CN104825555B - A kind of drug for treating Parkinson's disease, preparation method and preparation - Google Patents
A kind of drug for treating Parkinson's disease, preparation method and preparation Download PDFInfo
- Publication number
- CN104825555B CN104825555B CN201510196897.4A CN201510196897A CN104825555B CN 104825555 B CN104825555 B CN 104825555B CN 201510196897 A CN201510196897 A CN 201510196897A CN 104825555 B CN104825555 B CN 104825555B
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- drug
- disease
- wilsonii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of drugs for preventing Parkinson's disease, which is characterized in that in parts by weight, including following components：0.001~0.002 part of 9~27 parts of wilsonii, 10~15 parts of rhodiola root, 12~18 parts of giant knotweed, 8~13 parts of vinegar tortoise plastron, 1~5 part of deer horn glue, 8~12 parts of Herba Cistanches, 0.1~1 part of antelope's horn and borneol.Scientific formulation is exquisite; it is theoretical according to traditional Chinese medical science monarch; each component passes through scientific compatibility; energy Mutiple Targets play the role of Parkinson's disease pre- control; with dopaminergic neuron in anti-nigral neurons apoptosis, protection black substance; the effects that inhibiting brain monoamine oxidase B (MAO B), increasing the content of DA in corpus straitum, so as to achieve the effect that prevent Parkinson's disease.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of drug, preparation method and system for preventing Parkinson's disease
Agent.
Background technology
Parkinson's disease (PD) is the common nervous system degeneration disease of middle-aged and elderly people and the most common cone of middle-aged and elderly people
External is disease.Over-65s prevalence is 10,00/,100,000.Increase with the age, a little higher than women of incidence of male.
The sick major clinical feature：Static tremor, slow movement and reduction, hypermyotonia, posture shakiness etc. are main feature.
At present, the treatment for Parkinson's disease there is no the method that can clearly effect a radical cure or drug.At this stage, clinically use more
Levodopa and its compound formulation treatment, but it is present with curative effect decline, on-off phenomenon, agent end phenomenon, unusual fluctuation disease and essence after long term usage
The adverse reactions such as refreshing symptom.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of drug for preventing Parkinson's disease, and scientific formulation is exquisite, according to the traditional Chinese medical science
Monarch is theoretical, and each component passes through scientific compatibility, can Mutiple Targets play the role of to Parkinson's disease it is pre- control, have the anti-black substance neural
Dopaminergic neuron in Apoptosis, protection black substance, inhibits brain monoamine oxidase B (MAO-B), increases DA in corpus straitum
The effects that content, so as to achieve the effect that prevent Parkinson's disease.
The second object of the present invention is to provide a kind of preparation method of the drug, this method simplicity, easy to operate, energy
The active ingredient of enough high efficiency extraction each components, promotes each component to play significant synergistic function.
The third object of the present invention is to provide the preparation that a kind of medicine preparation forms, the Small side effects of said preparation,
It is rapid-action, it is evident in efficacy, patient can according to itself need select dosage form, it is easy to use.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of drug for preventing Parkinson's disease, in parts by weight, including following components：
9~27 parts of wilsonii, 10~15 parts of rhodiola root, 12~18 parts of giant knotweed, 8~13 parts of vinegar tortoise plastron, deer horn glue 1~5
0.001~0.002 part of part, 8~12 parts of Herba Cistanches, 0.1~1 part of antelope's horn and borneol.
The drug of prevention Parkinson's disease provided by the invention, scientific formulation is exquisite, theoretical according to traditional Chinese medical science monarch, each group
Distribution 5 together, has played significant collaboration enhancing effect.Compared with prior art, the medicine for the treatment of Parkinson's disease of the invention
Object, can Mutiple Targets play the role of to Parkinson's disease it is pre- control, have the dopaminergic in anti-nigral neurons apoptosis, protection black substance refreshing
Through member, the effects that inhibiting brain monoamine oxidase B (MAO-B), increase the content of DA in corpus straitum, so as to reach prevention pa gold
The effect of gloomy disease.
