrrhizae mediation monarch, the all medicines of monarch are made respectively to take charge of its position, yin yang complementarity, synergism, thus reach heat-clearing and toxic substances removing, removing heat from blood YIN nourishing, dispersing swelling and dissipating binds, eliminating carbuncle evacuation of pus, lowering the adverse-rising QI to resolve phlegm, analgesic therapy chase after the effects such as poison, all have very significant therapeutic effect to diseases such as dental ulcer of infant, suppurative tonsillitis, parotitiss, concrete effect refers to pharmacology and clinical trial.
Compared with prior art, Chinese medicine preparation of the present invention mainly contains some outstanding technical advantage following in treatment children's suppurative tonsillitis:
1, instant effect, cure rate are high, medical treatment combines, cure after not easily recur;
2, without any side effects, avoid using a large amount of antibiotic, very favourable to the growth promoter of infant;
3, preparation can be produced in batches, and the efficacy stability of preparation, individual variation are little, and the production technology of preparation and simple equipments are easy to apply, and benefit more patients.
Detailed description of the invention
Embodiment 1
Oral liquid is produced by the representational numerical value of the Chinese prescription of Chinese medicine preparation of the present invention various raw medicinal material scope and the optimized parameter of preparation technology of the present invention, select 7 groups of representational numerical value altogether, be numbered A, B, C, D, E, F, G respectively, wherein A, B, C are respectively the minima of each raw medicinal material numerical range, maximum and arbitrary value, D-G is respectively the numerical value of 4 preferred prescriptions, and the proportioning of each group raw material is as shown in table 1:
Table 1 is group proportioning raw materials table respectively
(1) by numerical value shown in table 1, take the ingredientss such as Radix Glehniae, Flos Lonicerae, Herba Houttuyniae, Herba Pogostemonis, Fructus Forsythiae, Radix Isatidis, Rhizoma Belamcandae, Radix Scrophulariae, Radix Platycodonis, Gypsum Fibrosum, Herba Taraxaci, Radix Peucedani, Rhizoma Phragmitis, Olibanum, Flos Chrysanthemi, Radix Glycyrrhizae respectively, pulverize respectively, for subsequent use;
(2) all medical materials are added the purified water of initial medical material 11 times of weight, soak 18 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.23-1.27 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 75% of 9 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.23-1.27 is for subsequent use;
(4) merged by the concentrated solution of step (2) and (3) gained, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5) Chinese medical concrete of step (4) is added adjuvant, utilize modern general Chinese medicine preparation technology to make oral liquid, specification: 0.36g crude drug/ml oral liquid.
Embodiment 2
The toxicity test of Chinese medicine preparation of the present invention
1, acute toxicity test
(1) test medicine: 7 kinds of oral liquids manufactured by the embodiment of the present invention 1.
(2) experimental animal: Kunming mouse, body weight 18g ± 2g, male and female half and half, female mice is all without pregnant.
(3) mouse stomach Chinese medicine oral liquid of the present invention, when given low reaches 837.6g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
(4) result of the test shows: the maximum dosage-feeding of the oral liquid manufactured by mouse stomach embodiment 1 is 837.6g crude drug/kg/d(LD
50> 837.6g crude drug/kg).Chinese medicine preparation adult (body weight is by 60 kilograms) clinical application every day total amount of the present invention is 0.36g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach oral liquid is 2326.7 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
2, long-term toxicity test for animals
(1) test medicine: 7 kinds of oral liquids manufactured by the embodiment of the present invention 1.
(2) experimental animal: regular grade SD rat, body weight 217g ± 8g, male and female half and half, female rats is all without pregnant.
(3) method and result:
7 kinds of Chinese medicine oral liquid: be divided into high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose; Experimental mouse is divided into 22 groups at random, and wherein the oral liquid of 21 groups of difference gavages, 7 kinds of three dosage, remains one group of gavage normal saline (20 times of patient's dose); All 21 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
Through long-term feeding, all there is not toxic reaction in 21 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 7 kinds of Chinese medicine oral liquid show without chronic toxicity animal.
By above two toxicity tests, prove that the Chinese medicine oral liquid that the present invention makes by embodiment 1 is safe, have no side effect, can be taken by patient.
Embodiment 3
The pharmacodynamic experiment of Chinese medicine preparation of the present invention
The oral liquid embodiment of the present invention 1 being numbered to D carries out pharmacodynamics test, and this oral liquid is hereinafter referred to as this product.
1. the refrigeration function of pair typhoid fever, paratyphoid fever, second triple vaccine pyrogenicity rabbit:
Get rabbit 60, experiment noon before that day and that morning, use electronic thermometer respectively, prediction anus temperature (in more than 39 DEG C or one day, body temperature fluctuation > 0.6 DEG C of person rejects) gets its meansigma methods as basal body temperature, by only weighing, through auricular vein, inject typhoid fever, paratyphoid fever, second triple vaccine 0.75ml/kg, survey its intensification degree after 1 hour, it is qualified to be considered as with >=0.8 DEG C.Be divided into this product high, medium and low dosage group, APC(APC (Aspirin Phenacetin and Caffeine)) organize and blank group, dosage is respectively 14.4g/kg, 7.2g/kg, 3.6g/kg, 0.0233g/kg, by the volume gavage that 5ml/kg rabbit is heavy, blank group to isopyknic normal saline gavage.Then respectively at administration 0.5h, 1.0h, 1.5h, 2.0h, 3.0h, 4.0h, 5.0h repetition measurement anus temperature, with basal body temperature more then calculating temperature difference, result with
represent, t inspection between statistical procedures method employing group, result is as shown in table 2, table 3.
The refrigeration function of table 2 this product oral liquid (
, n=10)
The refrigeration function of table 3 this product oral liquid (
, n=10) and (connecing table 1)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with APC group
△p < 0.05.
Table 1, table 2 data result shows that this product has obvious refrigeration function, within after high, medium and low dosed administration 30 minutes, gets final product onset, can the obvious heating peak of antagonism 90-120 minute, sustainable 4 hours of refrigeration function; Sustainable 5 hours of high dose refrigeration function.High dose is suitable with APC on the refrigeration function of 60-90 minute after medicine, is better than APC at the time period high dose successful of antagonistic 11 .5-4.0h.
2, to the inhibitory action of PGE2 synthesis in rat inflammation tissue
Get about 171 ± 9g rat 50, male and female are regardless of and are divided into 5 groups at random, Chinese medicine oral liquid of the present invention is high, in, low dosage, diclofenac matched group and blank group, often organize 10, dosage is the same, successive administration three days, after last medicine 1 hour, right back sufficient subcutaneous injection 1% carrageenin 0.1ml, cause scorching latter 4 hours, put to death rat, on ankle joint, 0.5cm place cuts swelling foot, peeling, shred, normal saline 5ml soaks 1 hour, soak centrifugal (1500rpm) 10 minutes, Aspirate supernatant 0.1ml, add the KOH-MeOH solution 2.0ml of 0.5mol/L, 50 DEG C of constant temperature isomeries 20 minutes, with methanol dilution to 20.0ml, at wavelength 278nm place, its absorbance (A) value is measured with UV-2100 ultraviolet spectrophotometer, result with
represent, t inspection between statistical procedures method employing group, result is as shown in table 4.
Table 4 Chinese medicine oral liquid of the present invention on the impact of PGE2 content in inflammatory tissue (
, n=10)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with diclofenac group
△p < 0.05.
Table 4 result shows, and the high, medium and low dosage of Chinese medicine oral liquid of the present invention can suppress the synthesis of PGE2 in rat inflammation tissue respectively to some extent, and high, medium and low dosage has pole significance, very significant and significant difference more respectively with blank group; Point out through statistical procedures: its effect of high dosage intensity is suitable with diclofenac.