Specifically, the combinatorial principle of inventive formulation is as follows：
Monarch drug in a prescription includes wilsonii and rhodiola root.Wilsonii acrid flavour, slight bitter, slightly warm in nature, return liver,spleen,kidney, the heart channel of Hang-Shaoyin, wind-damp dispelling,
Filling liver kidney, strengthening the bones and muscles, arteries and veins of invigorating blood circulation are felt at ease, strong will.Rhodiola root is sweet in flavor, bitter, flat, return lung, the heart channel of Hang-Shaoyin, can qi and activate blood circulation, promote blood circulation it is flat
Asthma, eliminating evil bad odor mend various symptims and signs of deficiency.The benefits of the two is monarch drug in a prescription, is shared up to tonifying Qi of the kidney, blood circulation and channel invigorating, strengthening the bones and muscles.
Ministerial drug includes vinegar tortoise plastron, deer horn glue, Herba Cistanches and giant knotweed.Vinegar tortoise plastron taste is salty sweet, flat, enters the heart, kidney, liver three and passes through, energy
Nourishing and suppressing Yang, the strong bone of kidney-nourishing, blood-nourishing bushing.Deer horn glue is sweet in flavor, salty, warm, returns kidney, Liver Channel, can warm filling liver kidney, strengthening the essence blood-nourishing.Meat
Desert cistanche is sweet in flavor, salty, warm, returns kidney, large intestine channel, and kidney-replenishing, benefiting essence-blood relax bowel.Giant knotweed is bitter, cold, Return liver, courage, lung channel, promoting blood circulation
Dredging collateral, clearing heat and promoting diuresis.Four medicines are combined into minister, and a tonifying yin, a yang-tonifying is reachable to tonify the liver and kidney, beneficial marrow blood-nourishing, Heibei provincial opera negative and positive, and has
The work(of dredging collateral and promoting blood circulation dehumidifying.
Antelope's horn is adjutant, and taste is salty, cold in nature, enters Liver Channel.《Compendium of Materia Medica》It records, " adult's apoplexy is twitched and passages through which vital energy circulates contraction is anxious,
Joint-running tug pain and antelope's horn can relax it ", therefore can auxiliary monarch-minister drug to the greatest extent reach calming the liver to stop the wind work(.
The benefits of borneol acrid flavour is bitter, cool, enters the heart, spleen, and lung channel has and leads to all keys, dissipates stagnated fire.This product is makes, resuscitation with aromatics, leads to
Blood-brain barrier is crossed, and it is long in brain depot accumulation time, amount is also quite high, can draw all medicines and enter brain.
Each component dosage in prescription of the present invention is also by scientific matching, and ingredients complements each other, it is various activity into
/ presence synergistic effect.Preferably, in parts by weight, the dosage of each component is：15~25 parts of wilsonii, rhodiola root 12~
15 parts, 15~18 parts of giant knotweed, 10~13 parts of vinegar tortoise plastron, 3~5 parts of deer horn glue, 10~12 parts of Herba Cistanches, antelope's horn 0.3~0.7
0.00125~0.002 part of part and borneol.
It is further preferred that in parts by weight, the dosage of each component is：18~20 parts of wilsonii, rhodiola root 12~13
Part, 15~16 parts of giant knotweed, 10~12 parts of vinegar tortoise plastron, 3~4 parts of deer horn glue, 10~12 parts of Herba Cistanches, 0.3~0.5 part of antelope's horn
With 0.00125~0.002 part of borneol.
A kind of preparation method of drug provided by the invention, includes the following steps：
(1) vinegar tortoise plastron add water to cook 1~1.5 it is small when after, sequentially add giant knotweed, wilsonii, rhodiola root, Herba Cistanches and continue to decoct
Boil 2~2.5 it is small when；
(2) filtered after decocting, collect filtrate and the dregs of a decoction；Slag of getting it filled add water to cook 1.5~2 it is small when after refilter, will
The filtrate being collected into merges with the filtrate that first time is collected by filtration；
(3) above-mentioned merging filtrate is heated, is put into deer horn glue molten, thick paste is made；The antelope's horn and ice of crushing are added in afterwards
Piece powder mixing is to get the drug.
The preparation method of prevention anti-parkinson drug provided by the invention is easy, easy to operate, being capable of high efficiency extraction each component
Active ingredient, each component is promoted to play significant synergistic function.
Active ingredient in medicinal material can be dissolved in the water by decoction process, therefore, the present invention in decocting herbs when except
It using the specific time, carries out outside decoction twice, it is preferable that in step (1) and step (2), in the decoction process, first use
Boil by intense fire, rear slow boiling keeps slight boiling condition, in order to avoid concoction overflow or it is too fast boil dry, slow down moisture evaporation, be conducive to effectively into
The dissolution of part.
Preferably, in step (3), the deer horn glue molten specifically includes：Deer horn glue is clayed into power, and is put into and is heated to 60
It in~70 DEG C of merging filtrate, is stirred continuously, until deer horn glue all dissolves.
The preparation that a kind of medicine preparation provided by the invention forms.
Drug provided by the invention can be prepared into pharmaceutical preparation, and the Small side effects of Chinese medicine preparation, rapid-action, curative effect is shown
Write, patient can according to itself need select dosage form, it is easy to use.
Preferably, the dosage form of the preparation includes any one in tablet, granule, capsule, pill.
In order to ensure the efficacy stability of preparation, longer time can be preserved, it is preferable that further include pharmaceutically acceptable
Auxiliary material.
Preferably, the auxiliary material includes wetting agent, adhesive, filler, disintegrant, lubricant, coating material, figuration
One or more in agent, preservative.
Compared with prior art, beneficial effects of the present invention are：
(1) drug of prevention Parkinson's disease provided by the invention, scientific formulation is exquisite, theoretical according to traditional Chinese medical science monarch,
Each component compatibility together, has played significant collaboration enhancing effect.Compared with prior art, treatment Parkinson's disease of the invention
Drug, can Mutiple Targets play the role of to Parkinson's disease it is pre- control, have anti-nigral neurons apoptosis, protect black substance in dopamine
The effects that serotonergic neuron inhibits brain monoamine oxidase B (MAO-B), increases the content of DA in corpus straitum, so as to reach prevention
The effect of Parkinson's disease.
(2) preparation method of prevention anti-parkinson drug provided by the invention is easy, easy to operate, being capable of high efficiency extraction each group
The active ingredient divided promotes each component to play significant synergistic function.
(3) pharmaceutical composition provided by the invention can be prepared into pharmaceutical preparation, and the Small side effects of pharmaceutical preparation work
Soon, it is evident in efficacy, patient can according to itself need select dosage form, it is easy to use.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person, the condition suggested according to normal condition or manufacturer carry out.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
Embodiment 1
1 embodiment of table, 1 each component dosage/g
| Wilsonii | Rhodiola root | Giant knotweed | Vinegar tortoise plastron | Deer horn glue | Herba Cistanches | Antelope's horn | Borneol |
| 9 | 10 | 12 | 8 | 1 | 8 | 0.1 | 0.001 |
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root, meat
Desert cistanche continue decoct 2 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition.It filters, receives after decoction
Collect filtrate and the dregs of a decoction；Slag of getting it filled add water to cook 1.5 it is small when after refilter, by the filtrate that is collected into being collected by filtration for the first time
Filtrate merges.Above-mentioned merging filtrate is heated to 60 DEG C, is put into the deer horn glue ground, carry out molten is stirred continuously, all dissolves
Thick paste is made afterwards；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
Embodiment 2
2 embodiment of table, 2 each component dosage/g
| Wilsonii | Rhodiola root | Giant knotweed | Vinegar tortoise plastron | Deer horn glue | Herba Cistanches | Antelope's horn | Borneol |
| 15 | 12 | 15 | 10 | 3 | 10 | 0.4 | 0.0013 |
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root, meat
Desert cistanche continue decoct 2 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition.It filters, receives after decoction
Collect filtrate and the dregs of a decoction；Slag of getting it filled add water to cook 1.5 it is small when after refilter, by the filtrate that is collected into being collected by filtration for the first time
Filtrate merges.Above-mentioned merging filtrate is heated to 65 DEG C, is put into the deer horn glue of chopping, carry out molten is stirred continuously, all dissolves
Thick paste is made afterwards；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
Embodiment 3
3 embodiment of table, 3 each component dosage/g
| Wilsonii | Rhodiola root | Giant knotweed | Vinegar tortoise plastron | Deer horn glue | Herba Cistanches | Antelope's horn | Borneol |
| 27 | 15 | 12 | 13 | 5 | 12 | 1 | 0.002 |
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1.5 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root,
Herba Cistanches continue decoct 2.5 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition..Mistake after decoction
Filtrate and the dregs of a decoction are collected in filter；Slag of getting it filled add water to cook 2 it is small when after refilter, by the filtrate being collected into and for the first time be collected by filtration
The filtrate arrived merges.Above-mentioned merging filtrate is heated to 70 DEG C, is put into the deer horn glue of chopping, is stirred continuously carry out molten, all
Thick paste is made after dissolving；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
Embodiment 4