3, to 0.6%HAC(acetic acid) cause mice pain reaction analgesic activity:
Get 18-20g male and healthy mice some, be divided into 6 groups at random, Chinese medicine oral liquid of the present invention is high, in, low dosage, Xiao'er Qingyan Granules group, Voltaren group and blank group, give Chinese medicine oral liquid 14.4g/kg of the present invention respectively, 7.2g/kg, 3.6g/kg, 10.24g/kg, Voltaren 9.75mg/kg, all by the volume gastric infusion of 0.25ml/10g body weight, blank group gives isopyknic water gastric infusion, for three days on end, 1 hour lumbar injection 0.6%HAC after mensuration last medicine respectively, 0.1ml/10g Mus is heavy, there is the writhing number of times in the incubation period and 15 minutes of writhing response in record, by formulae discovery pain suppression ratio (%), result with
represent, t inspection between statistical procedures method employing group, result is as shown in table 5.
Table 5 Chinese medicine oral liquid of the present invention to 0.6%HAC cause mice pain reaction effect (
, n=10)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with QINGYAN CHONGJI
△p < 0.05.
From table 5 result, high, the middle dosage of Chinese medicine oral liquid of the present invention all obviously can suppress the writhing incubation period of mice.The significant difference had in various degree is compared with water matched group; The high, medium and low dosage of Chinese medicine oral liquid of the present invention all obviously can reduce the writhing number of times of mice, compares with blank group the significant difference had in various degree, points out Chinese medicine preparation of the present invention to have good analgesic activity.From pain suppression ratio result: Chinese medicine preparation high dose of the present invention is suitable with diclofenac, is better than Xiao'er Qingyan Granules.In Chinese medicine oral liquid of the present invention, low dosage is suitable with Xiao'er Qingyan Granules.
In sum, pharmacodynamic experiment shows, and Chinese medicine oral liquid of the present invention has antipyretic, antiinflammatory preferably and analgesic activity.
Embodiment 4
The clinical trial of Chinese medicine oral liquid of the present invention
This clinical trial collect altogether suppurative tonsillitis patient 203 example, wherein 1-6 year 86 example, 6-14 year 117 example, oral ulcer merge suppurative tonsillitis 108 example, oral ulcer 23 example, parotitis 72 example.The oral liquid being numbered D by the embodiment of the present invention 1 is investigational agent.The oral oral liquid being numbered D of all patients, 1-6 year child, every day 2 times, each 10ml; The child in 6-14 year, every day 2 times, each 20ml; Within one week, be a course for the treatment of, treat 2 courses for the treatment of continuously.Statistical analysis is carried out to experimental result, finds healing 147 example, account for 72.4%; Effective 49 examples, account for 24.2%; Invalid 7 examples, account for 3.4%; Total effective rate is 96.6%.
Clinical test results proves further, and Chinese medicine preparation of the present invention shows very significant technical advantage when treating the diseases such as dental ulcer of infant, suppurative tonsillitis, parotitis, obtains beat all technological achievement.
Claims (8)
1. treat a Chinese medicine preparation for children's's suppurative tonsillitis, it is characterized in that being made up of the raw material of following weight portion: Radix Glehniae 10-24 part, Flos Lonicerae 13-27 part, Herba Houttuyniae 8-22 part, Herba Pogostemonis 7-15 part, Fructus Forsythiae 7-17 part, Radix Isatidis 11-25 part, Rhizoma Belamcandae 6-10 part, Radix Scrophulariae 12-28 part, Radix Platycodonis 7-19 part, Gypsum Fibrosum 16-28 part, Herba Taraxaci 12-26 part, Radix Peucedani 11-23 part, Rhizoma Phragmitis 10-22 part, Olibanum 4-8 part, Flos Chrysanthemi 12-26 part, Radix Glycyrrhizae 7-14 part.