4 embodiment of table, 4 each component dosage/g
| Wilsonii | Rhodiola root | Giant knotweed | Vinegar tortoise plastron | Deer horn glue | Herba Cistanches | Antelope's horn | Borneol |
| 25 | 13 | 16 | 13 | 4 | 11 | 0.7 | 0.0015 |
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1.5 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root,
Herba Cistanches continue decoct 2.5 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition..Mistake after decoction
Filtrate and the dregs of a decoction are collected in filter；Slag of getting it filled add water to cook 2 it is small when after refilter, by the filtrate being collected into and for the first time be collected by filtration
The filtrate arrived merges.Above-mentioned merging filtrate is heated to 70 DEG C, is put into the deer horn glue of chopping, is stirred continuously carry out molten, all
Thick paste is made after dissolving；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
Embodiment 5
5 embodiment of table, 5 each component dosage/g
| Wilsonii | Rhodiola root | Giant knotweed | Vinegar tortoise plastron | Deer horn glue | Herba Cistanches | Antelope's horn | Borneol |
| 20 | 13 | 16 | 12 | 4 | 12 | 0.5 | 0.0015 |
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1.5 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root,
Herba Cistanches continue decoct 2.5 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition..Mistake after decoction
Filtrate and the dregs of a decoction are collected in filter；Slag of getting it filled add water to cook 2 it is small when after refilter, by the filtrate being collected into and for the first time be collected by filtration
The filtrate arrived merges.Above-mentioned merging filtrate is heated to 70 DEG C, is put into the deer horn glue of chopping, is stirred continuously carry out molten, all
Thick paste is made after dissolving；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
Embodiment 6
6 embodiment of table, 6 each component dosage/g
Preparation method includes the following steps：
Vinegar tortoise plastron add water boil by intense fire after keep slight boiling condition 1 it is small when, sequentially add giant knotweed, wilsonii, rhodiola root, meat
Desert cistanche continue decoct 2 it is small when, decoct when equally boil with high heat, after be always maintained at slight boiling condition..It is filtered after decoction,
Collect filtrate and the dregs of a decoction；Slag of getting it filled add water to cook 1.5 it is small when after refilter, by the filtrate being collected into for the first time be collected by filtration
Filtrate merge.Above-mentioned merging filtrate is heated to 65 DEG C, is put into the deer horn glue of chopping, is stirred continuously carry out molten, it is all molten
Thick paste is made after solution；Add in afterwards crushing antelope's horn and borneol powder mixing to get the drug.
, it is necessary to illustrate the following in the preparation method of drug of the present invention：
(1) in decoction process for the first time, amount of water is with not excessively and higher than giant knotweed, wilsonii, rhodiola root and Herba Cistanches medicinal material
5~6cm of flat spreading part is advisable.If being found in decoction process, water is on the low side, can suitably supplement a certain amount of boiling water.
(2) the common filtered through gauze when filter method in the present invention can be used field of Chinese medicines decocting herbs, cooperation two
Secondary decoction, active ingredient that can be in high efficiency extraction medicinal material.Except filtered through gauze, other more efficient separation of solid and liquid sides also can be used
Method, such as be filtered under diminished pressure, centrifuge, UF membrane.Or dose it is larger when, the effective ingredient that may retain after decocting twice
It is more, it can suitably increase decoction number.
The particle of the Chinese medicine for the treatment of Parkinson's disease in the embodiment of the present invention is applied to clinic, and general use takes orally, and
It taken three times per day, take warm water and take within early, middle and late one hour after meal, 8 grams every time, 1 month as a treatment course.The course for the treatment of is January.Through
Clinical 122 verifications, significant curative effect rate are 85.6%, total effective rate 99%.Typical clinical case is as follows：
Case one：Female 67 years old, does not shake independently come the double upper limbs of patient when examining, apparent when static, with bradykinesia, limbs
Spasm, salivation, decrease of memory, festinating gait, receive sleep poor, urine tune, stool do, 3-4 days a line, tongue is dark red, and tongue is white, and arteries and veins is thin
String.Disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering is diagnosed as, this medicine is taken orally afterwards, taken three times per day, take warm water and take within one hour after meal,
It 8 grams every time, even served more than January, double upper limbs are not shaken independently, bradykinesia, limb spasm, and salivation improves earlier above, then takes 1 month,
Double upper limbs are not shaken independently, bradykinesia, limb spasm, and salivation is improved, modulation of defecating.
Case two：Man 75 years old, does not shake independently come patient's four limbs when examining, apparent when static, improves after activity, with movement
Slow, when walking, leans forward, slow in reacting, limb rigidity, spasm, salivation, decrease of memory, festinating gait, receives poor, urine of sleeping
It adjusts, stool is dry, and a line on the 4th, tongue is dark red, and tongue is white, the thin string of arteries and veins.Disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering is diagnosed as, it is rear to take orally this
Medicine taken three times per day, and takes warm water and takes within one hour after meal, 8 grams every time, even served more than January, and double upper limbs are not shaken independently, moved late
Slow, limb spasm, stiff, salivation improve, then take 2 months earlier above, and four limbs are not shaken independently, bradykinesia, limb rigidity, convulsion
Contraction, salivation etc. are improved, modulation of defecating.
Case three：Man 62 years old, does not shake independently come patient's right upper extremity when examining, apparent when static, improves after activity, under double
Limb is weak, and dragging step, random little step, bradykinesia, when walking leans forward, slow in reacting, limb rigidity, spasm, salivation, memory for walking
Decline, receive sleep poor, urine tune, stool do, a line on the 4th, tongue is dark red, and tongue is greasy in vain, the thin string of arteries and veins.It is diagnosed as quiver disease (deficiency of liver-yin and kidney-yin, muscle
Abrupt wind moves), this medicine is taken orally afterwards, be taken three times per day, is taken warm water and take within one hour after meal, 8 grams every time, even served more than January, right upper extremity is not
Autonomous shake, sleep, bradykinesia, limb spasm, stiff, salivation improve earlier above, modulation of defecating, then take 2 months, only right upper extremity
It does not shake independently slightly, action is apparent flexible earlier above, and no salivation, stool is adjusted.
Case four：Man 77 years old, does not shake independently come the double upper limbs of patient when examining, apparent when static, improves, reacts after activity
Blunt, limb rigidity, spasm, salivation, double lower limb is weak, heavy, and dragging step, random little step, bradykinesia, when walking leans forward for walking,
Receive sleep poor, urine tune, stool do, a line on the 3rd, tongue is dark red, and tongue is white, the thin string of arteries and veins.It is diagnosed as quiver disease (deficiency of liver-yin and kidney-yin, muscular contracture wind
It is dynamic), this medicine is taken orally afterwards, be taken three times per day, is taken warm water and take within one hour after meal, 8 grams every time, even served more than January, double upper limbs are not autonomous
Shake, sleep, bradykinesia, limb spasm, stiff, salivation improve earlier above, modulation of defecating, then take 2 months, and only double upper limbs are slight
It does not shake independently, action is apparent flexible earlier above, and no salivation, stool is adjusted.
Case five：Man, 77 years old, come patient's apathy such as mask face when examining, four limbs were stiff, spasm, and double upper limbs are not autonomous
Shake, it is apparent when static, it improves after activity, slow in reacting, salivation, double lower limb is weak, heavy, and dragging step, random little step moves for walking
Slow, when walking, leans forward, and receives poor, urine tune of sleeping, and stool does, and a line on the 3rd, tongue is dark red, and tongue is white, the thin string of arteries and veins.It is diagnosed as the disease (liver that quivers
Kidney-yin deficiency, muscular contracture are pneumatic), this medicine is taken orally afterwards, be taken three times per day, is taken warm water and take within one hour after meal, 8 grams every time, even served January
Remaining, facial expression is flexible earlier above, double upper limbs not independently shake, sleep, bradykinesia, limb spasm, it is stiff, salivation it is good earlier above
Turn, modulation of defecating, then take 2 months, action is apparent flexible earlier above, and stool is adjusted.