2. the Chinese medicine preparation for the treatment of children's suppurative tonsillitis as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Glehniae 17 parts, Flos Lonicerae 20 parts, Herba Houttuyniae 15 parts, Herba Pogostemonis 11 parts, Fructus Forsythiae 12 parts, Radix Isatidis 18 parts, Rhizoma Belamcandae 8 parts, Radix Scrophulariae 20 parts, Radix Platycodonis 13 parts, Gypsum Fibrosum 22 parts, Herba Taraxaci 19 parts, Radix Peucedani 17 parts, Rhizoma Phragmitis 16 parts, Olibanum 6 parts, Flos Chrysanthemi 19 parts, 11 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of children's suppurative tonsillitis as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Glehniae 19 parts, Flos Lonicerae 22 parts, Herba Houttuyniae 14 parts, Herba Pogostemonis 11 parts, Fructus Forsythiae 14 parts, Radix Isatidis 16 parts, Rhizoma Belamcandae 8 parts, Radix Scrophulariae 22 parts, Radix Platycodonis 15 parts, Gypsum Fibrosum 21 parts, Herba Taraxaci 18 parts, Radix Peucedani 16 parts, Rhizoma Phragmitis 15 parts, Olibanum 6 parts, Flos Chrysanthemi 18 parts, 12 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation for the treatment of children's suppurative tonsillitis as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Glehniae 18 parts, Flos Lonicerae 21 parts, Herba Houttuyniae 16 parts, Herba Pogostemonis 12 parts, Fructus Forsythiae 13 parts, Radix Isatidis 19 parts, Rhizoma Belamcandae 7 parts, Radix Scrophulariae 21 parts, Radix Platycodonis 12 parts, Gypsum Fibrosum 24 parts, Herba Taraxaci 17 parts, Radix Peucedani 16 parts, Rhizoma Phragmitis 14 parts, Olibanum 7 parts, Flos Chrysanthemi 18 parts, 12 parts, Radix Glycyrrhizae.
5. the Chinese medicine preparation for the treatment of children's suppurative tonsillitis as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Glehniae 16 parts, Flos Lonicerae 18 parts, Herba Houttuyniae 16 parts, Herba Pogostemonis 13 parts, Fructus Forsythiae 14 parts, Radix Isatidis 19 parts, Rhizoma Belamcandae 9 parts, Radix Scrophulariae 24 parts, Radix Platycodonis 14 parts, Gypsum Fibrosum 23 parts, Herba Taraxaci 20 parts, Radix Peucedani 18 parts, Rhizoma Phragmitis 14 parts, Olibanum 5 parts, Flos Chrysanthemi 17 parts, 11 parts, Radix Glycyrrhizae.
6. prepare as arbitrary in claim 1-5 as described in the method for Chinese medicine preparation for the treatment of children's suppurative tonsillitis, it is characterized in that comprising following processing step:
(1) take Radix Glehniae, Flos Lonicerae, Herba Houttuyniae, Herba Pogostemonis, Fructus Forsythiae, Radix Isatidis, Rhizoma Belamcandae, Radix Scrophulariae, Radix Platycodonis, Gypsum Fibrosum, Herba Taraxaci, Radix Peucedani, Rhizoma Phragmitis, Olibanum, Flos Chrysanthemi, Radix Glycyrrhizae ingredients respectively by Chinese prescription, pulverize respectively, for subsequent use;
(2) all medical materials are added the purified water of initial medical material 6-13 times weight, soak 6-24 hour, backflow decocts 1-5 hour, filter, add the purified water of initial weight 3-9 times weight again, backflow decocts 1-4 hour, filters and retains filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.23-1.27 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 50-80% of 5-11 times of weight, reflux, extract, 2 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.23-1.27 is for subsequent use;
(4) merged by the concentrated solution of step (2) and (3) gained, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(5) Chinese medical concrete of step (4) is added adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs.
7. the Chinese medicine preparation of the treatment children's suppurative tonsillitis as described in as arbitrary in claim 1-5, is characterized in that: described Chinese medicine preparation is pill, tincture, capsule, tablet, granule, oral liquid, powder or syrup.
8. the application of Chinese medicine preparation in preparation treatment dental ulcer of infant, children's's suppurative tonsillitis, infantile parotitis medicine of the arbitrary described treatment children's suppurative tonsillitis of claim 1-5.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040948A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Formula of traditional Chinese medicine for treating pediatric acute suppurative tonsillitis |
| CN104027572A (en) * | 2014-05-28 | 2014-09-10 | 丁元霞 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040948A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Formula of traditional Chinese medicine for treating pediatric acute suppurative tonsillitis |
| CN104027572A (en) * | 2014-05-28 | 2014-09-10 | 丁元霞 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
Non-Patent Citations (1)
| Title |
|---|
| 向楠: "《中药临床药理学》", 31 January 2010, 中国医药科技出版社 * |
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