Case six：Man 55 years old, does not shake independently come the double upper limbs of patient when examining, apparent when static, improves, reacts after activity
Blunt, salivation, double lower limb is weak, heavy, and apathy such as mask face, four limbs are stiff, spasm, and dragging step, random little step moves for walking
Slow, when walking, leans forward, and receives poor, urine tune of sleeping, and stool does, and a line on the 3rd, tongue is dark red, and tongue is white, the thin string of arteries and veins.Once DOPA silk was taken
125mg of hydrazine, day, but symptom control was still poor, is diagnosed as disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering three times, afterwards this oral medicine, day
Clothes three times, are taken warm water and are taken, 8 grams every time, even served more than January for one hour after meal, and double upper limbs are not shaken independently, sleep, movement is slow
Slow, limb spasm, stiff, salivation improve earlier above, and facial expression is flexible earlier above, modulation of defecating, then take 2 months, and action is bright earlier above
Make its presence or power felt work, stool is adjusted.Benserazide reduces to a 62.5mg, and day is three times.
Case seven：Female 63 years old, does not shake independently come patient's four limbs when examining, and left upper extremity is apparent, apparent when static, activity and
It improves after sleep, poor memory is slow in reacting, and salivation, double lower limb is weak, heavy, mask face, and four limbs are stiff, spasm, and walking is dragged
Step, random little step, bradykinesia, when walking, lean forward, and receive poor, urine tune of sleeping, and stool is dry, a line on the 4th, and pale tongue purple, tongue is white, and arteries and veins is thin
String.Once 250mg of Benserazide was taken, day, but symptom control was still poor, is diagnosed as quiver disease (deficiency of liver-yin and kidney-yin, muscular contracture wind three times
It is dynamic), this medicine is taken orally afterwards, be taken three times per day, is taken warm water and take within one hour after meal, 8 grams every time, even served more than January, double upper limbs are not autonomous
Shake, sleep, bradykinesia, limb spasm, stiff, salivation improve earlier above, and facial expression is flexible earlier above, modulation of defecating, then take 2
A month, salivation disappeared, and action is apparent flexible earlier above, and stool is adjusted.Benserazide reduces to a 125mg, and day is twice.
Case eight：Female, 68 years old, come patient's double lower limb when examining is weak, four limbs are not shaken independently, left upper extremity was apparent, activity and
It improves after sleep, poor memory is slow in reacting, and salivation, four limbs are stiff, spasm, random little step, bradykinesia, and when walking leans forward, and receives
It is poor to sleep, and urine tune, dry and hard excrement is difficult to resolve, a line on the 5th, and pale tongue is purple, and tongue is white, the thin string of arteries and veins.Once 125mg of Benserazide was taken,
Day three times, is diagnosed as disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering, and takes orally this medicine afterwards, taken three times per day, take warm water and send within one hour after meal
Clothes, 8 grams every time, even served more than January, double lower limb is weak, four limbs not independently shake, sleep, bradykinesia, limb spasm, it is stiff,
Salivation improves earlier above, stool a line on the one, then takes 2 months, and salivation disappears, and action is apparent flexible earlier above, and stool is adjusted.Benserazide
A 125mg is reduced to, day is twice.
Case nine：Man 78 years old, does not shake independently come patient's four limbs when examining, and right side limbs are apparent, apparent when static, activity
And improve after sleep, right upper extremity, which has, rubs the action of ball sample with the hands, and poor memory is slow in reacting, and salivation, four limbs are stiff, spasm, random little step,
Bradykinesia, receive sleep it is poor, urine tune, dry and hard excrement is difficult to resolve, a line on the 3rd, pale tongue purple, tongue is white, the thin string of arteries and veins.Take Benserazide one
Secondary 125mg, day twice, are diagnosed as disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering, and take orally this medicine afterwards, taken three times per day, and take within one hour after meal
It is taken, 8 grams every time, even served more than January with warm water, double lower limb is weak, and four limbs do not shake more apparent improvement independently, and sleep, movement are slow
Slow, limb spasm, stiff, salivation improve earlier above, a line on the one of defecating, then take 2 months, and salivation disappears, action apparent spirit earlier above
Living, stool is adjusted.Benserazide reduces to a 62.5mg, and day is twice.
Case ten：Man, 70 years old, slow come patient's nyctinastic movement when examining, poor memory was slow in reacting, salivation, four limbs are stiff,
Spasm, random little step, no Limb shaking, receive sleep it is poor, urine tune, dry and hard excrement is difficult to resolve, a line on the 3rd, pale tongue purple, tongue is white, the thin string of arteries and veins.
125mg of Benserazide is taken, day twice, is diagnosed as disease (deficiency of liver-yin and kidney-yin, muscular contracture are pneumatic) of quivering, this medicine is taken orally afterwards, day takes three
It is secondary, it takes warm water and takes within one hour after meal, 8 grams every time, even served more than January, bradykinesia, limb spasm, stiff, salivation is good earlier above
Turn, stool a line on the 2nd, then take 2 months, salivation disappears, and action is apparent flexible earlier above, and stool is adjusted.Benserazide is reduced to once
62.5mg, day is twice.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of drug for treating Parkinson's disease, which is characterized in that in parts by weight, be made of following components：Wilsonii 9~27
Part, 10~15 parts of rhodiola root, 12~18 parts of giant knotweed, 8~13 parts of vinegar tortoise plastron, 1~5 part of deer horn glue, 8~12 parts of Herba Cistanches, antelope
0.001~0.002 part of 0.1~1 part of angle and borneol.
2. drug according to claim 1, which is characterized in that in parts by weight, be made of following components：Wilsonii 15~
25 parts, 12~15 parts of rhodiola root, 15~18 parts of giant knotweed, 10~13 parts of vinegar tortoise plastron, 3~5 parts of deer horn glue, 10~12 parts of Herba Cistanches,
0.00125~0.002 part of 0.3~0.7 part of antelope's horn and borneol.
3. drug according to claim 1, which is characterized in that in parts by weight, be made of following components：Wilsonii 18~
20 parts, 12~13 parts of rhodiola root, 15~16 parts of giant knotweed, 10~12 parts of vinegar tortoise plastron, 3~4 parts of deer horn glue, 10~12 parts of Herba Cistanches,
0.00125~0.002 part of 0.3~0.5 part of antelope's horn and borneol.
4. the preparation method of any one of a kind of claims 1 to 3 drug, which is characterized in that include the following steps：
(1) vinegar tortoise plastron add water to cook 1~1.5 it is small when after, sequentially add giant knotweed, wilsonii, rhodiola root, Herba Cistanches and continue decoction 2
~2.5 it is small when；
(2) filtered after decocting, collect filtrate and the dregs of a decoction；Slag of getting it filled add water to cook 1.5~2 it is small when after refilter, will collect
To filtrate merge with the filtrate that is collected by filtration of first time；
(3) above-mentioned merging filtrate is heated, is put into deer horn glue molten, thick paste is made；The antelope's horn of crushing and borneol powder are added in afterwards
Last mixing is to get the drug.
5. preparation method according to claim 4, which is characterized in that described to decoct in step (1) and step (2)
Cheng Zhong first boils, keeps slight boiling condition afterwards with high heat.
6. preparation method according to claim 4, which is characterized in that in step (3), the deer horn glue molten is specifically wrapped
It includes：Deer horn glue is clayed into power, and is put into and is heated in 60~70 DEG C of merging filtrate, is stirred continuously, until deer horn glue all dissolves.
7. the preparation that a kind of any one of claims 1 to 3 medicine preparation forms.
8. preparation according to claim 7, which is characterized in that the dosage form of the preparation is selected from tablet, granule, capsule
Any one in agent, pill.
9. preparation according to claim 7, which is characterized in that be additionally added pharmaceutically acceptable auxiliary material.
10. preparation according to claim 9, which is characterized in that the auxiliary material is selected from wetting agent, adhesive, filler, collapses
Solve the one or more in agent, lubricant, coating material, preservative.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510196897.4A CN104825555B (en) | 2015-04-23 | 2015-04-23 | A kind of drug for treating Parkinson's disease, preparation method and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510196897.4A CN104825555B (en) | 2015-04-23 | 2015-04-23 | A kind of drug for treating Parkinson's disease, preparation method and preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104825555A CN104825555A (en) | 2015-08-12 |
| CN104825555B true CN104825555B (en) | 2018-06-01 |
Family
ID=53804006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510196897.4A Expired - Fee Related CN104825555B (en) | 2015-04-23 | 2015-04-23 | A kind of drug for treating Parkinson's disease, preparation method and preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104825555B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017030167A1 (en) * | 2015-08-18 | 2017-02-23 | レジリオ株式会社 | Agent for reconstructing/activating neural network |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549053A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Medicine for treating Parkinson's disease and production method thereof |
| CN104257876A (en) * | 2014-06-19 | 2015-01-07 | 三普药业有限公司 | Applications of Xinnaoxin capsule in preparation of medicines treating Parkinson's disease |
-
2015
- 2015-04-23 CN CN201510196897.4A patent/CN104825555B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549053A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Medicine for treating Parkinson's disease and production method thereof |
| CN104257876A (en) * | 2014-06-19 | 2015-01-07 | 三普药业有限公司 | Applications of Xinnaoxin capsule in preparation of medicines treating Parkinson's disease |
Non-Patent Citations (3)
| Title |
|---|
| 中医药治疗帕金森病研究进展;谭文澜;《实用中医内科杂志》;20120731;第26卷(第7期);第95-97页 * |
| 刺五加治疗帕金森病的临床研究;况时祥等;《吉林中医药》;20040131;第25卷(第1期);第14-15页 * |
| 龟鹿地黄汤治疗肝肾阴虚型帕金森病的安全性和有效性探讨;林善华;《中国处方药》;20140815;第12卷(第8期);第10-11页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104825555A (en) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109260298B (en) | Navel paste | |
| CN102228485B (en) | Composition for burn rehabilitation and preparation method thereof | |
| CN102100828A (en) | Medicament for treating diabetes mellitus | |
| CN102210844A (en) | Chinese medicinal composition for treating chronic hepatitis and preparation method thereof | |
| CN104825555B (en) | A kind of drug for treating Parkinson's disease, preparation method and preparation | |
| CN106036345A (en) | Kudzu vine root and cassia seed solid beverage and preparation method thereof | |
| CN102600343B (en) | Traditional Chinese medicinal preparation for treating oral diseases and/or toothache | |
| CN109453317A (en) | A kind of anaesthetic and its preparation process for strengthening by means of tonics | |
| CN102302550B (en) | Medicament for treating coronary heart disease | |
| CN104548049A (en) | Traditional Chinese medicine composition for treating senile osteoporosis and preparation method thereof | |
| CN102988747B (en) | Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof | |
| CN111407788A (en) | External traditional Chinese medicine or health product for dispelling wind, cold and dampness, stasis, arthralgia, pain and swelling, dredging channels and collaterals and tonifying yang | |
| CN110339323A (en) | A kind of Chinese medicine composition and its preparation method and application for treating bradycardia | |
| CN104771604B (en) | A kind of drug for treating apoplexy, preparation method and preparation | |
| CN104069271B (en) | A kind of medicine for treating hyperosteogeny | |
| CN108295215A (en) | A kind of Chinese medicine preparation and preparation method for treating the left paralysis and right paralysis of body after apoplexy | |
| CN103182035B (en) | Traditional Chinese medicine composition used for treating chronic arrhythmia of elderly people and preparation method of traditional Chinese medicine composition | |
| CN101396468B (en) | Traditional Chinese medicine for treating diabetes coronary heart disease | |
| CN107233406A (en) | A kind of traditional Chinese medicine for outer use for treating hormone face | |
| CN107137689A (en) | A kind of Chinese medicine composition for treating menopausal syndrome | |
| CN106420926A (en) | Traditional Chinese medicine for treating nasosinusitis and preparation method thereof | |
| CN105412322A (en) | Traditional Chinese medicine preparation for treating diabetic peripheral neuropathic pain and preparation method thereof | |
| CN100518801C (en) | Broad spectrumed antiseptic pure Chinese medicine preparation and its preparation method | |
| CN105031286A (en) | Chinese herb preparation for treating iron-deficiency anemia and preparation method thereof | |
| CN104922488A (en) | Traditional Chinese medicine composition for preventing and curing Parkinson's disease or Parkinson's disease motor complications and preparing method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180207 Address after: 550000 Nanming District, Guiyang, Guizhou Province, City East Road 50 Applicant after: Guiyang College of Traditional Chinese Medicine Address before: 550000 Guizhou province Yunyan District of Guiyang City Xin Xin Park District 38 Building 1 unit 301 room Applicant before: Wu Yuanhua |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 550025 No.4, Dongqing Road, Huaxi University Town, Huaxi District, Guiyang City, Guizhou Province Patentee after: Guizhou University of Traditional Chinese Medicine Address before: 550000 50 Shidong Road, Nanming District, Guiyang City, Guizhou Province Patentee before: GUIYANG College OF TRADITIONAL CHINESE MEDICINE |
|
| CP03 | Change of name, title or address | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180601 Termination date: 20210423 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |